ClinVar Miner

Variants in gene combination RAD51D, RAD51L3-RFFL

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
58 62 450 321 26 4 1 824

Condition and significance breakdown #

Total conditions: 9
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Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Hereditary cancer-predisposing syndrome 41 31 316 211 10 0 0 587
Breast-ovarian cancer, familial 4 36 35 254 54 5 4 0 374
not provided 14 11 100 113 15 0 1 240
not specified 0 0 21 98 18 0 0 127
Hereditary breast and ovarian cancer syndrome 4 3 34 1 0 0 0 42
Breast and Ovarian Cancer Susceptibility 0 0 15 14 0 0 0 29
Ovarian Neoplasms 2 2 0 0 0 0 0 4
Inborn genetic diseases 0 0 1 0 0 0 0 1
Lynch syndrome I 0 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 24
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Ambry Genetics 34 27 261 124 4 0 0 450
Invitae 36 21 239 118 11 0 0 425
Color 16 7 143 133 10 0 0 309
GeneDx 14 11 74 97 19 0 0 215
Counsyl 6 13 22 27 4 0 0 72
Mendelics 3 4 38 12 0 0 0 55
Integrated Genetics/Laboratory Corporation of America 3 1 32 10 4 0 0 50
Quest Diagnostics Nichols Institute San Juan Capistrano 4 1 23 17 6 0 0 49
Illumina Clinical Services Laboratory,Illumina 0 0 15 14 0 0 0 29
PreventionGenetics,PreventionGenetics 1 0 7 5 6 0 0 19
GeneKor MSA 0 0 13 0 0 0 0 13
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 1 0 6 3 2 0 0 12
Fulgent Genetics,Fulgent Genetics 2 1 6 0 0 0 0 9
True Health Diagnostics 0 0 1 6 1 0 0 8
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 5 1 0 0 0 6
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 2 0 3 0 0 5
OMIM 0 0 0 0 0 4 0 4
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 2 2 0 0 0 0 0 4
University of Washington Department of Laboratory Medicine, University of Washington 0 0 1 1 0 0 0 2
Genetic Services Laboratory, University of Chicago 0 0 0 1 0 0 0 1
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 1 0 0 0 0 1
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 1 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 1 1
Clinical Cancer Genetics and Family Consultants,Athens Medical Center 0 1 0 0 0 0 0 1

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