ClinVar Miner

Variants in gene combination RAD51D, RAD51L3-RFFL

See also:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
79 74 606 357 28 4 2 1032

Condition and significance breakdown #

Total conditions: 14
Download table as spreadsheet
Condition pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Breast-ovarian cancer, familial 4 53 49 429 169 15 4 1 688
Hereditary cancer-predisposing syndrome 42 33 363 247 10 0 0 670
not provided 17 12 107 52 11 0 1 189
not specified 0 0 36 101 20 0 0 143
Hereditary breast and ovarian cancer syndrome 6 7 36 1 0 0 0 48
Malignant tumor of breast 3 2 14 11 1 0 0 31
Breast and/or ovarian cancer 6 1 0 0 0 0 0 7
Neoplasm of ovary 2 2 0 0 0 0 0 4
Breast and Ovarian Cancer Susceptibility 0 0 3 0 0 0 0 3
Carcinoma of colon 0 0 1 0 0 0 0 1
Hereditary site-specific ovarian cancer syndrome 1 0 0 0 0 0 0 1
Inborn genetic diseases 0 0 1 0 0 0 0 1
Lynch syndrome I 0 1 0 0 0 0 0 1
See cases 0 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 34
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor not provided total
Invitae 53 32 413 151 12 0 0 661
Ambry Genetics 34 25 257 130 4 0 0 450
Color Health, Inc 23 16 214 182 10 0 0 445
GeneDx 14 11 74 97 19 0 0 215
Integrated Genetics/Laboratory Corporation of America 5 3 48 17 6 0 0 79
Counsyl 6 13 22 27 4 0 0 72
Quest Diagnostics Nichols Institute San Juan Capistrano 5 1 30 20 6 0 0 60
Mendelics 3 4 36 12 0 0 0 55
Department of Pathology and Laboratory Medicine,Sinai Health System 3 3 21 11 1 0 0 39
PreventionGenetics, PreventionGenetics 1 0 7 5 6 0 0 19
CeGaT Praxis fuer Humangenetik Tuebingen 3 0 8 3 0 0 0 14
GeneKor MSA 0 0 13 0 0 0 0 13
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 1 0 6 3 2 0 0 12
Fulgent Genetics,Fulgent Genetics 2 1 6 0 0 0 0 9
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 3 6 0 0 0 0 9
True Health Diagnostics 0 0 1 6 1 0 0 8
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 3 1 3 0 0 7
CZECANCA consortium 6 1 0 0 0 0 0 7
Institute of Human Genetics, University of Leipzig Medical Center 2 0 2 0 1 0 0 5
OMIM 0 0 0 0 0 4 0 4
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 2 2 0 0 0 0 0 4
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 2 2 0 0 0 0 0 4
King Laboratory,University of Washington 2 0 0 0 1 0 0 3
Illumina Clinical Services Laboratory,Illumina 0 0 3 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 0 2 2
University of Washington Department of Laboratory Medicine, University of Washington 0 0 1 1 0 0 0 2
Baylor Genetics 0 0 1 0 0 0 0 1
Genetic Services Laboratory, University of Chicago 0 0 0 1 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics,Children's Hospital of Philadelphia 0 0 1 0 0 0 0 1
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 1 0 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 0 0 1
Department of Molecular Diagnostics, Institute of Oncology Ljubljana 0 1 0 0 0 0 0 1
Clinical Cancer Genetics and Family Consultants,Athens Medical Center 0 1 0 0 0 0 0 1
Division of Medical Genetics, University of Washington 0 0 1 0 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.