List of variants in gene SDHB reported as likely benign for Hereditary cancer-predisposing syndrome

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 135

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HGVS	dbSNP	gnomAD frequency
NM_003000.3(SDHB):c.423+260G>A	rs77244636	0.00660
NM_003000.3(SDHB):c.24C>T (p.Ser8=)	rs148738139	0.00461
NM_003000.3(SDHB):c.72+1504C>T	rs182251750	0.00372
NM_003000.3(SDHB):c.424-170T>G	rs148115746	0.00320
NM_003000.3(SDHB):c.72+2942G>A	rs186998052	0.00319
NM_003000.3(SDHB):c.643-204G>A	rs12094223	0.00246
NM_003000.3(SDHB):c.32G>A (p.Arg11His)	rs111430410	0.00185
NM_003000.3(SDHB):c.300T>C (p.Ser100=)	rs11541235	0.00157
NM_003000.3(SDHB):c.765+29G>A	rs41273161	0.00058
NM_003000.3(SDHB):c.21C>T (p.Leu7=)	rs147815442	0.00054
NM_003000.3(SDHB):c.287-26A>G	rs201397253	0.00040
NM_003000.3(SDHB):c.455C>T (p.Ser152Phe)	rs200414835	0.00012
NM_003000.3(SDHB):c.113G>A (p.Arg38His)	rs143058777	0.00010
NM_003000.3(SDHB):c.440A>G (p.Tyr147Cys)	rs774568101	0.00010
NM_003000.3(SDHB):c.423C>T (p.Pro141=)	rs150542357	0.00009
NM_003000.3(SDHB):c.543C>T (p.Asp181=)	rs199809975	0.00009
NM_003000.3(SDHB):c.178A>G (p.Thr60Ala)	rs34599281	0.00007
NM_003000.3(SDHB):c.225T>C (p.Ala75=)	rs201762207	0.00007
NM_003000.3(SDHB):c.606C>T (p.Asn202=)	rs199653121	0.00005
NM_003000.3(SDHB):c.97G>A (p.Ala33Thr)	rs777898500	0.00005
NM_003000.3(SDHB):c.307A>G (p.Met103Val)	rs140178341	0.00004
NM_003000.3(SDHB):c.552C>T (p.Tyr184=)	rs202098600	0.00004
NM_003000.3(SDHB):c.709C>T (p.Pro237Ser)	rs186768244	0.00004
NM_003000.3(SDHB):c.828G>A (p.Lys276=)	rs1260768784	0.00003
NM_003000.3(SDHB):c.783A>G (p.Lys261=)	rs1060505014	0.00002
NM_003000.3(SDHB):c.123A>G (p.Lys41=)	rs137877851	0.00001
NM_003000.3(SDHB):c.144C>T (p.Asp48=)	rs1553178737	0.00001
NM_003000.3(SDHB):c.171T>C (p.His57=)	rs1280868219	0.00001
NM_003000.3(SDHB):c.183T>C (p.Tyr61=)	rs760169139	0.00001
NM_003000.3(SDHB):c.186A>G (p.Glu62=)	rs876658473	0.00001
NM_003000.3(SDHB):c.217T>C (p.Leu73=)	rs763734164	0.00001
NM_003000.3(SDHB):c.287-4T>C	rs200419171	0.00001
NM_003000.3(SDHB):c.312C>T (p.Asn104=)	rs876660346	0.00001
NM_003000.3(SDHB):c.33C>T (p.Arg11=)	rs146399542	0.00001
NM_003000.3(SDHB):c.34C>A (p.Arg12=)	rs761996626	0.00001
NM_003000.3(SDHB):c.365A>G (p.Asn122Ser)	rs1557741472	0.00001
NM_003000.3(SDHB):c.42G>A (p.Pro14=)	rs760753435	0.00001
NM_003000.3(SDHB):c.541-3C>T	rs751920183	0.00001
NM_003000.3(SDHB):c.624G>T (p.Gly208=)	rs1214592422	0.00001
NM_003000.3(SDHB):c.645C>G (p.Ala215=)	rs1473312934	0.00001
NM_003000.3(SDHB):c.696C>T (p.Ala232=)	rs779143585	0.00001
NM_003000.3(SDHB):c.700C>T (p.Leu234=)	rs201728852	0.00001
NM_003000.3(SDHB):c.720A>G (p.Leu240=)	rs759446340	0.00001
NM_003000.3(SDHB):c.771G>C (p.Leu257=)	rs199714034	0.00001
NM_003000.3(SDHB):c.84A>G (p.Gly28=)	rs1337602604	0.00001
NM_003000.3(SDHB):c.105A>C (p.Thr35=)
NM_003000.3(SDHB):c.108T>C (p.Ala36=)
NM_003000.3(SDHB):c.111C>G (p.Pro37=)
NM_003000.3(SDHB):c.111C>T (p.Pro37=)	rs1553178746
NM_003000.3(SDHB):c.12G>A (p.Val4=)	rs768683606
NM_003000.3(SDHB):c.138A>G (p.Arg46=)	rs1392672185
NM_003000.3(SDHB):c.153G>A (p.Lys51=)
NM_003000.3(SDHB):c.15C>A (p.Val5=)	rs1182998682
NM_003000.3(SDHB):c.15C>G (p.Val5=)	rs1182998682
NM_003000.3(SDHB):c.15C>T (p.Val5=)	rs1182998682
NM_003000.3(SDHB):c.162C>T (p.Asp54=)	rs2101541392
NM_003000.3(SDHB):c.18C>G (p.Ala6=)	rs2746462
NM_003000.3(SDHB):c.19C>G (p.Leu7Val)	rs745664191
NM_003000.3(SDHB):c.201-4T>A
NM_003000.3(SDHB):c.201A>G (p.Lys67=)	rs1436421650
NM_003000.3(SDHB):c.21C>G (p.Leu7=)	rs147815442
NM_003000.3(SDHB):c.252C>T (p.Asp84=)	rs1427902008
NM_003000.3(SDHB):c.25T>C (p.Leu9=)	rs1060503768
NM_003000.3(SDHB):c.264C>G (p.Thr88=)	rs41310416
NM_003000.3(SDHB):c.264C>T (p.Thr88=)	rs41310416
NM_003000.3(SDHB):c.267C>T (p.Phe89=)	rs1553178042
NM_003000.3(SDHB):c.288C>G (p.Gly96=)
NM_003000.3(SDHB):c.291C>T (p.Ile97=)
NM_003000.3(SDHB):c.297C>G (p.Gly99=)
NM_003000.3(SDHB):c.29G>A (p.Arg10Lys)	rs1570963545
NM_003000.3(SDHB):c.306A>G (p.Ala102=)	rs1553177766
NM_003000.3(SDHB):c.327C>T (p.Asn109=)	rs1570948639
NM_003000.3(SDHB):c.339C>T (p.Cys113=)	rs754582722
NM_003000.3(SDHB):c.33C>G (p.Arg11=)	rs146399542
NM_003000.3(SDHB):c.342C>G (p.Thr114=)
NM_003000.3(SDHB):c.346A>C (p.Arg116=)
NM_003000.3(SDHB):c.357C>T (p.Thr119=)	rs1553177749
NM_003000.3(SDHB):c.369G>A (p.Lys123=)
NM_003000.3(SDHB):c.39G>A (p.Leu13=)	rs201745731
NM_003000.3(SDHB):c.417T>C (p.Leu139=)	rs1570948513
NM_003000.3(SDHB):c.426T>C (p.Asp142=)
NM_003000.3(SDHB):c.441T>C (p.Tyr147=)	rs1060503763
NM_003000.3(SDHB):c.447G>A (p.Gln149=)	rs200353146
NM_003000.3(SDHB):c.45C>A (p.Ala15=)
NM_003000.3(SDHB):c.45C>T (p.Ala15=)	rs764875162
NM_003000.3(SDHB):c.465T>C (p.Pro155=)	rs1553177685
NM_003000.3(SDHB):c.468T>C (p.Tyr156=)	rs199718947
NM_003000.3(SDHB):c.46A>G (p.Thr16Ala)	rs1433760506
NM_003000.3(SDHB):c.477G>A (p.Lys159=)	rs2101521741
NM_003000.3(SDHB):c.480G>A (p.Lys160=)	rs1553177683
NM_003000.3(SDHB):c.486A>G (p.Glu162=)
NM_003000.3(SDHB):c.48A>C (p.Thr16=)	rs1570963474
NM_003000.3(SDHB):c.492G>A (p.Gln164=)	rs2101521670
NM_003000.3(SDHB):c.511C>T (p.Leu171=)	rs780870337
NM_003000.3(SDHB):c.513G>A (p.Leu171=)	rs2101521615
NM_003000.3(SDHB):c.516G>A (p.Gln172=)	rs138937650
NM_003000.3(SDHB):c.534G>A (p.Glu178=)	rs2077999274
NM_003000.3(SDHB):c.537A>G (p.Lys179=)
NM_003000.3(SDHB):c.541-30_541-2dup	rs751159957
NM_003000.3(SDHB):c.541-5T>C	rs2101516704
NM_003000.3(SDHB):c.549C>T (p.Leu183=)	rs1411654404
NM_003000.3(SDHB):c.555G>A (p.Glu185=)
NM_003000.3(SDHB):c.558C>T (p.Cys186=)	rs1570945906
NM_003000.3(SDHB):c.564C>T (p.Leu188=)	rs776487215
NM_003000.3(SDHB):c.573C>T (p.Cys191=)
NM_003000.3(SDHB):c.582C>T (p.Thr194=)	rs775450654
NM_003000.3(SDHB):c.585C>T (p.Ser195=)
NM_003000.3(SDHB):c.588C>T (p.Cys196=)	rs1060505015
NM_003000.3(SDHB):c.597C>T (p.Tyr199=)	rs1570945852
NM_003000.3(SDHB):c.609A>C (p.Gly203=)	rs1570945818
NM_003000.3(SDHB):c.615A>G (p.Lys205=)
NM_003000.3(SDHB):c.618T>C (p.Tyr206=)
NM_003000.3(SDHB):c.624G>A (p.Gly208=)
NM_003000.3(SDHB):c.645C>T (p.Ala215=)
NM_003000.3(SDHB):c.678C>T (p.Phe226=)	rs1570944907
NM_003000.3(SDHB):c.702G>A (p.Leu234=)
NM_003000.3(SDHB):c.711A>G (p.Pro237=)	rs1570944839
NM_003000.3(SDHB):c.718C>T (p.Leu240=)	rs1570944818
NM_003000.3(SDHB):c.723C>T (p.Tyr241=)	rs878854583
NM_003000.3(SDHB):c.738C>T (p.Ile246=)	rs1476198465
NM_003000.3(SDHB):c.753G>A (p.Arg251=)	rs201094649
NM_003000.3(SDHB):c.762T>C (p.Pro254=)	rs2101513519
NM_003000.3(SDHB):c.768T>C (p.Gly256=)	rs1060505017
NM_003000.3(SDHB):c.789T>C (p.Ile263=)	rs1395418494
NM_003000.3(SDHB):c.792A>G (p.Ala264=)
NM_003000.3(SDHB):c.798C>T (p.Ile266=)	rs760042733
NM_003000.3(SDHB):c.813A>T (p.Ala271=)
NM_003000.3(SDHB):c.816C>G (p.Thr272=)	rs1454454086
NM_003000.3(SDHB):c.819T>C (p.Tyr273=)
NM_003000.3(SDHB):c.834T>C (p.Ala278=)	rs1570942568
NM_003000.3(SDHB):c.837A>G (p.Ser279=)	rs770120161
NM_003000.3(SDHB):c.93A>G (p.Thr31=)
NM_003000.3(SDHB):c.93A>T (p.Thr31=)	rs2101541592
NM_003000.3(SDHB):c.96T>G (p.Ala32=)	rs1484330671
NM_003000.3(SDHB):c.9G>A (p.Ala3=)	rs1350879010

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