ClinVar Miner

Variants in gene SDHC

See also:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
40 28 270 96 42 3 447

Condition and significance breakdown #

Total conditions: 15
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Gastrointestinal stromal tumor; Paragangliomas 3 30 14 198 64 2 0 308
Hereditary cancer-predisposing syndrome 12 9 41 27 1 0 90
Hereditary Paraganglioma-Pheochromocytoma Syndromes 4 3 29 3 26 0 64
not provided 3 5 17 16 9 0 49
not specified 0 0 6 12 9 3 26
Pheochromocytoma 0 0 21 2 2 0 25
Paragangliomas 3 7 1 6 3 1 0 18
none provided 2 1 0 1 3 0 7
Carney triad 0 3 0 0 0 0 3
Carney-Stratakis syndrome 2 0 0 0 0 0 2
Gastrointestinal stromal tumor 1 0 0 0 0 0 1
Gastrointestinal stromal tumor; Carney-Stratakis syndrome; Paragangliomas 3 0 0 1 0 0 0 1
Malignant tumor of breast 0 0 0 1 0 0 1
Rhabdomyosarcoma (disease) 0 1 0 0 0 0 1
See cases 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 30
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 31 15 198 70 2 0 316
Ambry Genetics 12 9 41 26 1 0 89
Illumina Clinical Services Laboratory,Illumina 0 0 47 4 28 0 79
GeneDx 3 3 2 13 5 0 26
Quest Diagnostics Nichols Institute San Juan Capistrano 1 1 13 4 5 0 23
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 2 1 1 1 7 0 12
Counsyl 0 0 5 3 0 0 8
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 2 2 2 0 1 0 7
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 5 2 0 0 7
Section on Medical Neuroendocrinolgy,National Institutes of Health 4 1 1 0 0 0 6
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 1 0 2 0 2 0 5
OMIM 3 0 0 0 0 0 3
Center for Human Genetics, Inc,Center for Human Genetics, Inc 3 0 0 0 0 0 3
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 1 1 1 0 3
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 1 1 1 0 0 0 3
ITMI 0 0 0 0 0 3 3
Section on Endocrinology and Genetics,National Institutes of Health / The Eunice Kennedy Shriver National Institute of Child Health and Human Development 0 3 0 0 0 0 3
CSER _CC_NCGL, University of Washington 0 0 1 1 0 0 2
Baylor Genetics 1 0 0 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics,Children's Hospital of Philadelphia 0 0 0 0 1 0 1
PreventionGenetics, PreventionGenetics 0 0 0 0 1 0 1
Integrated Genetics/Laboratory Corporation of America 0 0 0 0 1 0 1
Fulgent Genetics,Fulgent Genetics 0 0 1 0 0 0 1
ISCA site 1 0 1 0 0 0 0 1
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 0 1 0 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 0 1 0 0 1
Gharavi Laboratory,Columbia University 0 1 0 0 0 0 1
Department of Medical Genetics,College of Basic Medicine, Army Medical University 1 0 0 0 0 0 1
University of Washington Department of Laboratory Medicine, University of Washington 0 0 0 1 0 0 1
New York Genome Center 1 0 0 0 0 0 1

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