ClinVar Miner

Variants in gene SDHC

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
21 19 169 55 26 3 269

Condition and significance breakdown #

Total conditions: 12
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Gastrointestinal stroma tumor; Paragangliomas 3 9 7 123 26 2 0 167
Pheochromocytoma 0 0 32 14 15 0 61
Hereditary cancer-predisposing syndrome 9 8 17 11 1 0 46
not provided 3 4 7 4 8 0 25
not specified 0 0 6 12 5 3 23
Paragangliomas 3 7 1 5 3 1 0 17
Hereditary Paraganglioma-Pheochromocytoma Syndromes 4 3 2 0 0 0 9
Carney triad 0 3 0 0 0 0 3
Gastrointestinal stroma tumor 1 0 0 0 0 0 1
Gastrointestinal stroma tumor; Paraganglioma and gastric stromal sarcoma; Paragangliomas 3 0 0 1 0 0 0 1
Paraganglioma and gastric stromal sarcoma 1 0 0 0 0 0 1
See cases 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 25
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 10 8 123 26 2 0 169
Illumina Clinical Services Laboratory,Illumina 0 0 31 14 15 0 60
Ambry Genetics 9 8 17 10 1 0 45
GeneDx 3 3 2 13 5 0 26
Quest Diagnostics Nichols Institute San Juan Capistrano 1 0 6 3 2 0 11
Counsyl 0 0 5 3 0 0 8
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 2 2 2 0 1 0 7
Section on Medical Neuroendocrinolgy,National Institutes of Health 4 1 1 0 0 0 6
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 1 0 2 0 2 0 5
OMIM 4 0 0 0 0 0 4
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 1 0 1 0 2 0 4
Center for Human Genetics, Inc 3 0 0 0 0 0 3
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 1 1 1 0 3
ITMI 0 0 0 0 0 3 3
Section on Endocrinology and Genetics,National Institutes of Health / The Eunice Kennedy Shriver National Institute of Child Health and Human Development 0 3 0 0 0 0 3
CSER_CC_NCGL; University of Washington Medical Center 0 0 1 1 0 0 2
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 0 0 1 0 1
PreventionGenetics 0 0 0 0 1 0 1
Integrated Genetics/Laboratory Corporation of America 0 0 0 0 1 0 1
Fulgent Genetics,Fulgent Genetics 0 0 1 0 0 0 1
ISCA site 1 0 1 0 0 0 0 1
Knight Diagnostic Laboratories,Oregon Health and Sciences University 0 0 1 0 0 0 1
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 0 1 0 0 1
Gharavi Laboratory,Columbia University 0 1 0 0 0 0 1
University of Washington Department of Laboratory Medicine,University of Washington 0 0 0 1 0 0 1

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