ClinVar Miner

Variants in gene STK11

See also:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
124 61 559 504 70 6 1165

Condition and significance breakdown #

Total conditions: 23
Download table as spreadsheet
Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Hereditary cancer-predisposing syndrome 54 15 308 354 16 0 719
Peutz-Jeghers syndrome 61 23 343 242 22 1 651
not specified 0 0 64 157 58 4 252
not provided 26 11 130 26 20 1 200
Neoplasm 0 8 0 0 0 0 8
Carcinoma of pancreas; Peutz-Jeghers syndrome; Malignant tumor of testis 0 1 6 0 0 0 7
Cutaneous malignant melanoma 1 4 0 0 0 0 0 4
Squamous cell lung carcinoma 0 4 0 0 0 0 4
Carcinoma of pancreas 3 0 0 0 0 0 3
Breast carcinoma 0 0 2 0 0 0 2
Lung adenocarcinoma 0 2 0 0 0 0 2
Pancreatic Neoplasms 0 2 0 0 0 0 2
Acute monocytic leukemia; Acute monoblastic leukemia 0 0 1 0 0 0 1
B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified 0 0 1 0 0 0 1
Breast cancer, susceptibility to 0 0 1 0 0 0 1
Cutaneous melanoma 0 1 0 0 0 0 1
Embryonal rhabdomyosarcoma 0 0 1 0 0 0 1
Hepatoblastoma 0 0 1 0 0 0 1
Inborn genetic diseases 0 1 0 0 0 0 1
Malignant tumor of testis 1 0 0 0 0 0 1
Non-small cell lung cancer 0 1 0 0 0 0 1
Periorbital hyperpigmentation; Intestinal polyposis 0 1 0 0 0 0 1
Retinoblastoma 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 37
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 42 6 288 185 20 0 541
Ambry Genetics 51 15 219 211 7 0 503
Color 1 1 168 241 12 0 423
GeneDx 21 6 119 133 46 0 324
Counsyl 0 2 59 56 1 0 118
Quest Diagnostics Nichols Institute San Juan Capistrano 3 2 35 26 13 0 73
Integrated Genetics/Laboratory Corporation of America 2 2 36 9 21 0 70
Illumina Clinical Services Laboratory,Illumina 0 0 34 24 2 0 60
PreventionGenetics 0 0 8 20 10 0 38
Database of Curated Mutations (DoCM) 0 27 0 0 0 0 27
OMIM 23 0 1 0 0 0 24
Mendelics 1 1 22 0 0 0 24
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 6 1 4 2 4 0 17
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic 0 1 8 2 5 0 16
True Health Diagnostics 0 0 2 8 0 0 10
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 7 1 1 0 9
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 1 0 1 2 4 0 8
Fulgent Genetics 0 1 6 0 0 0 7
University of Washington Department of Laboratory Medicine,University of Washington 0 0 1 6 0 0 7
Pathway Genomics 2 0 4 0 0 0 6
Gharavi Laboratory,Columbia University 0 0 6 0 0 0 6
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 1 4 0 0 5
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 5 0 0 0 5
ITMI 0 0 0 0 0 4 4
GeneKor MSA 0 1 3 0 0 0 4
Shenzhen Institute of Pediatrics,Shenzhen Children's Hospital 0 3 0 0 0 0 3
CSER_CC_NCGL; University of Washington Medical Center 0 0 3 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 1 2 0 0 0 3
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 2 0 0 0 2
GenomeConnect, ClinGen 0 0 0 0 0 2 2
Foundation Medicine, Inc. 0 0 1 0 0 0 1
Vantari Genetics 0 0 0 0 1 0 1
Zhongshan School of Medicine,Sun Yat-Sen University 1 0 0 0 0 0 1
Academic Center for Education, Culture and Research, Motamed Cancer Institute 1 0 0 0 0 0 1
National Molecular Genetics Centre of Cancer Research,N.N. Alexandrov National Cancer Centre of Belarus 1 0 0 0 0 0 1
Institutes of Biomedical Sciences,Shanxi University 1 0 0 0 0 0 1
Cancer Molecular Diagnostics Core,Tianjin Medical University Cancer Institute and Hospital 0 0 1 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.