ClinVar Miner

Variants in gene STK11

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
159 68 743 586 94 6 1460

Condition and significance breakdown #

Total conditions: 25
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Peutz-Jeghers syndrome 91 27 509 264 46 1 880
Hereditary cancer-predisposing syndrome 62 17 402 403 16 0 863
not provided 27 13 135 96 28 1 280
not specified 1 0 58 159 60 4 256
Neoplasm 0 8 0 0 0 0 8
Carcinoma of pancreas; Peutz-Jeghers syndrome; Malignant tumor of testis 0 1 6 0 0 0 7
Cutaneous malignant melanoma 1 4 0 0 0 0 0 4
Squamous cell lung carcinoma 0 4 0 0 0 0 4
Carcinoma of pancreas 3 0 0 0 0 0 3
Breast carcinoma 0 0 2 0 0 0 2
Hereditary breast and ovarian cancer syndrome 0 0 2 0 0 0 2
Lung adenocarcinoma 0 2 0 0 0 0 2
Pancreatic Neoplasms 0 2 0 0 0 0 2
Acute monocytic leukemia; Acute monoblastic leukemia 0 0 1 0 0 0 1
B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified 0 0 1 0 0 0 1
Breast cancer, susceptibility to 0 0 1 0 0 0 1
Cutaneous melanoma 0 1 0 0 0 0 1
Embryonal rhabdomyosarcoma 0 0 1 0 0 0 1
Hepatoblastoma 0 0 1 0 0 0 1
Inborn genetic diseases 0 1 0 0 0 0 1
Malignant tumor of testis 1 0 0 0 0 0 1
Marfanoid habitus and intellectual disability 0 0 1 0 0 0 1
Non-small cell lung cancer 0 1 0 0 0 0 1
Periorbital hyperpigmentation; Intestinal polyposis 0 1 0 0 0 0 1
Retinoblastoma 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 40
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 72 10 406 271 27 0 786
Ambry Genetics 58 17 331 273 7 0 686
Color 1 1 168 241 12 0 423
GeneDx 21 6 118 142 48 0 335
Counsyl 0 2 59 56 1 0 118
Illumina Clinical Services Laboratory,Illumina 0 0 80 10 27 0 117
Quest Diagnostics Nichols Institute San Juan Capistrano 5 4 45 24 21 0 94
Integrated Genetics/Laboratory Corporation of America 2 2 25 18 23 0 70
Mendelics 2 1 26 19 2 0 50
PreventionGenetics,PreventionGenetics 0 0 8 20 10 0 38
Database of Curated Mutations (DoCM) 0 27 0 0 0 0 27
OMIM 23 0 1 0 0 0 24
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 6 1 4 2 4 0 17
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic 0 1 8 2 5 0 16
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 2 0 1 2 9 0 14
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 5 5 0 0 10
True Health Diagnostics 0 0 2 8 0 0 10
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 0 7 1 1 0 9
Fulgent Genetics,Fulgent Genetics 0 1 6 0 0 0 7
University of Washington Department of Laboratory Medicine, University of Washington 0 0 1 6 0 0 7
Pathway Genomics 2 0 4 0 0 0 6
Gharavi Laboratory,Columbia University 0 0 6 0 0 0 6
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. 0 0 1 4 0 0 5
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 5 0 0 0 5
ITMI 0 0 0 0 0 4 4
GeneKor MSA 0 1 3 0 0 0 4
Shenzhen Institute of Pediatrics,Shenzhen Children's Hospital 0 3 0 0 0 0 3
CSER _CC_NCGL, University of Washington 0 0 3 0 0 0 3
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 1 2 0 0 0 3
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 2 0 0 0 2
GenomeConnect, ClinGen 0 0 0 0 0 2 2
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 0 2 0 0 0 2
Foundation Medicine, Inc. 0 0 1 0 0 0 1
Vantari Genetics 0 0 0 0 1 0 1
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 0 1 0 0 0 1
Zhongshan School of Medicine,Sun Yat-Sen University 1 0 0 0 0 0 1
Academic Center for Education, Culture and Research, Motamed Cancer Institute 1 0 0 0 0 0 1
National Molecular Genetics Centre of Cancer Research,N.N. Alexandrov National Cancer Centre of Belarus 1 0 0 0 0 0 1
Institutes of Biomedical Sciences,Shanxi University 1 0 0 0 0 0 1
Cancer Molecular Diagnostics Core,Tianjin Medical University Cancer Institute and Hospital 0 0 1 0 0 0 1

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