List of variants in gene TERT reported as uncertain significance by GeneDx

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 95

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HGVS	dbSNP	gnomAD frequency
NM_198253.3(TERT):c.1336C>A (p.Arg446Ser)	rs567650961	0.00084
NM_198253.3(TERT):c.769G>T (p.Ala257Ser)	rs964055372	0.00053
NM_198253.3(TERT):c.403G>A (p.Gly135Arg)	rs200843534	0.00025
NM_198253.3(TERT):c.2014C>T (p.Arg672Cys)	rs368430301	0.00024
NM_198253.3(TERT):c.1931C>T (p.Thr644Met)	rs201927653	0.00023
NM_198253.3(TERT):c.3257G>A (p.Arg1086His)	rs200288187	0.00021
NM_198253.3(TERT):c.2884C>T (p.Arg962Cys)	rs144697790	0.00019
NM_198253.3(TERT):c.2371G>A (p.Val791Ile)	rs141425941	0.00016
NM_198253.3(TERT):c.3164C>T (p.Ser1055Leu)	rs201330213	0.00009
NM_198253.3(TERT):c.3268G>A (p.Val1090Met)	rs121918664	0.00009
NM_198253.3(TERT):c.779G>A (p.Gly260Asp)	rs148798048	0.00009
NM_198253.3(TERT):c.569C>T (p.Ala190Val)	rs781435225	0.00007
NM_198253.3(TERT):c.887A>C (p.His296Pro)	rs778187343	0.00007
NM_198253.3(TERT):c.1936C>T (p.Arg646Cys)	rs147521473	0.00006
NM_198253.3(TERT):c.2177C>T (p.Thr726Met)	rs149566858	0.00006
NM_198253.3(TERT):c.2141C>T (p.Thr714Met)	rs772441504	0.00005
NM_198253.3(TERT):c.2287-5G>A	rs561426406	0.00005
NM_198253.3(TERT):c.3302C>T (p.Thr1101Met)	rs764602705	0.00005
NM_198253.3(TERT):c.2652C>T (p.Leu884=)	rs374309472	0.00004
NM_198253.3(TERT):c.3150G>C (p.Lys1050Asn)	rs373400596	0.00004
NM_198253.3(TERT):c.3323C>T (p.Pro1108Leu)	rs376255453	0.00004
NM_198253.3(TERT):c.3329C>T (p.Thr1110Met)	rs199422306	0.00004
NM_198253.3(TERT):c.1099G>T (p.Gly367Cys)	rs1751163506	0.00003
NM_198253.3(TERT):c.1393G>C (p.Val465Leu)	rs758110675	0.00003
NM_198253.3(TERT):c.2387C>T (p.Ser796Phe)	rs369810792	0.00003
NM_198253.3(TERT):c.2432G>A (p.Arg811His)	rs552708120	0.00003
NM_198253.3(TERT):c.611A>T (p.Asn204Ile)	rs764473257	0.00003
NM_198253.3(TERT):c.751G>A (p.Val251Ile)	rs776569822	0.00003
NM_198253.3(TERT):c.863C>T (p.Ala288Val)	rs774657340	0.00003
NM_198253.3(TERT):c.968C>G (p.Pro323Arg)	rs139342764	0.00003
NM_198253.3(TERT):c.976G>A (p.Ala326Thr)	rs1030156757	0.00003
NM_198253.3(TERT):c.2251G>A (p.Ala751Thr)	rs772070672	0.00002
NM_198253.3(TERT):c.2353C>G (p.Pro785Ala)	rs755822641	0.00002
NM_198253.3(TERT):c.3304C>A (p.Gln1102Lys)	rs1042447238	0.00002
NM_198253.3(TERT):c.550G>A (p.Ala184Thr)	rs773758089	0.00002
NM_198253.3(TERT):c.619G>A (p.Val207Ile)	rs943176303	0.00002
NM_198253.3(TERT):c.724G>C (p.Ala242Pro)	rs766054124	0.00002
NM_198253.3(TERT):c.1331A>G (p.Asp444Gly)	rs878855299	0.00001
NM_198253.3(TERT):c.1490T>G (p.Leu497Arg)	rs1751116306	0.00001
NM_198253.3(TERT):c.1615G>A (p.Glu539Lys)	rs1203927893	0.00001
NM_198253.3(TERT):c.1954G>A (p.Glu652Lys)	rs1228165704	0.00001
NM_198253.3(TERT):c.2185A>G (p.Ile729Val)	rs753929279	0.00001
NM_198253.3(TERT):c.2213C>T (p.Thr738Met)	rs1749789095	0.00001
NM_198253.3(TERT):c.2225G>A (p.Arg742His)	rs727503468	0.00001
NM_198253.3(TERT):c.2354C>T (p.Pro785Leu)	rs483352771	0.00001
NM_198253.3(TERT):c.2411G>T (p.Gly804Val)	rs1442845192	0.00001
NM_198253.3(TERT):c.2655G>C (p.Arg885Ser)	rs754372863	0.00001
NM_198253.3(TERT):c.2831G>A (p.Ser944Asn)	rs759314942	0.00001
NM_198253.3(TERT):c.3172G>T (p.Ala1058Ser)	rs1478959357	0.00001
NM_198253.3(TERT):c.708G>C (p.Lys236Asn)	rs1250720718	0.00001
NM_198253.3(TERT):c.922C>G (p.Pro308Ala)	rs753366759	0.00001
NM_198253.3(TERT):c.1151A>T (p.Gln384Leu)	rs1167344136
NM_198253.3(TERT):c.1304T>A (p.Val435Glu)	rs1561213530
NM_198253.3(TERT):c.1474AAG[1] (p.Lys493del)
NM_198253.3(TERT):c.1499A>T (p.His500Leu)	rs2126683887
NM_198253.3(TERT):c.1765A>C (p.Ile589Leu)	rs1561205289
NM_198253.3(TERT):c.1824G>T (p.Gln608His)	rs769540249
NM_198253.3(TERT):c.1885G>A (p.Gly629Arg)	rs2126644343
NM_198253.3(TERT):c.1895C>T (p.Pro632Leu)	rs1749925286
NM_198253.3(TERT):c.1990G>A (p.Val664Met)	rs797046042
NM_198253.3(TERT):c.1990G>C (p.Val664Leu)	rs797046042
NM_198253.3(TERT):c.2032G>A (p.Ala678Thr)	rs1278095401
NM_198253.3(TERT):c.2072G>A (p.Arg691His)	rs202123213
NM_198253.3(TERT):c.2081T>A (p.Val694Glu)	rs1026167666
NM_198253.3(TERT):c.2221G>A (p.Val741Met)	rs150819225
NM_198253.3(TERT):c.2377G>A (p.Glu793Lys)	rs1043358053
NM_198253.3(TERT):c.2495C>T (p.Pro832Leu)	rs1748794843
NM_198253.3(TERT):c.2542G>A (p.Asp848Asn)	rs1003575407
NM_198253.3(TERT):c.2581G>A (p.Gly861Arg)	rs1554039721
NM_198253.3(TERT):c.2608T>A (p.Phe870Ile)	rs1748617178
NM_198253.3(TERT):c.2768C>T (p.Pro923Leu)	rs387907251
NM_198253.3(TERT):c.2813G>A (p.Arg938Gln)	rs199741493
NM_198253.3(TERT):c.2836T>C (p.Tyr946His)	rs1748447400
NM_198253.3(TERT):c.2869A>G (p.Ser957Gly)	rs1748158034
NM_198253.3(TERT):c.2947C>T (p.His983Tyr)	rs1554038803
NM_198253.3(TERT):c.3002T>C (p.Ile1001Thr)	rs2126573449
NM_198253.3(TERT):c.3042A>T (p.Ala1014=)	rs1337149388
NM_198253.3(TERT):c.3100C>G (p.Arg1034Gly)	rs777672180
NM_198253.3(TERT):c.3118G>T (p.Ala1040Ser)	rs770144114
NM_198253.3(TERT):c.316G>T (p.Gly106Trp)	rs1751265277
NM_198253.3(TERT):c.3300G>C (p.Gln1100His)
NM_198253.3(TERT):c.3326G>A (p.Gly1109Glu)
NM_198253.3(TERT):c.3362C>T (p.Pro1121Leu)	rs1554038054
NM_198253.3(TERT):c.411G>T (p.Trp137Cys)	rs1554043076
NM_198253.3(TERT):c.421C>G (p.Leu141Val)	rs775225240
NM_198253.3(TERT):c.444G>T (p.Val148=)
NM_198253.3(TERT):c.508G>C (p.Val170Leu)	rs387907248
NM_198253.3(TERT):c.567C>A (p.His189Gln)	rs747935528
NM_198253.3(TERT):c.751G>C (p.Val251Leu)	rs776569822
NM_198253.3(TERT):c.785C>T (p.Thr262Met)	rs150277224
NM_198253.3(TERT):c.823C>T (p.Pro275Ser)
NM_198253.3(TERT):c.875C>G (p.Thr292Arg)	rs1751193051
NM_198253.3(TERT):c.931T>A (p.Ser311Thr)	rs1060502998
NM_198253.3(TERT):c.937C>A (p.Pro313Thr)
NM_198253.3(TERT):c.941C>T (p.Pro314Leu)	rs1306142415

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