ClinVar Miner

Variants in gene TNNT2

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
57 104 485 328 114 898

Condition and significance breakdown #

Total conditions: 39
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
Hypertrophic cardiomyopathy 2; Dilated cardiomyopathy 1D; Cardiomyopathy, familial restrictive, 3 39 28 276 216 21 574
not provided 27 30 108 71 83 289
Cardiomyopathy 9 12 148 92 15 267
Dilated cardiomyopathy 1D 14 29 124 63 26 250
Hypertrophic cardiomyopathy 2 13 25 126 62 27 246
Cardiomyopathy, familial restrictive, 3 8 18 119 62 26 233
Cardiovascular phenotype 11 8 96 45 6 166
not specified 0 1 72 50 44 148
Hypertrophic cardiomyopathy 8 14 15 7 7 47
Primary dilated cardiomyopathy 5 13 7 0 0 24
Left ventricular noncompaction cardiomyopathy 1 0 11 8 0 20
Primary familial hypertrophic cardiomyopathy 7 4 5 1 2 19
Dilated Cardiomyopathy, Dominant 0 0 8 8 0 16
TNNT2-related condition 0 1 4 9 1 15
Familial restrictive cardiomyopathy 0 0 4 7 0 11
Primary familial dilated cardiomyopathy 0 5 1 0 0 6
Dilated cardiomyopathy 1DD 1 0 4 0 0 5
Hypertrophic cardiomyopathy 1 0 1 4 0 0 5
Hypertrophic cardiomyopathy 2; Dilated cardiomyopathy 1D 0 3 2 0 0 5
Left ventricular noncompaction 0 1 1 0 0 2
See cases 0 1 1 0 0 2
Costello syndrome 0 0 1 0 0 1
Dilated cardiomyopathy 1S 0 0 1 0 0 1
Familial isolated dilated cardiomyopathy 1 0 0 0 0 1
Hypokinetic non-dilated cardiomyopathy 0 0 1 0 0 1
Inborn genetic diseases 0 0 1 0 0 1
Increased left ventricular wall thickness 0 0 1 0 0 1
Left ventricular hypertrophy 0 0 0 1 0 1
Primary dilated cardiomyopathy; Hypertrophic cardiomyopathy 1 0 0 0 0 1
Primary dilated cardiomyopathy; Hypertrophic cardiomyopathy; Sudden unexplained death 0 0 0 0 1 1
Primary dilated cardiomyopathy; Myocarditis 0 1 0 0 0 1
Restrictive cardiomyopathy 0 1 0 0 0 1
Sudden cardiac death 0 0 1 0 0 1
Supraventricular tachycardia 0 0 0 1 0 1
TNNT2 -related cardiomyopathies 1 0 0 0 0 1
TNNT2-Related Cardiomyopathy 0 0 1 0 0 1
TNNT2-related disorder 0 1 0 0 0 1
Wolff-Parkinson-White pattern 0 1 0 0 0 1
Wolff-Parkinson-White pattern; Hypertrophic cardiomyopathy 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 83
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Invitae 39 26 271 213 21 570
GeneDx 22 14 74 71 85 266
Color Diagnostics, LLC DBA Color Health 2 5 121 85 12 225
Genome-Nilou Lab 7 18 100 61 26 212
Ambry Genetics 10 8 97 45 6 166
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 12 21 59 19 11 122
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario 7 7 42 16 5 77
Clinical Genetics, Academic Medical Center 4 1 12 4 23 44
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+ 5 2 5 11 17 40
Illumina Laboratory Services, Illumina 0 0 26 9 0 35
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 5 3 15 5 6 34
Fulgent Genetics, Fulgent Genetics 3 3 21 5 1 33
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 3 2 4 8 13 30
PreventionGenetics, part of Exact Sciences 0 1 4 11 12 28
Stanford Center for Inherited Cardiovascular Disease, Stanford University 7 10 11 0 0 28
Blueprint Genetics 5 6 11 2 0 24
Genome Diagnostics Laboratory, University Medical Center Utrecht 1 3 4 8 7 23
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease, Montreal Heart Institute 5 8 2 1 5 21
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 3 1 5 8 3 20
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 4 3 10 1 0 18
CeGaT Center for Human Genetics Tuebingen 0 0 6 10 2 18
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 1 4 0 11 16
AiLife Diagnostics, AiLife Diagnostics 0 2 12 0 0 14
OMIM 12 0 0 0 0 12
Agnes Ginges Centre for Molecular Cardiology, Centenary Institute 0 2 9 0 1 12
Mayo Clinic Laboratories, Mayo Clinic 3 0 7 0 0 10
Cohesion Phenomics 0 0 0 0 9 9
Evolutionary and Medical Genetics Laboratory, Centre for Cellular and Molecular Biology 2 0 4 0 0 6
3billion 2 2 2 0 0 6
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 4 0 1 5
Mendelics 0 0 2 0 3 5
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 2 2 1 0 0 5
Center for Human Genetics, University of Leuven 1 2 2 0 0 5
New York Genome Center 1 2 2 0 0 5
Revvity Omics, Revvity 0 0 4 0 0 4
Eurofins Ntd Llc (ga) 1 0 2 0 1 4
CSER _CC_NCGL, University of Washington 0 1 3 0 0 4
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 4 0 0 4
Institute of Human Genetics, University of Leipzig Medical Center 0 1 3 0 0 4
Center for Medical Genetics Ghent, University of Ghent 1 1 1 0 0 3
Laboratory of Genetics and Molecular Cardiology, University of São Paulo 0 3 0 0 0 3
Center of Genomic medicine, Geneva, University Hospital of Geneva 1 0 2 0 0 3
Klaassen Lab, Charite University Medicine Berlin 1 2 1 0 0 3
Genetics and Genomics Program, Sidra Medicine 0 1 2 0 0 3
Baylor Genetics 0 1 1 0 0 2
Clinical Molecular Genetics Laboratory, Johns Hopkins All Children's Hospital 0 0 1 1 0 2
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 0 2 0 0 2
Laboratory of Medical Genetics, National & Kapodistrian University of Athens 0 2 0 0 0 2
Center for Advanced Laboratory Medicine, UC San Diego Health, University of California San Diego 0 1 0 1 0 2
KTest Genetics, KTest 2 0 0 0 0 2
Clinical Center for Gene Diagnosis and Therapy, Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University 1 0 1 0 0 2
Genomics England Pilot Project, Genomics England 0 2 0 0 0 2
Human Genetics Bochum, Ruhr University Bochum 0 1 1 0 0 2
Research Unit of Cardiovascular and Metabolic Disease, Inserm 0 2 0 0 0 2
Greenwood Genetic Center Diagnostic Laboratories, Greenwood Genetic Center 0 1 0 0 0 1
Centogene AG - the Rare Disease Company 1 0 0 0 0 1
Richard Lifton Laboratory, Yale University School of Medicine 0 0 1 0 0 1
Human Genetics Research Centre, St George's University of London 0 0 1 0 0 1
Institute Of Human Genetics Munich, Klinikum Rechts Der Isar, Tu München 0 1 0 0 0 1
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 0 1 0 0 1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 1 0 0 0 1
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden 0 1 0 0 0 1
Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics 0 0 1 0 0 1
Petrovsky National Research Centre of Surgery, The Federal Agency for Scientific Organizations 1 0 0 0 0 1
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen 0 0 1 0 0 1
Institute of Human Genetics, University of Wuerzburg 0 0 1 0 0 1
Genetics and Molecular Pathology, SA Pathology 0 0 1 0 0 1
Phosphorus, Inc. 0 0 1 0 0 1
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 1 0 0 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 1
Broad Center for Mendelian Genomics, Broad Institute of MIT and Harvard 0 1 0 0 0 1
Gharavi Laboratory, Columbia University 0 1 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 0 0 1 0 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 0 1 0 0 1
Cardiology unit, Meyer University Hospital 0 1 0 0 0 1
Institute of Human Genetics, University Hospital Muenster 0 0 1 0 0 1
Loeys Lab, Universiteit Antwerpen 0 0 1 0 0 1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 0 0 1 0 0 1
Neuberg Supratech Reference Laboratories Pvt Ltd, Neuberg Centre for Genomic Medicine 1 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 1 0 0 0 1
ICMR Centre for Advanced Research and Excellence in Heart Failure, Sree Chitra Tirunal Institute for Medical Sciences & Technology, KERALA, INDIA 0 0 1 0 0 1
Arcensus 0 1 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 0 0 1 0 0 1

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