ClinVar Miner

Variants in gene TNNT2

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
44 74 198 115 52 391

Condition and significance breakdown #

Total conditions: 32
Download table as spreadsheet
Condition pathogenic likely pathogenic uncertain significance likely benign benign total
not provided 26 39 45 47 31 173
not specified 0 1 69 55 27 140
Familial hypertrophic cardiomyopathy 2; Left ventricular noncompaction 6; Familial restrictive cardiomyopathy 3 16 6 82 13 0 117
Cardiomyopathy 2 2 21 13 12 50
Hypertrophic cardiomyopathy 8 13 14 8 0 43
Cardiovascular phenotype 8 5 15 3 4 35
Left ventricular noncompaction cardiomyopathy 0 0 12 8 0 20
Dilated Cardiomyopathy, Dominant 0 0 11 8 0 19
Familial restrictive cardiomyopathy 0 0 11 8 0 19
Primary dilated cardiomyopathy 4 11 5 0 0 19
Left ventricular noncompaction 6 9 1 8 0 0 18
Primary familial hypertrophic cardiomyopathy 6 5 5 1 2 18
Familial hypertrophic cardiomyopathy 2 6 6 4 0 3 17
Familial hypertrophic cardiomyopathy 1 0 1 5 0 0 6
Dilated cardiomyopathy 1DD 1 0 4 0 0 5
Familial dilated cardiomyopathy 0 4 1 0 0 5
Familial restrictive cardiomyopathy 3 2 0 1 0 0 3
Costello syndrome 0 0 1 0 0 1
Dilated cardiomyopathy 0 0 1 0 0 1
Dilated cardiomyopathy 1S 0 0 1 0 0 1
Familial hypertrophic cardiomyopathy 2; Left ventricular noncompaction 6 0 0 1 0 0 1
Familial isolated dilated cardiomyopathy 1 0 0 0 0 1
Hypertrophic cardiomyopathy; Sudden unexplained death; Dilated cardiomyopathy 0 0 0 0 1 1
Hypokinetic non-dilated cardiomyopathy 0 0 1 0 0 1
Increased left ventricular wall thickness 0 0 1 0 0 1
Left ventricular hypertrophy 0 0 0 1 0 1
Primary dilated cardiomyopathy; Hypertrophic cardiomyopathy 1 0 0 0 0 1
Restrictive cardiomyopathy 0 1 0 0 0 1
Sudden cardiac death 0 0 1 0 0 1
Supraventricular tachycardia 0 0 0 1 0 1
TNNT2-Related Cardiomyopathy 0 0 1 0 0 1
Wolff-Parkinson-White pattern 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 43
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
GeneDx 23 26 30 55 30 164
Invitae 17 6 83 42 11 159
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 12 21 59 19 11 122
Ambry Genetics 7 5 15 3 4 34
Stanford Center for Inherited Cardiovascular Disease, Stanford University 7 9 10 0 0 26
Color 0 0 7 9 10 26
Blueprint Genetics 5 6 11 2 0 24
Illumina Clinical Services Laboratory,Illumina 0 0 13 8 0 21
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 1 1 14 3 1 20
Integrated Genetics/Laboratory Corporation of America 2 1 7 2 5 17
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 5 8 1 1 2 17
PreventionGenetics,PreventionGenetics 0 0 0 2 11 13
OMIM 12 0 0 0 0 12
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 1 1 0 6 8
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 1 6 0 1 8
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 6 2 0 8
Evolutionary and Medical Genetics Laboratory, Centre for Cellular and Molecular Biology 2 0 4 0 0 6
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 4 0 1 5
Mendelics 0 0 2 0 3 5
CSER _CC_NCGL, University of Washington 0 2 3 0 0 5
Center for Human Genetics,University of Leuven 1 2 2 0 0 5
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 1 0 2 0 1 4
Center for Medical Genetics Ghent,University of Ghent 1 1 1 0 0 3
Laboratory of Genetics and Molecular Cardiology, University of São Paulo 0 3 0 0 0 3
Center of Genomic medicine, Geneva,University Hospital of Geneva 1 0 2 0 0 3
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 1 1 0 2
Human Genome Sequencing Center Clinical Lab,Baylor College of Medicine 2 0 0 0 0 2
Equipe Genetique des Anomalies du Developpement,Université de Bourgogne 0 0 2 0 0 2
Klaassen Lab,Charite University Medicine Berlin 0 1 1 0 0 2
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 1 0 1 0 2
Fulgent Genetics,Fulgent Genetics 0 1 0 0 0 1
Richard Lifton Laboratory, Yale University School of Medicine 0 0 1 0 0 1
Human Genetics Research Centre, St George's University of London 0 0 1 0 0 1
Institute of Human Genetics,Klinikum rechts der Isar 0 1 0 0 0 1
Knight Diagnostic Laboratories,Oregon Health and Sciences University 0 0 1 0 0 1
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 1 0 0 0 1
Center for Pediatric Genomic Medicine,Children's Mercy Hospital and Clinics 0 0 1 0 0 1
Petrovsky Russian Research Center of Surgery, The Federal Agency for Scientific Organizations 1 0 0 0 0 1
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 0 1 0 0 1
Institute of Human Genetics,University of Wuerzburg 0 0 1 0 0 1
Phosphorus, Inc. 0 0 1 0 0 1
Broad Institute Rare Disease Group,Broad Institute 0 1 0 0 0 1
Gharavi Laboratory,Columbia University 0 1 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.