ClinVar Miner

Variants in gene combination TP53, WRAP53

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
3 1 12 7 3 24

Condition and significance breakdown #

Total conditions: 5
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
Li-Fraumeni syndrome 3 1 5 5 1 15
not specified 0 0 3 2 3 8
Dyskeratosis Congenita, Recessive 0 0 3 2 2 7
not provided 0 0 3 0 0 3
Hereditary cancer-predisposing syndrome 0 0 0 1 0 1

Submitter and significance breakdown #

Total submitters: 8
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Illumina Clinical Services Laboratory,Illumina 0 0 3 5 2 9
Invitae 3 1 4 0 0 8
GeneDx 0 0 3 1 0 4
Genetic Services Laboratory, University of Chicago 0 0 3 0 0 3
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 0 0 3 3
PreventionGenetics 0 0 0 1 2 3
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 0 0 0 2 2
University of Washington Department of Laboratory Medicine,University of Washington 0 0 0 1 0 1

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