ClinVar Miner

List of variants in gene TP53 reported as benign for Li-Fraumeni syndrome 1

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Gene type:
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Total variants: 44
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HGVS dbSNP gnomAD frequency
NM_000546.6(TP53):c.376-283T>C rs1794287 0.84958
NM_000546.6(TP53):c.376-91G>A rs2909430 0.83528
NM_000546.6(TP53):c.672+62A>G rs1625895 0.83418
NM_000546.6(TP53):c.74+38C>G rs1642785 0.66254
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) rs1042522 0.62654
NM_000546.6(TP53):c.782+92T>G rs12951053 0.09904
NM_000546.6(TP53):c.782+72C>T rs12947788 0.09901
NM_000546.6(TP53):c.97-29C>A rs17883323 0.07310
NM_000546.6(TP53):c.*773C>T rs200378797 0.06166
NM_000546.6(TP53):c.*826G>A rs17884306 0.05075
NM_000546.6(TP53):c.993+352C>T rs77697176 0.03428
NM_000546.6(TP53):c.*485G>A rs4968187 0.01815
NM_000546.6(TP53):c.993+12T>C rs1800899 0.01614
NM_000546.6(TP53):c.639A>G (p.Arg213=) rs1800372 0.01275
NM_000546.6(TP53):c.108G>A (p.Pro36=) rs1800370 0.00974
NM_000546.6(TP53):c.*1175A>C rs78378222 0.00849
NM_000546.6(TP53):c.97-6C>T rs35117667 0.00847
NM_000546.6(TP53):c.*205G>A rs16956880 0.00497
NM_000546.6(TP53):c.672+31A>G rs34949160 0.00479
NM_000546.6(TP53):c.*328G>A rs17881366 0.00463
NM_000546.6(TP53):c.*613C>A rs17879353 0.00271
NM_000546.6(TP53):c.139C>T (p.Pro47Ser) rs1800371 0.00123
NM_000546.6(TP53):c.216C>T (p.Pro72=) rs56275308 0.00022
NM_000546.6(TP53):c.1014C>T (p.Phe338=) rs150293825 0.00018
NM_000546.6(TP53):c.672+18G>C rs199578278 0.00014
NM_000546.6(TP53):c.869G>A (p.Arg290His) rs55819519 0.00014
NM_000546.6(TP53):c.6G>A (p.Glu2=) rs143458271 0.00009
NM_000546.6(TP53):c.1149C>T (p.Leu383=) rs373710656 0.00004
NM_000546.6(TP53):c.255T>C (p.Pro85=) rs775515332 0.00004
NM_000546.6(TP53):c.180A>C (p.Pro60=) rs749289195 0.00003
NM_000546.6(TP53):c.30C>T (p.Val10=) rs568171603 0.00003
NM_000546.6(TP53):c.903A>G (p.Pro301=) rs72661120 0.00003
NM_000546.6(TP53):c.234A>G (p.Ala78=) rs375099397 0.00002
NM_000546.6(TP53):c.249G>A (p.Ala83=) rs55754907 0.00002
NM_000546.6(TP53):c.510G>A (p.Thr170=) rs757544615 0.00002
NM_000546.6(TP53):c.1023C>T (p.Phe341=) rs864622369 0.00001
NM_000546.6(TP53):c.222C>T (p.Ala74=) rs786201577 0.00001
NM_000546.6(TP53):c.408A>G (p.Gln136=) rs758781593 0.00001
NM_000546.6(TP53):c.885T>C (p.Pro295=) rs200073907 0.00001
NC_000017.11:g.7668174_7668179dup rs17880560
NM_000546.6(TP53):c.*1070C>T rs114831472
NM_000546.6(TP53):c.666G>T (p.Pro222=) rs72661118
NM_000546.6(TP53):c.673-36G>C rs17880604
NM_000546.6(TP53):c.96+41_97-54del rs59758982

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