ClinVar Miner

List of variants in gene TP53 reported as uncertain significance by Department of Pathology and Laboratory Medicine, Sinai Health System

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Gene type:
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Total variants: 59
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HGVS dbSNP gnomAD frequency
NM_000546.6(TP53):c.869G>A (p.Arg290His) rs55819519 0.00014
NM_000546.6(TP53):c.847C>T (p.Arg283Cys) rs149633775 0.00009
NM_000546.6(TP53):c.1149C>T (p.Leu383=) rs373710656 0.00004
NM_000546.6(TP53):c.141G>A (p.Pro47=) rs201741778 0.00004
NM_000546.6(TP53):c.998G>A (p.Arg333His) rs573154688 0.00004
NM_000546.6(TP53):c.214C>G (p.Pro72Ala) rs587782769 0.00003
NM_000546.6(TP53):c.329G>A (p.Arg110His) rs11540654 0.00003
NM_000546.6(TP53):c.467G>A (p.Arg156His) rs371524413 0.00003
NM_000546.6(TP53):c.466C>T (p.Arg156Cys) rs563378859 0.00002
NM_000546.6(TP53):c.1066G>C (p.Gly356Arg) rs766786605 0.00001
NM_000546.6(TP53):c.1093C>T (p.His365Tyr) rs267605075 0.00001
NM_000546.6(TP53):c.245C>T (p.Pro82Leu) rs534447939 0.00001
NM_000546.6(TP53):c.328C>T (p.Arg110Cys) rs587781371 0.00001
NM_000546.6(TP53):c.376-2dup rs751253294 0.00001
NM_000546.6(TP53):c.469G>A (p.Val157Ile) rs121912654 0.00001
NM_000546.6(TP53):c.472C>T (p.Arg158Cys) rs587780068 0.00001
NM_000546.6(TP53):c.587G>A (p.Arg196Gln) rs483352697 0.00001
NM_000546.6(TP53):c.605G>A (p.Arg202His) rs587778719 0.00001
NM_000546.6(TP53):c.607G>A (p.Val203Met) rs730882003 0.00001
NM_000546.6(TP53):c.642T>G (p.His214Gln) rs587781386 0.00001
NM_000546.6(TP53):c.760A>G (p.Ile254Val) rs746601313 0.00001
NM_000546.6(TP53):c.800G>A (p.Arg267Gln) rs587780075 0.00001
NM_000546.6(TP53):c.848G>A (p.Arg283His) rs371409680 0.00001
NM_000546.6(TP53):c.850A>T (p.Thr284Ser) rs1204379654 0.00001
NM_000546.6(TP53):c.*8C>T
NM_000546.6(TP53):c.1007A>G (p.Glu336Gly)
NM_000546.6(TP53):c.1013T>C (p.Phe338Ser) rs1064796401
NM_000546.6(TP53):c.1015G>C (p.Glu339Gln) rs17882252
NM_000546.6(TP53):c.1063G>T (p.Ala355Ser) rs1157427821
NM_000546.6(TP53):c.107C>T (p.Pro36Leu) rs587781866
NM_000546.6(TP53):c.1136G>T (p.Arg379Leu) rs863224682
NM_000546.6(TP53):c.116C>T (p.Ala39Val) rs1353016807
NM_000546.6(TP53):c.176G>A (p.Gly59Asp) rs1597374828
NM_000546.6(TP53):c.205G>A (p.Ala69Thr) rs1567556618
NM_000546.6(TP53):c.275C>T (p.Pro92Leu) rs1210700121
NM_000546.6(TP53):c.292C>T (p.Pro98Ser) rs1597374015
NM_000546.6(TP53):c.293C>T (p.Pro98Leu) rs1245723119
NM_000546.6(TP53):c.314G>A (p.Gly105Asp) rs587781504
NM_000546.6(TP53):c.359A>C (p.Lys120Thr)
NM_000546.6(TP53):c.359A>G (p.Lys120Arg) rs2073450819
NM_000546.6(TP53):c.427G>A (p.Val143Met) rs587782620
NM_000546.6(TP53):c.471C>A (p.Val157=) rs1057522496
NM_000546.6(TP53):c.478A>G (p.Met160Val) rs377274728
NM_000546.6(TP53):c.514G>T (p.Val172Phe) rs1131691043
NM_000546.6(TP53):c.516T>G (p.Val172=) rs749309577
NM_000546.6(TP53):c.527G>A (p.Cys176Tyr) rs786202962
NM_000546.6(TP53):c.560-9T>A rs794727781
NM_000546.6(TP53):c.652G>A (p.Val218Met) rs878854072
NM_000546.6(TP53):c.672+15T>G rs140756213
NM_000546.6(TP53):c.673-9A>G rs754628512
NM_000546.6(TP53):c.684C>G (p.Asp228Glu) rs2073267220
NM_000546.6(TP53):c.715_720del (p.Asn239_Ser240del)
NM_000546.6(TP53):c.761T>C (p.Ile254Thr) rs1330865474
NM_000546.6(TP53):c.80C>T (p.Pro27Leu) rs1555526933
NM_000546.6(TP53):c.827C>T (p.Ala276Val)
NM_000546.6(TP53):c.830G>A (p.Cys277Tyr) rs763098116
NM_000546.6(TP53):c.892G>A (p.Glu298Lys) rs201744589
NM_000546.6(TP53):c.917G>A (p.Arg306Gln) rs1048095040
NM_000546.6(TP53):c.962A>C (p.Lys321Thr)

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