ClinVar Miner

List of variants in gene TP53 reported as uncertain significance by Ambry Genetics

Minimum submission review status: Collection method:
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Gene type:
ClinVar version:
Total variants: 269
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HGVS dbSNP
NM_000546.5(TP53):c.1000G>A (p.Gly334Arg) rs730882028
NM_000546.5(TP53):c.1000G>C (p.Gly334Arg) rs730882028
NM_000546.5(TP53):c.1003C>T (p.Arg335Cys) rs375444154
NM_000546.5(TP53):c.1004G>A (p.Arg335His) rs771939956
NM_000546.5(TP53):c.100C>G (p.Pro34Ala) rs786201968
NM_000546.5(TP53):c.1014C>G (p.Phe338Leu) rs150293825
NM_000546.5(TP53):c.1015G>A (p.Glu339Lys) rs17882252
NM_000546.5(TP53):c.1015G>C (p.Glu339Gln) rs17882252
NM_000546.5(TP53):c.1025G>A (p.Arg342Gln) rs375338359
NM_000546.5(TP53):c.1038G>C (p.Glu346Asp) rs1555524406
NM_000546.5(TP53):c.103T>A (p.Leu35Met) rs1060501211
NM_000546.5(TP53):c.1040C>T (p.Ala347Val) rs397516434
NM_000546.5(TP53):c.1048C>T (p.Leu350Phe) rs768046010
NM_000546.5(TP53):c.1051A>G (p.Lys351Glu) rs141402957
NM_000546.5(TP53):c.1054G>T (p.Asp352Tyr) rs1555524394
NM_000546.5(TP53):c.105G>C (p.Leu35Phe) rs121912661
NM_000546.5(TP53):c.1060C>A (p.Gln354Lys) rs755394212
NM_000546.5(TP53):c.1066G>C (p.Gly356Arg) rs766786605
NM_000546.5(TP53):c.1072G>A (p.Glu358Lys) rs587782237
NM_000546.5(TP53):c.1073A>T (p.Glu358Val) rs773553186
NM_000546.5(TP53):c.1078G>A (p.Gly360Arg) rs786203298
NM_000546.5(TP53):c.1078G>T (p.Gly360Trp) rs786203298
NM_000546.5(TP53):c.1079G>A (p.Gly360Glu) rs35993958
NM_000546.5(TP53):c.107C>A (p.Pro36Gln) rs587781866
NM_000546.5(TP53):c.1081G>C (p.Gly361Arg) rs1555524361
NM_000546.5(TP53):c.1082G>A (p.Gly361Glu) rs587781663
NM_000546.5(TP53):c.1085G>T (p.Ser362Ile) rs768803947
NM_000546.5(TP53):c.1088G>A (p.Arg363Lys) rs876660285
NM_000546.5(TP53):c.1093C>T (p.His365Tyr) rs267605075
NM_000546.5(TP53):c.1096T>G (p.Ser366Ala) rs17881470
NM_000546.5(TP53):c.1099A>G (p.Ser367Gly) rs876659459
NM_000546.5(TP53):c.1100+13A>G rs77881630
NM_000546.5(TP53):c.1102C>T (p.His368Tyr) rs786204227
NM_000546.5(TP53):c.1104C>G (p.His368Gln) rs1289241865
NM_000546.5(TP53):c.1115A>G (p.Lys372Arg) rs876658876
NM_000546.5(TP53):c.1120G>A (p.Gly374Ser) rs587781858
NM_000546.5(TP53):c.1123C>T (p.Gln375Ter) rs1555524156
NM_000546.5(TP53):c.1133C>G (p.Ser378Cys) rs1555524130
NM_000546.5(TP53):c.1135C>A (p.Arg379Ser) rs749061599
NM_000546.5(TP53):c.1135C>T (p.Arg379Cys) rs749061599
NM_000546.5(TP53):c.1136G>T (p.Arg379Leu) rs863224682
NM_000546.5(TP53):c.1139del (p.His380fs) rs1131691012
NM_000546.5(TP53):c.1150A>G (p.Met384Val) rs730882009
NM_000546.5(TP53):c.1151T>C (p.Met384Thr) rs1060501196
NM_000546.5(TP53):c.1153T>C (p.Phe385Leu) rs1555524094
NM_000546.5(TP53):c.1163A>C (p.Glu388Ala) rs587781736
NM_000546.5(TP53):c.1179dup (p.Ter394LeuextTer?) rs1131691024
NM_000546.5(TP53):c.1180T>G (p.Ter394Gly) rs1555524079
NM_000546.5(TP53):c.119T>C (p.Met40Thr) rs587782877
NM_000546.5(TP53):c.11C>T (p.Pro4Leu) rs878854064
NM_000546.5(TP53):c.121G>A (p.Asp41Asn) rs1555526789
NM_000546.5(TP53):c.125A>G (p.Asp42Gly) rs587781767
NM_000546.5(TP53):c.136T>C (p.Ser46Pro) rs876659630
NM_000546.5(TP53):c.144C>A (p.Asp48Glu) rs587781460
NM_000546.5(TP53):c.145G>C (p.Asp49His) rs587780728
NM_000546.5(TP53):c.146A>G (p.Asp49Gly) rs759728549
NM_000546.5(TP53):c.149T>A (p.Ile50Asn) rs370502517
NM_000546.5(TP53):c.149T>C (p.Ile50Thr) rs370502517
NM_000546.5(TP53):c.14A>G (p.Gln5Arg) rs781595324
NM_000546.5(TP53):c.155A>G (p.Gln52Arg) rs774656101
NM_000546.5(TP53):c.171C>A (p.Asp57Glu) rs587782776
NM_000546.5(TP53):c.187G>A (p.Ala63Thr) rs876658902
NM_000546.5(TP53):c.188C>G (p.Ala63Gly) rs372201428
NM_000546.5(TP53):c.188C>T (p.Ala63Val) rs372201428
NM_000546.5(TP53):c.198G>A (p.Met66Ile) rs1555526711
NM_000546.5(TP53):c.19G>C (p.Asp7His) rs587782646
NM_000546.5(TP53):c.214C>A (p.Pro72Thr) rs587782769
NM_000546.5(TP53):c.214C>G (p.Pro72Ala) rs587782769
NM_000546.5(TP53):c.214C>T (p.Pro72Ser) rs587782769
NM_000546.5(TP53):c.214_215delinsTG (p.Pro72Cys) rs730882014
NM_000546.5(TP53):c.215C>A (p.Pro72His) rs1042522
NM_000546.5(TP53):c.221C>T (p.Ala74Val) rs587781832
NM_000546.5(TP53):c.229C>A (p.Pro77Thr) rs753085009
NM_000546.5(TP53):c.232G>A (p.Ala78Thr) rs1555526673
NM_000546.5(TP53):c.233C>G (p.Ala78Gly) rs876658527
NM_000546.5(TP53):c.234_263del (p.Ala79_Ala88del) rs754312472
NM_000546.5(TP53):c.238C>T (p.Pro80Ser) rs1060501204
NM_000546.5(TP53):c.244C>G (p.Pro82Ala) rs1555526664
NM_000546.5(TP53):c.245C>T (p.Pro82Leu) rs534447939
NM_000546.5(TP53):c.248C>A (p.Ala83Glu) rs201717599
NM_000546.5(TP53):c.250G>A (p.Ala84Thr) rs587781307
NM_000546.5(TP53):c.263C>T (p.Ala88Val) rs1555526631
NM_000546.5(TP53):c.275C>T (p.Pro92Leu) rs1210700121
NM_000546.5(TP53):c.28G>C (p.Val10Leu) rs535274413
NM_000546.5(TP53):c.305C>T (p.Thr102Ile) rs786202717
NM_000546.5(TP53):c.307_309dup (p.Tyr103dup) rs1555526586
NM_000546.5(TP53):c.30C>T (p.Val10=) rs568171603
NM_000546.5(TP53):c.31G>A (p.Glu11Lys) rs201382018
NM_000546.5(TP53):c.320A>C (p.Tyr107Ser) rs587782447
NM_000546.5(TP53):c.320A>G (p.Tyr107Cys) rs587782447
NM_000546.5(TP53):c.322G>A (p.Gly108Ser) rs587782461
NM_000546.5(TP53):c.328C>A (p.Arg110Ser) rs587781371
NM_000546.5(TP53):c.328C>T (p.Arg110Cys) rs587781371
NM_000546.5(TP53):c.329G>A (p.Arg110His) rs11540654
NM_000546.5(TP53):c.337T>G (p.Phe113Val) rs587781642
NM_000546.5(TP53):c.343C>A (p.His115Asn) rs1555526532
NM_000546.5(TP53):c.344A>G (p.His115Arg) rs730881996
NM_000546.5(TP53):c.349G>A (p.Gly117Arg) rs1555526518
NM_000546.5(TP53):c.353C>T (p.Thr118Ile) rs1064794141
NM_000546.5(TP53):c.355G>C (p.Ala119Pro) rs1555526506
NM_000546.5(TP53):c.358A>G (p.Lys120Glu) rs121912658
NM_000546.5(TP53):c.364G>A (p.Val122Met) rs587781495
NM_000546.5(TP53):c.368C>T (p.Thr123Ile) rs1555526486
NM_000546.5(TP53):c.370T>A (p.Cys124Ser) rs730881997
NM_000546.5(TP53):c.370T>G (p.Cys124Gly) rs730881997
NM_000546.5(TP53):c.375+5G>A rs1555526466
NM_000546.5(TP53):c.376-2dupA rs751253294
NM_000546.5(TP53):c.376-4A>T rs1221388024
NM_000546.5(TP53):c.376T>A (p.Tyr126Asn) rs886039483
NM_000546.5(TP53):c.376T>G (p.Tyr126Asp) rs886039483
NM_000546.5(TP53):c.37C>T (p.Pro13Ser) rs1060501208
NM_000546.5(TP53):c.382C>A (p.Pro128Thr) rs1555526327
NM_000546.5(TP53):c.388C>G (p.Leu130Val) rs863224683
NM_000546.5(TP53):c.388C>T (p.Leu130Phe) rs863224683
NM_000546.5(TP53):c.38C>G (p.Pro13Arg) rs878854070
NM_000546.5(TP53):c.390_392CAA[1] (p.Asn131del) rs879254214
NM_000546.5(TP53):c.393C>A (p.Asn131Lys) rs769270327
NM_000546.5(TP53):c.400T>A (p.Phe134Ile) rs267605077
NM_000546.5(TP53):c.403T>G (p.Cys135Gly) rs1057519975
NM_000546.5(TP53):c.406C>G (p.Gln136Glu) rs1555526268
NM_000546.5(TP53):c.408A>C (p.Gln136His) rs758781593
NM_000546.5(TP53):c.408A>T (p.Gln136His) rs758781593
NM_000546.5(TP53):c.413C>T (p.Ala138Val) rs750600586
NM_000546.5(TP53):c.419C>A (p.Thr140Asn) rs786202561
NM_000546.5(TP53):c.427G>A (p.Val143Met) rs587782620
NM_000546.5(TP53):c.427G>T (p.Val143Leu) rs587782620
NM_000546.5(TP53):c.428T>G (p.Val143Gly) rs1555526241
NM_000546.5(TP53):c.431A>C (p.Gln144Pro) rs786203071
NM_000546.5(TP53):c.434T>A (p.Leu145Gln) rs587782197
NM_000546.5(TP53):c.434T>C (p.Leu145Pro) rs587782197
NM_000546.5(TP53):c.436T>G (p.Trp146Gly) rs786203064
NM_000546.5(TP53):c.442G>T (p.Asp148Tyr) rs1131691007
NM_000546.5(TP53):c.443A>C (p.Asp148Ala) rs1046611742
NM_000546.5(TP53):c.446C>T (p.Ser149Phe) rs1555526214
NM_000546.5(TP53):c.454C>T (p.Pro152Ser) rs767328513
NM_000546.5(TP53):c.457C>T (p.Pro153Ser) rs1064795860
NM_000546.5(TP53):c.460G>A (p.Gly154Ser) rs137852789
NM_000546.5(TP53):c.460G>C (p.Gly154Arg) rs137852789
NM_000546.5(TP53):c.461G>A (p.Gly154Asp) rs762846821
NM_000546.5(TP53):c.466C>T (p.Arg156Cys) rs563378859
NM_000546.5(TP53):c.469G>A (p.Val157Ile) rs121912654
NM_000546.5(TP53):c.480G>A (p.Met160Ile) rs772354334
NM_000546.5(TP53):c.481G>A (p.Ala161Thr) rs193920817
NM_000546.5(TP53):c.492G>C (p.Lys164Asn) rs1131691034
NM_000546.5(TP53):c.509C>T (p.Thr170Met) rs779000871
NM_000546.5(TP53):c.511G>A (p.Glu171Lys) rs587781845
NM_000546.5(TP53):c.515T>G (p.Val172Gly) rs1131691021
NM_000546.5(TP53):c.523C>T (p.Arg175Cys) rs138729528
NM_000546.5(TP53):c.526T>A (p.Cys176Ser) rs967461896
NM_000546.5(TP53):c.528C>G (p.Cys176Trp) rs1057519980
NM_000546.5(TP53):c.529C>A (p.Pro177Thr) rs147002414
NM_000546.5(TP53):c.530_532dup (p.Pro177dup) rs786202525
NM_000546.5(TP53):c.541C>A (p.Arg181Ser) rs587782596
NM_000546.5(TP53):c.548C>T (p.Ser183Leu) rs1555525970
NM_000546.5(TP53):c.554G>A (p.Ser185Asn) rs150607408
NM_000546.5(TP53):c.556G>A (p.Asp186Asn) rs1060501206
NM_000546.5(TP53):c.558T>A (p.Asp186Glu) rs375275361
NM_000546.5(TP53):c.566C>T (p.Ala189Val) rs121912665
NM_000546.5(TP53):c.568C>A (p.Pro190Thr) rs876660254
NM_000546.5(TP53):c.569C>G (p.Pro190Arg) rs876660825
NM_000546.5(TP53):c.572C>G (p.Pro191Arg) rs587778718
NM_000546.5(TP53):c.581T>A (p.Leu194His) rs1057519998
NM_000546.5(TP53):c.581T>G (p.Leu194Arg) rs1057519998
NM_000546.5(TP53):c.586C>G (p.Arg196Gly) rs397516435
NM_000546.5(TP53):c.589G>C (p.Val197Leu) rs786204041
NM_000546.5(TP53):c.58T>C (p.Ser20Pro) rs876659913
NM_000546.5(TP53):c.604C>G (p.Arg202Gly) rs587780072
NM_000546.5(TP53):c.607G>A (p.Val203Met) rs730882003
NM_000546.5(TP53):c.607G>C (p.Val203Leu) rs730882003
NM_000546.5(TP53):c.607G>T (p.Val203Leu) rs730882003
NM_000546.5(TP53):c.634T>A (p.Phe212Ile) rs1064795766
NM_000546.5(TP53):c.640C>A (p.His214Asn) rs876658466
NM_000546.5(TP53):c.643A>C (p.Ser215Arg) rs886039484
NM_000546.5(TP53):c.644G>C (p.Ser215Thr) rs587782177
NM_000546.5(TP53):c.657_668del (p.Tyr220_Pro223del) rs876660749
NM_000546.5(TP53):c.658T>C (p.Tyr220His) rs530941076
NM_000546.5(TP53):c.661G>A (p.Glu221Lys) rs786201592
NM_000546.5(TP53):c.664C>T (p.Pro222Ser) rs1060501203
NM_000546.5(TP53):c.665C>T (p.Pro222Leu) rs146340390
NM_000546.5(TP53):c.668C>T (p.Pro223Leu) rs138983188
NM_000546.5(TP53):c.670G>A (p.Glu224Lys) rs1555525707
NM_000546.5(TP53):c.671A>C (p.Glu224Ala) rs1131691028
NM_000546.5(TP53):c.673-4C>G rs1555525586
NM_000546.5(TP53):c.673-5C>G rs876658684
NM_000546.5(TP53):c.673G>A (p.Val225Ile) rs746504075
NM_000546.5(TP53):c.677G>T (p.Gly226Val) rs970212462
NM_000546.5(TP53):c.685T>C (p.Cys229Arg) rs1064794312
NM_000546.5(TP53):c.694A>C (p.Ile232Leu) rs1555525562
NM_000546.5(TP53):c.698A>G (p.His233Arg) rs879254233
NM_000546.5(TP53):c.706T>A (p.Tyr236Asn) rs587782289
NM_000546.5(TP53):c.710T>C (p.Met237Thr) rs765848205
NM_000546.5(TP53):c.727A>C (p.Met243Leu) rs786203117
NM_000546.5(TP53):c.727A>G (p.Met243Val) rs786203117
NM_000546.5(TP53):c.740A>T (p.Asn247Ile) rs786201762
NM_000546.5(TP53):c.745A>T (p.Arg249Trp) rs587782082
NM_000546.5(TP53):c.746G>A (p.Arg249Lys) rs587782329
NM_000546.5(TP53):c.753C>G (p.Ile251Met) rs878854074
NM_000546.5(TP53):c.760A>G (p.Ile254Val) rs746601313
NM_000546.5(TP53):c.764T>A (p.Ile255Asn) rs876659675
NM_000546.5(TP53):c.776A>T (p.Asp259Val) rs745425759
NM_000546.5(TP53):c.779C>A (p.Ser260Tyr) rs876658916
NM_000546.5(TP53):c.782G>C (p.Ser261Thr) rs786203396
NM_000546.5(TP53):c.784G>A (p.Gly262Ser) rs200579969
NM_000546.5(TP53):c.785G>T (p.Gly262Val) rs1131691025
NM_000546.5(TP53):c.787A>G (p.Asn263Asp) rs72661119
NM_000546.5(TP53):c.789T>A (p.Asn263Lys) rs770598448
NM_000546.5(TP53):c.791T>C (p.Leu264Pro) rs1555525353
NM_000546.5(TP53):c.797G>T (p.Gly266Val) rs193920774
NM_000546.5(TP53):c.800G>A (p.Arg267Gln) rs587780075
NM_000546.5(TP53):c.80C>T (p.Pro27Leu) rs1555526933
NM_000546.5(TP53):c.813_814delinsTA (p.Glu271_Val272delinsAspMet) rs1555525303
NM_000546.5(TP53):c.814G>A (p.Val272Met) rs121912657
NM_000546.5(TP53):c.815T>G (p.Val272Gly) rs876660333
NM_000546.5(TP53):c.832C>G (p.Pro278Ala) rs17849781
NM_000546.5(TP53):c.832C>T (p.Pro278Ser) rs17849781
NM_000546.5(TP53):c.833C>G (p.Pro278Arg) rs876659802
NM_000546.5(TP53):c.835G>A (p.Gly279Arg) rs1555525248
NM_000546.5(TP53):c.838_846del (p.Asp281_Arg283del) rs1555525215
NM_000546.5(TP53):c.83A>T (p.Glu28Val) rs786202289
NM_000546.5(TP53):c.845G>A (p.Arg282Gln) rs730882008
NM_000546.5(TP53):c.845G>T (p.Arg282Leu) rs730882008
NM_000546.5(TP53):c.847C>T (p.Arg283Cys) rs149633775
NM_000546.5(TP53):c.848G>C (p.Arg283Pro) rs371409680
NM_000546.5(TP53):c.850A>T (p.Thr284Ser) rs1204379654
NM_000546.5(TP53):c.851C>T (p.Thr284Ile) rs863224685
NM_000546.5(TP53):c.859G>A (p.Glu287Lys) rs587782006
NM_000546.5(TP53):c.85_87AAC[1] (p.Asn30del) rs587782270
NM_000546.5(TP53):c.861G>C (p.Glu287Asp) rs748891343
NM_000546.5(TP53):c.868C>T (p.Arg290Cys) rs770374782
NM_000546.5(TP53):c.869G>A (p.Arg290His) rs55819519
NM_000546.5(TP53):c.871A>G (p.Lys291Glu) rs1555525126
NM_000546.5(TP53):c.875A>G (p.Lys292Arg) rs121912663
NM_000546.5(TP53):c.877G>A (p.Gly293Arg) rs587780076
NM_000546.5(TP53):c.877G>T (p.Gly293Trp) rs587780076
NM_000546.5(TP53):c.890A>G (p.His297Arg) rs876659477
NM_000546.5(TP53):c.8A>G (p.Glu3Gly) rs786203938
NM_000546.5(TP53):c.902C>T (p.Pro301Leu) rs1555525067
NM_000546.5(TP53):c.907A>G (p.Ser303Gly) rs587782391
NM_000546.5(TP53):c.908G>A (p.Ser303Asn) rs876658714
NM_000546.5(TP53):c.910A>G (p.Thr304Ala) rs587782654
NM_000546.5(TP53):c.917G>A (p.Arg306Gln) rs1048095040
NM_000546.5(TP53):c.919+3A>G rs876659784
NM_000546.5(TP53):c.919+5G>C rs766127339
NM_000546.5(TP53):c.91G>A (p.Val31Ile) rs201753350
NM_000546.5(TP53):c.91G>T (p.Val31Phe) rs201753350
NM_000546.5(TP53):c.920-3T>C rs1367689213
NM_000546.5(TP53):c.920-5C>T rs34361146
NM_000546.5(TP53):c.920C>G (p.Ala307Gly) rs1457582183
NM_000546.5(TP53):c.925C>T (p.Pro309Ser) rs1555525012
NM_000546.5(TP53):c.930C>A (p.Asn310Lys) rs876660829
NM_000546.5(TP53):c.930C>G (p.Asn310Lys) rs876660829
NM_000546.5(TP53):c.941C>T (p.Ser314Phe) rs751440465
NM_000546.5(TP53):c.943T>A (p.Ser315Thr) rs762620193
NM_000546.5(TP53):c.946C>A (p.Pro316Thr) rs772773208
NM_000546.5(TP53):c.949C>A (p.Gln317Lys) rs764735889
NM_000546.5(TP53):c.964C>A (p.Pro322Thr) rs863224687
NM_000546.5(TP53):c.964C>T (p.Pro322Ser) rs863224687
NM_000546.5(TP53):c.97-3C>T rs786203749
NM_000546.5(TP53):c.97-4A>T rs746791390
NM_000546.5(TP53):c.970G>C (p.Asp324His) rs1064794810
NM_000546.5(TP53):c.973G>A (p.Gly325Arg) rs863224500
NM_000546.5(TP53):c.974G>A (p.Gly325Glu) rs121912659
NM_000546.5(TP53):c.974G>T (p.Gly325Val) rs121912659
NM_000546.5(TP53):c.98C>A (p.Ser33Tyr) rs1555526832
NM_000546.5(TP53):c.993+4del rs876660156
NM_000546.5(TP53):c.993+5T>C rs1310956961
NM_000546.5(TP53):c.994-5T>C rs375273756
NM_000546.5(TP53):c.997C>T (p.Arg333Cys) rs769934890
NM_000546.5(TP53):c.998G>A (p.Arg333His) rs573154688

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