ClinVar Miner

Variants in gene VCL

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
3 11 225 128 42 1 344

Condition and significance breakdown #

Total conditions: 19
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Dilated cardiomyopathy 1W 2 0 93 48 27 0 170
not specified 0 0 39 79 34 0 138
not provided 0 0 66 5 5 0 73
Dilated Cardiomyopathy, Dominant 0 0 50 12 0 0 62
Cardiovascular phenotype 0 0 20 14 13 0 47
Cardiomyopathy 0 1 13 2 9 0 25
Primary dilated cardiomyopathy 0 9 1 0 0 0 10
Dilated cardiomyopathy 1W; Familial hypertrophic cardiomyopathy 15 0 0 4 0 0 1 5
Familial hypertrophic cardiomyopathy 15 2 1 2 0 0 0 5
Hypertrophic cardiomyopathy 0 0 2 1 0 0 3
Wolff-Parkinson-White pattern 0 0 3 0 0 0 3
Familial dilated cardiomyopathy 0 0 2 0 0 0 2
Primary familial hypertrophic cardiomyopathy 0 0 2 0 0 0 2
Congestive heart failure 0 0 1 0 0 0 1
Dilated cardiomyopathy 0 0 0 1 0 0 1
Dilated cardiomyopathy 1S 0 0 1 0 0 0 1
Dilated cardiomyopathy with left ventricular noncompaction 0 0 1 0 0 0 1
Long QT syndrome 0 0 1 0 0 0 1
Paroxysmal familial ventricular fibrillation 1 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 27
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 0 0 91 48 27 0 166
GeneDx 0 0 42 54 29 0 125
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 9 34 32 21 0 96
Illumina Clinical Services Laboratory,Illumina 0 0 51 12 0 0 63
Ambry Genetics 0 0 20 14 13 0 47
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 1 12 2 7 0 22
Biesecker Lab/Human Development Section,National Institutes of Health 0 0 13 6 0 0 19
Integrated Genetics/Laboratory Corporation of America 0 0 3 2 9 0 14
PreventionGenetics 0 0 0 2 9 0 11
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 6 1 3 0 10
Stanford Center for Inherited Cardiovascular Disease,Stanford University 0 0 8 0 0 0 8
Blueprint Genetics, 0 0 7 0 0 0 7
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 3 0 3 0 6
OMIM 3 0 0 0 0 0 3
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Lupski Lab, Baylor-Hopkins CMG,Baylor College of Medicine 0 0 3 0 0 0 3
Center for Human Genetics,University of Leuven 0 0 2 1 0 0 3
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 3 0 0 0 3
Fulgent Genetics 0 0 2 0 0 0 2
Division of Human Genetics,Children's Hospital of Philadelphia 0 0 2 0 0 0 2
Center of Genomic medicine, Geneva,University Hospital of Geneva 0 0 2 0 0 0 2
Developmental Genetics Unit,King Faisal Specialist Hospital & Research Centre 0 0 0 1 0 0 1
Laboratory of Genetics and Molecular Cardiology,University of São Paulo 0 1 0 0 0 0 1
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 0 1 0 0 0 1
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 1 0 0 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1

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