ClinVar Miner

Variants in gene VCL

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
3 9 408 193 69 1 602

Condition and significance breakdown #

Total conditions: 23
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Dilated cardiomyopathy 1W 2 0 319 108 33 0 432
not specified 0 0 44 83 37 0 147
not provided 0 0 76 48 26 0 145
Cardiovascular phenotype 0 0 17 17 13 0 47
Cardiomyopathy 0 1 19 7 14 0 39
Primary dilated cardiomyopathy 0 7 6 2 1 0 16
none provided 0 0 3 2 8 0 13
Dilated Cardiomyopathy, Dominant 0 0 9 1 0 0 10
Hypertrophic cardiomyopathy 0 0 6 1 0 0 7
Primary familial dilated cardiomyopathy 0 0 6 0 0 0 6
Dilated cardiomyopathy 1W; Familial hypertrophic cardiomyopathy 15 0 0 4 0 0 1 5
Familial hypertrophic cardiomyopathy 15 2 1 2 0 0 0 5
Wolff-Parkinson-White pattern 0 0 3 0 0 0 3
Primary familial hypertrophic cardiomyopathy 0 0 2 0 0 0 2
Aborted sudden cardiac death 0 0 1 0 0 0 1
Cardiac arrest 0 0 1 0 0 0 1
Congestive heart failure 0 0 1 0 0 0 1
Dilated cardiomyopathy 1S 0 0 1 0 0 0 1
Dilated cardiomyopathy with left ventricular noncompaction 0 0 1 0 0 0 1
Hirschsprung disease 0 0 1 0 0 0 1
Long QT syndrome 0 0 1 0 0 0 1
Paroxysmal familial ventricular fibrillation 1 0 0 1 0 0 0 1
Ventricular tachycardia 0 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 36
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 0 0 258 112 28 0 398
GeneDx 0 0 42 61 51 0 154
Illumina Clinical Services Laboratory,Illumina 0 0 83 11 9 0 103
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 0 7 38 32 22 0 99
Ambry Genetics 0 0 17 17 13 0 47
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 1 17 6 12 0 36
Integrated Genetics/Laboratory Corporation of America 0 0 3 4 17 0 24
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 13 6 0 0 19
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 6 3 9 0 18
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 11 7 0 0 18
PreventionGenetics, PreventionGenetics 0 0 0 2 9 0 11
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 6 1 3 0 10
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 8 1 0 0 9
Stanford Center for Inherited Cardiovascular Disease,Stanford University 0 0 8 0 0 0 8
Blueprint Genetics 0 0 7 0 0 0 7
Genetics and Genomics Program,Sidra Medicine 0 0 4 1 0 0 5
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 4 0 0 0 4
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 0 1 2 1 0 4
OMIM 3 0 0 0 0 0 3
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 3 0 0 0 3
Center of Genomic medicine, Geneva,University Hospital of Geneva 0 0 3 0 0 0 3
Center for Human Genetics,University of Leuven 0 0 2 1 0 0 3
Baylor Genetics 0 0 2 0 0 0 2
Mendelics 0 0 1 0 1 0 2
Fulgent Genetics,Fulgent Genetics 0 0 2 0 0 0 2
Division of Human Genetics,Children's Hospital of Philadelphia 0 0 2 0 0 0 2
Developmental Genetics Unit,King Faisal Specialist Hospital & Research Centre 0 0 0 1 0 0 1
Laboratory of Genetics and Molecular Cardiology, University of São Paulo 0 1 0 0 0 0 1
Clinical Genetics, Erasmus University Medical Center 0 0 1 0 0 0 1
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 0 1 0 0 0 1
Institute of Human Genetics,University of Wuerzburg 0 0 1 0 0 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Loeys Lab,Universiteit Antwerpen 0 0 1 0 0 0 1

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