ClinVar Miner

Variants in gene VCL

See also:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
3 10 320 160 68 1 485

Condition and significance breakdown #

Total conditions: 24
Download table as spreadsheet
Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Dilated cardiomyopathy 1W 2 0 223 56 33 0 285
not provided 0 0 76 47 27 0 145
not specified 0 0 41 80 36 0 142
Cardiovascular phenotype 0 0 18 16 13 0 47
Cardiomyopathy 0 1 19 7 14 0 39
Dilated Cardiomyopathy, Dominant 0 0 9 1 0 0 10
Primary dilated cardiomyopathy 0 7 2 0 0 0 9
Familial dilated cardiomyopathy 0 0 6 0 0 0 6
Hypertrophic cardiomyopathy 0 0 5 1 0 0 6
Dilated cardiomyopathy 1W; Familial hypertrophic cardiomyopathy 15 0 0 4 0 0 1 5
Familial hypertrophic cardiomyopathy 15 2 1 2 0 0 0 5
Wolff-Parkinson-White pattern 0 0 3 0 0 0 3
Dilated cardiomyopathy 0 0 0 1 1 0 2
Primary familial hypertrophic cardiomyopathy 0 0 2 0 0 0 2
Aborted sudden cardiac death 0 0 1 0 0 0 1
Cardiac arrest 0 0 1 0 0 0 1
Congestive heart failure 0 0 1 0 0 0 1
Dilated cardiomyopathy 1S 0 0 1 0 0 0 1
Dilated cardiomyopathy with left ventricular noncompaction 0 0 1 0 0 0 1
Hirschsprung disease 0 0 1 0 0 0 1
Long QT syndrome 0 0 1 0 0 0 1
Paroxysmal familial ventricular fibrillation 1 0 0 1 0 0 0 1
Primary dilated cardiomyopathy; Left ventricular noncompaction 0 1 0 0 0 0 1
Ventricular tachycardia 0 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 32
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 0 0 161 75 28 0 264
GeneDx 0 0 42 61 51 0 154
Illumina Clinical Services Laboratory,Illumina 0 0 83 11 9 0 103
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 0 8 35 32 22 0 97
Ambry Genetics 0 0 18 16 13 0 47
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario 0 1 17 6 12 0 36
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 13 6 0 0 19
CeGaT Praxis fuer Humangenetik Tuebingen 0 0 11 6 0 0 17
Integrated Genetics/Laboratory Corporation of America 0 0 3 2 9 0 14
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 4 1 7 0 12
PreventionGenetics,PreventionGenetics 0 0 0 2 9 0 11
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 6 1 3 0 10
Stanford Center for Inherited Cardiovascular Disease,Stanford University 0 0 8 0 0 0 8
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease,Montreal Heart Institute 0 0 8 0 0 0 8
Blueprint Genetics 0 0 7 0 0 0 7
Agnes Ginges Centre for Molecular Cardiology,Centenary Institute 0 0 4 0 0 0 4
Center for Advanced Laboratory Medicine, UC San Diego Health,University of California San Diego 0 0 1 2 1 0 4
OMIM 3 0 0 0 0 0 3
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 0 0 3 0 0 0 3
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 0 0 3 0 0 0 3
Center of Genomic medicine, Geneva,University Hospital of Geneva 0 0 3 0 0 0 3
Center for Human Genetics,University of Leuven 0 0 2 1 0 0 3
Mendelics 0 0 1 0 1 0 2
Fulgent Genetics,Fulgent Genetics 0 0 2 0 0 0 2
Division of Human Genetics,Children's Hospital of Philadelphia 0 0 2 0 0 0 2
Developmental Genetics Unit,King Faisal Specialist Hospital & Research Centre 0 0 0 1 0 0 1
Laboratory of Genetics and Molecular Cardiology, University of São Paulo 0 1 0 0 0 0 1
Clinical Genetics, Erasmus University Medical Center 0 0 1 0 0 0 1
Erich and Hanna Klessmann Institute for Cardiovascular Research and Development,Heart and Diabetes Center North Rhine-Westphalia 0 0 1 0 0 0 1
Institute of Human Genetics,University of Wuerzburg 0 0 1 0 0 0 1
Phosphorus, Inc. 0 0 1 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.