List of variants in gene VCL reported as uncertain significance by GeneDx

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 113

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HGVS	dbSNP	gnomAD frequency
NM_014000.3(VCL):c.1294C>G (p.Leu432Val)	rs144146254	0.00025
NM_014000.3(VCL):c.787A>T (p.Thr263Ser)	rs142233726	0.00022
NM_014000.3(VCL):c.2969C>T (p.Ala990Val)	rs150595117	0.00019
NM_014000.3(VCL):c.590C>T (p.Thr197Ile)	rs189242810	0.00019
NM_014000.3(VCL):c.2828_2829del (p.Pro943fs)	rs781036800	0.00014
NM_014000.3(VCL):c.1403C>T (p.Thr468Met)	rs147957747	0.00013
NM_014000.3(VCL):c.688C>T (p.Arg230Cys)	rs139312390	0.00010
NM_014000.3(VCL):c.829C>A (p.Leu277Met)	rs71579353	0.00010
NM_014000.3(VCL):c.1490T>C (p.Ile497Thr)	rs572757800	0.00008
NM_014000.3(VCL):c.1621C>G (p.Leu541Val)	rs370229150	0.00008
NM_014000.3(VCL):c.2444A>G (p.Lys815Arg)	rs373010557	0.00008
NM_014000.3(VCL):c.2531C>T (p.Pro844Leu)	rs145393322	0.00006
NM_014000.3(VCL):c.1287T>A (p.Asp429Glu)	rs139371702	0.00005
NM_014000.3(VCL):c.1583G>A (p.Arg528His)	rs746095066	0.00005
NM_014000.3(VCL):c.1192C>T (p.Pro398Ser)	rs201528612	0.00004
NM_014000.3(VCL):c.1511T>C (p.Ile504Thr)	rs745343813	0.00004
NM_014000.3(VCL):c.1607C>A (p.Pro536His)	rs200624351	0.00004
NM_014000.3(VCL):c.1871A>T (p.Glu624Val)	rs775238596	0.00004
NM_014000.3(VCL):c.2046A>T (p.Leu682Phe)	rs565398652	0.00004
NM_014000.3(VCL):c.2399A>T (p.Asp800Val)	rs919509789	0.00004
NM_014000.3(VCL):c.788C>G (p.Thr263Ser)	rs150443513	0.00004
NM_014000.3(VCL):c.1015C>T (p.Arg339Cys)	rs759961842	0.00003
NM_014000.3(VCL):c.1039C>T (p.Pro347Ser)	rs566961713	0.00003
NM_014000.3(VCL):c.1040C>T (p.Pro347Leu)	rs148619523	0.00003
NM_014000.3(VCL):c.1247G>A (p.Arg416Gln)	rs758811315	0.00003
NM_014000.3(VCL):c.1352+5G>A	rs374522164	0.00003
NM_014000.3(VCL):c.1535G>A (p.Arg512His)	rs367568441	0.00003
NM_014000.3(VCL):c.1841C>T (p.Thr614Met)	rs748140302	0.00003
NM_014000.3(VCL):c.1844C>T (p.Ala615Val)	rs148669762	0.00003
NM_014000.3(VCL):c.1940C>T (p.Ala647Val)	rs534449109	0.00003
NM_014000.3(VCL):c.2006G>A (p.Arg669Gln)	rs759771302	0.00003
NM_014000.3(VCL):c.1031G>C (p.Gly344Ala)	rs778875353	0.00002
NM_014000.3(VCL):c.1756C>T (p.Arg586Trp)	rs770778046	0.00002
NM_014000.3(VCL):c.2038C>T (p.Arg680Cys)	rs759356162	0.00002
NM_014000.3(VCL):c.224C>T (p.Pro75Leu)	rs373830664	0.00002
NM_014000.3(VCL):c.676G>A (p.Ala226Thr)	rs146910007	0.00002
NM_014000.3(VCL):c.1006G>A (p.Ala336Thr)	rs565546734	0.00001
NM_014000.3(VCL):c.1105A>G (p.Asn369Asp)	rs1421516056	0.00001
NM_014000.3(VCL):c.1226G>A (p.Arg409Gln)	rs1018998675	0.00001
NM_014000.3(VCL):c.1229G>A (p.Gly410Asp)	rs1064796607	0.00001
NM_014000.3(VCL):c.1238C>T (p.Ala413Val)	rs794729190	0.00001
NM_014000.3(VCL):c.1292T>G (p.Ile431Ser)	rs766192312	0.00001
NM_014000.3(VCL):c.1298G>A (p.Arg433His)	rs754046223	0.00001
NM_014000.3(VCL):c.1436G>A (p.Arg479Gln)	rs1271589037	0.00001
NM_014000.3(VCL):c.1465G>A (p.Ala489Thr)	rs1449290312	0.00001
NM_014000.3(VCL):c.1681A>G (p.Arg561Gly)	rs1321164216	0.00001
NM_014000.3(VCL):c.1798A>C (p.Ser600Arg)	rs397517236	0.00001
NM_014000.3(VCL):c.2000C>T (p.Thr667Met)	rs794729187	0.00001
NM_014000.3(VCL):c.2005C>T (p.Arg669Ter)	rs780856981	0.00001
NM_014000.3(VCL):c.2241G>C (p.Gln747His)	rs770019329	0.00001
NM_014000.3(VCL):c.2284C>T (p.Arg762Trp)	rs1334643090	0.00001
NM_014000.3(VCL):c.2353G>A (p.Ala785Thr)	rs778554042	0.00001
NM_014000.3(VCL):c.2365G>A (p.Glu789Lys)	rs745419923	0.00001
NM_014000.3(VCL):c.238A>C (p.Lys80Gln)	rs775532257	0.00001
NM_014000.3(VCL):c.239+6T>G	rs752335603	0.00001
NM_014000.3(VCL):c.2428G>A (p.Asp810Asn)	rs751458490	0.00001
NM_014000.3(VCL):c.2528C>T (p.Pro843Leu)	rs764302249	0.00001
NM_014000.3(VCL):c.2539C>T (p.Pro847Ser)	rs372711612	0.00001
NM_014000.3(VCL):c.2766G>T (p.Glu922Asp)	rs1036173576	0.00001
NM_014000.3(VCL):c.2807C>T (p.Ala936Val)	rs754681045	0.00001
NM_014000.3(VCL):c.2834T>C (p.Met945Thr)	rs1443843519	0.00001
NM_014000.3(VCL):c.2852C>G (p.Pro951Arg)	rs368570586	0.00001
NM_014000.3(VCL):c.292G>A (p.Asp98Asn)	rs794729193	0.00001
NM_014000.3(VCL):c.3226C>T (p.Arg1076Trp)	rs397517241	0.00001
NM_014000.3(VCL):c.562C>T (p.Arg188Ter)	rs397517244	0.00001
NM_014000.3(VCL):c.610G>C (p.Val204Leu)	rs727504585	0.00001
NM_014000.3(VCL):c.844G>T (p.Gly282Cys)	rs766091503	0.00001
NM_014000.3(VCL):c.1097A>T (p.Lys366Ile)
NM_014000.3(VCL):c.1198G>T (p.Gly400Cys)	rs201361282
NM_014000.3(VCL):c.1216G>T (p.Glu406Ter)
NM_014000.3(VCL):c.1296_1297inv (p.Arg433Cys)
NM_014000.3(VCL):c.1346G>A (p.Arg449Gln)	rs755234443
NM_014000.3(VCL):c.1537G>A (p.Gly513Arg)
NM_014000.3(VCL):c.1543+1G>T
NM_014000.3(VCL):c.1648C>G (p.Gln550Glu)	rs1406371942
NM_014000.3(VCL):c.1652T>C (p.Leu551Pro)	rs1057524278
NM_014000.3(VCL):c.1708C>T (p.Arg570Ter)	rs794729191
NM_014000.3(VCL):c.1744-1G>T	rs1057524654
NM_014000.3(VCL):c.1791T>A (p.Asp597Glu)	rs1839983396
NM_014000.3(VCL):c.1810A>G (p.Thr604Ala)	rs754470470
NM_014000.3(VCL):c.1819A>C (p.Lys607Gln)	rs794729192
NM_014000.3(VCL):c.1861A>C (p.Asn621His)	rs374309823
NM_014000.3(VCL):c.2050A>T (p.Arg684Trp)	rs730880249
NM_014000.3(VCL):c.2069C>A (p.Ala690Asp)	rs1057524826
NM_014000.3(VCL):c.2125dup (p.Met709fs)
NM_014000.3(VCL):c.2267T>C (p.Ile756Thr)	rs1554818898
NM_014000.3(VCL):c.2389A>G (p.Met797Val)
NM_014000.3(VCL):c.2434+5G>C	rs1459081905
NM_014000.3(VCL):c.2435-1G>A	rs794729188
NM_014000.3(VCL):c.248A>T (p.Asn83Ile)	rs1554816646
NM_014000.3(VCL):c.2728C>G (p.Arg910Gly)
NM_014000.3(VCL):c.2775_2780del (p.Gly926_Val927del)	rs757018106
NM_014000.3(VCL):c.2827C>A (p.Pro943Thr)	rs71579375
NM_014000.3(VCL):c.2906C>T (p.Ala969Val)
NM_014000.3(VCL):c.2950-1G>A
NM_014000.3(VCL):c.2977C>T (p.Arg993Cys)	rs1591719960
NM_014000.3(VCL):c.3008G>A (p.Arg1003Gln)	rs1085307604
NM_014000.3(VCL):c.3144C>A (p.Asn1048Lys)	rs2131939961
NM_014000.3(VCL):c.3163C>T (p.Arg1055Ter)	rs727505159
NM_014000.3(VCL):c.3164G>A (p.Arg1055Gln)	rs878973480
NM_014000.3(VCL):c.3184C>T (p.Gln1062Ter)
NM_014000.3(VCL):c.379G>A (p.Asp127Asn)	rs1554816666
NM_014000.3(VCL):c.448G>T (p.Val150Leu)
NM_014000.3(VCL):c.472G>T (p.Val158Phe)
NM_014000.3(VCL):c.482C>G (p.Thr161Arg)	rs376226543
NM_014000.3(VCL):c.565G>T (p.Val189Leu)	rs151045204
NM_014000.3(VCL):c.597del (p.Glu200fs)	rs777492997
NM_014000.3(VCL):c.646A>G (p.Lys216Glu)
NM_014000.3(VCL):c.686dup (p.Asn229fs)	rs776583302
NM_014000.3(VCL):c.736C>T (p.Arg246Cys)	rs794729194
NM_014000.3(VCL):c.780C>G (p.Ser260Arg)	rs774377548
NM_014000.3(VCL):c.818T>C (p.Ile273Thr)	rs762380935
NM_014000.3(VCL):c.953G>T (p.Arg318Leu)	rs1322859960

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