List of variants in gene WRN reported by GeneDx

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
		ClinVar version:

Total variants: 157

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HGVS	dbSNP	gnomAD frequency
NM_000553.6(WRN):c.2089-182T>A	rs2194846	0.98328
NM_000553.6(WRN):c.3819+255G>A	rs2737337	0.98028
NM_000553.6(WRN):c.3572+25_3572+26insC	rs3087415	0.97612
NM_000553.6(WRN):c.96+26T>C	rs2737316	0.96130
NM_000553.6(WRN):c.356-85C>T	rs2725346	0.95846
NM_000553.6(WRN):c.2089-3168C>T	rs1425295	0.82605
NM_000553.6(WRN):c.513C>T (p.Cys171=)	rs1800389	0.66802
NM_000553.6(WRN):c.839+56C>T	rs4733221	0.52342
NM_000553.6(WRN):c.1350+22T>C	rs2737325	0.52238
NM_000553.6(WRN):c.2631-67G>T	rs3087417	0.49744
NM_000553.6(WRN):c.3222G>T (p.Leu1074Phe)	rs1801195	0.46398
NM_000553.6(WRN):c.3138+7G>A	rs2737335	0.46283
NM_000553.6(WRN):c.2449-42T>C	rs2725352	0.45569
NM_000553.6(WRN):c.2361G>T (p.Leu787=)	rs1800392	0.44630
NM_000553.6(WRN):c.3138+6C>T	rs3024239	0.39769
NM_000553.6(WRN):c.2967+88G>A	rs2252480	0.38822
NM_000553.6(WRN):c.3309+26T>C	rs2725365	0.38249
NM_000553.6(WRN):c.1899-26C>T	rs201709613	0.36170
NM_000553.6(WRN):c.2449-269C>T	rs4733069	0.34448
NM_000553.6(WRN):c.2449-313T>C	rs2725351	0.32727
NM_000553.6(WRN):c.2089-2858C>T	rs2113950	0.32657
NM_000553.6(WRN):c.3233+103A>G	rs2725363	0.32399
NM_000553.6(WRN):c.4083C>T (p.Ser1361=)	rs1801196	0.28751
NM_000553.6(WRN):c.-76-261G>A	rs7016874	0.27604
NM_000553.6(WRN):c.3983-95C>T	rs4987036	0.27502
NM_000553.6(WRN):c.2826-191C>T	rs3213202	0.26024
NM_000553.6(WRN):c.3572+304T>A	rs7014045	0.24230
NM_000553.6(WRN):c.3384-104T>A	rs17652297	0.22764
NM_000553.6(WRN):c.4099T>C (p.Cys1367Arg)	rs1346044	0.22492
NM_000553.6(WRN):c.1899-19C>T	rs747018901	0.17689
NM_000553.6(WRN):c.2448+304G>A	rs11574306	0.16395
NM_000553.6(WRN):c.1982-133A>G	rs11574273	0.12619
NM_000553.6(WRN):c.2089-3140T>A	rs3213199	0.12465
NM_000553.6(WRN):c.840-95G>C	rs11574221	0.09842
NM_000553.6(WRN):c.1577-3C>A	rs3087409	0.07869
NM_000553.6(WRN):c.1720+116C>A	rs3087418	0.07863
NM_000553.6(WRN):c.1981+143C>G	rs7829687	0.07856
NM_000553.6(WRN):c.340G>A (p.Val114Ile)	rs2230009	0.07797
NM_000553.6(WRN):c.210-52A>G	rs7003607	0.07774
NM_000553.6(WRN):c.3310-206G>A	rs7001440	0.07189
NM_000553.6(WRN):c.2825+36G>C	rs3087421	0.06529
NM_000553.6(WRN):c.2274-228C>T	rs11574302	0.06506
NM_000553.6(WRN):c.3982+258C>T	rs7844211	0.06112
NM_000553.6(WRN):c.1161G>A (p.Met387Ile)	rs1800391	0.06046
NM_000553.6(WRN):c.-76-214A>C	rs11574175	0.05921
NM_000553.6(WRN):c.2968-65del	rs3087426	0.05527
NM_000553.6(WRN):c.355+20A>T	rs4987239	0.04393
NM_000553.6(WRN):c.1269+204C>G	rs2725381	0.04227
NM_000553.6(WRN):c.1720+24T>A	rs2247189	0.04214
NM_000553.6(WRN):c.655-23T>A	rs3087431	0.04124
NM_000553.6(WRN):c.3233+137T>C	rs6982140	0.03917
NM_000553.6(WRN):c.2273+81C>T	rs11574290	0.03554
NM_000553.6(WRN):c.2089-2944A>G	rs61746808	0.03536
NM_000553.6(WRN):c.2968-268C>T	rs11574341	0.02883
NM_000553.6(WRN):c.2088+33A>G	rs73670447	0.02855
NM_000553.6(WRN):c.2449-105C>T	rs11574313	0.02443
NM_000553.6(WRN):c.1155G>A (p.Glu385=)	rs2230010	0.01974
NM_000553.6(WRN):c.1898+291T>C	rs73581722	0.01974
NM_000553.6(WRN):c.2088+121A>T	rs11574275	0.01874
NM_000553.6(WRN):c.1350+115dup	rs11574230	0.01866
NM_000553.6(WRN):c.2826-234T>C	rs11574332	0.01845
NM_000553.6(WRN):c.2448+51A>G	rs3087412	0.01627
NM_000553.6(WRN):c.2732+64A>G	rs11574322	0.01597
NM_000553.6(WRN):c.209+106A>G	rs11574178	0.01586
NM_000553.6(WRN):c.3236C>T (p.Ser1079Leu)	rs3087414	0.01577
NM_000553.6(WRN):c.2274-30G>A	rs3087423	0.01503
NM_000553.6(WRN):c.3820-49G>A	rs11574384	0.01440
NM_000553.6(WRN):c.3384-3T>C	rs3087424	0.01376
NM_000553.6(WRN):c.2967+244A>G	rs11574334	0.01372
NM_000553.6(WRN):c.2826-207C>T	rs11574333	0.01367
NM_000553.6(WRN):c.1982-156T>C	rs11574272	0.01366
NM_000553.6(WRN):c.3573-130G>T	rs11574371	0.01255
NM_000553.6(WRN):c.1577-294A>G	rs11574239	0.01212
NM_000553.6(WRN):c.724+74C>T	rs3087408	0.01112
NM_000553.6(WRN):c.1270-60_1270-32del	rs11574229	0.01082
NM_000553.6(WRN):c.2631-17A>C	rs3087433	0.01054
NM_000553.6(WRN):c.654+135C>A	rs11574205	0.01007
NM_000553.6(WRN):c.2732+19A>G	rs77434316	0.00923
NM_000553.6(WRN):c.2241T>G (p.Leu747=)	rs2230011	0.00921
NM_000553.6(WRN):c.209+129C>T	rs76077884	0.00813
NM_000553.6(WRN):c.654+216A>G	rs76337727	0.00807
NM_000553.6(WRN):c.1829+254T>C	rs111241363	0.00710
NM_000553.6(WRN):c.3234-141A>G	rs139326961	0.00679
NM_000553.6(WRN):c.654+210T>C	rs114641318	0.00674
NM_000553.6(WRN):c.1953C>T (p.Gly651=)	rs11574263	0.00627
NM_000553.6(WRN):c.3310-306C>T	rs117801356	0.00601
NM_000553.6(WRN):c.839+46del	rs199946539	0.00597
NM_000553.6(WRN):c.209+99G>A	rs188604526	0.00578
NM_000553.6(WRN):c.2089-3294T>C	rs180934065	0.00562
NM_000553.6(WRN):c.2273+135C>T	rs149280471	0.00540
NM_000553.6(WRN):c.1982-135T>A	rs181046205	0.00538
NM_000553.6(WRN):c.1898+65C>T	rs115351572	0.00518
NM_000553.6(WRN):c.1725T>C (p.Tyr575=)	rs13438802	0.00516
NM_000553.6(WRN):c.1788T>C (p.Ser596=)	rs13438803	0.00512
NM_000553.6(WRN):c.3459+66A>G	rs146471227	0.00508
NM_000553.6(WRN):c.2273+299A>G	rs144437633	0.00505
NM_000553.6(WRN):c.3983-39G>A	rs145212074	0.00500
NM_000553.6(WRN):c.4015G>A (p.Val1339Ile)	rs11574395	0.00418
NM_000553.6(WRN):c.*194C>T	rs11574411	0.00413
NM_000553.6(WRN):c.724+120A>G	rs113947509	0.00398
NM_000553.6(WRN):c.1577-17T>G	rs145080962	0.00363
NM_000553.6(WRN):c.1431+149T>A	rs146967731	0.00362
NM_000553.6(WRN):c.3820-101C>T	rs189096241	0.00361
NM_000553.6(WRN):c.95A>G (p.Lys32Arg)	rs34477820	0.00310
NM_000553.6(WRN):c.3785C>G (p.Thr1262Arg)	rs78488552	0.00276
NM_000553.6(WRN):c.970A>G (p.Thr324Ala)	rs1800390	0.00245
NM_000553.6(WRN):c.2983G>A (p.Ala995Thr)	rs140768346	0.00193
NM_000553.6(WRN):c.1717A>G (p.Thr573Ala)	rs150148567	0.00169
NM_000553.6(WRN):c.355+4G>C	rs145764920	0.00156
NM_000553.6(WRN):c.1149G>T (p.Leu383Phe)	rs4987238	0.00148
NM_000553.6(WRN):c.3875C>A (p.Ser1292Tyr)	rs142614369	0.00132
NM_000553.6(WRN):c.107G>A (p.Arg36Gln)	rs34084741	0.00091
NM_000553.6(WRN):c.1105C>T (p.Arg369Ter)	rs17847577	0.00033
NM_000553.6(WRN):c.130C>G (p.Leu44Val)	rs139775895	0.00031
NM_000553.6(WRN):c.3259A>G (p.Lys1087Glu)	rs374154973	0.00028
NM_000553.6(WRN):c.229G>C (p.Asp77His)	rs144670883	0.00025
NM_000553.6(WRN):c.514A>C (p.Thr172Pro)	rs367991517	0.00010
NM_000553.6(WRN):c.3375T>C (p.Ser1125=)	rs377535272	0.00009
NM_000553.6(WRN):c.4018C>T (p.Pro1340Ser)	rs747312018	0.00006
NM_000553.6(WRN):c.2735T>G (p.Ile912Ser)	rs11574323	0.00005
NM_000553.6(WRN):c.1172G>T (p.Cys391Phe)	rs145445994	0.00004
NM_000553.6(WRN):c.2716A>G (p.Ser906Gly)	rs751795043	0.00004
NM_000553.6(WRN):c.201A>G (p.Glu67=)	rs764589321	0.00003
NM_000553.6(WRN):c.3977A>G (p.Asn1326Ser)	rs1304095043	0.00003
NM_000553.6(WRN):c.654+4C>T	rs769275170	0.00003
NM_000553.6(WRN):c.1628A>C (p.Tyr543Ser)	rs151001436	0.00002
NM_000553.6(WRN):c.3134A>G (p.Lys1045Arg)	rs369095273	0.00002
NM_000553.6(WRN):c.1439A>T (p.Glu480Val)	rs775240079	0.00001
NM_000553.6(WRN):c.2596G>A (p.Val866Ile)	rs776463866	0.00001
NM_000553.6(WRN):c.3100T>C (p.Tyr1034His)	rs1468633117	0.00001
NM_000553.6(WRN):c.968C>T (p.Ser323Leu)	rs369277330	0.00001
NM_000553.6(WRN):c.1165del (p.Arg389fs)	rs878854131
NM_000553.6(WRN):c.1181C>T (p.Ser394Leu)	rs200487813
NM_000553.6(WRN):c.1431+168G>A	rs147561551
NM_000553.6(WRN):c.1431+236del	rs1038655830
NM_000553.6(WRN):c.1573A>G (p.Lys525Glu)	rs1813600027
NM_000553.6(WRN):c.1982-5del	rs397723919
NM_000553.6(WRN):c.2088+26C>T	rs73670446
NM_000553.6(WRN):c.2089-3135del
NM_000553.6(WRN):c.210-53C>T	rs6983980
NM_000553.6(WRN):c.2273+53dup	rs111854110
NM_000553.6(WRN):c.2274-207del
NM_000553.6(WRN):c.2274-59C>T	rs11574304
NM_000553.6(WRN):c.2449-63A>G	rs4987034
NM_000553.6(WRN):c.2569_2571dup (p.Arg857dup)	rs775125764
NM_000553.6(WRN):c.2630+132dup	rs368026803
NM_000553.6(WRN):c.2630+139T>G	rs11574314
NM_000553.6(WRN):c.2631-236_2631-234del
NM_000553.6(WRN):c.2968-276del	rs11574340
NM_000553.6(WRN):c.3234-130T>C	rs2725364
NM_000553.6(WRN):c.3384-126T>C	rs17652261
NM_000553.6(WRN):c.355+176A>G	rs3213197
NM_000553.6(WRN):c.355+91C>T	rs11574198
NM_000553.6(WRN):c.3983-12dup	rs368931913
NM_000553.6(WRN):c.4191+182A>T	rs117133984
NM_000553.6(WRN):c.725-260T>C	rs2737321
NM_000553.6(WRN):c.725-9del	rs543830844

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