ClinVar Miner

Variants in gene WT1

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
42 20 220 134 41 5 413

Condition and significance breakdown #

Total conditions: 27
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Drash syndrome; Frasier syndrome; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 18 4 162 97 10 0 291
Nephrotic syndrome, type 4 8 2 51 16 9 0 86
Meacham syndrome 2 0 36 7 30 0 75
Wilms tumor 1 9 1 30 9 18 0 67
not provided 11 3 7 17 7 0 45
not specified 0 0 5 6 10 5 22
Nephroblastoma 0 0 16 3 2 0 21
Drash syndrome 12 2 1 3 2 0 20
Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 0 0 16 3 0 0 19
Frasier syndrome 5 1 1 0 0 0 7
Familial idiopathic steroid-resistant nephrotic syndrome 2 1 0 0 0 0 3
none provided 0 0 0 1 2 0 3
Acute myeloid leukemia 0 1 1 0 0 0 2
Drash syndrome; Frasier syndrome; Nephrotic syndrome, type 4; Wilms tumor 1 1 0 0 0 1 0 2
Nephrotic range proteinuria 0 2 0 0 0 0 2
Ambiguous genitalia 1 0 0 0 0 0 1
Aniridia 1; Drash syndrome; Frasier syndrome; Meacham syndrome; Mesothelioma, malignant; Nephrotic syndrome, type 4; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 1 0 0 0 0 0 1
Drash syndrome; Frasier syndrome 1 0 0 0 0 0 1
Drash syndrome; Frasier syndrome; Wilms tumor 1 1 0 0 0 0 0 1
Drash syndrome; Nephrotic syndrome, type 4 0 1 0 0 0 0 1
Focal segmental glomerulosclerosis 0 0 1 0 0 0 1
Mesothelioma 1 0 0 0 0 0 1
Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged 0 0 1 0 0 0 1
Nephrotic syndrome 0 0 1 0 0 0 1
Premature ovarian failure 0 1 0 0 0 0 1
Proteinuria 0 0 1 0 0 0 1
Steroid-resistant nephrotic syndrome; Nephrotic range proteinuria 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 43
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 18 4 162 105 11 0 300
Illumina Clinical Services Laboratory,Illumina 0 0 48 26 30 0 73
OMIM 20 0 0 0 0 0 20
GeneDx 6 1 1 4 7 0 19
Athena Diagnostics Inc 5 0 1 0 4 0 10
PreventionGenetics, PreventionGenetics 0 0 0 2 8 0 10
Mendelics 2 1 4 3 0 0 10
Bioscientia Institut fuer Medizinische Diagnostik GmbH,Sonic Healthcare 2 1 3 0 0 0 6
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 1 0 4 0 0 0 5
ITMI 0 0 0 0 0 5 5
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 3 0 1 0 4
Blueprint Genetics 2 1 1 0 0 0 4
Baylor Genetics 2 0 1 0 0 0 3
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories 0 0 0 1 2 0 3
Integrated Genetics/Laboratory Corporation of America 0 0 0 0 3 0 3
GeneReviews 3 0 0 0 0 0 3
Human Genetics Disease in Children – Taif University,Taif University 1 0 0 0 2 0 3
NIHR Bioresource Rare Diseases, University of Cambridge 0 3 0 0 0 0 3
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 2 0 0 0 0 0 2
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 1 1 0 0 0 0 2
Gharavi Laboratory,Columbia University 0 1 1 0 0 0 2
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 1 0 0 0 1
Fulgent Genetics,Fulgent Genetics 1 0 0 0 0 0 1
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 0 1 0 0 0 0 1
Institute of Human Genetics, Klinikum rechts der Isar 1 0 0 0 0 0 1
Centre for Translational Omics - GOSgene,University College London 0 1 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory,Baylor College of Medicine 1 0 0 0 0 0 1
CeGaT Praxis fuer Humangenetik Tuebingen 0 1 0 0 0 0 1
Database of Curated Mutations (DoCM) 0 1 0 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 0 1 0 0 0 0 1
Institute of Human Genetics, University of Leipzig Medical Center 0 0 1 0 0 0 1
Molecular Medicine Center, Medical University of Sofia 1 0 0 0 0 0 1
Department of Pathology and Laboratory Medicine,Sinai Health System 0 0 1 0 0 0 1
Medical Cytogenetics and Molecular Genetics Laboratory,IRCCS Istituto Auxologico Italiano 0 1 0 0 0 0 1
Broad Institute Rare Disease Group, Broad Institute 1 0 0 0 0 0 1
UNC Molecular Genetics Laboratory,University of North Carolina at Chapel Hill 0 0 1 0 0 0 1
St. Jude Clinical Genomics Lab, St. Jude Children's Research Hospital 0 0 1 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 1 0 0 0 0 0 1
Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital,All India Institute of Medical Sciences 0 0 1 0 0 0 1
Institute of Molecular Biology and Genetics,National Academy of Sciences of Ukraine 1 0 0 0 0 0 1
Sydney Genome Diagnostics,Children's Hospital Westmead 0 0 1 0 0 0 1
Precision Medicine Center,Zhengzhou University 1 0 0 0 0 0 1

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