ClinVar Miner

Variants in gene WT1

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Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
29 10 123 62 19 5 233

Condition and significance breakdown #

Total conditions: 19
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Condition pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Drash syndrome; Frasier syndrome; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 8 1 77 40 6 0 132
Diffuse mesangial sclerosis 7 1 35 19 5 0 67
Meacham syndrome 2 0 33 19 5 0 59
Wilms Tumor 0 0 33 19 5 0 57
Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 0 0 33 19 5 0 57
not specified 0 0 5 6 9 5 22
not provided 6 3 6 0 6 0 21
Drash syndrome 11 1 0 0 2 0 14
Wilms tumor 1 6 0 4 1 0 0 11
Frasier syndrome 5 1 0 0 0 0 6
Hereditary nephrotic syndrome 2 1 0 0 0 0 3
Acute myeloid leukemia 0 1 1 0 0 0 2
Drash syndrome; Frasier syndrome; Wilms tumor 1 2 0 0 0 0 0 2
Aniridia 1; Drash syndrome; Frasier syndrome; Meacham syndrome; Mesothelioma, malignant; Diffuse mesangial sclerosis; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 1 0 0 0 0 0 1
Drash syndrome; Diffuse mesangial sclerosis 0 1 0 0 0 0 1
Drash syndrome; Frasier syndrome; Diffuse mesangial sclerosis; Wilms tumor 1 0 0 0 0 1 0 1
Mesothelioma 1 0 0 0 0 0 1
Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged 0 0 1 0 0 0 1
Proteinuria 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 26
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 10 1 77 40 6 0 134
Illumina Clinical Services Laboratory,Illumina 0 0 33 19 5 0 57
OMIM 20 0 0 0 0 0 20
GeneDx 6 1 1 4 7 0 19
PreventionGenetics 0 0 0 2 8 0 10
Mendelics 1 0 4 1 0 0 6
Athena Diagnostics Inc 1 0 1 0 3 0 5
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 1 0 4 0 0 0 5
ITMI 0 0 0 0 0 5 5
Bioscientia Institut fuer Medizinische Diagnostik GmbH,Sonic Healthcare 2 1 2 0 0 0 5
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 3 0 1 0 4
Blueprint Genetics 2 1 1 0 0 0 4
Integrated Genetics/Laboratory Corporation of America 0 0 0 0 3 0 3
Human Genetics Disease in Children – Taif University,Taif University 1 0 0 0 2 0 3
Molecular Diagnostics Laboratory,M Health: University of Minnesota 1 1 0 0 0 0 2
Gharavi Laboratory,Columbia University 0 1 1 0 0 0 2
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 0 0 1 0 0 0 1
Fulgent Genetics,Fulgent Genetics 1 0 0 0 0 0 1
Centre for Translational Omics - GOSgene,University College London 0 1 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology,Institute of Human Genetics 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory,Baylor College of Medicine 1 0 0 0 0 0 1
CeGaT Praxis fuer Humangenetik Tuebingen 0 1 0 0 0 0 1
Database of Curated Mutations (DoCM) 0 1 0 0 0 0 1
Broad Institute Rare Disease Group,Broad Institute 1 0 0 0 0 0 1
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 1 0 0 0 1
Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital,All India Institute of Medical Sciences 0 0 1 0 0 0 1

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