ClinVar Miner

Variants in gene XRCC2

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If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
7 12 181 92 14 279

Condition and significance breakdown #

Total conditions: 9
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Condition pathogenic likely pathogenic uncertain significance likely benign benign total
not provided 2 7 139 26 6 174
Hereditary cancer-predisposing syndrome 3 8 74 37 2 121
not specified 0 0 17 50 8 75
Fanconi anemia, complementation group U 0 0 13 3 0 16
Hereditary Cancer Syndrome 0 0 15 1 0 16
Hereditary breast and ovarian cancer syndrome 1 0 1 0 0 2
Colon cancer 0 0 1 0 0 1
Colorectal cancer 0 0 1 0 0 1
Ovarian Neoplasms 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 18
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
GeneDx 1 7 61 48 9 126
Invitae 0 0 93 25 5 123
Ambry Genetics 3 7 69 30 2 111
Leiden Open Variation Database 1 0 28 1 0 30
Mendelics 0 0 15 3 0 18
University of Washington Department of Laboratory Medicine, University of Washington 0 0 3 7 0 10
CeGaT Praxis fuer Humangenetik Tuebingen 0 1 3 1 0 5
GeneKor MSA 0 1 2 0 0 3
Genetic Services Laboratory, University of Chicago 0 0 1 1 0 2
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 0 0 2 0 0 2
Fulgent Genetics,Fulgent Genetics 0 0 2 0 0 2
CSER _CC_NCGL, University of Washington 0 0 2 0 0 2
OMIM 0 0 1 0 0 1
Lineagen, Inc 0 0 1 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 1 0 0 1
Genomics Laboratory,Virgen de la Arrixaca University Clinical Hospital 1 0 0 0 0 1
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne 1 0 0 0 0 1
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 0 1 0 0 1

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