ClinVar Miner

Variants in gene XRCC2

Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
6 9 214 95 14 309

Condition and significance breakdown #

Total conditions: 10
Download table as spreadsheet
Condition pathogenic likely pathogenic uncertain significance likely benign benign total
not provided 1 2 185 32 6 220
Hereditary cancer-predisposing syndrome 3 8 82 37 2 127
not specified 0 0 17 50 8 75
Fanconi anemia, complementation group U 0 1 15 3 0 19
Hereditary breast and ovarian cancer syndrome 1 0 1 0 0 2
Colorectal cancer 0 0 1 0 0 1
Malignant tumor of colon 0 0 1 0 0 1
Premature ovarian failure 17 1 0 0 0 0 1
Short stature, microcephaly, and endocrine dysfunction 0 1 0 0 0 1
Spermatogenic failures 50 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 20
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign total
Invitae 0 0 142 31 5 178
GeneDx 0 2 61 48 9 120
Ambry Genetics 3 7 69 30 2 111
Leiden Open Variation Database 1 0 28 1 0 30
Mendelics 0 0 15 3 0 18
University of Washington Department of Laboratory Medicine, University of Washington 0 0 3 7 0 10
CeGaT Praxis fuer Humangenetik Tuebingen 0 1 3 1 0 5
GeneKor MSA 0 1 2 0 0 3
OMIM 1 0 1 0 0 2
Baylor Genetics 0 0 2 0 0 2
Genetic Services Laboratory, University of Chicago 0 0 1 1 0 2
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics 0 0 2 0 0 2
Fulgent Genetics,Fulgent Genetics 0 0 2 0 0 2
CSER _CC_NCGL, University of Washington 0 0 2 0 0 2
Centogene AG - the Rare Disease Company 0 1 0 0 0 1
Lineagen, Inc 0 0 1 0 0 1
Center of Medical Genetics and Primary Health Care 0 0 1 0 0 1
Genomics Laboratory,Virgen de la Arrixaca University Clinical Hospital 1 0 0 0 0 1
Pathology and Clinical Laboratory Medicine,King Fahad Medical City 0 1 0 0 0 1
Cancer Genomics Group,Japanese Foundation For Cancer Research 0 0 1 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.