ClinVar Miner

List of variants reported as uncertain significance for Lynch syndrome 2 by Baylor Genetics

Included ClinVar conditions (4):
Minimum submission review status: Collection method:
Minimum conflict level:
ClinVar version:
Total variants: 169
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HGVS dbSNP gnomAD frequency
NM_000249.4(MLH1):c.1166G>A (p.Arg389Gln) rs63750361 0.00020
NM_000249.3(MLH1):c.-42C>T rs41285097 0.00009
NM_000249.4(MLH1):c.1709A>G (p.Asn570Ser) rs375853155 0.00009
NM_000249.4(MLH1):c.2038T>G (p.Cys680Gly) rs63750809 0.00007
NM_000249.4(MLH1):c.453G>A (p.Thr151=) rs369521379 0.00006
NM_000249.4(MLH1):c.1154G>A (p.Arg385His) rs63750430 0.00005
NM_000249.4(MLH1):c.1937A>G (p.Tyr646Cys) rs35045067 0.00005
NM_000249.4(MLH1):c.80G>A (p.Arg27Gln) rs138705565 0.00005
NM_000249.4(MLH1):c.1148T>C (p.Met383Thr) rs141344760 0.00004
NM_000249.4(MLH1):c.1227G>C (p.Gln409His) rs775776362 0.00004
NM_000249.4(MLH1):c.1270G>A (p.Ala424Thr) rs377433038 0.00004
NM_000249.4(MLH1):c.1474G>A (p.Ala492Thr) rs63751145 0.00004
NM_000249.4(MLH1):c.1565G>A (p.Arg522Gln) rs63751630 0.00004
NM_000249.4(MLH1):c.1633A>G (p.Thr545Ala) rs267607840 0.00004
NM_000249.4(MLH1):c.299G>A (p.Arg100Gln) rs63750266 0.00004
NM_000249.4(MLH1):c.52C>T (p.Arg18Cys) rs367654552 0.00004
NM_000249.4(MLH1):c.945C>G (p.His315Gln) rs587779959 0.00004
NM_000249.4(MLH1):c.1051G>A (p.Gly351Arg) rs1437454428 0.00003
NM_000249.4(MLH1):c.116+5G>A rs267607710 0.00003
NM_000249.4(MLH1):c.1165C>T (p.Arg389Trp) rs61751644 0.00003
NM_000249.4(MLH1):c.1487C>T (p.Pro496Leu) rs63750226 0.00003
NM_000249.4(MLH1):c.1514G>A (p.Ser505Asn) rs771044689 0.00003
NM_000249.4(MLH1):c.1730C>T (p.Ser577Leu) rs56185292 0.00003
NM_000249.4(MLH1):c.191A>G (p.Asn64Ser) rs63750952 0.00003
NM_000249.4(MLH1):c.286A>G (p.Thr96Ala) rs770276731 0.00003
NM_000249.4(MLH1):c.376T>A (p.Tyr126Asn) rs200076893 0.00003
NM_000249.4(MLH1):c.539T>G (p.Val180Gly) rs63750102 0.00003
NM_000249.4(MLH1):c.1256T>C (p.Ile419Thr) rs377484262 0.00002
NM_000249.4(MLH1):c.226G>A (p.Val76Ile) rs878853788 0.00002
NM_000249.4(MLH1):c.530T>C (p.Leu177Ser) rs758040210 0.00002
NM_000249.4(MLH1):c.595G>C (p.Glu199Gln) rs63749887 0.00002
NM_000249.4(MLH1):c.776T>C (p.Leu259Ser) rs56250509 0.00002
NM_000249.4(MLH1):c.925C>T (p.Pro309Ser) rs267607808 0.00002
NM_000249.4(MLH1):c.-11C>T rs776898290 0.00001
NM_000249.4(MLH1):c.1063C>T (p.Pro355Ser) rs756347993 0.00001
NM_000249.4(MLH1):c.107T>C (p.Ile36Thr) rs267607707 0.00001
NM_000249.4(MLH1):c.1103C>T (p.Ser368Leu) rs201673334 0.00001
NM_000249.4(MLH1):c.1202G>A (p.Ser401Asn) rs587779951 0.00001
NM_000249.4(MLH1):c.1243G>A (p.Asp415Asn) rs373767220 0.00001
NM_000249.4(MLH1):c.1277A>T (p.Gln426Leu) rs876659252 0.00001
NM_000249.4(MLH1):c.1344G>T (p.Glu448Asp) rs587779952 0.00001
NM_000249.4(MLH1):c.1415G>A (p.Arg472Lys) rs63750498 0.00001
NM_000249.4(MLH1):c.1421G>A (p.Arg474Gln) rs63751083 0.00001
NM_000249.4(MLH1):c.1538T>C (p.Ile513Thr) rs876658689 0.00001
NM_000249.4(MLH1):c.1591G>A (p.Val531Met) rs764663152 0.00001
NM_000249.4(MLH1):c.1637A>G (p.Lys546Arg) rs587779954 0.00001
NM_000249.4(MLH1):c.1669G>A (p.Glu557Lys) rs63751244 0.00001
NM_000249.4(MLH1):c.1761G>A (p.Met587Ile) rs747665234 0.00001
NM_000249.4(MLH1):c.1775G>C (p.Ser592Thr) rs587782621 0.00001
NM_000249.4(MLH1):c.1834G>A (p.Val612Ile) rs587779956 0.00001
NM_000249.4(MLH1):c.1842T>G (p.Phe614Leu) rs758353338 0.00001
NM_000249.4(MLH1):c.1850A>C (p.Lys617Thr) rs780199021 0.00001
NM_000249.4(MLH1):c.1876T>C (p.Phe626Leu) rs377241633 0.00001
NM_000249.4(MLH1):c.2016T>G (p.Cys672Trp) rs1312172811 0.00001
NM_000249.4(MLH1):c.2017T>C (p.Phe673Leu) rs587780680 0.00001
NM_000249.4(MLH1):c.2060G>A (p.Arg687Gln) rs587781310 0.00001
NM_000249.4(MLH1):c.2162A>G (p.Tyr721Cys) rs587778986 0.00001
NM_000249.4(MLH1):c.221A>T (p.Asp74Val) rs751894165 0.00001
NM_000249.4(MLH1):c.2240C>G (p.Pro747Arg) rs1224959447 0.00001
NM_000249.4(MLH1):c.306+4A>G rs267607733 0.00001
NM_000249.4(MLH1):c.346A>G (p.Thr116Ala) rs750353040 0.00001
NM_000249.4(MLH1):c.359C>G (p.Ala120Gly) rs267607740 0.00001
NM_000249.4(MLH1):c.386G>A (p.Ser129Asn) rs755678310 0.00001
NM_000249.4(MLH1):c.452C>T (p.Thr151Met) rs776969475 0.00001
NM_000249.4(MLH1):c.532G>C (p.Glu178Gln) rs1248251121 0.00001
NM_000249.4(MLH1):c.563C>T (p.Ala188Val) rs777971431 0.00001
NM_000249.4(MLH1):c.589-17T>A rs754180618 0.00001
NM_000249.4(MLH1):c.5C>T (p.Ser2Leu) rs587779029 0.00001
NM_000249.4(MLH1):c.650G>A (p.Arg217His) rs762099920 0.00001
NM_000249.4(MLH1):c.652T>C (p.Ser218Pro) rs750650349 0.00001
NM_000249.4(MLH1):c.678-4A>G rs766711342 0.00001
NM_000249.4(MLH1):c.682C>A (p.Leu228Met) rs751628735 0.00001
NM_000249.4(MLH1):c.743A>G (p.Asn248Ser) rs587782800 0.00001
NM_000249.4(MLH1):c.788A>G (p.Asn263Ser) rs104894997 0.00001
NM_000249.4(MLH1):c.797T>C (p.Leu266Pro) rs747697495 0.00001
NM_000249.4(MLH1):c.79C>T (p.Arg27Trp) rs756398627 0.00001
NM_000249.4(MLH1):c.880C>T (p.Leu294Phe) rs2082757345 0.00001
NM_000249.4(MLH1):c.887T>C (p.Leu296Ser) rs63750547 0.00001
NM_000249.4(MLH1):c.979C>G (p.Gln327Glu) rs587782087 0.00001
NM_000249.4(MLH1):c.-167del
NM_000249.4(MLH1):c.1012A>G (p.Asn338Asp)
NM_000249.4(MLH1):c.1026G>A (p.Met342Ile) rs1060500704
NM_000249.4(MLH1):c.1088CAA[1] (p.Thr364del) rs876660192
NM_000249.4(MLH1):c.1117G>A (p.Gly373Arg) rs766904735
NM_000249.4(MLH1):c.1147A>G (p.Met383Val) rs1559552349
NM_000249.4(MLH1):c.1148T>G (p.Met383Arg)
NM_000249.4(MLH1):c.1154G>C (p.Arg385Pro) rs63750430
NM_000249.4(MLH1):c.116+3A>T
NM_000249.4(MLH1):c.1223C>A (p.Pro408His) rs1241839317
NM_000249.4(MLH1):c.1259C>T (p.Ser420Phe) rs63751179
NM_000249.4(MLH1):c.125C>T (p.Ala42Val) rs587778901
NM_000249.4(MLH1):c.1285GAG[1] (p.Glu430del) rs1064795262
NM_000249.4(MLH1):c.1325C>A (p.Ala442Asp) rs765563111
NM_000249.4(MLH1):c.133A>G (p.Thr45Ala) rs876658416
NM_000249.4(MLH1):c.1420C>T (p.Arg474Trp) rs147939838
NM_000249.4(MLH1):c.1453G>T (p.Asp485Tyr) rs63750314
NM_000249.4(MLH1):c.1484C>T (p.Thr495Ile) rs1060500685
NM_000249.4(MLH1):c.1524T>G (p.Ser508Arg) rs886058383
NM_000249.4(MLH1):c.1572G>C (p.Met524Ile) rs587779953
NM_000249.4(MLH1):c.1598G>C (p.Cys533Ser) rs564240478
NM_000249.4(MLH1):c.1667+4A>C rs983986337
NM_000249.4(MLH1):c.1667+4A>G rs983986337
NM_000249.4(MLH1):c.1690C>T (p.Leu564Phe) rs786202693
NM_000249.4(MLH1):c.1706C>T (p.Ala569Val) rs1559578814
NM_000249.4(MLH1):c.1714G>A (p.Gly572Ser) rs587781796
NM_000249.4(MLH1):c.1757C>T (p.Ala586Val) rs63750587
NM_000249.4(MLH1):c.1766C>T (p.Ala589Val) rs63750016
NM_000249.4(MLH1):c.1782G>C (p.Glu594Asp) rs915595144
NM_000249.4(MLH1):c.17G>T (p.Gly6Val)
NM_000249.4(MLH1):c.1808C>T (p.Pro603Leu) rs63750876
NM_000249.4(MLH1):c.1823C>T (p.Ala608Val) rs267607864
NM_000249.4(MLH1):c.1838A>G (p.Glu613Gly)
NM_000249.4(MLH1):c.1853A>T (p.Lys618Met) rs63750449
NM_000249.4(MLH1):c.1874A>G (p.Tyr625Cys) rs748851107
NM_000249.4(MLH1):c.1894G>A (p.Glu632Lys)
NM_000249.4(MLH1):c.1897-2A>G rs267607871
NM_000249.4(MLH1):c.1910T>C (p.Ile637Thr) rs1575627499
NM_000249.4(MLH1):c.1928T>C (p.Ile643Thr) rs1553663856
NM_000249.4(MLH1):c.2014T>A (p.Cys672Ser) rs2085466553
NM_000249.4(MLH1):c.2024G>A (p.Ser675Asn) rs781637991
NM_000249.4(MLH1):c.2024G>C (p.Ser675Thr) rs781637991
NM_000249.4(MLH1):c.2029A>T (p.Ser677Cys) rs587780681
NM_000249.4(MLH1):c.2065C>A (p.Gln689Lys) rs41542214
NM_000249.4(MLH1):c.2080_2081inv (p.Glu694Ser)
NM_000249.4(MLH1):c.2084C>G (p.Ser695Trp) rs63749995
NM_000249.4(MLH1):c.2110G>A (p.Val704Met) rs587781811
NM_000249.4(MLH1):c.2128A>G (p.Asn710Asp) rs1559595840
NM_000249.4(MLH1):c.214G>A (p.Asp72Asn) rs1553640187
NM_000249.4(MLH1):c.2155A>G (p.Ile719Val) rs754225520
NM_000249.4(MLH1):c.2162A>C (p.Tyr721Ser) rs587778986
NM_000249.4(MLH1):c.2191C>T (p.Pro731Ser) rs876661188
NM_000249.4(MLH1):c.2192C>A (p.Pro731His) rs2148524373
NM_000249.4(MLH1):c.2194A>C (p.Lys732Gln) rs267607906
NM_000249.4(MLH1):c.2198A>G (p.His733Arg) rs770579083
NM_000249.4(MLH1):c.2227C>T (p.Leu743Phe) rs1575641138
NM_000249.4(MLH1):c.2239C>T (p.Pro747Ser) rs587779958
NM_000249.4(MLH1):c.25C>G (p.Arg9Gly) rs587779000
NM_000249.4(MLH1):c.25C>T (p.Arg9Trp) rs587779000
NM_000249.4(MLH1):c.28C>T (p.Arg10Trp) rs1193754562
NM_000249.4(MLH1):c.36C>G (p.Asp12Glu) rs587782181
NM_000249.4(MLH1):c.373G>A (p.Ala125Thr)
NM_000249.4(MLH1):c.37G>A (p.Glu13Lys) rs587779008
NM_000249.4(MLH1):c.37G>C (p.Glu13Gln) rs587779008
NM_000249.4(MLH1):c.410C>G (p.Ala137Gly)
NM_000249.4(MLH1):c.415C>G (p.Pro139Ala) rs779562531
NM_000249.4(MLH1):c.424T>C (p.Cys142Arg) rs780232692
NM_000249.4(MLH1):c.434A>G (p.Asn145Ser) rs1553642117
NM_000249.4(MLH1):c.439G>C (p.Gly147Arg) rs267607747
NM_000249.4(MLH1):c.466T>C (p.Phe156Leu) rs1060500691
NM_000249.4(MLH1):c.47T>G (p.Val16Gly) rs1553637237
NM_000249.4(MLH1):c.485G>A (p.Arg162Lys)
NM_000249.4(MLH1):c.508A>G (p.Ser170Gly) rs1287294691
NM_000249.4(MLH1):c.532G>A (p.Glu178Lys) rs1248251121
NM_000249.4(MLH1):c.637G>T (p.Val213Leu) rs2308317
NM_000249.4(MLH1):c.668C>G (p.Ala223Gly) rs756045117
NM_000249.4(MLH1):c.670G>A (p.Val224Ile) rs1553644251
NM_000249.4(MLH1):c.677+3A>T rs267607780
NM_000249.4(MLH1):c.70G>A (p.Val24Ile) rs1348994712
NM_000249.4(MLH1):c.755C>T (p.Ser252Leu) rs63750198
NM_000249.4(MLH1):c.790C>G (p.His264Asp) rs63751597
NM_000249.4(MLH1):c.848A>T (p.Tyr283Phe) rs201931669
NM_000249.4(MLH1):c.931A>G (p.Lys311Glu) rs876658657
NM_000249.4(MLH1):c.940G>A (p.Val314Ile)
NM_000249.4(MLH1):c.941T>G (p.Val314Gly) rs2082977512
NM_000249.4(MLH1):c.954C>A (p.His318Gln) rs146777069
NM_000249.4(MLH1):c.973C>G (p.Arg325Gly)
NM_000249.4(MLH1):c.976G>T (p.Val326Leu) rs730881739
NM_000249.4(MLH1):c.986A>C (p.His329Pro) rs63750710
NM_000249.4(MLH1):c.986A>G (p.His329Arg) rs63750710

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