ClinVar Miner

Variants studied for brain cancer

Included ClinVar conditions (12):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
24 254 8 6 2 1 3 1 292

Gene and significance breakdown #

Total genes and gene combinations: 28
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
TP53 17 164 6 5 2 0 0 0 187
PIK3CA 0 34 0 0 0 0 0 0 34
EGFR 0 10 0 0 0 0 0 0 10
DICER1 6 1 0 0 0 0 0 0 7
IDH1 0 5 0 0 0 0 0 0 5
NRAS 0 5 0 0 0 0 0 0 5
ACVR1 0 4 0 0 0 0 0 0 4
BRAF 0 4 0 0 0 0 0 0 4
IDH2 0 4 0 0 0 0 0 0 4
PTEN 0 4 0 0 0 0 0 0 4
ALK 0 3 0 0 0 0 0 0 3
FGFR1 0 3 0 0 0 0 0 0 3
PTPN11 0 3 0 0 0 0 0 0 3
CTNNB1, LOC126806658 0 2 0 0 0 0 0 0 2
H3-3A 0 2 0 0 0 0 0 0 2
H3C11 0 2 0 0 0 0 0 0 2
PIK3R1 0 2 0 0 0 0 0 0 2
ACRBP 0 0 0 0 0 1 0 0 1
ATM 0 0 1 0 0 0 0 0 1
BRCA2 1 0 0 0 0 0 0 0 1
BRIP1 0 1 0 0 0 0 0 0 1
FOXO3 0 0 0 0 0 0 1 0 1
NF1 0 0 1 0 0 0 0 0 1
NF2 0 0 0 0 0 0 1 0 1
NSD1 0 0 0 0 0 0 1 0 1
PMS2 0 1 0 0 0 0 0 0 1
STK11 0 0 0 1 0 0 0 0 1
TSC2 0 0 0 0 0 0 0 1 1

Submitter and significance breakdown #

Total submitters: 13
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Database of Curated Mutations (DoCM) 0 249 0 0 0 0 0 0 249
Fulgent Genetics, Fulgent Genetics 13 2 6 5 2 0 0 0 28
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine 6 0 0 0 0 0 0 0 6
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 1 2 1 0 0 0 0 0 4
Donald Williams Parsons Laboratory, Baylor College of Medicine 0 0 0 0 0 0 3 0 3
OMIM 2 0 0 0 0 0 0 0 2
Department of Pathology and Laboratory Medicine, Sinai Health System 0 0 1 1 0 0 0 0 2
Tuberous sclerosis database (TSC2) 0 0 0 0 0 0 0 1 1
Michigan Center for Translational Pathology, University of Michigan 1 0 0 0 0 0 0 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 1 0 0 0 0 0 0 1
Pediatric Oncology, Johns Hopkins University 0 1 0 0 0 0 0 0 1
Department of Neurosurgery, Guangxi Colleges and Universities Key Laboratory of Preclinical Medicine Research 0 0 0 0 0 1 0 0 1
Suma Genomics 1 0 0 0 0 0 0 0 1

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