ClinVar Miner

Variants studied for adenocarcinoma of liver and intrahepatic biliary tract

Included ClinVar conditions (11):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign other total
37 256 50 0 1 5 338

Gene and significance breakdown #

Total genes and gene combinations: 35
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Gene or gene combination pathogenic likely pathogenic uncertain significance benign other total
TP53 8 158 4 0 0 168
APC 11 1 27 1 0 40
CTNNB1 6 28 0 0 2 30
PIK3CA 4 17 2 0 0 20
HRAS, LRRC56 0 10 0 0 0 10
MET 0 0 10 0 0 10
IDH1 0 5 0 0 0 5
NRAS 0 5 0 0 0 5
CDKN2A 0 4 0 0 0 4
CREBBP 0 4 0 0 0 4
IDH2 0 4 0 0 0 4
NFE2L2 0 4 0 0 0 4
TERT 2 0 2 0 0 4
GNAS 0 3 0 0 0 3
CNOT9 0 2 0 0 0 2
FGFR1 0 2 0 0 0 2
IGF2R 2 0 0 0 0 2
KRAS 0 2 0 0 0 2
RXRA 0 2 0 0 0 2
SF3B1 0 2 0 0 0 2
​intergenic 1 0 0 0 0 1
AKT1 0 1 0 0 0 1
ARID1A 0 0 0 0 1 1
AXIN1 1 0 0 0 0 1
CASP8 1 0 0 0 0 1
CDK4 0 0 1 0 0 1
LOC100507346, PTCH1 0 0 1 0 0 1
LOC110806263, TERT 0 1 0 0 0 1
MN1 0 0 0 0 1 1
MSH6 0 0 1 0 0 1
PDGFRL 1 0 0 0 0 1
RAF1 0 0 1 0 0 1
SET 0 0 0 0 1 1
SF3B2 0 1 0 0 0 1
STK11 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 8
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Submitter pathogenic likely pathogenic uncertain significance benign other total
Database of Curated Mutations (DoCM) 0 253 0 0 0 253
Fulgent Genetics 16 2 38 1 0 57
OMIM 18 0 0 0 0 18
Donald Williams Parsons Laboratory,Baylor College of Medicine 0 0 0 0 5 5
Metabolic Liver Diseases Lab,Fondazione IRCCS Ca Granda Policlinico, University of Milan 2 1 2 0 0 5
3DMed Clinical Laboratory Inc 0 0 5 0 0 5
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 5 0 0 5
OSU Cancer Genomics Laboratory, Ohio State University Medical Center 1 0 0 0 0 1

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