List of variants reported as uncertain significance for Noonan syndrome by Neuberg Centre For Genomic Medicine, NCGM

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Total variants: 15

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HGVS	dbSNP	gnomAD frequency
NM_002880.4(RAF1):c.1879C>T (p.Arg627Trp)	rs730881005	0.00003
NM_001085049.3(MRAS):c.13G>A (p.Ala5Thr)	rs767548259	0.00001
NM_002834.5(PTPN11):c.188A>G (p.Tyr63Cys)	rs121918459	0.00001
NM_006767.4(LZTR1):c.2369G>C (p.Arg790Pro)	rs555586109	0.00001
NM_002880.4(RAF1):c.1296C>A (p.His432Gln)
NM_002880.4(RAF1):c.1850A>C (p.Asn617Thr)	rs933142627
NM_005633.4(SOS1):c.3399T>C (p.Ala1133=)	rs2528879545
NM_005633.4(SOS1):c.543A>C (p.Glu181Asp)	rs201068374
NM_006767.4(LZTR1):c.2102C>T (p.Pro701Leu)	rs1327579827
NM_006767.4(LZTR1):c.2350C>T (p.Gln784Ter)	rs1489766065
NM_006767.4(LZTR1):c.360C>G (p.His120Gln)
NM_006912.6(RIT1):c.650C>G (p.Ser217Ter)	rs767498196
NM_006939.4(SOS2):c.1141C>G (p.Leu381Val)	rs765776650
NM_006939.4(SOS2):c.3542C>T (p.Pro1181Leu)
NM_012250.6(RRAS2):c.139A>G (p.Ile47Val)

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