ClinVar Miner

Variants studied for acute leukemia of ambiguous lineage

Included ClinVar conditions (7):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor total
10 8 17 0 0 1 35

Gene and significance breakdown #

Total genes and gene combinations: 25
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Gene or gene combination pathogenic likely pathogenic uncertain significance risk factor total
JAK3 0 7 0 0 7
MIR181A1HG 4 0 0 0 4
NF1 0 0 2 0 2
​intergenic 1 0 0 0 1
ACPP 0 0 1 0 1
APC 0 0 1 0 1
CORO7, CORO7-PAM16 0 0 1 0 1
DICER1 0 0 1 0 1
ERBB3 0 1 0 1 1
GATA1 1 0 0 0 1
KMT2A, SEPTIN9 1 0 0 0 1
LOC107303340, VHL 1 0 0 0 1
MDGA1 0 0 1 0 1
MSH2 0 0 1 0 1
MT-ND6 0 0 1 0 1
PCF11 0 0 1 0 1
PTEN 1 0 0 0 1
RASAL3 0 0 1 0 1
SHOC2 0 0 1 0 1
SLC9A2 0 0 1 0 1
SOS1 0 0 1 0 1
STK11 0 0 1 0 1
TMEM127 0 0 1 0 1
TP53 1 0 0 0 1
TSC2 0 0 1 0 1

Submitter and significance breakdown #

Total submitters: 7
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Submitter pathogenic likely pathogenic uncertain significance risk factor total
Clinical Genomics Lab,St. Jude Children's Research Hospital 1 0 10 0 11
McDonnell Genome Institute,Washington University in St. Louis 2 0 7 0 9
Database of Curated Mutations (DoCM) 0 7 0 0 7
Fujian Institute of Hematology,Fujian Medical University 5 0 0 0 5
OMIM 1 0 0 1 2
Baylor-Hopkins Center for Mendelian Genomics,Johns Hopkins University 0 1 0 0 1
Pediatric Leukemia/Lymphoma,Memorial Sloan Kettering Cancer Center 1 0 0 0 1

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