List of variants in gene RRAS reported as likely benign for Noonan syndrome and Noonan-related syndrome

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 103

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HGVS	dbSNP	gnomAD frequency
NM_006270.5(RRAS):c.568G>C (p.Val190Leu)	rs2230917	0.00128
NM_006270.5(RRAS):c.362A>G (p.Lys121Arg)	rs138124318	0.00121
NM_006270.5(RRAS):c.145T>C (p.Phe49Leu)	rs151014532	0.00109
NM_006270.5(RRAS):c.379C>T (p.Leu127=)	rs145907892	0.00101
NM_006270.5(RRAS):c.573-12G>A	rs201690554	0.00088
NM_006270.5(RRAS):c.174C>T (p.Tyr58=)	rs145282813	0.00055
NM_006270.5(RRAS):c.154-4C>G	rs372925843	0.00042
NM_006270.5(RRAS):c.345-4G>A	rs377672475	0.00029
NM_006270.5(RRAS):c.454-9T>C	rs1490597941	0.00027
NM_006270.5(RRAS):c.600G>A (p.Pro200=)	rs183538580	0.00021
NM_006270.5(RRAS):c.345-19C>G	rs369700575	0.00019
NM_006270.5(RRAS):c.516G>C (p.Ser172=)	rs199924228	0.00016
NM_006270.5(RRAS):c.255G>A (p.Ala85=)	rs142801791	0.00015
NM_006270.5(RRAS):c.81C>T (p.Ser27=)	rs375821724	0.00011
NM_006270.5(RRAS):c.540C>T (p.Asp180=)	rs781054110	0.00009
NM_006270.5(RRAS):c.344+17G>A	rs761080520	0.00008
NM_006270.5(RRAS):c.652C>T (p.Leu218=)	rs781768996	0.00008
NM_006270.5(RRAS):c.229G>A (p.Ala77Thr)	rs200611081	0.00006
NM_006270.5(RRAS):c.645C>T (p.Cys215=)	rs149038492	0.00005
NM_006270.5(RRAS):c.154-5G>A	rs753238136	0.00004
NM_006270.5(RRAS):c.543G>A (p.Glu181=)	rs370876982	0.00004
NM_006270.5(RRAS):c.162C>T (p.Phe54=)	rs751721094	0.00003
NM_006270.5(RRAS):c.241+9G>A	rs750643775	0.00003
NM_006270.5(RRAS):c.242-12_242-11del	rs767471796	0.00003
NM_006270.5(RRAS):c.291C>T (p.Tyr97=)	rs780638908	0.00003
NM_006270.5(RRAS):c.306C>T (p.His102=)	rs1159717303	0.00003
NM_006270.5(RRAS):c.324C>T (p.Phe108=)	rs578092373	0.00003
NM_006270.5(RRAS):c.495C>T (p.His165=)	rs765681955	0.00003
NM_006270.5(RRAS):c.573-13C>T	rs372538436	0.00003
NM_006270.5(RRAS):c.573-19C>G	rs377060262	0.00003
NM_006270.5(RRAS):c.242-8C>T	rs370459010	0.00002
NM_006270.5(RRAS):c.252C>T (p.Thr84=)	rs202189880	0.00002
NM_006270.5(RRAS):c.270C>T (p.Phe90=)	rs772623819	0.00002
NM_006270.5(RRAS):c.345-5C>T	rs369157989	0.00002
NM_006270.5(RRAS):c.454-11C>G	rs1316671612	0.00002
NM_006270.5(RRAS):c.454-13C>T	rs775638060	0.00002
NM_006270.5(RRAS):c.454-19G>A	rs776793181	0.00002
NM_006270.5(RRAS):c.630C>T (p.Gly210=)	rs745391652	0.00002
NM_006270.5(RRAS):c.94C>T (p.Leu32=)	rs764926027	0.00002
NM_006270.5(RRAS):c.102C>T (p.Val34=)	rs754204165	0.00001
NM_006270.5(RRAS):c.153+10C>A	rs1484904489	0.00001
NM_006270.5(RRAS):c.154-6C>T	rs756472044	0.00001
NM_006270.5(RRAS):c.201G>A (p.Thr67=)	rs1421164782	0.00001
NM_006270.5(RRAS):c.241+13A>G	rs765391621	0.00001
NM_006270.5(RRAS):c.241+20A>G	rs967945950	0.00001
NM_006270.5(RRAS):c.351C>T (p.Asn117=)	rs374077706	0.00001
NM_006270.5(RRAS):c.363G>A (p.Lys121=)	rs557007484	0.00001
NM_006270.5(RRAS):c.372G>A (p.Thr124=)	rs368978550	0.00001
NM_006270.5(RRAS):c.37C>A (p.Arg13=)	rs1272875791	0.00001
NM_006270.5(RRAS):c.396C>T (p.Arg132=)	rs748366671	0.00001
NM_006270.5(RRAS):c.420C>T (p.Val140=)	rs576507390	0.00001
NM_006270.5(RRAS):c.454-4C>T	rs749106517	0.00001
NM_006270.5(RRAS):c.480C>T (p.Phe160=)	rs1353880358	0.00001
NM_006270.5(RRAS):c.498G>A (p.Val166=)	rs1411684410	0.00001
NM_006270.5(RRAS):c.534C>T (p.Asn178=)	rs773121618	0.00001
NM_006270.5(RRAS):c.572+13C>A	rs2080992973	0.00001
NM_006270.5(RRAS):c.609C>T (p.Pro203=)	rs1297251901	0.00001
NM_006270.5(RRAS):c.624G>A (p.Lys208=)	rs775471738	0.00001
NM_006270.5(RRAS):c.69C>T (p.Asp23=)	rs1458889244	0.00001
NM_006270.5(RRAS):c.153+17C>A	rs376005750
NM_006270.5(RRAS):c.153+18G>A	rs2081014508
NM_006270.5(RRAS):c.154-10A>T	rs1010709642
NM_006270.5(RRAS):c.198C>T (p.Tyr66=)
NM_006270.5(RRAS):c.231C>A (p.Ala77=)	rs557964716
NM_006270.5(RRAS):c.241+17T>C	rs2513706946
NM_006270.5(RRAS):c.242-17del
NM_006270.5(RRAS):c.242-4G>A
NM_006270.5(RRAS):c.242-8C>G	rs370459010
NM_006270.5(RRAS):c.288G>A (p.Gln96=)	rs769130245
NM_006270.5(RRAS):c.30G>C (p.Gly10=)	rs901769495
NM_006270.5(RRAS):c.344+19G>C
NM_006270.5(RRAS):c.345-15C>T
NM_006270.5(RRAS):c.345-19_345-18del	rs2122419483
NM_006270.5(RRAS):c.360C>T (p.Gly120=)
NM_006270.5(RRAS):c.393C>T (p.Asp131=)
NM_006270.5(RRAS):c.408C>G (p.Pro136=)	rs114187560
NM_006270.5(RRAS):c.42C>T (p.Pro14=)	rs1354856207
NM_006270.5(RRAS):c.438G>T (p.Leu146=)	rs1599813671
NM_006270.5(RRAS):c.43C>A (p.Arg15=)	rs544651800
NM_006270.5(RRAS):c.453+16_453+17del
NM_006270.5(RRAS):c.453+17T>C	rs2513706286
NM_006270.5(RRAS):c.453+18T>C	rs2122418915
NM_006270.5(RRAS):c.453+7G>A	rs2122418958
NM_006270.5(RRAS):c.454-12C>T
NM_006270.5(RRAS):c.454-20C>T	rs564198320
NM_006270.5(RRAS):c.454-6C>T	rs1568436933
NM_006270.5(RRAS):c.454-7C>T	rs2122417189
NM_006270.5(RRAS):c.454-9T>A	rs1490597941
NM_006270.5(RRAS):c.465A>C (p.Ser155=)
NM_006270.5(RRAS):c.492C>T (p.His164=)	rs2122416934
NM_006270.5(RRAS):c.516G>A (p.Ser172=)	rs199924228
NM_006270.5(RRAS):c.516G>T (p.Ser172=)	rs199924228
NM_006270.5(RRAS):c.51G>T (p.Gly17=)	rs2081015423
NM_006270.5(RRAS):c.567T>C (p.Ala189=)	rs779217242
NM_006270.5(RRAS):c.572+10G>A
NM_006270.5(RRAS):c.572+20T>G	rs1017127642
NM_006270.5(RRAS):c.573-15G>A	rs1413308540
NM_006270.5(RRAS):c.573-15G>C
NM_006270.5(RRAS):c.573-16del	rs2513705270
NM_006270.5(RRAS):c.642C>T (p.Pro214=)	rs749613582
NM_006270.5(RRAS):c.66G>A (p.Gly22=)	rs1249345635
NM_006270.5(RRAS):c.75G>C (p.Pro25=)	rs2122429854
NM_006270.5(RRAS):c.99G>A (p.Val33=)

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