List of variants in gene SDHD reported as uncertain significance for adrenal gland neoplasm

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 263

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HGVS	dbSNP	gnomAD frequency
NM_003002.4(SDHD):c.*369A>G	rs200753024	0.00157
NM_003002.4(SDHD):c.*822T>C	rs201472512	0.00133
NM_003002.4(SDHD):c.278A>G (p.Tyr93Cys)	rs142135772	0.00049
NM_003002.4(SDHD):c.101T>G (p.Phe34Cys)	rs141802836	0.00016
NM_003002.4(SDHD):c.255G>C (p.Leu85Phe)	rs199517389	0.00013
NM_003002.4(SDHD):c.53C>T (p.Ala18Val)	rs192332761	0.00011
NM_003002.4(SDHD):c.107A>G (p.Gln36Arg)	rs759143732	0.00003
NM_003002.4(SDHD):c.118A>G (p.Ile40Val)	rs146276662	0.00003
NM_003002.4(SDHD):c.158C>T (p.Pro53Leu)	rs149516118	0.00003
NM_003002.4(SDHD):c.116C>T (p.Pro39Leu)	rs752689382	0.00002
NM_003002.4(SDHD):c.122C>T (p.Pro41Leu)	rs753724042	0.00002
NM_003002.4(SDHD):c.398C>A (p.Ala133Asp)	rs755584530	0.00002
NM_003002.4(SDHD):c.464T>A (p.Met155Lys)	rs1060503776	0.00002
NM_003002.4(SDHD):c.479G>T (p.Ter160Leu)	rs201372601	0.00002
NM_003002.4(SDHD):c.56T>C (p.Leu19Pro)	rs574698019	0.00002
NM_003002.4(SDHD):c.113G>A (p.Arg38Gln)	rs199901239	0.00001
NM_003002.4(SDHD):c.124G>A (p.Glu42Lys)	rs756995021	0.00001
NM_003002.4(SDHD):c.148C>T (p.His50Tyr)	rs779249550	0.00001
NM_003002.4(SDHD):c.167A>C (p.His56Pro)	rs1555186817	0.00001
NM_003002.4(SDHD):c.180G>T (p.Lys60Asn)	rs750688879	0.00001
NM_003002.4(SDHD):c.211G>A (p.Val71Ile)	rs1428042303	0.00001
NM_003002.4(SDHD):c.217A>G (p.Ser73Gly)	rs748545223	0.00001
NM_003002.4(SDHD):c.230T>C (p.Leu77Pro)	rs777963699	0.00001
NM_003002.4(SDHD):c.243G>A (p.Pro81=)	rs575262156	0.00001
NM_003002.4(SDHD):c.281C>G (p.Ser94Cys)	rs199754684	0.00001
NM_003002.4(SDHD):c.293C>T (p.Ala98Val)	rs200980609	0.00001
NM_003002.4(SDHD):c.301C>T (p.Leu101Phe)	rs1165258369	0.00001
NM_003002.4(SDHD):c.310C>G (p.His104Asp)	rs779863605	0.00001
NM_003002.4(SDHD):c.328G>A (p.Val110Ile)	rs1060503771	0.00001
NM_003002.4(SDHD):c.331G>A (p.Val111Ile)	rs201869798	0.00001
NM_003002.4(SDHD):c.335C>T (p.Thr112Ile)	rs199869408	0.00001
NM_003002.4(SDHD):c.344T>C (p.Val115Ala)	rs1489012268	0.00001
NM_003002.4(SDHD):c.353A>G (p.Asp118Gly)	rs750857413	0.00001
NM_003002.4(SDHD):c.356C>T (p.Ala119Val)	rs758784300	0.00001
NM_003002.4(SDHD):c.375G>T (p.Lys125Asn)	rs878854595	0.00001
NM_003002.4(SDHD):c.388G>C (p.Ala130Pro)	rs1312671864	0.00001
NM_003002.4(SDHD):c.400T>G (p.Leu134Val)	rs200851392	0.00001
NM_003002.4(SDHD):c.421T>C (p.Tyr141His)	rs1394514096	0.00001
NM_003002.4(SDHD):c.422A>G (p.Tyr141Cys)	rs199772639	0.00001
NM_003002.4(SDHD):c.428A>G (p.Asn143Ser)	rs770909248	0.00001
NM_003002.4(SDHD):c.430T>C (p.Tyr144His)	rs774243340	0.00001
NM_003002.4(SDHD):c.431A>G (p.Tyr144Cys)	rs745732631	0.00001
NM_003002.4(SDHD):c.433C>A (p.His145Asn)	rs121908984	0.00001
NM_003002.4(SDHD):c.82C>A (p.Pro28Thr)	rs541477171	0.00001
NM_003002.4(SDHD):c.82C>T (p.Pro28Ser)	rs541477171	0.00001
NM_003002.4(SDHD):c.85G>C (p.Ala29Pro)	rs776930864	0.00001
NM_003002.4(SDHD):c.88C>T (p.His30Tyr)	rs561759202	0.00001
NM_003002.4(SDHD):c.89A>C (p.His30Pro)	rs1592778803	0.00001
NC_000011.10:g.(?_112086823)_(112086969_?)dup
NC_000011.10:g.(?_112086823)_(112094970_?)dup
NC_000011.10:g.(?_112087802)_(112094970_?)dup
NC_000011.9:g.(?_111957547)_(111959745_?)dup
NC_000011.9:g.(?_111957632)_(111965694_?)dup
NM_003002.4(SDHD):c.*340A>G	rs201280702
NM_003002.4(SDHD):c.102T>A (p.Phe34Leu)
NM_003002.4(SDHD):c.102T>G (p.Phe34Leu)
NM_003002.4(SDHD):c.107A>C (p.Gln36Pro)	rs759143732
NM_003002.4(SDHD):c.108G>T (p.Gln36His)	rs766884646
NM_003002.4(SDHD):c.109G>A (p.Asp37Asn)	rs1865654125
NM_003002.4(SDHD):c.110A>T (p.Asp37Val)	rs1865654258
NM_003002.4(SDHD):c.113G>C (p.Arg38Pro)	rs199901239
NM_003002.4(SDHD):c.115C>A (p.Pro39Thr)	rs1043566340
NM_003002.4(SDHD):c.115C>T (p.Pro39Ser)
NM_003002.4(SDHD):c.118A>C (p.Ile40Leu)	rs146276662
NM_003002.4(SDHD):c.119T>C (p.Ile40Thr)	rs1592778916
NM_003002.4(SDHD):c.120C>G (p.Ile40Met)	rs2135267285
NM_003002.4(SDHD):c.121C>G (p.Pro41Ala)	rs764006625
NM_003002.4(SDHD):c.121C>T (p.Pro41Ser)	rs764006625
NM_003002.4(SDHD):c.125A>G (p.Glu42Gly)
NM_003002.4(SDHD):c.131G>A (p.Cys44Tyr)	rs1566692479
NM_003002.4(SDHD):c.136G>A (p.Val46Met)	rs886047699
NM_003002.4(SDHD):c.136G>T (p.Val46Leu)	rs886047699
NM_003002.4(SDHD):c.140A>G (p.Gln47Arg)	rs899706404
NM_003002.4(SDHD):c.145A>G (p.Ile49Val)
NM_003002.4(SDHD):c.146T>C (p.Ile49Thr)	rs1555186808
NM_003002.4(SDHD):c.147A>G (p.Ile49Met)	rs1566692534
NM_003002.4(SDHD):c.150C>G (p.His50Gln)
NM_003002.4(SDHD):c.154T>G (p.Ser52Ala)
NM_003002.4(SDHD):c.155C>T (p.Ser52Leu)	rs587782210
NM_003002.4(SDHD):c.156_158del (p.Pro53del)
NM_003002.4(SDHD):c.157C>G (p.Pro53Ala)	rs1865656629
NM_003002.4(SDHD):c.160A>C (p.Ser54Arg)	rs2135267524
NM_003002.4(SDHD):c.164A>G (p.His55Arg)
NM_003002.4(SDHD):c.164A>T (p.His55Leu)	rs1865656869
NM_003002.4(SDHD):c.167A>G (p.His56Arg)	rs1555186817
NM_003002.4(SDHD):c.168T>A (p.His56Gln)	rs1865657093
NM_003002.4(SDHD):c.169+3A>G	rs1865657168
NM_003002.4(SDHD):c.169+5G>C	rs1865657237
NM_003002.4(SDHD):c.170-12T>A
NM_003002.4(SDHD):c.170-5T>A	rs1218549926
NM_003002.4(SDHD):c.170-6T>G	rs753703004
NM_003002.4(SDHD):c.170C>G (p.Ser57Cys)
NM_003002.4(SDHD):c.170C>T (p.Ser57Phe)	rs2135269128
NM_003002.4(SDHD):c.172G>A (p.Gly58Ser)	rs1865684789
NM_003002.4(SDHD):c.173G>A (p.Gly58Asp)
NM_003002.4(SDHD):c.175T>C (p.Ser59Pro)	rs1592780294
NM_003002.4(SDHD):c.176C>T (p.Ser59Phe)	rs1592780300
NM_003002.4(SDHD):c.179A>C (p.Lys60Thr)
NM_003002.4(SDHD):c.179A>G (p.Lys60Arg)
NM_003002.4(SDHD):c.180G>A (p.Lys60=)	rs750688879
NM_003002.4(SDHD):c.181G>C (p.Ala61Pro)
NM_003002.4(SDHD):c.182C>T (p.Ala61Val)
NM_003002.4(SDHD):c.190C>G (p.Leu64Val)
NM_003002.4(SDHD):c.194A>G (p.His65Arg)	rs780226013
NM_003002.4(SDHD):c.199A>G (p.Thr67Ala)	rs2135269250
NM_003002.4(SDHD):c.200C>A (p.Thr67Asn)	rs1592780362
NM_003002.4(SDHD):c.203G>C (p.Ser68Thr)
NM_003002.4(SDHD):c.204C>A (p.Ser68Arg)
NM_003002.4(SDHD):c.209G>A (p.Arg70Lys)	rs755047928
NM_003002.4(SDHD):c.209G>C (p.Arg70Thr)	rs755047928
NM_003002.4(SDHD):c.211G>T (p.Val71Phe)	rs1428042303
NM_003002.4(SDHD):c.220G>A (p.Val74Ile)
NM_003002.4(SDHD):c.224T>C (p.Leu75Ser)	rs1060503777
NM_003002.4(SDHD):c.225G>C (p.Leu75Phe)	rs1865687714
NM_003002.4(SDHD):c.226C>T (p.Leu76Phe)	rs1865687801
NM_003002.4(SDHD):c.227T>C (p.Leu76Pro)	rs1865687896
NM_003002.4(SDHD):c.231G>A (p.Leu77=)	rs1187106228
NM_003002.4(SDHD):c.232G>A (p.Gly78Ser)
NM_003002.4(SDHD):c.232G>C (p.Gly78Arg)	rs1592780479
NM_003002.4(SDHD):c.233G>T (p.Gly78Val)	rs1865688426
NM_003002.4(SDHD):c.238C>T (p.Leu80Phe)	rs1592780488
NM_003002.4(SDHD):c.242C>G (p.Pro81Arg)	rs80338844
NM_003002.4(SDHD):c.244G>C (p.Ala82Pro)	rs745559875
NM_003002.4(SDHD):c.244G>T (p.Ala82Ser)	rs745559875
NM_003002.4(SDHD):c.247G>A (p.Ala83Thr)
NM_003002.4(SDHD):c.248C>T (p.Ala83Val)	rs370165653
NM_003002.4(SDHD):c.251A>C (p.Tyr84Ser)
NM_003002.4(SDHD):c.255G>T (p.Leu85Phe)	rs199517389
NM_003002.4(SDHD):c.259C>T (p.Pro87Ser)	rs1279566824
NM_003002.4(SDHD):c.260C>A (p.Pro87His)
NM_003002.4(SDHD):c.263G>T (p.Cys88Phe)	rs1592780559
NM_003002.4(SDHD):c.268G>A (p.Ala90Thr)	rs765102002
NM_003002.4(SDHD):c.268_269delinsTT (p.Ala90Leu)	rs1555187033
NM_003002.4(SDHD):c.269C>G (p.Ala90Gly)
NM_003002.4(SDHD):c.271A>T (p.Met91Leu)	rs2135269615
NM_003002.4(SDHD):c.272T>A (p.Met91Lys)	rs1592780595
NM_003002.4(SDHD):c.272T>C (p.Met91Thr)
NM_003002.4(SDHD):c.274G>A (p.Asp92Asn)
NM_003002.4(SDHD):c.276C>G (p.Asp92Glu)
NM_003002.4(SDHD):c.277T>C (p.Tyr93His)	rs1592780620
NM_003002.4(SDHD):c.281C>T (p.Ser94Phe)	rs199754684
NM_003002.4(SDHD):c.283C>G (p.Leu95Val)	rs1865691704
NM_003002.4(SDHD):c.286G>A (p.Ala96Thr)	rs1265437700
NM_003002.4(SDHD):c.288_290del (p.Ala98del)	rs1566694825
NM_003002.4(SDHD):c.290C>T (p.Ala97Val)	rs756533450
NM_003002.4(SDHD):c.292G>C (p.Ala98Pro)	rs1865692235
NM_003002.4(SDHD):c.292G>T (p.Ala98Ser)	rs1865692235
NM_003002.4(SDHD):c.295C>G (p.Leu99Val)	rs1865692425
NM_003002.4(SDHD):c.298A>G (p.Thr100Ala)	rs1555187065
NM_003002.4(SDHD):c.299C>T (p.Thr100Ile)	rs557454864
NM_003002.4(SDHD):c.301C>G (p.Leu101Val)	rs1165258369
NM_003002.4(SDHD):c.302T>A (p.Leu101His)	rs2135269810
NM_003002.4(SDHD):c.307G>C (p.Gly103Arg)
NM_003002.4(SDHD):c.308G>A (p.Gly103Asp)
NM_003002.4(SDHD):c.313T>C (p.Trp105Arg)
NM_003002.4(SDHD):c.314+2C>T	rs1340664447
NM_003002.4(SDHD):c.314+3A>C	rs1555187084
NM_003002.4(SDHD):c.314+4A>G	rs1592780789
NM_003002.4(SDHD):c.314+5G>A	rs1566695035
NM_003002.4(SDHD):c.314+6T>C	rs1555187085
NM_003002.4(SDHD):c.315-2A>G	rs2135277333
NM_003002.4(SDHD):c.315-3T>C	rs1555187565
NM_003002.4(SDHD):c.315-3del	rs1566702297
NM_003002.4(SDHD):c.315-7_315-5delinsAAA	rs1060503775
NM_003002.4(SDHD):c.315G>T (p.Trp105Cys)
NM_003002.4(SDHD):c.319C>T (p.Leu107Phe)	rs1209781530
NM_003002.4(SDHD):c.323_324delinsTT (p.Gly108Val)
NM_003002.4(SDHD):c.328GTT[1] (p.Val111del)	rs1555187580
NM_003002.4(SDHD):c.331G>C (p.Val111Leu)
NM_003002.4(SDHD):c.332T>C (p.Val111Ala)	rs1592786183
NM_003002.4(SDHD):c.334A>G (p.Thr112Ala)	rs1865809730
NM_003002.4(SDHD):c.337G>C (p.Asp113His)
NM_003002.4(SDHD):c.338A>G (p.Asp113Gly)	rs786202513
NM_003002.4(SDHD):c.338A>T (p.Asp113Val)	rs786202513
NM_003002.4(SDHD):c.340T>C (p.Tyr114His)	rs876659276
NM_003002.4(SDHD):c.346C>T (p.His116Tyr)	rs2135277443
NM_003002.4(SDHD):c.347A>T (p.His116Leu)	rs2135277447
NM_003002.4(SDHD):c.352G>A (p.Asp118Asn)	rs1865810526
NM_003002.4(SDHD):c.352_353delinsAT (p.Asp118Ile)
NM_003002.4(SDHD):c.353A>C (p.Asp118Ala)
NM_003002.4(SDHD):c.354T>G (p.Asp118Glu)	rs911663426
NM_003002.4(SDHD):c.355G>T (p.Ala119Ser)	rs930768406
NM_003002.4(SDHD):c.356C>A (p.Ala119Asp)	rs758784300
NM_003002.4(SDHD):c.365A>G (p.Lys122Arg)
NM_003002.4(SDHD):c.370G>A (p.Ala124Thr)	rs1865811145
NM_003002.4(SDHD):c.370G>T (p.Ala124Ser)
NM_003002.4(SDHD):c.371C>T (p.Ala124Val)	rs1865811210
NM_003002.4(SDHD):c.374A>G (p.Lys125Arg)	rs1592786256
NM_003002.4(SDHD):c.376G>A (p.Ala126Thr)	rs1592786265
NM_003002.4(SDHD):c.376G>T (p.Ala126Ser)
NM_003002.4(SDHD):c.377C>T (p.Ala126Val)
NM_003002.4(SDHD):c.380G>A (p.Gly127Glu)
NM_003002.4(SDHD):c.386T>C (p.Leu129Ser)	rs201726097
NM_003002.4(SDHD):c.386T>G (p.Leu129Trp)	rs201726097
NM_003002.4(SDHD):c.388G>T (p.Ala130Ser)	rs1312671864
NM_003002.4(SDHD):c.389C>G (p.Ala130Gly)	rs1049692537
NM_003002.4(SDHD):c.389C>T (p.Ala130Val)
NM_003002.4(SDHD):c.394T>G (p.Ser132Ala)	rs2135277611
NM_003002.4(SDHD):c.397G>A (p.Ala133Thr)	rs1060503774
NM_003002.4(SDHD):c.397G>C (p.Ala133Pro)	rs1060503774
NM_003002.4(SDHD):c.398C>G (p.Ala133Gly)
NM_003002.4(SDHD):c.404C>T (p.Thr135Ile)	rs2135277637
NM_003002.4(SDHD):c.408T>A (p.Phe136Leu)
NM_003002.4(SDHD):c.409G>A (p.Ala137Thr)	rs1555187611
NM_003002.4(SDHD):c.409G>C (p.Ala137Pro)	rs1555187611
NM_003002.4(SDHD):c.410C>T (p.Ala137Val)	rs749250498
NM_003002.4(SDHD):c.419G>A (p.Cys140Tyr)	rs2135277691
NM_003002.4(SDHD):c.426C>G (p.Phe142Leu)	rs2135277712
NM_003002.4(SDHD):c.427A>C (p.Asn143His)
NM_003002.4(SDHD):c.427A>G (p.Asn143Asp)	rs1865812863
NM_003002.4(SDHD):c.430_435del (p.Tyr144_His145del)
NM_003002.4(SDHD):c.431A>T (p.Tyr144Phe)	rs745732631
NM_003002.4(SDHD):c.433C>T (p.His145Tyr)
NM_003002.4(SDHD):c.436G>A (p.Asp146Asn)	rs1592786384
NM_003002.4(SDHD):c.436G>T (p.Asp146Tyr)	rs1592786384
NM_003002.4(SDHD):c.439G>A (p.Val147Met)	rs1865813583
NM_003002.4(SDHD):c.443G>A (p.Gly148Asp)
NM_003002.4(SDHD):c.445A>G (p.Ile149Val)	rs1865813813
NM_003002.4(SDHD):c.446T>G (p.Ile149Ser)	rs1295620545
NM_003002.4(SDHD):c.449G>C (p.Cys150Ser)
NM_003002.4(SDHD):c.453A>C (p.Lys151Asn)	rs761953172
NM_003002.4(SDHD):c.454G>A (p.Ala152Thr)	rs1865814160
NM_003002.4(SDHD):c.455_463del (p.Ala152_Met155delinsVal)	rs1592786423
NM_003002.4(SDHD):c.458T>C (p.Val153Ala)	rs1555187644
NM_003002.4(SDHD):c.461C>T (p.Ala154Val)
NM_003002.4(SDHD):c.463A>G (p.Met155Val)	rs2135277828
NM_003002.4(SDHD):c.464T>C (p.Met155Thr)
NM_003002.4(SDHD):c.466C>G (p.Leu156Val)
NM_003002.4(SDHD):c.473_*3dup (p.Lys158_Ter160=)	rs878854596
NM_003002.4(SDHD):c.474G>T (p.Lys158Asn)	rs1377208267
NM_003002.4(SDHD):c.474_475delinsTT (p.Lys158_Leu159delinsAsnPhe)
NM_003002.4(SDHD):c.476T>C (p.Leu159Pro)	rs2135277858
NM_003002.4(SDHD):c.478T>A (p.Ter160Arg)	rs1555187655
NM_003002.4(SDHD):c.478T>G (p.Ter160Gly)
NM_003002.4(SDHD):c.479G>C (p.Ter160Ser)
NM_003002.4(SDHD):c.480A>G (p.Ter160Trp)	rs587778663
NM_003002.4(SDHD):c.480A>T (p.Ter160Cys)
NM_003002.4(SDHD):c.53-10_53-9del
NM_003002.4(SDHD):c.53-11T>C
NM_003002.4(SDHD):c.53-16A>G	rs915385437
NM_003002.4(SDHD):c.53-3C>T
NM_003002.4(SDHD):c.53-6C>A	rs757454290
NM_003002.4(SDHD):c.53-7_53-3del	rs1865650219
NM_003002.4(SDHD):c.53-9_53-6del	rs1592778629
NM_003002.4(SDHD):c.58T>A (p.Leu20Met)	rs1298878168
NM_003002.4(SDHD):c.61C>T (p.Leu21Phe)	rs1592778703
NM_003002.4(SDHD):c.62T>C (p.Leu21Pro)
NM_003002.4(SDHD):c.64C>A (p.Arg22=)	rs104894306
NM_003002.4(SDHD):c.65G>A (p.Arg22Gln)	rs1555186772
NM_003002.4(SDHD):c.65G>C (p.Arg22Pro)
NM_003002.4(SDHD):c.70C>T (p.Pro24Ser)	rs775986509
NM_003002.4(SDHD):c.71C>T (p.Pro24Leu)	rs1865651909
NM_003002.4(SDHD):c.73G>T (p.Val25Leu)	rs878854597
NM_003002.4(SDHD):c.82C>G (p.Pro28Ala)	rs541477171
NM_003002.4(SDHD):c.83C>A (p.Pro28His)	rs2135267114
NM_003002.4(SDHD):c.85G>A (p.Ala29Thr)
NM_003002.4(SDHD):c.86C>T (p.Ala29Val)	rs1555186774
NM_003002.4(SDHD):c.91A>G (p.Ile31Val)	rs1865653068
NM_003002.4(SDHD):c.93C>G (p.Ile31Met)
NM_003002.4(SDHD):c.94T>G (p.Ser32Ala)
NM_003002.4(SDHD):c.95C>T (p.Ser32Leu)	rs104894305
NM_003002.4(SDHD):c.97G>A (p.Ala33Thr)	rs2135267174
NM_003002.4(SDHD):c.98C>A (p.Ala33Glu)

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