List of variants in gene BRCA1 reported as uncertain significance for digestive system cancer

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 33

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HGVS	dbSNP	gnomAD frequency
NM_007294.4(BRCA1):c.446A>C (p.Glu149Ala)	rs397507233	0.00004
NM_007294.4(BRCA1):c.1259A>G (p.Asp420Gly)	rs730881442	0.00002
NM_007294.4(BRCA1):c.1723G>A (p.Glu575Lys)	rs397508902	0.00002
NM_007294.4(BRCA1):c.5068A>C (p.Lys1690Gln)	rs397507239	0.00002
NM_007294.4(BRCA1):c.1381T>C (p.Phe461Leu)	rs62625300	0.00001
NM_007294.4(BRCA1):c.1745C>T (p.Thr582Met)	rs786202386	0.00001
NM_007294.4(BRCA1):c.2050C>T (p.Pro684Ser)	rs397508934	0.00001
NM_007294.4(BRCA1):c.20G>A (p.Arg7His)	rs144792613	0.00001
NM_007294.4(BRCA1):c.301+6T>C	rs753859240	0.00001
NM_007294.4(BRCA1):c.4231A>G (p.Met1411Val)	rs587781768	0.00001
NM_007294.4(BRCA1):c.4384G>A (p.Glu1462Lys)	rs141255461	0.00001
NM_007294.4(BRCA1):c.4649C>T (p.Thr1550Ile)	rs80357076	0.00001
NM_007294.4(BRCA1):c.4843G>A (p.Ala1615Thr)	rs80356987	0.00001
NM_007294.4(BRCA1):c.527C>T (p.Thr176Met)	rs587782747	0.00001
NM_007294.4(BRCA1):c.982T>C (p.Cys328Arg)	rs748156170	0.00001
NM_007294.4(BRCA1):c.1662G>C (p.Glu554Asp)	rs876659028
NM_007294.4(BRCA1):c.1886G>T (p.Arg629Ile)	rs876660144
NM_007294.4(BRCA1):c.2663A>C (p.His888Pro)	rs876658843
NM_007294.4(BRCA1):c.3080G>C (p.Ser1027Thr)	rs80357386
NM_007294.4(BRCA1):c.3104T>C (p.Val1035Ala)	rs1555588389
NM_007294.4(BRCA1):c.4333C>A (p.Pro1445Thr)	rs876660684
NM_007294.4(BRCA1):c.442-2A>G	rs80358155
NM_007294.4(BRCA1):c.4654T>C (p.Tyr1552His)	rs1265352633
NM_007294.4(BRCA1):c.4664G>A (p.Arg1555Lys)	rs786202165
NM_007294.4(BRCA1):c.4983A>G (p.Glu1661=)	rs2052354666
NM_007294.4(BRCA1):c.502A>G (p.Lys168Glu)	rs886040263
NM_007294.4(BRCA1):c.5056C>T (p.His1686Tyr)	rs1555579648
NM_007294.4(BRCA1):c.5232A>G (p.Arg1744=)	rs2051514714
NM_007294.4(BRCA1):c.5341G>A (p.Glu1781Lys)	rs397509268
NM_007294.4(BRCA1):c.5461T>C (p.Phe1821Leu)	rs2050978032
NM_007294.4(BRCA1):c.5470A>G (p.Ile1824Val)	rs587782026
NM_007294.4(BRCA1):c.851A>G (p.Gln284Arg)	rs80357039
NM_007294.4(BRCA1):c.922A>G (p.Ser308Gly)	rs55767801

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