List of variants reported as pathogenic for central nervous system cancer by Myriad Genetics, Inc.

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 101

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HGVS	dbSNP	gnomAD frequency
NM_004168.4(SDHA):c.91C>T (p.Arg31Ter)	rs142441643	0.00025
NM_004168.4(SDHA):c.1A>G (p.Met1Val)	rs1061517	0.00013
NM_004168.4(SDHA):c.1534C>T (p.Arg512Ter)	rs748089700	0.00005
NM_003000.3(SDHB):c.136C>T (p.Arg46Ter)	rs74315370	0.00003
NM_003000.3(SDHB):c.79C>T (p.Arg27Ter)	rs74315369	0.00003
NM_004168.4(SDHA):c.223C>T (p.Arg75Ter)	rs781764920	0.00003
NM_003000.3(SDHB):c.137G>A (p.Arg46Gln)	rs772551056	0.00001
NM_003000.3(SDHB):c.268C>T (p.Arg90Ter)	rs74315366	0.00001
NM_003000.3(SDHB):c.423+1G>A	rs398122805	0.00001
NM_003000.3(SDHB):c.600G>T (p.Trp200Cys)	rs397516836	0.00001
NM_004168.4(SDHA):c.1054C>T (p.Arg352Ter)	rs746165168	0.00001
NM_004168.4(SDHA):c.1151C>G (p.Ser384Ter)	rs151170408	0.00001
NM_004168.4(SDHA):c.1338del (p.His447fs)	rs1735791499	0.00001
NM_004168.4(SDHA):c.1471G>T (p.Glu491Ter)	rs778207102	0.00001
NM_004168.4(SDHA):c.1629T>G (p.Tyr543Ter)	rs747249998	0.00001
NM_004168.4(SDHA):c.553C>T (p.Gln185Ter)	rs775827529	0.00001
NM_004168.4(SDHA):c.985C>T (p.Arg329Ter)	rs771328239	0.00001
NM_003000.3(SDHB):c.166_170del (p.Pro56fs)	rs786202100
NM_003000.3(SDHB):c.18_21delinsACT (p.Ser8fs)
NM_003000.3(SDHB):c.19_41dup (p.Pro14_Ala15insSerProTer)	rs1553179340
NM_003000.3(SDHB):c.1A>G (p.Met1Val)
NM_003000.3(SDHB):c.200+1G>A	rs2101541309
NM_003000.3(SDHB):c.210dup (p.Met71fs)	rs794728947
NM_003000.3(SDHB):c.286+1G>A	rs786201063
NM_003000.3(SDHB):c.286+2T>A	rs587781270
NM_003000.3(SDHB):c.287-1G>C	rs397516833
NM_003000.3(SDHB):c.287-2A>G	rs1064794270
NM_003000.3(SDHB):c.311delinsGG (p.Asn104fs)	rs786201316
NM_003000.3(SDHB):c.375_376delinsGT (p.Lys126Ter)
NM_003000.3(SDHB):c.3G>A (p.Met1Ile)	rs1131691061
NM_003000.3(SDHB):c.445C>T (p.Gln149Ter)	rs876658451
NM_003000.3(SDHB):c.505C>T (p.Gln169Ter)	rs1553177676
NM_003000.3(SDHB):c.541-2A>G	rs786201161
NM_003000.3(SDHB):c.574T>C (p.Cys192Arg)	rs786202732
NM_003000.3(SDHB):c.587G>A (p.Cys196Tyr)	rs876658367
NM_003000.3(SDHB):c.603G>A (p.Trp201Ter)
NM_003000.3(SDHB):c.640C>T (p.Gln214Ter)	rs876658461
NM_003000.3(SDHB):c.653G>A (p.Trp218Ter)	rs1553177290
NM_003000.3(SDHB):c.716_719del (p.Ser239fs)	rs587781266
NM_003000.3(SDHB):c.71dup (p.Ala25fs)	rs1131691057
NM_003000.3(SDHB):c.72+1G>T	rs587782703
NM_004168.4(SDHA):c.1012del (p.Ala338fs)	rs1295239305
NM_004168.4(SDHA):c.1045_1046del (p.Leu349fs)
NM_004168.4(SDHA):c.1192del (p.Glu398fs)
NM_004168.4(SDHA):c.124_125dup (p.Ala43fs)	rs1385076821
NM_004168.4(SDHA):c.1257del (p.Gln420fs)
NM_004168.4(SDHA):c.1258C>T (p.Gln420Ter)	rs1579407009
NM_004168.4(SDHA):c.1283_1298del (p.Gln428fs)
NM_004168.4(SDHA):c.1367C>A (p.Ser456Ter)
NM_004168.4(SDHA):c.1373T>A (p.Leu458Ter)
NM_004168.4(SDHA):c.1468G>T (p.Glu490Ter)	rs1554000360
NM_004168.4(SDHA):c.1473del (p.Glu491fs)
NM_004168.4(SDHA):c.1526_1527delinsGA (p.Ser509Ter)	rs1064793567
NM_004168.4(SDHA):c.1579del (p.Arg527fs)	rs1579437839
NM_004168.4(SDHA):c.1586del (p.Gly529fs)
NM_004168.4(SDHA):c.1608del (p.Cys536fs)
NM_004168.4(SDHA):c.160C>T (p.Gln54Ter)	rs1560985916
NM_004168.4(SDHA):c.1615dup (p.Ile539fs)	rs1554001843
NM_004168.4(SDHA):c.1663G>T (p.Gly555Ter)
NM_004168.4(SDHA):c.1665_1670delinsTCCC (p.Met556fs)
NM_004168.4(SDHA):c.1740C>G (p.Tyr580Ter)
NM_004168.4(SDHA):c.1755_1759del (p.Lys586fs)	rs1561010916
NM_004168.4(SDHA):c.1A>C (p.Met1Leu)	rs1061517
NM_004168.4(SDHA):c.1A>T (p.Met1Leu)	rs1061517
NM_004168.4(SDHA):c.23C>A (p.Ser8Ter)	rs878854631
NM_004168.4(SDHA):c.242_243insA (p.Ser81_Glu82insTer)	rs2126542910
NM_004168.4(SDHA):c.244G>T (p.Glu82Ter)
NM_004168.4(SDHA):c.2T>A (p.Met1Lys)	rs750380279
NM_004168.4(SDHA):c.2T>C (p.Met1Thr)	rs750380279
NM_004168.4(SDHA):c.2T>G (p.Met1Arg)	rs750380279
NM_004168.4(SDHA):c.310C>T (p.Gln104Ter)	rs1423978863
NM_004168.4(SDHA):c.324dup (p.Ala109fs)
NM_004168.4(SDHA):c.356G>A (p.Trp119Ter)	rs1734957331
NM_004168.4(SDHA):c.378del (p.Thr126_Val127insTer)	rs1553997617
NM_004168.4(SDHA):c.3G>A (p.Met1Ile)
NM_004168.4(SDHA):c.403del (p.Asp135fs)
NM_004168.4(SDHA):c.464del (p.Asn155fs)
NM_004168.4(SDHA):c.46_52dup (p.Leu18fs)	rs1560980939
NM_004168.4(SDHA):c.554dup (p.Ala186fs)	rs1173940446
NM_004168.4(SDHA):c.55_57delinsCA (p.Ala19fs)
NM_004168.4(SDHA):c.596_599del (p.Ser199fs)
NM_004168.4(SDHA):c.5dup (p.Val4fs)
NM_004168.4(SDHA):c.615T>A (p.Tyr205Ter)	rs876658486
NM_004168.4(SDHA):c.628C>T (p.Arg210Ter)	rs775143272
NM_004168.4(SDHA):c.637dup (p.Thr213fs)
NM_004168.4(SDHA):c.649dup (p.Val217fs)
NM_004168.4(SDHA):c.667del (p.Asp223fs)	rs587782077
NM_004168.4(SDHA):c.688del (p.Glu230fs)	rs1553998199
NM_004168.4(SDHA):c.722_726del (p.Asp241fs)	rs1553998229
NM_004168.4(SDHA):c.775del (p.Tyr259fs)	rs1553998606
NM_004168.4(SDHA):c.777C>G (p.Tyr259Ter)
NM_004168.4(SDHA):c.786del (p.Tyr263fs)	rs1553998613
NM_004168.4(SDHA):c.862C>T (p.Gln288Ter)
NM_004168.4(SDHA):c.870dup (p.Glu291fs)
NM_004168.4(SDHA):c.880C>T (p.Gln294Ter)	rs1560992565
NM_004168.4(SDHA):c.944dup (p.Gly316fs)	rs1579402180
NM_004168.4(SDHA):c.990C>A (p.Tyr330Ter)
NM_004168.4(SDHA):c.990del (p.Arg329_Tyr330insTer)	rs886041867
NM_004168.4(SDHA):c.995_996del (p.Pro332fs)	rs1560994766
NM_004168.4(SDHA):c.99dup (p.His34fs)
NM_004168.4(SDHA):c.9_10dup (p.Val4fs)

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