ClinVar Miner

List of variants in gene CDH1 reported as uncertain significance for prostate disorder

Included ClinVar conditions (29):

Androgen resistance syndrome; Kennedy disease; Partial androgen insensitivity syndrome; Hypospadias 1, X-linked; Malignant tumor of prostate
Endometrial carcinoma; Macrocephaly-autism syndrome; Familial meningioma; Squamous cell carcinoma of the head and neck; Bannayan-Riley-Ruvalcaba syndrome; Malignant tumor of prostate; Thyroid cancer, nonmedullary, 2; VACTERL with hydrocephalus; Glioma susceptibility 2; Cowden syndrome 1; Melanoma, cutaneous malignant, susceptibility to, 1
Familial cancer of breast; Blepharocheilodontic syndrome 1; Endometrial carcinoma; Hereditary diffuse gastric adenocarcinoma; Ovarian neoplasm; Malignant tumor of prostate
Familial cancer of breast; Blepharocheilodontic syndrome 1; Hereditary diffuse gastric adenocarcinoma; Malignant tumor of prostate
Familial cancer of breast; Breast-ovarian cancer, familial, susceptibility to, 2; Fanconi anemia complementation group D1; Malignant tumor of prostate
Familial cancer of breast; Breast-ovarian cancer, familial, susceptibility to, 2; Fanconi anemia complementation group D1; Medulloblastoma; Wilms tumor 1; Malignant tumor of prostate; Pancreatic cancer, susceptibility to, 2; Glioma susceptibility 3
Familial cancer of breast; Breast-ovarian cancer, familial, susceptibility to, 2; Fanconi anemia complementation group D1; Medulloblastoma; Wilms tumor 1; Malignant tumor of prostate; Pancreatic cancer, susceptibility to, 2; Glioma susceptibility 3; Melanoma, cutaneous malignant, susceptibility to, 1
Familial cancer of breast; Breast-ovarian cancer, familial, susceptibility to, 2; Fanconi anemia complementation group D1; Medulloblastoma; Wilms tumor 1; Malignant tumor of prostate; Pancreatic cancer, susceptibility to, 2; Glioma susceptibility 3; Tracheoesophageal fistula
Familial cancer of breast; Breast-ovarian cancer, familial, susceptibility to, 2; Malignant tumor of prostate
Familial cancer of breast; Li-Fraumeni syndrome 2; Bone osteosarcoma; Malignant tumor of prostate
Familial cancer of breast; Li-Fraumeni syndrome 2; Bone osteosarcoma; Malignant tumor of prostate; Colorectal cancer
Familial cancer of breast; Lung carcinoma; Malignant tumor of prostate; Carcinoma of colon
Familial cancer of breast; Malignant tumor of prostate; Colorectal cancer
Familial prostate cancer
Macrocephaly-autism syndrome; Familial meningioma; Malignant tumor of prostate; Glioma susceptibility 2; Cowden syndrome 1
Macrocephaly-autism syndrome; Familial meningioma; Malignant tumor of prostate; VACTERL with hydrocephalus; Glioma susceptibility 2; PTEN hamartoma tumor syndrome; Cowden syndrome 1
Malignant tumor of prostate
Malignant tumor of prostate; Metastatic Prostate Small Cell Carcinoma
Malignant tumor of prostate; Prostate neoplasm
Prostate adenocarcinoma
Prostate cancer, hereditary, 1
Prostate cancer, hereditary, 12
Prostate cancer, hereditary, 13
Prostate cancer, hereditary, 2
Prostate cancer, hereditary, 2, susceptibility to
Prostate cancer, hereditary, 2; Combined oxidative phosphorylation defect type 17
Prostate cancer, hereditary, 9
Prostate cancer/brain cancer susceptibility
Prostate neoplasm

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 19

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HGVS	dbSNP	gnomAD frequency
NM_004360.5(CDH1):c.2474C>T (p.Pro825Leu)	rs587781312	0.00004
NM_004360.5(CDH1):c.377C>T (p.Pro126Leu)	rs746703615	0.00004
NM_004360.5(CDH1):c.2371C>T (p.Leu791Phe)	rs786202598	0.00002
NM_004360.5(CDH1):c.2595G>C (p.Trp865Cys)	rs778019174	0.00002
NM_004360.5(CDH1):c.1171G>A (p.Val391Ile)	rs556110297	0.00001
NM_004360.5(CDH1):c.1250A>G (p.Asn417Ser)	rs773441320	0.00001
NM_004360.5(CDH1):c.1370C>T (p.Thr457Met)	rs587778170	0.00001
NM_004360.5(CDH1):c.1843A>G (p.Ile615Val)	rs1003012321	0.00001
NM_004360.5(CDH1):c.2398C>T (p.Arg800Cys)	rs587782162	0.00001
NM_004360.5(CDH1):c.2543T>C (p.Leu848Pro)	rs767315263	0.00001
NM_004360.5(CDH1):c.2602C>A (p.Arg868Ser)	rs864622630	0.00001
NM_004360.5(CDH1):c.631A>G (p.Thr211Ala)	rs587781766	0.00001
NM_004360.5(CDH1):c.1107C>A (p.Asn369Lys)
NM_004360.5(CDH1):c.1234G>A (p.Val412Ile)	rs587782189
NM_004360.5(CDH1):c.1492G>A (p.Asp498Asn)	rs2152135021
NM_004360.5(CDH1):c.1741C>T (p.Leu581Phe)	rs1567512154
NM_004360.5(CDH1):c.1774G>T (p.Ala592Ser)	rs35187787
NM_004360.5(CDH1):c.202T>G (p.Tyr68Asp)	rs1060501218
NM_004360.5(CDH1):c.2435A>G (p.Asp812Gly)	rs878854684

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