ClinVar Miner

List of variants in gene HRAS, LRRC56 studied for respiratory system cancer

Included ClinVar conditions (34):

Adrenocortical carcinoma, hereditary; Familial cancer of breast; Glioma susceptibility 1; Bone osteosarcoma; Li-Fraumeni syndrome 1; Nasopharyngeal carcinoma; Carcinoma of pancreas; Choroid plexus papilloma; Basal cell carcinoma, susceptibility to, 7; Hepatocellular carcinoma; Colorectal cancer; Bone marrow failure syndrome 5
Adrenocortical carcinoma, hereditary; Familial cancer of breast; Glioma susceptibility 1; Bone osteosarcoma; Li-Fraumeni syndrome 1; Nasopharyngeal carcinoma; Carcinoma of pancreas; Choroid plexus papilloma; Carcinoma of colon; Basal cell carcinoma, susceptibility to, 7; Hepatocellular carcinoma
Autoimmune lymphoproliferative syndrome type 1; Lung cancer
Autosomal recessive juvenile Parkinson disease 2; Ovarian neoplasm; Lung cancer
Bone osteosarcoma; Malignant tumor of urinary bladder; Small cell lung carcinoma; Retinoblastoma
Cardiofaciocutaneous syndrome 1; LEOPARD syndrome 3; Noonan syndrome 7; Melanoma, cutaneous malignant, susceptibility to, 1; Colorectal cancer; Lung cancer
Cardiofaciocutaneous syndrome 1; Lung carcinoma; Noonan syndrome 1; LEOPARD syndrome 3; Noonan syndrome 7
Cardiofaciocutaneous syndrome 1; Noonan syndrome 1; LEOPARD syndrome 3; Noonan syndrome 7; Melanoma, cutaneous malignant, susceptibility to, 1; Colorectal cancer; Lung cancer
DE SANCTIS-CACCHIONE SYNDROME; Cerebrooculofacioskeletal syndrome 1; Cockayne syndrome type 2; Lung carcinoma; UV-sensitive syndrome 1; Age related macular degeneration 5; Premature ovarian failure 11
DE SANCTIS-CACCHIONE SYNDROME; Cerebrooculofacioskeletal syndrome 1; Cockayne syndrome type 2; UV-sensitive syndrome 1; Age related macular degeneration 5; Premature ovarian failure 11; Lung cancer
Euthyroid goiter; Pleuropulmonary blastoma
Euthyroid goiter; Rhabdomyosarcoma, embryonal, 2; Pleuropulmonary blastoma; Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Familial cancer of breast; Autoimmune lymphoproliferative syndrome type 2B; Hepatocellular carcinoma; Lung cancer
Familial cancer of breast; Hereditary diffuse gastric adenocarcinoma; Lung carcinoma; Noonan syndrome 3; Linear nevus sebaceous syndrome; Cerebral arteriovenous malformation; Malignant tumor of urinary bladder; Carcinoma of pancreas; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2
Familial cancer of breast; Lung carcinoma; Malignant tumor of prostate; Carcinoma of colon
Familial cancer of breast; Megalencephaly-capillary malformation-polymicrogyria syndrome; Congenital macrodactylia; Seborrheic keratosis; Epidermal nevus; Ovarian neoplasm; CLAPO syndrome; CLOVES syndrome; Cowden syndrome 5; Hepatocellular carcinoma; Gastric cancer; Colorectal cancer; Lung cancer
Familial cancer of breast; Megalencephaly-capillary malformation-polymicrogyria syndrome; Lung carcinoma; Congenital macrodactylia; Seborrheic keratosis; Epidermal nevus; Ovarian neoplasm; CLAPO syndrome; CLOVES syndrome; Carcinoma of colon; Neoplasm of stomach; Cowden syndrome 5; Hepatocellular carcinoma
Familial cancer of breast; Noonan syndrome 3; Linear nevus sebaceous syndrome; Toriello-Lacassie-Droste syndrome; Cerebral arteriovenous malformation; Malignant tumor of urinary bladder; Carcinoma of pancreas; Autoimmune lymphoproliferative syndrome type 4; Acute myeloid leukemia; Cardiofaciocutaneous syndrome 2; Gastric cancer; Lung cancer
Familial cancer of breast; Ovarian neoplasm; Lung cancer
Inflammatory skin and bowel disease, neonatal, 2; Lung cancer
Laryngeal squamous cell carcinoma
Leprosy, susceptibility to, 2; Lung carcinoma; Autosomal recessive juvenile Parkinson disease 2; Ovarian neoplasm
Lung adenocarcinoma
Lung cancer
Lung carcinoma
Lung sarcomatoid carcinoma
Nasopharyngeal carcinoma
Nasopharyngeal carcinoma, susceptibility to, 3
Non-small cell lung carcinoma
Non-small cell lung carcinoma; Neoplasm of the large intestine
Pleuropulmonary blastoma
Rhabdomyosarcoma, embryonal, 2; Pleuropulmonary blastoma
Small cell lung carcinoma
Squamous cell lung carcinoma

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
		ClinVar version:

Total variants: 21

Download table as spreadsheet

HGVS	dbSNP	gnomAD frequency
NM_005343.4(HRAS):c.81T>C (p.His27=)	rs12628	0.34645
NM_005343.4(HRAS):c.450+35A>C	rs749486358	0.00012
NM_005343.4(HRAS):c.111+18G>C	rs759743352
NM_005343.4(HRAS):c.175G>A (p.Ala59Thr)	rs727503093
NM_005343.4(HRAS):c.181C>G (p.Gln61Glu)	rs28933406
NM_005343.4(HRAS):c.182A>C (p.Gln61Pro)	rs121913233
NM_005343.4(HRAS):c.182A>T (p.Gln61Leu)	rs121913233
NM_005343.4(HRAS):c.183G>T (p.Gln61His)	rs121913496
NM_005343.4(HRAS):c.34G>A (p.Gly12Ser)	rs104894229
NM_005343.4(HRAS):c.34G>T (p.Gly12Cys)	rs104894229
NM_005343.4(HRAS):c.35G>C (p.Gly12Ala)	rs104894230
NM_005343.4(HRAS):c.37G>A (p.Gly13Ser)	rs104894228
NM_005343.4(HRAS):c.37G>C (p.Gly13Arg)	rs104894228
NM_005343.4(HRAS):c.37G>T (p.Gly13Cys)	rs104894228
NM_005343.4(HRAS):c.38G>C (p.Gly13Ala)	rs104894226
NM_005343.4(HRAS):c.38G>T (p.Gly13Val)	rs104894226
NM_005343.4(HRAS):c.436G>A (p.Ala146Thr)	rs104894231
NM_005343.4(HRAS):c.436G>C (p.Ala146Pro)	rs104894231
NM_005343.4(HRAS):c.437C>T (p.Ala146Val)	rs121917759
NM_005343.4(HRAS):c.450+31A>G	rs1300614609
NM_005343.4(HRAS):c.450+38dup	rs1851232069

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