ClinVar Miner

Variants studied for acute lymphoblastic leukemia

Included ClinVar conditions (14):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
43 147 63 14 22 2 3 287

Gene and significance breakdown #

Total genes and gene combinations: 48
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
NBN 7 9 39 10 20 0 1 81
TP53 2 55 0 0 0 0 0 57
IKZF1 1 6 9 0 0 2 0 18
PAX5 1 13 2 0 0 0 0 15
FBXW7 0 10 0 0 0 0 0 10
BRAF 0 7 0 0 0 0 0 7
HRAS, LRRC56 0 7 0 0 0 0 0 7
SF3B1 0 6 0 0 0 0 0 6
ERG 0 0 5 0 0 0 0 5
GNB1 2 1 0 2 0 0 0 5
NRAS 0 5 0 0 0 0 0 5
BCR 0 0 3 1 0 0 0 4
CDKN2A 0 2 2 0 0 0 0 4
INSL6, JAK2 4 0 0 0 0 0 0 4
MYC 4 0 0 0 0 0 0 4
PTPN11 1 3 0 0 0 0 0 4
ABL1 1 2 0 0 0 0 0 3
FLT3 3 0 0 0 0 0 0 3
JAK1, LOC126805749 0 3 0 0 0 0 0 3
LOC126860438, NBN 1 0 0 1 2 0 0 3
PLCG2 0 3 0 0 0 0 0 3
XPO1 0 3 0 0 0 0 0 3
ATM 2 0 0 0 0 0 0 2
ATM, C11orf65 2 0 0 0 0 0 0 2
BAX 2 0 0 0 0 0 0 2
FGFR1 0 2 0 0 0 0 0 2
JAK3 0 2 0 0 0 0 0 2
LOC105376032, PAX5 0 1 1 0 0 0 0 2
SF3B2 0 2 0 0 0 0 0 2
BCL10 1 0 0 0 0 0 0 1
BRCA1 0 0 1 0 0 0 0 1
BTK 0 0 0 0 0 0 1 1
CDKN2B, LOC130001608 0 0 1 0 0 0 0 1
CRLF2 1 0 0 0 0 0 0 1
CSF3R 1 0 0 0 0 0 0 1
DNMT3A 1 0 0 0 0 0 0 1
ERCC4 1 0 0 0 0 0 0 1
ETV6 1 0 0 0 0 0 0 1
ETV6, LOC126861452 1 0 0 0 0 0 0 1
IL7R 0 1 0 0 0 0 0 1
KRAS 0 1 0 0 0 0 0 1
LOC107982234, WT1 0 1 0 0 0 0 0 1
MYD88 0 1 0 0 0 0 0 1
NF1 0 1 0 0 0 0 0 1
NOTCH1 1 0 0 0 0 0 0 1
NT5C2 0 0 0 0 0 0 1 1
PALB2 1 0 0 0 0 0 0 1
PMS2 1 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 20
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
Database of Curated Mutations (DoCM) 5 113 0 0 0 0 2 120
Fulgent Genetics, Fulgent Genetics 8 6 36 10 2 0 0 62
Genomic Diagnostics Laboratory, National Institute of Medical Genomics 1 22 12 0 0 0 0 35
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 3 22 0 0 25
OMIM 17 0 0 0 0 0 0 17
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 3 2 7 0 0 0 0 12
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 1 5 1 0 0 0 7
Center for Advanced Molecular Diagnostics, Cytogenetics Laboratory, Brigham and Women's Hospital 4 0 0 0 0 0 0 4
Diagnostic Molecular Genetics Laboratory, Memorial Sloan Kettering Cancer Center 2 0 0 0 0 0 0 2
Laboratorios de Investigación en Biología Molecular e Inmunología, Universidad Autónoma de Nayarit 0 0 0 0 0 2 0 2
University Health Network, Princess Margaret Cancer Centre 2 0 0 0 0 0 0 2
Baylor Genetics 0 1 0 0 0 0 0 1
Genetic Services Laboratory, University of Chicago 0 1 0 0 0 0 0 1
Mendelics 1 0 0 0 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 1 0 0 0 0 1
Pele Pequeno Principe Research Institute, Faculdades Pequeno Principe 0 0 1 0 0 0 0 1
Mayo Clinic Genomics Laboratory, Mayo Clinic 1 0 0 0 0 0 0 1
Molecular Genetics Lab, CHRU Brest 0 1 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 1 1

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