ClinVar Miner

Variants studied for acute lymphoblastic leukemia

Included ClinVar conditions (13):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
38 77 88 17 22 2 1 238

Gene and significance breakdown #

Total genes and gene combinations: 29
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
NBN 12 49 57 13 20 0 1 147
IKZF1 1 6 12 0 0 2 0 21
PAX5 1 13 2 0 0 0 0 15
GNB1 2 2 1 2 0 0 0 7
ERG 0 0 5 0 0 0 0 5
BCR 0 0 3 1 0 0 0 4
CDKN2A 0 2 2 0 0 0 0 4
LOC126860438, NBN 1 1 0 1 2 0 0 4
NUP214 0 0 4 0 0 0 0 4
FLT3 3 0 0 0 0 0 0 3
ATM 2 0 0 0 0 0 0 2
ATM, C11orf65 2 0 0 0 0 0 0 2
BAX 2 0 0 0 0 0 0 2
LOC105376032, PAX5 0 1 1 0 0 0 0 2
TP53 2 0 0 0 0 0 0 2
ABL1 1 0 0 0 0 0 0 1
BCL10 1 0 0 0 0 0 0 1
CDKN2B, LOC130001608 0 0 1 0 0 0 0 1
CSF3R 1 0 0 0 0 0 0 1
DNMT3A 1 0 0 0 0 0 0 1
ERCC4 1 0 0 0 0 0 0 1
ETV6 1 0 0 0 0 0 0 1
ETV6, LOC126861452 1 0 0 0 0 0 0 1
JAK2, ZBTB20 0 1 0 0 0 0 0 1
LOC107982234, WT1 0 1 0 0 0 0 0 1
NF1 0 1 0 0 0 0 0 1
NOTCH1 1 0 0 0 0 0 0 1
PALB2 1 0 0 0 0 0 0 1
PTPN11 1 0 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 22
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign association not provided total
Fulgent Genetics, Fulgent Genetics 13 47 54 10 2 0 0 126
Genomic Diagnostics Laboratory, National Institute of Medical Genomics 1 22 12 0 0 0 0 35
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 3 22 0 0 25
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 2 2 10 0 0 0 0 14
OMIM 13 0 0 0 0 0 0 13
Department of Pathology and Laboratory Medicine, Sinai Health System 2 0 6 4 0 0 0 12
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 1 5 1 0 0 0 7
Center for Advanced Molecular Diagnostics, Cytogenetics Laboratory, Brigham and Women's Hospital 4 0 0 0 0 0 0 4
Diagnostic Molecular Genetics Laboratory, Memorial Sloan Kettering Cancer Center 2 0 0 0 0 0 0 2
Juno Genomics, Hangzhou Juno Genomics, Inc 0 2 0 0 0 0 0 2
Laboratorios de Investigación en Biología Molecular e Inmunología, Universidad Autónoma de Nayarit 0 0 0 0 0 2 0 2
University Health Network, Princess Margaret Cancer Centre 2 0 0 0 0 0 0 2
Baylor Genetics 0 1 0 0 0 0 0 1
Genetic Services Laboratory, University of Chicago 0 1 0 0 0 0 0 1
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 0 1 0 0 0 0 0 1
Mendelics 1 0 0 0 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 0 0 1 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 0 1 0 0 0 0 1
Mayo Clinic Genomics Laboratory, Mayo Clinic 1 0 0 0 0 0 0 1
Molecular Genetics Lab, CHRU Brest 0 1 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 1 1
Solve-RD Consortium 0 1 0 0 0 0 0 1

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