List of variants in gene APC reported as uncertain significance for adenocarcinoma

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 77

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HGVS	dbSNP	gnomAD frequency
NM_000038.6(APC):c.7036C>T (p.Pro2346Ser)	rs200756935	0.00022
NM_000038.6(APC):c.8462A>G (p.Asp2821Gly)	rs780049836	0.00021
NM_000038.6(APC):c.1606G>A (p.Glu536Lys)	rs138098808	0.00015
NM_000038.6(APC):c.5801C>T (p.Pro1934Leu)	rs587780600	0.00012
NM_000038.6(APC):c.6724A>G (p.Ser2242Gly)	rs201375478	0.00008
NM_000038.6(APC):c.8389A>G (p.Ser2797Gly)	rs147287751	0.00007
NM_000038.6(APC):c.1193A>G (p.Lys398Arg)	rs145912662	0.00006
NM_000038.6(APC):c.2527A>G (p.Ser843Gly)	rs536223189	0.00006
NM_000038.6(APC):c.8332G>T (p.Ala2778Ser)	rs587778046	0.00006
NM_000038.6(APC):c.1553C>T (p.Thr518Met)	rs371453363	0.00005
NM_000038.6(APC):c.4372C>T (p.Pro1458Ser)	rs143796828	0.00005
NM_000038.6(APC):c.1762G>A (p.Val588Ile)	rs372416031	0.00004
NM_000038.6(APC):c.5894A>C (p.His1965Pro)	rs773776516	0.00004
NM_000038.6(APC):c.6639G>A (p.Met2213Ile)	rs35540155	0.00004
NM_000038.6(APC):c.7531C>T (p.Leu2511Phe)	rs72541815	0.00004
NM_000038.6(APC):c.776G>A (p.Arg259Gln)	rs767457050	0.00004
NM_001127511.3(APC):c.-167G>A	rs1278244063	0.00004
NM_000038.6(APC):c.1241G>A (p.Arg414His)	rs730881233	0.00003
NM_000038.6(APC):c.7808A>G (p.Glu2603Gly)	rs587779807	0.00003
NM_000038.6(APC):c.791A>G (p.Gln264Arg)	rs369345931	0.00003
NM_000038.6(APC):c.854A>G (p.Asp285Gly)	rs201093383	0.00003
NM_001127511.3(APC):c.-32C>T	rs1015952631	0.00003
NM_001127511.3(APC):c.-88T>G	rs531931776	0.00003
NM_001127511.3(APC):c.1A>G (p.Met1Val)	rs189807660	0.00003
NM_000038.6(APC):c.1538T>C (p.Val513Ala)	rs876658167	0.00002
NM_000038.6(APC):c.1984C>A (p.Leu662Ile)	rs756859993	0.00002
NM_000038.6(APC):c.3661C>T (p.Pro1221Ser)	rs760999992	0.00002
NM_000038.6(APC):c.4399C>T (p.Pro1467Ser)	rs749142480	0.00002
NM_000038.6(APC):c.5363G>A (p.Arg1788His)	rs201472075	0.00002
NM_000038.6(APC):c.7105C>T (p.Pro2369Ser)	rs377308875	0.00002
NM_000038.6(APC):c.7166G>A (p.Ser2389Asn)	rs779287035	0.00002
NM_000038.6(APC):c.8017A>G (p.Arg2673Gly)	rs767286063	0.00002
NM_000038.6(APC):c.2114G>A (p.Ser705Asn)	rs752874220	0.00001
NM_000038.6(APC):c.212G>A (p.Arg71His)	rs750503329	0.00001
NM_000038.6(APC):c.2474A>G (p.Tyr825Cys)	rs186641437	0.00001
NM_000038.6(APC):c.3515A>T (p.His1172Leu)	rs1024630299	0.00001
NM_000038.6(APC):c.4430A>G (p.Gln1477Arg)	rs1479009365	0.00001
NM_000038.6(APC):c.4963A>G (p.Thr1655Ala)	rs759441332	0.00001
NM_000038.6(APC):c.5105G>A (p.Gly1702Glu)	rs769273526	0.00001
NM_000038.6(APC):c.5282A>C (p.Asn1761Thr)	rs752038930	0.00001
NM_000038.6(APC):c.5615T>A (p.Val1872Asp)	rs748389037	0.00001
NM_000038.6(APC):c.5627G>T (p.Arg1876Met)	rs773201570	0.00001
NM_000038.6(APC):c.6736G>A (p.Val2246Ile)	rs1055180096	0.00001
NM_000038.6(APC):c.7136C>G (p.Thr2379Ser)	rs767691072	0.00001
NM_000038.6(APC):c.811A>G (p.Met271Val)	rs587781464	0.00001
NM_000038.6(APC):c.8276G>A (p.Arg2759His)	rs538289470	0.00001
NM_000038.6(APC):c.8282C>T (p.Pro2761Leu)	rs757874563	0.00001
NM_000038.6(APC):c.1015A>T (p.Ser339Cys)
NM_000038.6(APC):c.1333C>G (p.Gln445Glu)	rs876658802
NM_000038.6(APC):c.1463T>C (p.Leu488Pro)	rs368434773
NM_000038.6(APC):c.2160G>A (p.Met720Ile)	rs1283428855
NM_000038.6(APC):c.2558A>G (p.Glu853Gly)	rs1554084263
NM_000038.6(APC):c.2573T>C (p.Ile858Thr)	rs1765215022
NM_000038.6(APC):c.3160C>T (p.His1054Tyr)	rs1195583636
NM_000038.6(APC):c.3263A>C (p.Lys1088Thr)	rs1580633119
NM_000038.6(APC):c.3365A>G (p.Asn1122Ser)	rs372855304
NM_000038.6(APC):c.3490A>G (p.Ile1164Val)	rs1554085052
NM_000038.6(APC):c.3747C>A (p.Cys1249Ter)	rs2149898263
NM_000038.6(APC):c.4332A>T (p.Gln1444His)	rs748342378
NM_000038.6(APC):c.4440G>C (p.Gln1480His)	rs876659881
NM_000038.6(APC):c.4658C>T (p.Ala1553Val)	rs1554086050
NM_000038.6(APC):c.4847A>T (p.Lys1616Ile)	rs1554086241
NM_000038.6(APC):c.4987G>A (p.Glu1663Lys)	rs758987855
NM_000038.6(APC):c.5011G>A (p.Ala1671Thr)	rs587781600
NM_000038.6(APC):c.6152A>G (p.Lys2051Arg)	rs1554087256
NM_000038.6(APC):c.6218G>A (p.Gly2073Asp)	rs1766164614
NM_000038.6(APC):c.6257C>G (p.Pro2086Arg)	rs786202975
NM_000038.6(APC):c.6727A>G (p.Thr2243Ala)	rs773539706
NM_000038.6(APC):c.7097A>G (p.Tyr2366Cys)	rs1561612604
NM_000038.6(APC):c.7757G>T (p.Ser2586Ile)	rs199806334
NM_000038.6(APC):c.7832C>T (p.Thr2611Ile)	rs587778037
NM_000038.6(APC):c.7946C>T (p.Pro2649Leu)	rs1766608503
NM_000038.6(APC):c.813G>A (p.Met271Ile)	rs1064793903
NM_000038.6(APC):c.8281C>T (p.Pro2761Ser)	rs1060503332
NM_000038.6(APC):c.8461G>A (p.Asp2821Asn)	rs1554089164
NM_001127511.3(APC):c.-128G>C	rs543098847
NM_001127511.3(APC):c.-142G>A	rs951500465

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