List of variants in gene SOS1 reported as likely benign for immune system disorder

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 108

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HGVS	dbSNP	gnomAD frequency
NM_005633.4(SOS1):c.*1731A>G	rs79270739	0.01859
NM_005633.4(SOS1):c.1964C>T (p.Pro655Leu)	rs56219475	0.00787
NM_005633.4(SOS1):c.*3458A>C	rs114232209	0.00673
NM_005633.4(SOS1):c.1074+5G>C	rs145155424	0.00655
NM_005633.4(SOS1):c.2167+6T>G	rs186640807	0.00510
NM_005633.4(SOS1):c.*3569T>C	rs115465194	0.00421
NM_005633.4(SOS1):c.345+15C>T	rs75937422	0.00407
NM_005633.4(SOS1):c.*2983C>T	rs190454003	0.00352
NM_005633.4(SOS1):c.2997T>C (p.Asn999=)	rs145364368	0.00352
NM_005633.4(SOS1):c.*2517C>T	rs150628082	0.00321
NM_005633.4(SOS1):c.2673+14T>C	rs183998234	0.00304
NM_005633.4(SOS1):c.2122G>A (p.Ala708Thr)	rs140811086	0.00280
NM_005633.4(SOS1):c.*2160C>T	rs116651056	0.00276
NM_005633.4(SOS1):c.570C>T (p.Asp190=)	rs55980502	0.00233
NM_005633.4(SOS1):c.3081+13A>G	rs189695571	0.00223
NM_005633.4(SOS1):c.3032A>G (p.Asn1011Ser)	rs8192671	0.00164
NM_005633.4(SOS1):c.*3592C>T	rs550315455	0.00113
NM_005633.4(SOS1):c.*3367G>A	rs145904123	0.00108
NM_005633.4(SOS1):c.2238T>C (p.Asn746=)	rs75877625	0.00084
NM_005633.4(SOS1):c.3391+7A>G	rs201982464	0.00066
NM_005633.4(SOS1):c.*44T>C	rs182657531	0.00060
NM_005633.4(SOS1):c.749T>C (p.Val250Ala)	rs139290271	0.00054
NM_005633.4(SOS1):c.*1085A>G	rs539192287	0.00039
NM_005633.4(SOS1):c.*1552T>A	rs139679723	0.00021
NM_005633.4(SOS1):c.1705C>G (p.Leu569Val)	rs200786705	0.00019
NM_005633.4(SOS1):c.1489C>A (p.Arg497=)	rs542368621	0.00018
NM_005633.4(SOS1):c.1962G>A (p.Glu654=)	rs144382701	0.00014
NM_005633.4(SOS1):c.1668A>C (p.Val556=)	rs376314461	0.00013
NM_005633.4(SOS1):c.1647A>G (p.Thr549=)	rs139683425	0.00011
NM_005633.4(SOS1):c.3357C>T (p.Thr1119=)	rs373319212	0.00011
NM_005633.4(SOS1):c.1269C>T (p.Asn423=)	rs138459502	0.00010
NM_005633.4(SOS1):c.1566T>C (p.Asn522=)	rs145325119	0.00010
NM_005633.4(SOS1):c.2510+19C>G	rs375675348	0.00009
NM_005633.4(SOS1):c.280A>G (p.Ile94Val)	rs144757941	0.00009
NM_005633.4(SOS1):c.*4221C>T	rs565544523	0.00008
NM_005633.4(SOS1):c.1854C>T (p.Tyr618=)	rs727505181	0.00007
NM_005633.4(SOS1):c.*1516G>A	rs550823381	0.00006
NM_005633.4(SOS1):c.1095A>G (p.Glu365=)	rs767540464	0.00004
NM_005633.4(SOS1):c.1490G>A (p.Arg497Gln)	rs371314838	0.00004
NM_005633.4(SOS1):c.1621T>C (p.Leu541=)	rs371286473	0.00004
NM_005633.4(SOS1):c.1842G>A (p.Thr614=)	rs143750479	0.00004
NM_005633.4(SOS1):c.1905C>T (p.Cys635=)	rs762900789	0.00004
NM_005633.4(SOS1):c.3942C>T (p.His1314=)	rs778838515	0.00004
NM_005633.4(SOS1):c.3697C>A (p.Leu1233Ile)	rs777373438	0.00003
NM_005633.4(SOS1):c.1251A>C (p.Leu417=)	rs144027132	0.00002
NM_005633.4(SOS1):c.2007C>G (p.Pro669=)	rs529749913	0.00002
NM_005633.4(SOS1):c.3384T>C (p.His1128=)	rs1412775460	0.00002
NM_005633.4(SOS1):c.3836C>T (p.Thr1279Ile)	rs758258471	0.00002
NM_005633.4(SOS1):c.396A>T (p.Ala132=)	rs727505385	0.00002
NM_005633.4(SOS1):c.1191A>G (p.Lys397=)	rs770175415	0.00001
NM_005633.4(SOS1):c.1458A>G (p.Ala486=)	rs772746896	0.00001
NM_005633.4(SOS1):c.1848T>C (p.His616=)	rs1344852617	0.00001
NM_005633.4(SOS1):c.1863C>T (p.Pro621=)	rs759125551	0.00001
NM_005633.4(SOS1):c.1956G>A (p.Glu652=)	rs1365773428	0.00001
NM_005633.4(SOS1):c.1995T>C (p.Asn665=)	rs779262456	0.00001
NM_005633.4(SOS1):c.2454T>C (p.Ser818=)	rs748802612	0.00001
NM_005633.4(SOS1):c.2604T>C (p.Phe868=)	rs756520305	0.00001
NM_005633.4(SOS1):c.2739G>A (p.Lys913=)	rs997339872	0.00001
NM_005633.4(SOS1):c.3033C>T (p.Asn1011=)	rs1196614292	0.00001
NM_005633.4(SOS1):c.3060C>T (p.Asn1020=)	rs142431345	0.00001
NM_005633.4(SOS1):c.3093T>C (p.Tyr1031=)	rs766864647	0.00001
NM_005633.4(SOS1):c.3114T>G (p.Pro1038=)	rs777755307	0.00001
NM_005633.4(SOS1):c.3282T>G (p.Gly1094=)	rs145357714	0.00001
NM_005633.4(SOS1):c.3438A>G (p.Glu1146=)	rs1226908698	0.00001
NM_005633.4(SOS1):c.3504A>G (p.Pro1168=)	rs748617507	0.00001
NM_005633.4(SOS1):c.3732T>C (p.His1244=)	rs1391583247	0.00001
NM_005633.4(SOS1):c.3795T>G (p.Ser1265=)	rs538954728	0.00001
NM_005633.4(SOS1):c.3832T>C (p.Leu1278=)	rs750354913	0.00001
NM_005633.4(SOS1):c.3987T>C (p.Asn1329=)	rs936986823	0.00001
NM_005633.4(SOS1):c.429G>A (p.Lys143=)	rs773264070	0.00001
NM_005633.4(SOS1):c.543A>G (p.Glu181=)	rs201068374	0.00001
NM_005633.4(SOS1):c.552T>C (p.Asn184=)	rs727503438	0.00001
NM_005633.4(SOS1):c.783C>A (p.Gly261=)	rs951992465	0.00001
NM_005633.4(SOS1):c.795T>C (p.Asp265=)	rs777745085	0.00001
NM_005633.4(SOS1):c.984C>T (p.Gly328=)	rs778223456	0.00001
NM_005633.4(SOS1):c.1333_1336dup	rs35969619
NM_005633.4(SOS1):c.*1606del	rs34248802
NM_005633.4(SOS1):c.*2138G>T	rs184227916
NM_005633.4(SOS1):c.2244_2245dup	rs3832123
NM_005633.4(SOS1):c.*2439del	rs377250198
NM_005633.4(SOS1):c.*2574A>G	rs539933930
NM_005633.4(SOS1):c.399_400insCA	rs144104838
NM_005633.4(SOS1):c.1035C>G (p.Ala345=)	rs557313301
NM_005633.4(SOS1):c.1203-8T>C	rs1669853901
NM_005633.4(SOS1):c.1522A>G (p.Asn508Asp)
NM_005633.4(SOS1):c.1663G>A (p.Asp555Asn)
NM_005633.4(SOS1):c.1707G>A (p.Leu569=)	rs1479407572
NM_005633.4(SOS1):c.2063+44T>C	rs111576630
NM_005633.4(SOS1):c.2064-20A>T	rs756707478
NM_005633.4(SOS1):c.213+14_213+16del	rs768872084
NM_005633.4(SOS1):c.2183A>C (p.Lys728Thr)
NM_005633.4(SOS1):c.2511-13_2511-9del	rs727503436
NM_005633.4(SOS1):c.2517T>C (p.Ile839=)	rs776366413
NM_005633.4(SOS1):c.2674-9del	rs532594344
NM_005633.4(SOS1):c.2674-9dup	rs532594344
NM_005633.4(SOS1):c.273A>G (p.Gln91=)	rs914110575
NM_005633.4(SOS1):c.2775A>T (p.Pro925=)	rs397517160
NM_005633.4(SOS1):c.2861A>C (p.Glu954Ala)
NM_005633.4(SOS1):c.3195T>C (p.Tyr1065=)	rs1280224224
NM_005633.4(SOS1):c.3600C>A (p.Asp1200Glu)	rs141594736
NM_005633.4(SOS1):c.3693A>G (p.Leu1231=)	rs772625418
NM_005633.4(SOS1):c.3813G>A (p.Arg1271=)	rs863224405
NM_005633.4(SOS1):c.511-9_511-6del	rs986512473
NM_005633.4(SOS1):c.706T>C (p.Leu236=)	rs1418372765
NM_005633.4(SOS1):c.771A>G (p.Val257=)	rs1671007109
NM_005633.4(SOS1):c.836T>C (p.Val279Ala)
NM_005633.4(SOS1):c.891G>A (p.Ser297=)	rs1572841459
NM_005633.4(SOS1):c.976-5dup	rs771586560

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