List of variants in gene ALK reported as benign for embryonal neoplasm

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 99

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HGVS	dbSNP	gnomAD frequency
NM_004304.5(ALK):c.*298C>T	rs1728828	0.99040
NM_004304.5(ALK):c.4381A>G (p.Ile1461Val)	rs1670283	0.99030
NM_004304.5(ALK):c.27C>G (p.Leu9=)	rs4358080	0.88526
NM_004304.5(ALK):c.1500A>G (p.Gln500=)	rs2293564	0.79300
NM_004304.5(ALK):c.2535T>C (p.Gly845=)	rs2256740	0.63034
NM_004304.5(ALK):c.4587C>G (p.Asp1529Glu)	rs1881421	0.47503
NM_004304.5(ALK):c.3375C>A (p.Gly1125=)	rs3795850	0.27292
NM_004304.5(ALK):c.4472A>G (p.Lys1491Arg)	rs1881420	0.26767
NM_004304.5(ALK):c.1155-8508A>G	rs4322799	0.25712
NM_004304.5(ALK):c.3359+6C>T	rs4622670	0.24182
NM_004304.5(ALK):c.4165-6C>T	rs17007646	0.20768
NM_004304.5(ALK):c.3036G>A (p.Thr1012=)	rs2293563	0.17851
NM_004304.5(ALK):c.4338C>T (p.Thr1446=)	rs56132472	0.10831
NM_004304.5(ALK):c.3408C>T (p.Ser1136=)	rs56146053	0.02769
NM_004304.5(ALK):c.*53G>C	rs80088378	0.02692
NM_004304.5(ALK):c.1427T>C (p.Val476Ala)	rs35093491	0.02566
NM_004304.5(ALK):c.4596C>T (p.Asn1532=)	rs1881422	0.01874
NM_004304.5(ALK):c.4203T>C (p.Tyr1401=)	rs55772745	0.01865
NM_004304.5(ALK):c.*111C>T	rs74669215	0.01748
NM_004304.5(ALK):c.*63A>G	rs182561050	0.01679
NM_004304.5(ALK):c.2039C>T (p.Thr680Ile)	rs35228363	0.01598
NM_004304.5(ALK):c.952+16C>T	rs112736234	0.01371
NM_004304.5(ALK):c.-5G>A	rs56270786	0.01336
NM_004304.5(ALK):c.645T>C (p.Leu215=)	rs115392387	0.00889
NM_004304.5(ALK):c.2175C>T (p.Ile725=)	rs57881134	0.00677
NM_004304.5(ALK):c.2133C>T (p.Ser711=)	rs77102810	0.00647
NM_004304.5(ALK):c.1464C>T (p.Gly488=)	rs56165377	0.00615
NM_004304.5(ALK):c.1719C>T (p.Thr573=)	rs74830770	0.00577
NM_004304.5(ALK):c.267C>A (p.Gly89=)	rs192127241	0.00557
NM_004304.5(ALK):c.3515+18C>T	rs79325200	0.00409
NM_004304.5(ALK):c.4836G>A (p.Lys1612=)	rs78174819	0.00363
NM_004304.5(ALK):c.2268C>T (p.Gly756=)	rs149853746	0.00304
NM_004304.5(ALK):c.3837-9_3837-7dup	rs373764155	0.00279
NM_004304.5(ALK):c.1943C>T (p.Thr648Ile)	rs116202066	0.00232
NM_004304.5(ALK):c.592G>A (p.Val198Met)	rs77677701	0.00221
NM_004304.5(ALK):c.2632+11dup	rs766699720	0.00205
NM_004304.5(ALK):c.1110G>A (p.Glu370=)	rs138784554	0.00195
NM_004304.5(ALK):c.3594C>T (p.Leu1198=)	rs56071005	0.00166
NM_004304.5(ALK):c.2676C>T (p.Ala892=)	rs138668699	0.00164
NM_004304.5(ALK):c.2915-9T>C	rs373765395	0.00144
NM_004304.5(ALK):c.1817+11T>C	rs185559774	0.00139
NM_004304.5(ALK):c.4785C>T (p.Ala1595=)	rs76150405	0.00104
NM_004304.5(ALK):c.2148C>T (p.Ser716=)	rs55733526	0.00096
NM_004304.5(ALK):c.776G>A (p.Arg259His)	rs138686378	0.00096
NM_004304.5(ALK):c.2613C>T (p.Asn871=)	rs150557024	0.00093
NM_004304.5(ALK):c.2430C>T (p.Ser810=)	rs150292405	0.00086
NM_004304.5(ALK):c.2041+15C>T	rs183024732	0.00082
NM_004304.5(ALK):c.932G>A (p.Arg311His)	rs150966028	0.00063
NM_004304.5(ALK):c.3939-8A>G	rs3738869	0.00054
NM_004304.5(ALK):c.1234C>T (p.Arg412Cys)	rs147102592	0.00053
NM_004304.5(ALK):c.2343C>T (p.Asp781=)	rs61754933	0.00048
NM_004304.5(ALK):c.3057C>A (p.Val1019=)	rs138406372	0.00043
NM_004304.5(ALK):c.3067+17del	rs781479217	0.00041
NM_004304.5(ALK):c.2451C>T (p.Gly817=)	rs183314518	0.00039
NM_004304.5(ALK):c.2204+15G>C	rs200910314	0.00035
NM_004304.5(ALK):c.2632+16C>T	rs200835934	0.00035
NM_004304.5(ALK):c.2526C>T (p.Ala842=)	rs145271283	0.00029
NM_004304.5(ALK):c.4573A>G (p.Lys1525Glu)	rs139437088	0.00024
NM_004304.5(ALK):c.3291C>T (p.Cys1097=)	rs370170353	0.00022
NM_004304.5(ALK):c.3035C>T (p.Thr1012Met)	rs35073634	0.00021
NM_004304.5(ALK):c.3336G>A (p.Pro1112=)	rs146074150	0.00019
NM_004304.5(ALK):c.3645+16T>A	rs141531355	0.00019
NM_004304.5(ALK):c.487G>T (p.Val163Leu)	rs55697431	0.00019
NM_004304.5(ALK):c.2149G>A (p.Glu717Lys)	rs147858673	0.00016
NM_004304.5(ALK):c.2478C>T (p.Tyr826=)	rs142126984	0.00016
NM_004304.5(ALK):c.2307C>T (p.Asp769=)	rs553770508	0.00014
NM_004304.5(ALK):c.3359+17C>T	rs200832204	0.00014
NM_004304.5(ALK):c.*45G>A	rs186421480	0.00013
NM_004304.5(ALK):c.597C>T (p.Gly199=)	rs200868013	0.00012
NM_004304.5(ALK):c.1111G>A (p.Ala371Thr)	rs149968229	0.00011
NM_004304.5(ALK):c.2928C>T (p.His976=)	rs75895956	0.00011
NM_004304.5(ALK):c.3139G>A (p.Ala1047Thr)	rs370049091	0.00011
NM_004304.5(ALK):c.1128C>T (p.Leu376=)	rs200396075	0.00009
NM_004304.5(ALK):c.2632+8G>A	rs199653862	0.00009
NM_004304.5(ALK):c.1547-5C>T	rs764739691	0.00008
NM_004304.5(ALK):c.4473G>A (p.Lys1491=)	rs148987382	0.00007
NM_004304.5(ALK):c.2011C>T (p.Pro671Ser)	rs145780832	0.00006
NM_004304.5(ALK):c.1107C>T (p.Asn369=)	rs114429299	0.00005
NM_004304.5(ALK):c.1689C>T (p.Asn563=)	rs565743321	0.00005
NM_004304.5(ALK):c.2109C>T (p.Asn703=)	rs560163657	0.00005
NM_004304.5(ALK):c.2127C>A (p.Asn709Lys)	rs376175333	0.00003
NM_004304.5(ALK):c.4480G>A (p.Gly1494Arg)	rs199940609	0.00002
NM_004304.5(ALK):c.3855G>A (p.Lys1285=)	rs776547376	0.00001
NM_004304.5(ALK):c.846C>T (p.Asp282=)	rs56116528	0.00001
NM_004304.5(ALK):c.-539G>A	rs200662898
NM_004304.5(ALK):c.1155-20_1155-19del	rs140451928
NM_004304.5(ALK):c.1720G>C (p.Gly574Arg)	rs762358335
NM_004304.5(ALK):c.1912+19del
NM_004304.5(ALK):c.2356-11dup
NM_004304.5(ALK):c.2356-16C>T	rs551864909
NM_004304.5(ALK):c.2577G>C (p.Glu859Asp)	rs61754865
NM_004304.5(ALK):c.2772T>G (p.Gly924=)	rs749286400
NM_004304.5(ALK):c.2775A>G (p.Gly925=)	rs777406442
NM_004304.5(ALK):c.3451-13dup
NM_004304.5(ALK):c.3600G>A (p.Ala1200=)	rs56247462
NM_004304.5(ALK):c.3600G>C (p.Ala1200=)	rs56247462
NM_004304.5(ALK):c.3837-8dup	rs2148152286
NM_004304.5(ALK):c.4297GAG[2] (p.Glu1435del)	rs138827116
NM_004304.5(ALK):c.702T>A (p.Pro234=)	rs2246745

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