ClinVar Miner

List of variants in gene MLH1 reported as benign for colorectal cancer

Included ClinVar conditions (75):
Minimum submission review status: Collection method:
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Gene type:
ClinVar version:
Total variants: 161
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HGVS dbSNP gnomAD frequency
NM_000249.4(MLH1):c.1668-19A>G rs9876116 0.41821
NM_000249.4(MLH1):c.790+955C>A rs1558528 0.41529
NM_000249.4(MLH1):c.453+79A>G rs4234259 0.41512
NM_000249.4(MLH1):c.1990-121C>T rs2241031 0.41163
NM_000249.4(MLH1):c.207+571C>T rs9852378 0.39684
NM_000249.4(MLH1):c.1038+1005G>T rs3774338 0.39669
NM_000249.4(MLH1):c.1668-885T>C rs748766 0.37254
NM_000249.4(MLH1):c.1039-78A>G rs11129748 0.36570
NM_000249.4(MLH1):c.1558+2204A>C rs3774335 0.36225
NM_000249.4(MLH1):c.1559-3171A>G rs4678925 0.35667
NM_000249.4(MLH1):c.791-1406C>T rs4647269 0.35636
NM_000249.4(MLH1):c.306+416A>C rs4647222 0.35615
NM_000249.4(MLH1):c.655A>G (p.Ile219Val) rs1799977 0.23048
NM_000249.3(MLH1):c.-93G>A rs1800734 0.22121
NM_000249.4(MLH1):c.307-1403A>T rs1540354 0.14330
NM_000249.4(MLH1):c.1558+14G>A rs41562513 0.05554
NM_000249.4(MLH1):c.1558+4245A>G rs3774332 0.05535
NM_000249.4(MLH1):c.1410-54C>T rs7633154 0.04850
NM_000249.4(MLH1):c.454-51T>C rs4647255 0.03218
NM_000249.4(MLH1):c.1668-254C>T rs41552415 0.03054
NM_000249.4(MLH1):c.2152C>T (p.His718Tyr) rs2020873 0.02345
NM_000249.4(MLH1):c.1039-35A>T rs867680022 0.02046
NM_000249.4(MLH1):c.885-81G>C rs104894999 0.02021
NM_000249.4(MLH1):c.381-41A>G rs4647245 0.01794
NM_000249.4(MLH1):c.474C>T (p.Asn158=) rs4647256 0.01161
NM_000249.4(MLH1):c.1039-8T>A rs193922367 0.01153
NM_000249.4(MLH1):c.588+11G>C rs4647258 0.00993
NM_000249.4(MLH1):c.1732-19T>A rs77120160 0.00923
NM_000249.4(MLH1):c.1959G>T (p.Leu653=) rs1800146 0.00913
NM_000249.4(MLH1):c.637G>A (p.Val213Met) rs2308317 0.00818
NM_000249.4(MLH1):c.1038+51C>T rs55986674 0.00582
NM_000249.4(MLH1):c.589-15C>T rs55658850 0.00582
NM_000249.4(MLH1):c.545+20A>T rs121909453 0.00424
NM_000249.4(MLH1):c.453+25A>G rs4647246 0.00414
NM_000249.4(MLH1):c.1852A>G (p.Lys618Glu) rs35001569 0.00399
NM_000249.4(MLH1):c.307-29C>A rs139620056 0.00398
NM_000249.4(MLH1):c.1963A>G (p.Ile655Val) rs55907433 0.00297
NM_000249.4(MLH1):c.790+10A>G rs182733777 0.00188
NM_000249.4(MLH1):c.2146G>A (p.Val716Met) rs35831931 0.00143
NM_000249.4(MLH1):c.-7C>T rs104894994 0.00115
NM_000249.4(MLH1):c.-28A>G rs56198082 0.00110
NM_000249.4(MLH1):c.1217G>A (p.Ser406Asn) rs41294980 0.00087
NM_000249.4(MLH1):c.1151T>A (p.Val384Asp) rs63750447 0.00077
NM_000249.4(MLH1):c.2104-11G>A rs147984696 0.00072
NM_000249.4(MLH1):c.375A>G (p.Ala125=) rs1800144 0.00062
NM_000249.4(MLH1):c.1410-10T>G rs372053184 0.00044
NM_000249.4(MLH1):c.702G>A (p.Glu234=) rs35908749 0.00041
NM_000249.4(MLH1):c.198C>T (p.Thr66=) rs61751642 0.00040
NM_000249.4(MLH1):c.977T>C (p.Val326Ala) rs63751049 0.00037
NM_000249.4(MLH1):c.1321G>A (p.Ala441Thr) rs63750365 0.00034
NM_000249.4(MLH1):c.588+19G>T rs943235715 0.00031
NM_000249.4(MLH1):c.1897-17C>G rs2308316 0.00029
NM_000249.4(MLH1):c.487A>C (p.Arg163=) rs748500860 0.00029
NM_000249.4(MLH1):c.2066A>G (p.Gln689Arg) rs63750702 0.00022
NM_000249.4(MLH1):c.1166G>A (p.Arg389Gln) rs63750361 0.00020
NM_000249.4(MLH1):c.394G>C (p.Asp132His) rs28930073 0.00019
NM_000249.4(MLH1):c.1040C>A (p.Thr347Asn) rs201541505 0.00017
NM_000249.4(MLH1):c.2101C>A (p.Gln701Lys) rs63750114 0.00016
NM_000249.4(MLH1):c.65G>C (p.Gly22Ala) rs41295280 0.00016
NM_000249.4(MLH1):c.803A>G (p.Glu268Gly) rs63750650 0.00014
NM_000249.4(MLH1):c.1050A>G (p.Pro350=) rs137937003 0.00012
NM_000249.4(MLH1):c.19G>T (p.Val7Phe) rs730881746 0.00011
NM_000249.4(MLH1):c.626A>G (p.Asn209Ser) rs150478207 0.00011
NM_000249.4(MLH1):c.884+16A>G rs377598055 0.00011
NM_000249.4(MLH1):c.1808C>G (p.Pro603Arg) rs63750876 0.00009
NM_000249.4(MLH1):c.1558+5G>A rs199935667 0.00008
NM_000249.4(MLH1):c.1742C>T (p.Pro581Leu) rs63751684 0.00008
NM_000249.4(MLH1):c.1379A>C (p.Glu460Ala) rs202038499 0.00007
NM_000249.4(MLH1):c.277A>G (p.Ser93Gly) rs41295282 0.00007
NM_000249.4(MLH1):c.42A>C (p.Thr14=) rs369737664 0.00007
NM_000249.4(MLH1):c.649C>T (p.Arg217Cys) rs4986984 0.00007
NM_000249.4(MLH1):c.1013A>G (p.Asn338Ser) rs63751467 0.00006
NM_000249.4(MLH1):c.1104G>A (p.Ser368=) rs769364808 0.00006
NM_000249.4(MLH1):c.1360G>C (p.Gly454Arg) rs63750527 0.00006
NM_000249.4(MLH1):c.1733A>G (p.Glu578Gly) rs63751612 0.00006
NM_000249.4(MLH1):c.2174G>A (p.Arg725His) rs566928243 0.00006
NM_000249.4(MLH1):c.69A>G (p.Glu23=) rs63750555 0.00006
NM_000249.4(MLH1):c.954C>T (p.His318=) rs146777069 0.00006
NM_000249.4(MLH1):c.955G>A (p.Glu319Lys) rs63750796 0.00006
NM_000249.4(MLH1):c.1128T>C (p.Asp376=) rs267607824 0.00005
NM_000249.4(MLH1):c.1154G>A (p.Arg385His) rs63750430 0.00005
NM_000249.4(MLH1):c.1392T>C (p.Pro464=) rs63750201 0.00005
NM_000249.4(MLH1):c.438A>G (p.Gln146=) rs377279035 0.00005
NM_000249.4(MLH1):c.80G>A (p.Arg27Gln) rs138705565 0.00005
NM_000249.4(MLH1):c.1269G>A (p.Arg423=) rs373076967 0.00004
NM_000249.4(MLH1):c.1284T>C (p.Asp428=) rs772555970 0.00004
NM_000249.4(MLH1):c.2252A>G (p.Lys751Arg) rs140195825 0.00004
NM_000249.4(MLH1):c.579A>G (p.Ser193=) rs587781038 0.00004
NM_000249.4(MLH1):c.1039-33_1039-29del rs148615368 0.00003
NM_000249.4(MLH1):c.1743G>A (p.Pro581=) rs567838745 0.00003
NM_000249.4(MLH1):c.303T>G (p.Gly101=) rs4647220 0.00002
NM_000249.4(MLH1):c.1038+9G>A rs267607817 0.00001
NM_000249.4(MLH1):c.1039-5T>C rs587782626 0.00001
NM_000249.4(MLH1):c.1202G>A (p.Ser401Asn) rs587779951 0.00001
NM_000249.4(MLH1):c.1652A>G (p.Asn551Ser) rs63750271 0.00001
NM_000249.4(MLH1):c.1731+8T>C rs370108219 0.00001
NM_000249.4(MLH1):c.1896+7C>T rs863224339 0.00001
NM_000249.4(MLH1):c.1990-6G>A rs117221851 0.00001
NM_000249.4(MLH1):c.2172G>A (p.Leu724=) rs780045031 0.00001
NM_000249.4(MLH1):c.24T>A (p.Ile8=) rs748406142 0.00001
NM_000249.4(MLH1):c.636C>T (p.Thr212=) rs138735345 0.00001
NM_000249.4(MLH1):c.652T>C (p.Ser218Pro) rs750650349 0.00001
NM_000249.4(MLH1):c.665A>G (p.Asn222Ser) rs766517126 0.00001
NM_000249.4(MLH1):c.791-14T>C rs751254837 0.00001
NM_000249.4(MLH1):c.845C>G (p.Ala282Gly) rs63750360 0.00001
NM_000249.3(MLH1):c.-107C>G rs587778886
NM_000249.4(MLH1):c.*32CTT[1] rs193922366
NM_000249.4(MLH1):c.1038+86T>C rs2286939
NM_000249.4(MLH1):c.1039-10_1039-8dup rs57509953
NM_000249.4(MLH1):c.1039-13_1039-8dup rs57509953
NM_000249.4(MLH1):c.1039-31_1039-26del rs1178900468
NM_000249.4(MLH1):c.1039-6dup rs1553650466
NM_000249.4(MLH1):c.1039-8_1039-7insTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTAA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-8_1039-7insTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTA rs535965616
NM_000249.4(MLH1):c.1039-9_1039-8dup rs57509953
NM_000249.4(MLH1):c.116+199C>T
NM_000249.4(MLH1):c.1210C>T (p.Leu404=) rs1057517538
NM_000249.4(MLH1):c.1266C>T (p.Gly422=) rs63750791
NM_000249.4(MLH1):c.1559-10dup rs2084629884
NM_000249.4(MLH1):c.1559-11T>C rs730881750
NM_000249.4(MLH1):c.1668-9del
NM_000249.4(MLH1):c.1799A>G (p.Glu600Gly) rs267607861
NM_000249.4(MLH1):c.1852_1853delinsGC (p.Lys618Ala) rs35502531
NM_000249.4(MLH1):c.1853A>C (p.Lys618Thr) rs63750449
NM_000249.4(MLH1):c.1853A>G (p.Lys618Arg) rs63750449
NM_000249.4(MLH1):c.18G>A (p.Gly6=) rs786202312
NM_000249.4(MLH1):c.2040C>T (p.Cys680=) rs63749867
NM_000249.4(MLH1):c.2074T>C (p.Ser692Pro) rs587779957
NM_000249.4(MLH1):c.2088C>G (p.Thr696=) rs1060504015
NM_000249.4(MLH1):c.2104-5del
NM_000249.4(MLH1):c.453+554C>T rs267607748
NM_000249.4(MLH1):c.479C>T (p.Ala160Val) rs63749924
NM_000249.4(MLH1):c.546-16del rs1559529693
NM_000249.4(MLH1):c.655A>C (p.Ile219Leu) rs1799977
NM_000249.4(MLH1):c.677+26del rs755619350
NM_000249.4(MLH1):c.677+26dup rs755619350
NM_000249.4(MLH1):c.705T>C (p.Asp235=) rs876658869
NM_000249.4(MLH1):c.885-21TC[2] rs267607804
NM_000249.4(MLH1):c.91_92delinsTG (p.Ala31Cys) rs63749994
NM_000249.4(MLH1):c.927C>T (p.Pro309=) rs63749896

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