List of variants in gene FAS reported as uncertain significance for autoimmune disease

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 167

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HGVS	dbSNP	gnomAD frequency
NM_000043.6(FAS):c.183G>A (p.Lys61=)	rs3218613	0.00606
NM_000043.6(FAS):c.580G>A (p.Glu194Lys)	rs56006128	0.00138
NM_000043.6(FAS):c.578A>G (p.Lys193Arg)	rs150489856	0.00026
NM_000043.6(FAS):c.914C>T (p.Thr305Ile)	rs3218611	0.00018
NM_000043.6(FAS):c.*1294A>T	rs9658778	0.00016
NM_000043.6(FAS):c.956C>T (p.Thr319Ile)	rs372459755	0.00011
NM_000043.6(FAS):c.251C>T (p.Pro84Leu)	rs778483787	0.00009
NM_000043.6(FAS):c.38C>T (p.Thr13Met)	rs372880667	0.00009
NM_000043.6(FAS):c.961G>A (p.Asp321Asn)	rs137898188	0.00008
NM_000043.6(FAS):c.*520T>C	rs886047462	0.00006
NM_000043.6(FAS):c.667A>C (p.Asn223His)	rs143318339	0.00005
NM_000043.6(FAS):c.196+3A>C	rs370162732	0.00003
NM_000043.6(FAS):c.247G>A (p.Val83Met)	rs199790261	0.00003
NM_000043.6(FAS):c.488C>T (p.Thr163Ile)	rs563551720	0.00003
NM_000043.6(FAS):c.867A>C (p.Glu289Asp)	rs377337130	0.00003
NM_000043.6(FAS):c.976A>C (p.Asn326His)	rs770595930	0.00003
NM_000043.6(FAS):c.97A>G (p.Lys33Glu)	rs55766344	0.00003
NM_000043.6(FAS):c.*386A>G	rs1186205053	0.00002
NM_000043.6(FAS):c.*839A>G	rs779728201	0.00002
NM_000043.6(FAS):c.*874T>A	rs1436430653	0.00002
NM_000043.6(FAS):c.347A>G (p.Glu116Gly)	rs749714005	0.00002
NM_000043.6(FAS):c.413C>T (p.Thr138Ile)	rs760912307	0.00002
NM_000043.6(FAS):c.628C>T (p.His210Tyr)	rs1428151683	0.00002
NM_000043.6(FAS):c.943C>T (p.Leu315Phe)	rs1475820915	0.00002
NM_000043.6(FAS):c.*1313G>A	rs192544176	0.00001
NM_000043.6(FAS):c.163G>C (p.Asp55His)	rs148677058	0.00001
NM_000043.6(FAS):c.176G>T (p.Cys59Phe)	rs886047459	0.00001
NM_000043.6(FAS):c.217T>G (p.Cys73Gly)	rs751654768	0.00001
NM_000043.6(FAS):c.334+3A>C	rs1848316496	0.00001
NM_000043.6(FAS):c.379T>G (p.Cys127Gly)	rs1848386782	0.00001
NM_000043.6(FAS):c.432C>A (p.Asp144Glu)	rs574338716	0.00001
NM_000043.6(FAS):c.524G>A (p.Gly175Glu)	rs752208395	0.00001
NM_000043.6(FAS):c.533G>A (p.Cys178Tyr)	rs372866793	0.00001
NM_000043.6(FAS):c.608G>T (p.Arg203Ile)	rs756880278	0.00001
NM_000043.6(FAS):c.637C>T (p.Pro213Ser)	rs755532307	0.00001
NM_000043.6(FAS):c.666A>G (p.Ile222Met)	rs767806688	0.00001
NM_000043.6(FAS):c.674C>G (p.Ser225Cys)	rs1848626473	0.00001
NM_000043.6(FAS):c.694T>C (p.Tyr232His)	rs767866112	0.00001
NM_000043.6(FAS):c.700A>G (p.Thr234Ala)	rs962274229	0.00001
NM_000043.6(FAS):c.79G>A (p.Val27Met)	rs201624874	0.00001
NM_000043.6(FAS):c.885T>G (p.Ile295Met)	rs1170990745	0.00001
NM_000043.6(FAS):c.937A>G (p.Ile313Val)	rs751341397	0.00001
NM_000043.6(FAS):c.950A>G (p.Asp317Gly)	rs200864612	0.00001
NM_000043.6(FAS):c.95C>A (p.Ser32Tyr)	rs866603022	0.00001
NM_000043.6(FAS):c.*1153A>T	rs986613204
NM_000043.6(FAS):c.*119C>T	rs1848699181
NM_000043.6(FAS):c.*566C>G	rs886047463
NM_000043.6(FAS):c.*586G>A	rs1848730964
NM_000043.6(FAS):c.*88T>C	rs886047461
NM_000043.6(FAS):c.1002G>T (p.Leu334Phe)	rs1848690736
NM_000043.6(FAS):c.1008G>C (p.Ter336Tyr)
NM_000043.6(FAS):c.103T>A (p.Leu35Met)
NM_000043.6(FAS):c.104T>G (p.Leu35Trp)	rs2133471258
NM_000043.6(FAS):c.136A>C (p.Thr46Pro)
NM_000043.6(FAS):c.155_169dup (p.Gly56_Gln57insLeuHisHisAspGly)
NM_000043.6(FAS):c.161A>G (p.His54Arg)	rs759152311
NM_000043.6(FAS):c.175T>A (p.Cys59Ser)
NM_000043.6(FAS):c.179A>G (p.His60Arg)	rs753767914
NM_000043.6(FAS):c.185C>G (p.Pro62Arg)	rs757780022
NM_000043.6(FAS):c.187T>C (p.Cys63Arg)
NM_000043.6(FAS):c.195A>G (p.Pro65=)
NM_000043.6(FAS):c.196+2dup
NM_000043.6(FAS):c.196+5G>T
NM_000043.6(FAS):c.204G>T (p.Arg68Ser)
NM_000043.6(FAS):c.218G>C (p.Cys73Ser)	rs2133502355
NM_000043.6(FAS):c.226A>C (p.Asn76His)
NM_000043.6(FAS):c.230G>A (p.Gly77Glu)
NM_000043.6(FAS):c.245G>A (p.Cys82Tyr)
NM_000043.6(FAS):c.259G>A (p.Glu87Lys)	rs2133503091
NM_000043.6(FAS):c.279C>A (p.Asp93Glu)
NM_000043.6(FAS):c.287A>G (p.His96Arg)	rs1589475804
NM_000043.6(FAS):c.31-8T>G	rs1589464585
NM_000043.6(FAS):c.31-9A>G	rs886047458
NM_000043.6(FAS):c.310T>C (p.Cys104Arg)
NM_000043.6(FAS):c.32T>C (p.Val11Ala)
NM_000043.6(FAS):c.333T>C (p.His111=)
NM_000043.6(FAS):c.335-4C>G
NM_000043.6(FAS):c.340G>A (p.Glu114Lys)
NM_000043.6(FAS):c.383G>A (p.Arg128Lys)	rs2133514262
NM_000043.6(FAS):c.386G>A (p.Cys129Tyr)
NM_000043.6(FAS):c.38C>A (p.Thr13Lys)
NM_000043.6(FAS):c.391C>A (p.Pro131Thr)
NM_000043.6(FAS):c.397T>C (p.Phe133Leu)
NM_000043.6(FAS):c.398T>A (p.Phe133Tyr)
NM_000043.6(FAS):c.404G>T (p.Cys135Phe)	rs1404280764
NM_000043.6(FAS):c.415G>A (p.Val139Ile)
NM_000043.6(FAS):c.418T>G (p.Cys140Gly)
NM_000043.6(FAS):c.430G>T (p.Asp144Tyr)
NM_000043.6(FAS):c.432C>T (p.Asp144=)	rs574338716
NM_000043.6(FAS):c.444-5del	rs751798922
NM_000043.6(FAS):c.466G>A (p.Glu156Lys)
NM_000043.6(FAS):c.473C>T (p.Thr158Ile)
NM_000043.6(FAS):c.478A>G (p.Thr160Ala)	rs1589482084
NM_000043.6(FAS):c.485A>T (p.Asn162Ile)	rs993150748
NM_000043.6(FAS):c.490A>G (p.Lys164Glu)
NM_000043.6(FAS):c.494G>A (p.Cys165Tyr)
NM_000043.6(FAS):c.506-11C>T
NM_000043.6(FAS):c.506-6C>G	rs1589482683
NM_000043.6(FAS):c.506G>T (p.Gly169Val)	rs1848488731
NM_000043.6(FAS):c.526T>C (p.Trp176Arg)
NM_000043.6(FAS):c.529C>T (p.Leu177Phe)
NM_000043.6(FAS):c.530T>G (p.Leu177Arg)	rs1848490280
NM_000043.6(FAS):c.554C>T (p.Pro185Leu)
NM_000043.6(FAS):c.55T>C (p.Ser19Pro)
NM_000043.6(FAS):c.565_566insACAAGA (p.Trp189delinsTyrLysArg)	rs2133530271
NM_000043.6(FAS):c.566_568delinsACAAGAATT (p.Trp189_Val190delinsTyrLysAsnLeu)	rs1564695523
NM_000043.6(FAS):c.568+5G>C
NM_000043.6(FAS):c.56C>T (p.Ser19Leu)
NM_000043.6(FAS):c.575G>A (p.Arg192Lys)
NM_000043.6(FAS):c.634T>A (p.Ser212Thr)	rs1848559695
NM_000043.6(FAS):c.635C>T (p.Ser212Phe)
NM_000043.6(FAS):c.641_642delinsAC (p.Thr214Asn)	rs1848560803
NM_000043.6(FAS):c.641_642delinsTC (p.Thr214Ile)	rs1848560803
NM_000043.6(FAS):c.652-12T>A	rs1214604414
NM_000043.6(FAS):c.652G>A (p.Glu218Lys)
NM_000043.6(FAS):c.658G>A (p.Val220Met)	rs755437276
NM_000043.6(FAS):c.670_676del (p.Leu224fs)
NM_000043.6(FAS):c.673T>A (p.Ser225Thr)	rs891207457
NM_000043.6(FAS):c.676+12A>C	rs777843173
NM_000043.6(FAS):c.676+3A>G	rs1848626772
NM_000043.6(FAS):c.67G>A (p.Val23Ile)
NM_000043.6(FAS):c.680T>C (p.Val227Ala)
NM_000043.6(FAS):c.695A>G (p.Tyr232Cys)	rs121913079
NM_000043.6(FAS):c.704C>T (p.Thr235Ile)	rs2119445212
NM_000043.6(FAS):c.704_706del (p.Thr235del)	rs1848666809
NM_000043.6(FAS):c.715G>T (p.Val239Phe)
NM_000043.6(FAS):c.719T>A (p.Met240Lys)	rs2119445378
NM_000043.6(FAS):c.719T>G (p.Met240Arg)
NM_000043.6(FAS):c.734T>G (p.Val245Gly)	rs200778245
NM_000043.6(FAS):c.746T>C (p.Val249Ala)
NM_000043.6(FAS):c.760G>T (p.Val254Phe)	rs2119445796
NM_000043.6(FAS):c.761T>C (p.Val254Ala)	rs1848671288
NM_000043.6(FAS):c.767A>G (p.Glu256Gly)	rs2119445897
NM_000043.6(FAS):c.772A>G (p.Lys258Glu)
NM_000043.6(FAS):c.77A>G (p.Gln26Arg)	rs2133470846
NM_000043.6(FAS):c.781G>A (p.Glu261Lys)
NM_000043.6(FAS):c.792T>G (p.Asn264Lys)	rs2119446116
NM_000043.6(FAS):c.796A>C (p.Asn266His)
NM_000043.6(FAS):c.809C>T (p.Thr270Ile)	rs121913081
NM_000043.6(FAS):c.817C>A (p.Gln273Lys)	rs121913077
NM_000043.6(FAS):c.818A>G (p.Gln273Arg)	rs1848677745
NM_000043.6(FAS):c.820A>G (p.Lys274Glu)
NM_000043.6(FAS):c.823G>A (p.Val275Ile)
NM_000043.6(FAS):c.828A>C (p.Gln276His)
NM_000043.6(FAS):c.836G>A (p.Arg279His)
NM_000043.6(FAS):c.841T>A (p.Trp281Arg)
NM_000043.6(FAS):c.841T>G (p.Trp281Gly)
NM_000043.6(FAS):c.84T>C (p.Thr28=)	rs1848023281
NM_000043.6(FAS):c.857G>A (p.Gly286Glu)
NM_000043.6(FAS):c.862A>G (p.Lys288Glu)
NM_000043.6(FAS):c.866A>G (p.Glu289Gly)
NM_000043.6(FAS):c.869C>A (p.Ala290Glu)	rs760993872
NM_000043.6(FAS):c.869C>T (p.Ala290Val)
NM_000043.6(FAS):c.874G>C (p.Asp292His)
NM_000043.6(FAS):c.878C>T (p.Thr293Ile)	rs2119447206
NM_000043.6(FAS):c.900A>C (p.Lys300Asn)
NM_000043.6(FAS):c.901G>A (p.Ala301Thr)	rs1449711911
NM_000043.6(FAS):c.905A>G (p.Asn302Ser)
NM_000043.6(FAS):c.908T>G (p.Leu303Arg)
NM_000043.6(FAS):c.910T>C (p.Cys304Arg)
NM_000043.6(FAS):c.913A>G (p.Thr305Ala)
NM_000043.6(FAS):c.929T>G (p.Ile310Ser)	rs2119448150
NM_000043.6(FAS):c.953T>C (p.Ile318Thr)	rs1848687177
NM_000043.6(FAS):c.963C>G (p.Asp321Glu)
NM_000043.6(FAS):c.976A>G (p.Asn326Asp)	rs770595930
NM_000043.6(FAS):c.976A>T (p.Asn326Tyr)
NM_000043.6(FAS):c.97A>C (p.Lys33Gln)	rs55766344

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