List of variants in gene MLH1 reported as uncertain significance by Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 25

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HGVS	dbSNP	gnomAD frequency
NM_000249.4(MLH1):c.1217G>A (p.Ser406Asn)	rs41294980	0.00087
NM_000249.4(MLH1):c.1321G>A (p.Ala441Thr)	rs63750365	0.00034
NM_000249.4(MLH1):c.2066A>G (p.Gln689Arg)	rs63750702	0.00022
NM_000249.4(MLH1):c.1166G>A (p.Arg389Gln)	rs63750361	0.00020
NM_000249.4(MLH1):c.394G>C (p.Asp132His)	rs28930073	0.00019
NM_000249.4(MLH1):c.1040C>A (p.Thr347Asn)	rs201541505	0.00017
NM_000249.4(MLH1):c.65G>C (p.Gly22Ala)	rs41295280	0.00016
NM_000249.4(MLH1):c.803A>G (p.Glu268Gly)	rs63750650	0.00014
NM_000249.3(MLH1):c.-42C>T	rs41285097	0.00009
NM_000249.4(MLH1):c.1742C>T (p.Pro581Leu)	rs63751684	0.00008
NM_000249.4(MLH1):c.1379A>C (p.Glu460Ala)	rs202038499	0.00007
NM_000249.4(MLH1):c.1013A>G (p.Asn338Ser)	rs63751467	0.00006
NM_000249.4(MLH1):c.1360G>C (p.Gly454Arg)	rs63750527	0.00006
NM_000249.4(MLH1):c.1733A>G (p.Glu578Gly)	rs63751612	0.00006
NM_000249.4(MLH1):c.453G>A (p.Thr151=)	rs369521379	0.00006
NM_000249.4(MLH1):c.1153C>T (p.Arg385Cys)	rs63750760	0.00005
NM_000249.4(MLH1):c.1148T>C (p.Met383Thr)	rs141344760	0.00004
NM_000249.4(MLH1):c.794G>A (p.Arg265His)	rs63751448	0.00004
NM_000249.4(MLH1):c.1487C>T (p.Pro496Leu)	rs63750226	0.00003
NM_000249.4(MLH1):c.1976G>A (p.Arg659Gln)	rs63749900	0.00003
NM_000249.4(MLH1):c.1268G>A (p.Arg423Lys)	rs370687064
NM_000249.4(MLH1):c.1524T>G (p.Ser508Arg)	rs886058383
NM_000249.4(MLH1):c.1714G>A (p.Gly572Ser)	rs587781796
NM_000249.4(MLH1):c.379A>C (p.Arg127=)	rs587779007
NM_000249.4(MLH1):c.457G>A (p.Glu153Lys)	rs1553642660

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