List of variants in gene BRCA1 reported as uncertain significance by PreventionGenetics, part of Exact Sciences

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 42

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HGVS	dbSNP	gnomAD frequency
NM_007294.4(BRCA1):c.2155A>G (p.Lys719Glu)	rs80357147	0.00021
NM_007294.4(BRCA1):c.694G>A (p.Asp232Asn)	rs55975699	0.00011
NM_007294.4(BRCA1):c.2351C>T (p.Ser784Leu)	rs55914168	0.00004
NM_007294.4(BRCA1):c.2473G>T (p.Asp825Tyr)	rs80357328	0.00004
NM_007294.4(BRCA1):c.4261C>T (p.His1421Tyr)	rs80357013	0.00004
NM_007294.4(BRCA1):c.2447A>G (p.His816Arg)	rs80357108	0.00003
NM_007294.4(BRCA1):c.612G>C (p.Leu204Phe)	rs80357394	0.00003
NM_007294.4(BRCA1):c.1336A>G (p.Arg446Gly)	rs587781715	0.00001
NM_007294.4(BRCA1):c.1381T>C (p.Phe461Leu)	rs62625300	0.00001
NM_007294.4(BRCA1):c.1384G>A (p.Gly462Arg)	rs80357221	0.00001
NM_007294.4(BRCA1):c.1396C>T (p.Arg466Trp)	rs80356964	0.00001
NM_007294.4(BRCA1):c.1712T>C (p.Ile571Thr)	rs80357159	0.00001
NM_007294.4(BRCA1):c.1897C>T (p.Pro633Ser)	rs80356902	0.00001
NM_007294.4(BRCA1):c.2483_2485del (p.Gly828_Phe829delinsVal)	rs80358331	0.00001
NM_007294.4(BRCA1):c.259T>G (p.Leu87Val)	rs80357091	0.00001
NM_007294.4(BRCA1):c.3211G>A (p.Glu1071Lys)	rs41293445	0.00001
NM_007294.4(BRCA1):c.4534A>T (p.Ser1512Cys)	rs80357137	0.00001
NM_007294.4(BRCA1):c.4679G>T (p.Gly1560Val)	rs564757581	0.00001
NM_007294.4(BRCA1):c.4846G>A (p.Ala1616Thr)	rs890599236	0.00001
NM_007294.4(BRCA1):c.995G>A (p.Arg332Gln)	rs80357464	0.00001
NM_007294.4(BRCA1):c.1763_1764delinsTT (p.Ser588Ile)	rs1555591274
NM_007294.4(BRCA1):c.1837A>G (p.Arg613Gly)	rs863224753
NM_007294.4(BRCA1):c.1895G>A (p.Ser632Asn)	rs80356983
NM_007294.4(BRCA1):c.2083G>A (p.Asp695Asn)	rs28897681
NM_007294.4(BRCA1):c.2123C>T (p.Ser708Phe)	rs80357182
NM_007294.4(BRCA1):c.2153T>G (p.Leu718Arg)	rs748550848
NM_007294.4(BRCA1):c.2346T>A (p.Ser782Arg)	rs1555589837
NM_007294.4(BRCA1):c.2774T>C (p.Ile925Thr)	rs1567794296
NM_007294.4(BRCA1):c.3091A>G (p.Ile1031Val)	rs786203979
NM_007294.4(BRCA1):c.4358-2755C>G
NM_007294.4(BRCA1):c.4441G>A (p.Ala1481Thr)	rs1135401828
NM_007294.4(BRCA1):c.4492C>T (p.Pro1498Ser)	rs1597836625
NM_007294.4(BRCA1):c.4697C>A (p.Ser1566Tyr)	rs1060502325
NM_007294.4(BRCA1):c.4988T>A (p.Met1663Lys)	rs80357205
NM_007294.4(BRCA1):c.5210GAG[1] (p.Gly1738del)	rs80358347
NM_007294.4(BRCA1):c.5234A>G (p.Asn1745Ser)	rs1567764456
NM_007294.4(BRCA1):c.5333-46G>A	rs1347755058
NM_007294.4(BRCA1):c.5380G>A (p.Glu1794Lys)	rs776323117
NM_007294.4(BRCA1):c.5485G>A (p.Glu1829Lys)	rs869320789
NM_007294.4(BRCA1):c.5571_5579del (p.Gln1857_Pro1859del)	rs775417240
NM_007294.4(BRCA1):c.626C>T (p.Pro209Leu)	rs201596327
NM_007294.4(BRCA1):c.66A>C (p.Leu22Phe)	rs786202533

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