List of variants in gene FLNB reported as uncertain significance by GeneDx

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 103

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HGVS	dbSNP	gnomAD frequency
NM_001457.4(FLNB):c.6683T>C (p.Ile2228Thr)	rs149629209	0.00148
NM_001457.4(FLNB):c.2453G>A (p.Arg818Gln)	rs151259375	0.00091
NM_001457.4(FLNB):c.4307G>A (p.Arg1436Gln)	rs140018418	0.00067
NM_001457.4(FLNB):c.6173A>G (p.Lys2058Arg)	rs141698427	0.00048
NM_001457.4(FLNB):c.4058C>G (p.Thr1353Ser)	rs142718547	0.00043
NM_001457.4(FLNB):c.4730C>T (p.Ala1577Val)	rs148101195	0.00043
NM_001457.4(FLNB):c.7510G>A (p.Ala2504Thr)	rs148364272	0.00042
NM_001457.4(FLNB):c.6515G>A (p.Arg2172His)	rs139846706	0.00034
NM_001457.4(FLNB):c.4903G>A (p.Gly1635Ser)	rs139046903	0.00031
NM_001457.4(FLNB):c.6193G>A (p.Val2065Met)	rs371167931	0.00027
NM_001457.4(FLNB):c.1588G>T (p.Gly530Trp)	rs773943113	0.00022
NM_001457.4(FLNB):c.3052G>A (p.Val1018Met)	rs2276742	0.00022
NM_001457.4(FLNB):c.1868A>T (p.Asp623Val)	rs145314043	0.00016
NM_001457.4(FLNB):c.2095C>T (p.Arg699Trp)	rs200554477	0.00015
NM_001457.4(FLNB):c.4814G>A (p.Arg1605His)	rs201630300	0.00015
NM_001457.4(FLNB):c.5506G>A (p.Ala1836Thr)	rs199964133	0.00015
NM_001457.4(FLNB):c.1290C>G (p.Ile430Met)	rs147854989	0.00014
NM_001457.4(FLNB):c.3886C>T (p.Pro1296Ser)	rs148350434	0.00014
NM_001457.4(FLNB):c.3967A>T (p.Thr1323Ser)	rs202156074	0.00013
NM_001457.4(FLNB):c.6028C>T (p.Arg2010Cys)	rs138034708	0.00013
NM_001457.4(FLNB):c.3032A>C (p.Glu1011Ala)	rs754708052	0.00012
NM_001457.4(FLNB):c.2071C>T (p.Arg691Cys)	rs776421446	0.00011
NM_001457.4(FLNB):c.2104G>A (p.Gly702Ser)	rs374090457	0.00011
NM_001457.4(FLNB):c.3476C>T (p.Ser1159Leu)	rs201254275	0.00011
NM_001457.4(FLNB):c.3673G>A (p.Ala1225Thr)	rs371610564	0.00009
NM_001457.4(FLNB):c.7120C>T (p.Arg2374Cys)	rs146963572	0.00009
NM_001457.4(FLNB):c.5380G>A (p.Gly1794Arg)	rs149600652	0.00006
NM_001457.4(FLNB):c.5843G>A (p.Arg1948Gln)	rs143752722	0.00006
NM_001457.4(FLNB):c.2096G>A (p.Arg699Gln)	rs752842243	0.00005
NM_001457.4(FLNB):c.3655C>T (p.Arg1219Trp)	rs763607287	0.00005
NM_001457.4(FLNB):c.1505A>G (p.Lys502Arg)	rs1258934756	0.00004
NM_001457.4(FLNB):c.3661A>G (p.Lys1221Glu)	rs537630384	0.00004
NM_001457.4(FLNB):c.3784G>A (p.Gly1262Arg)	rs139932035	0.00004
NM_001457.4(FLNB):c.6792C>G (p.Ile2264Met)	rs142747695	0.00004
NM_001457.4(FLNB):c.1249G>A (p.Val417Met)	rs146583950	0.00003
NM_001457.4(FLNB):c.2005A>G (p.Thr669Ala)	rs147481678	0.00003
NM_001457.4(FLNB):c.3265G>A (p.Asp1089Asn)	rs369045614	0.00003
NM_001457.4(FLNB):c.3652G>A (p.Ala1218Thr)	rs370716086	0.00003
NM_001457.4(FLNB):c.1628T>C (p.Val543Ala)	rs773177128	0.00002
NM_001457.4(FLNB):c.1897A>G (p.Met633Val)	rs937051879	0.00002
NM_001457.4(FLNB):c.2098A>C (p.Met700Leu)	rs762991925	0.00002
NM_001457.4(FLNB):c.3325G>A (p.Val1109Ile)	rs200947960	0.00002
NM_001457.4(FLNB):c.5188G>A (p.Glu1730Lys)	rs773991765	0.00002
NM_001457.4(FLNB):c.5596A>G (p.Ile1866Val)	rs752719887	0.00002
NM_001457.4(FLNB):c.1679A>G (p.His560Arg)	rs749965480	0.00001
NM_001457.4(FLNB):c.1781T>C (p.Ile594Thr)	rs776866741	0.00001
NM_001457.4(FLNB):c.1876G>T (p.Asp626Tyr)	rs762150314	0.00001
NM_001457.4(FLNB):c.3176C>T (p.Ala1059Val)	rs570950728	0.00001
NM_001457.4(FLNB):c.3209C>T (p.Thr1070Ile)	rs201533113	0.00001
NM_001457.4(FLNB):c.3973G>A (p.Gly1325Ser)	rs374307701	0.00001
NM_001457.4(FLNB):c.4774G>A (p.Val1592Ile)	rs754360853	0.00001
NM_001457.4(FLNB):c.484A>T (p.Asn162Tyr)	rs777678654	0.00001
NM_001457.4(FLNB):c.5066G>A (p.Arg1689His)	rs139001404	0.00001
NM_001457.4(FLNB):c.6029G>A (p.Arg2010His)	rs188216614	0.00001
NM_001457.4(FLNB):c.6310C>T (p.Arg2104Trp)	rs751795794	0.00001
NM_001457.4(FLNB):c.6508A>G (p.Lys2170Glu)	rs900284459	0.00001
NM_001457.4(FLNB):c.6590G>A (p.Arg2197Gln)	rs749488943	0.00001
NM_001457.4(FLNB):c.6623C>T (p.Ala2208Val)	rs368617386	0.00001
NM_001457.4(FLNB):c.6863G>A (p.Arg2288His)	rs775239285	0.00001
NM_001457.4(FLNB):c.-5C>T	rs2106654616
NM_001457.4(FLNB):c.1259C>T (p.Pro420Leu)	rs1270447838
NM_001457.4(FLNB):c.1327G>A (p.Val443Ile)	rs200902568
NM_001457.4(FLNB):c.1367G>A (p.Arg456Gln)	rs377737248
NM_001457.4(FLNB):c.1484-6C>G
NM_001457.4(FLNB):c.1859T>A (p.Ile620Asn)	rs2107107153
NM_001457.4(FLNB):c.2057A>C (p.Asp686Ala)
NM_001457.4(FLNB):c.2299G>A (p.Val767Met)	rs2097265195
NM_001457.4(FLNB):c.2324G>A (p.Gly775Asp)	rs1247642284
NM_001457.4(FLNB):c.2437C>T (p.Pro813Ser)	rs1324274482
NM_001457.4(FLNB):c.2773G>T (p.Gly925Cys)	rs139875974
NM_001457.4(FLNB):c.2973C>G (p.Cys991Trp)	rs750262364
NM_001457.4(FLNB):c.3068A>G (p.His1023Arg)
NM_001457.4(FLNB):c.3256G>A (p.Glu1086Lys)	rs1350556067
NM_001457.4(FLNB):c.3537A>T (p.Glu1179Asp)	rs2107176033
NM_001457.4(FLNB):c.3550A>T (p.Asn1184Tyr)
NM_001457.4(FLNB):c.3623A>G (p.Tyr1208Cys)	rs2107176335
NM_001457.4(FLNB):c.4051G>A (p.Val1351Met)
NM_001457.4(FLNB):c.4066G>A (p.Ala1356Thr)	rs764743602
NM_001457.4(FLNB):c.4076G>T (p.Gly1359Val)
NM_001457.4(FLNB):c.4096G>C (p.Glu1366Gln)
NM_001457.4(FLNB):c.4219_4221delinsTCT (p.Pro1407Ser)
NM_001457.4(FLNB):c.4229C>T (p.Pro1410Leu)
NM_001457.4(FLNB):c.458T>A (p.Ile153Asn)	rs2106946743
NM_001457.4(FLNB):c.4625T>C (p.Ile1542Thr)	rs1356745912
NM_001457.4(FLNB):c.4642G>A (p.Gly1548Arg)
NM_001457.4(FLNB):c.4749C>G (p.Asp1583Glu)	rs2107224656
NM_001457.4(FLNB):c.478A>G (p.Asn160Asp)
NM_001457.4(FLNB):c.5110G>T (p.Ala1704Ser)
NM_001457.4(FLNB):c.5171T>G (p.Phe1724Cys)	rs767365016
NM_001457.4(FLNB):c.5446G>C (p.Val1816Leu)	rs2097335219
NM_001457.4(FLNB):c.571C>A (p.Pro191Thr)
NM_001457.4(FLNB):c.5999G>A (p.Gly2000Asp)	rs2107271493
NM_001457.4(FLNB):c.6181T>C (p.Tyr2061His)	rs2107275609
NM_001457.4(FLNB):c.6317C>T (p.Pro2106Leu)	rs1349150592
NM_001457.4(FLNB):c.647C>T (p.Thr216Ile)
NM_001457.4(FLNB):c.6902A>G (p.Lys2301Arg)
NM_001457.4(FLNB):c.6904G>A (p.Val2302Ile)	rs2107307756
NM_001457.4(FLNB):c.7162T>C (p.Ser2388Pro)	rs1172338396
NM_001457.4(FLNB):c.7238G>A (p.Gly2413Asp)	rs2107339782
NM_001457.4(FLNB):c.7327A>G (p.Thr2443Ala)	rs2107339978
NM_001457.4(FLNB):c.7534G>A (p.Ala2512Thr)	rs142878980
NM_001457.4(FLNB):c.7760G>T (p.Trp2587Leu)	rs144321868
NM_001457.4(FLNB):c.982A>G (p.Lys328Glu)	rs1057523117

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