ClinVar Miner

Variants from PharmGKB

Location: United States  Primary collection method: curation
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign drug response total
0 0 0 0 0 136 136

Gene and significance breakdown #

Total genes and gene combinations: 40
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Gene or gene combination drug response total
RYR1 38 38
CFTR 21 21
DPYD 20 20
VKORC1 7 7
CFTR, LOC111674472 6 6
CFTR, LOC111674475 5 5
CACNA1S 2 2
CYP2B6 2 2
EGFR 2 2
IFNL3 2 2
ITPA 2 2
​intergenic 1 1
ABCG2 1 1
ACE 1 1
ADD1 1 1
ADRB2, LOC129994952 1 1
ALDH2 1 1
APOE 1 1
ATIC 1 1
CES1 1 1
CFTR, LOC113664106 1 1
CHRNA5 1 1
CYP3A4 1 1
CYP3A4, LOC110366355 1 1
CYP4F2 1 1
EPAS1 1 1
F5 1 1
IFNL3, IFNL4 1 1
KIF6 1 1
MT-ND1, MT-RNR1 1 1
MT-RNR1 1 1
MT-RNR1, MT-TS1 1 1
MTHFR 1 1
NUDT15 1 1
SCN1A 1 1
SLC19A1 1 1
SLCO1B1 1 1
TNF 1 1
UGT1A, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9 1 1
XRCC1 1 1

Condition and significance breakdown #

Total conditions: 77
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Condition drug response total
desflurane response - Toxicity 40 40
enflurane response - Toxicity 40 40
halothane response - Toxicity 40 40
isoflurane response - Toxicity 40 40
methoxyflurane response - Toxicity 40 40
sevoflurane response - Toxicity 40 40
succinylcholine response - Toxicity 40 40
ivacaftor response - Efficacy 32 32
fluorouracil response - Other 14 14
fluorouracil response - Toxicity 14 14
capecitabine response - Toxicity 11 11
warfarin response - Dosage 9 9
acenocoumarol response - Dosage 3 3
aminoglycoside antibacterials response - Toxicity 3 3
gentamicin response - Toxicity 3 3
kanamycin response - Toxicity 3 3
streptomycin response - Toxicity 3 3
tegafur response - Toxicity 3 3
gefitinib response - Efficacy 2 2
methotrexate response - Efficacy 2 2
peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, and telaprevir response - Efficacy 2 2
peginterferon alfa-2b and ribavirin response - Toxicity 2 2
phenprocoumon response - Dosage 2 2
rosuvastatin response - Metabolism/PK 2 2
tacrolimus response - Metabolism/PK 2 2
tobramycin response - Toxicity 2 2
Platinum compounds response - Efficacy 1 1
amikacin response - Toxicity 1 1
atorvastatin response - Efficacy 1 1
atorvastatin response - Metabolism/PK 1 1
atorvastatin response - Toxicity 1 1
azathioprine response - Toxicity 1 1
boceprevir, peginterferon alfa-2a, peginterferon alfa-2b and ribavirin response - Efficacy 1 1
captopril response - Efficacy 1 1
carbamazepine response - Dosage 1 1
clopidogrel response - Efficacy 1 1
clopidogrel response - Metabolism/PK 1 1
efavirenz response - Metabolism/PK 1 1
efavirenz response - Toxicity 1 1
erlotinib response - Efficacy 1 1
etanercept response - Efficacy 1 1
ethanol response - Toxicity 1 1
fentanyl response - Dosage 1 1
fluvastatin response - Metabolism/PK 1 1
fluvastatin response - Toxicity 1 1
hmg coa reductase inhibitors response - Toxicity 1 1
hormonal contraceptives for systemic use response - Toxicity 1 1
hydrochlorothiazide response - Efficacy 1 1
interferons, peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy 1 1
irinotecan response - Toxicity 1 1
ivacaftor / lumacaftor response - Efficacy 1 1
ivacaftor / tezacaftor response - Efficacy 1 1
lovastatin acid response - Metabolism/PK 1 1
lovastatin response - Metabolism/PK 1 1
lovastatin response - Toxicity 1 1
mercaptopurine response - Dosage 1 1
methotrexate response - Toxicity 1 1
nevirapine response - Metabolism/PK 1 1
nevirapine response - Toxicity 1 1
nicotine response - Toxicity 1 1
peginterferon alfa-2a response - Efficacy 1 1
peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy 1 1
peginterferon alfa-2b response - Efficacy 1 1
phenprocoumon response - Toxicity 1 1
pitavastatin response - Metabolism/PK 1 1
pravastatin response - Efficacy 1 1
pravastatin response - Toxicity 1 1
ribavirin response - Efficacy 1 1
rosuvastatin response - Efficacy 1 1
rosuvastatin response - Toxicity 1 1
salmeterol response - Efficacy 1 1
simvastatin acid response - Metabolism/PK 1 1
simvastatin response - Metabolism/PK 1 1
simvastatin response - Toxicity 1 1
sorafenib response - Toxicity 1 1
warfarin response - Efficacy 1 1
warfarin response - Toxicity 1 1

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