ClinVar Miner

Variants from PharmGKB

Location: United States — Primary collection method: curation
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign drug response total
0 0 0 0 0 248 248

Gene and significance breakdown #

Total genes and gene combinations: 120
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Gene or gene combination drug response total
RYR1 44 44
CFTR 23 23
DPYD 9 9
VKORC1 9 9
CYP2C9 7 7
CFTR, LOC111674472 6 6
CFTR, LOC111674475 6 6
TANC1 6 6
CYP2B6 5 5
​intergenic 3 3
CYP2C19 3 3
EGFR 3 3
SLCO1B1 3 3
UGT1A, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9 3 3
ABCB1 2 2
CACNA1S 2 2
CHRNA3 2 2
DRD2 2 2
EPHX1 2 2
HTR2C 2 2
IFNL3 2 2
ITPA 2 2
MC4R 2 2
MT-RNR1 2 2
NAT2 2 2
SLC28A3 2 2
ABCC4 1 1
ABCC8, KCNJ11 1 1
ABCG2 1 1
ACE 1 1
ACYP2 1 1
ADD1 1 1
ADORA2A, SPECC1L-ADORA2A 1 1
ADRB2 1 1
ANKK1, DRD2 1 1
APOA5 1 1
APOE 1 1
ATIC 1 1
C11orf65 1 1
C8orf34 1 1
CALU 1 1
CBR3 1 1
CCHCR1 1 1
CD3EAP, ERCC1 1 1
CDCA3, GNB3 1 1
CES1 1 1
CETP 1 1
CFTR, LOC113633877 1 1
CFTR, LOC113664106 1 1
CHRNA5 1 1
CHRNB2 1 1
COL22A1 1 1
COMT 1 1
COMT, TXNRD2 1 1
COQ2 1 1
CRHR1, LINC02210-CRHR1 1 1
CRHR2 1 1
CYP19A1, MIR4713HG, PIRC66 1 1
CYP2C19, LOC110599570 1 1
CYP2C8 1 1
CYP2D6 1 1
CYP3A4, LOC110366354 1 1
CYP3A5, ZSCAN25 1 1
CYP4F2 1 1
DPP6 1 1
DYNC2H1 1 1
EGF 1 1
ENOSF1, TYMS 1 1
ERCC1 1 1
F5 1 1
FCGR2A 1 1
FCGR3A 1 1
FDPS 1 1
FKBP5 1 1
FLT3 1 1
G6PD 1 1
GATM 1 1
GGCX 1 1
GP1BA 1 1
GRIK4 1 1
GSTP1 1 1
HAS3 1 1
HMGCR 1 1
HTR1A 1 1
HTR2A 1 1
IFNL3, IFNL4 1 1
IFNL4 1 1
KIF6 1 1
KRAS 1 1
LOC100996325 1 1
LOC110121472, TCF7L2 1 1
LPA 1 1
LTC4S 1 1
MT-RNR1, MT-TS1 1 1
MTHFR 1 1
MTRR 1 1
NEDD4L 1 1
NQO1 1 1
NT5C2 1 1
NUDT15 1 1
OPRD1 1 1
OPRM1 1 1
PNPLA3 1 1
PRKCA 1 1
PTGFR 1 1
PTGS1 1 1
SCN1A 1 1
SEMA3C 1 1
SOD2 1 1
TMEM43, XPC 1 1
TNF 1 1
TP53 1 1
UGT1A, UGT1A10, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9 1 1
UGT1A, UGT1A10, UGT1A8, UGT1A9 1 1
UGT2B10 1 1
UGT2B15 1 1
UMPS 1 1
VDR 1 1
XRCC1 1 1
YEATS4 1 1

Condition and significance breakdown #

Total conditions: 254
Download table as spreadsheet
Condition drug response total
desflurane response - Toxicity/ADR 46 46
enflurane response - Toxicity/ADR 46 46
halothane response - Toxicity/ADR 46 46
isoflurane response - Toxicity/ADR 46 46
methoxyflurane response - Toxicity/ADR 46 46
sevoflurane response - Toxicity/ADR 46 46
succinylcholine response - Toxicity/ADR 46 46
ivacaftor response - Efficacy 33 33
warfarin response - Dosage 19 19
radiotherapy response - Toxicity/ADR 6 6
antipsychotics response - Toxicity/ADR 5 5
acenocoumarol response - Dosage 4 4
anthracyclines and related substances response - Toxicity/ADR 4 4
cisplatin response - Toxicity/ADR 4 4
efavirenz response - Metabolism/PK 4 4
fluorouracil response - Other 4 4
fluorouracil response - Toxicity/ADR 4 4
phenprocoumon response - Dosage 4 4
volatile anesthetics response - Toxicity/ADR 4 4
Platinum compounds response - Toxicity/ADR 3 3
SN-38 response - Other 3 3
Selective serotonin reuptake inhibitors response - Efficacy 3 3
amikacin response - Toxicity/ADR 3 3
aminoglycoside antibacterials response - Toxicity/ADR 3 3
antidepressants response - Efficacy 3 3
ataluren response - Efficacy 3 3
atorvastatin response - Efficacy 3 3
capecitabine response - Toxicity/ADR 3 3
carbamazepine response - Dosage 3 3
citalopram response - Efficacy 3 3
clozapine response - Toxicity/ADR 3 3
gefitinib response - Efficacy 3 3
gentamicin response - Toxicity/ADR 3 3
hmg coa reductase inhibitors response - Toxicity/ADR 3 3
hydrochlorothiazide response - Efficacy 3 3
irinotecan response - Toxicity/ADR 3 3
kanamycin response - Toxicity/ADR 3 3
methotrexate response - Toxicity/ADR 3 3
neomycin response - Toxicity/ADR 3 3
nevirapine response - Toxicity/ADR 3 3
olanzapine response - Toxicity/ADR 3 3
pravastatin response - Efficacy 3 3
risperidone response - Toxicity/ADR 3 3
salbutamol response - Efficacy 3 3
simvastatin response - Efficacy 3 3
simvastatin response - Toxicity/ADR 3 3
streptomycin response - Toxicity/ADR 3 3
tobramycin response - Toxicity/ADR 3 3
HMG CoA reductase inhibitors response - Efficacy 2 2
Pyrimidine analogues response - Toxicity/ADR, Metabolism/PK 2 2
acenocoumarol response - Toxicity/ADR 2 2
aspirin response - Efficacy 2 2
capecitabine response - Toxicity/ADR, Metabolism/PK 2 2
carboplatin response - Efficacy 2 2
cisplatin response - Efficacy, Toxicity/ADR 2 2
clopidogrel response - Efficacy 2 2
clopidogrel response - Efficacy, Toxicity/ADR 2 2
cyclophosphamide response - Efficacy 2 2
cyclophosphamide response - Toxicity/ADR 2 2
erlotinib response - Efficacy 2 2
ethanol response - Toxicity/ADR 2 2
fluorouracil response - Efficacy 2 2
fluorouracil response - Toxicity/ADR, Metabolism/PK 2 2
methadone response - Dosage, Efficacy 2 2
morphine response - Dosage, Efficacy 2 2
nevirapine response - Other 2 2
nicotine response - Toxicity/ADR 2 2
ondansetron response - Efficacy 2 2
opioids response - Dosage, Efficacy 2 2
oxycodone response - Dosage, Efficacy 2 2
paroxetine response - Efficacy 2 2
peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, and telaprevir response - Efficacy 2 2
peginterferon alfa-2b and ribavirin response - Toxicity/ADR 2 2
peginterferon alfa-2b response - Efficacy 2 2
ribavirin response - Efficacy 2 2
sulfonamides, urea derivatives response - Efficacy 2 2
tegafur response - Toxicity/ADR 2 2
tegafur response - Toxicity/ADR, Metabolism/PK 2 2
tramadol response - Dosage, Efficacy 2 2
trastuzumab response - Efficacy 2 2
vincristine response - Toxicity/ADR 2 2
warfarin response - Toxicity/ADR 2 2
Alkylating Agents, anthracyclines and related substances, fluorouracil, and Platinum compounds response - Efficacy 1 1
Antiinflammatory agents, non-steroids response - Toxicity/ADR 1 1
Bisphosphonates response - Efficacy 1 1
Drugs used in opioid dependence response - Dosage, Efficacy, Metabolism/PK 1 1
Ivacaftor response 1 1
Platinum compounds response - Efficacy 1 1
Platinum compounds response - Efficacy, Toxicity/ADR 1 1
Pyrimidine analogues response - Toxicity/ADR 1 1
Tumor necrosis factor alpha (TNF-alpha) inhibitors response - Efficacy 1 1
acenocoumarol response - Dosage, Toxicity/ADR 1 1
adalimumab response - Efficacy 1 1
alfentanil response - Dosage, Efficacy, Metabolism/PK 1 1
allopurinol response - Dosage, Efficacy 1 1
amisulpride response - Toxicity/ADR 1 1
amitriptyline response - Dosage, Toxicity/ADR 1 1
amitriptyline response - Efficacy 1 1
anastrozole response - Efficacy 1 1
antidepressants response - Dosage, Toxicity/ADR 1 1
antiepileptics response - Efficacy 1 1
antineoplastic agents response - Efficacy, Toxicity/ADR 1 1
aripiprazole response - Toxicity/ADR 1 1
asparaginase response - Toxicity/ADR 1 1
aspirin response - Toxicity/ADR 1 1
atazanavir and ritonavir response - Toxicity/ADR 1 1
atazanavir response - Other 1 1
atorvastatin response - Toxicity/ADR 1 1
azathioprine response - Dosage, Toxicity/ADR 1 1
azathioprine response - Toxicity/ADR 1 1
boceprevir response - Efficacy 1 1
boceprevir, peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, simeprevir, and telaprevir response - Efficacy 1 1
budesonide response - Efficacy 1 1
buprenorphine response - Dosage 1 1
buprenorphine response - Dosage, Efficacy, Metabolism/PK 1 1
buprenorphine response - Efficacy 1 1
bupropion response - Efficacy 1 1
caffeine response - Toxicity/ADR 1 1
capecitabine response - Efficacy 1 1
captopril response - Efficacy 1 1
carbamazepine response - Efficacy 1 1
carboplatin response - Efficacy, Toxicity/ADR 1 1
carboplatin, docetaxel, erlotinib, gemcitabine, and paclitaxel response - Efficacy 1 1
celecoxib response - Dosage 1 1
celecoxib response - Toxicity/ADR 1 1
cerivastatin response - Toxicity/ADR 1 1
cetuximab response - Dosage 1 1
cetuximab response - Efficacy 1 1
chlorproguanil and dapsone response - Toxicity/ADR 1 1
cisplatin response - Efficacy 1 1
citalopram response - Metabolism/PK 1 1
clomipramine response - Dosage, Toxicity/ADR 1 1
clomipramine response - Efficacy 1 1
clopidogrel response - Dosage, Efficacy, Toxicity/ADR 1 1
cocaine response - Toxicity/ADR 1 1
corticosteroids response - Efficacy 1 1
cyclophosphamide and epirubicin response - Efficacy, Toxicity/ADR 1 1
cyclophosphamide response - Efficacy, Toxicity/ADR 1 1
cyclosporine response - Dosage, Metabolism/PK 1 1
daunorubicin response - Toxicity/ADR 1 1
desipramine response - Dosage, Toxicity/ADR 1 1
diclofenac response - Toxicity/ADR 1 1
digoxin response - Other 1 1
diuretics response - Efficacy 1 1
docetaxel response - Efficacy 1 1
doxepin response - Dosage, Toxicity/ADR 1 1
doxorubicin response - Efficacy 1 1
efavirenz response - Dosage 1 1
efavirenz response - Toxicity/ADR 1 1
epirubicin response - Efficacy 1 1
escitalopram response - Metabolism/PK 1 1
etanercept response - Efficacy 1 1
ethambutol, isoniazid, pyrazinamide, and rifampin response - Toxicity/ADR 1 1
ethambutol, isoniazid, pyrazinamide, and rifampin response - Toxicity/ADR, Metabolism/PK 1 1
etoposide response - Toxicity/ADR 1 1
exemestane response - Efficacy 1 1
fentanyl response - Dosage 1 1
fentanyl response - Dosage, Efficacy 1 1
fentanyl response - Dosage, Efficacy, Metabolism/PK 1 1
fluorouracil and oxaliplatin response - Efficacy 1 1
fluorouracil response - Efficacy, Toxicity/ADR 1 1
fluoxetine response - Efficacy 1 1
fluticasone propionate response - Efficacy 1 1
fluticasone/salmeterol response - Efficacy 1 1
furosemide and spironolactone response - Efficacy 1 1
gemcitabine response - Other 1 1
glibenclamide response - Efficacy 1 1
gliclazide response - Efficacy 1 1
glimepiride response - Efficacy 1 1
glipizide response - Efficacy 1 1
gliquidone response - Efficacy 1 1
haloperidol response - Toxicity/ADR 1 1
heroin response - Dosage, Efficacy, Metabolism/PK 1 1
hmg coa reductase inhibitors response - Efficacy, Toxicity/ADR 1 1
hmg coa reductase inhibitors response - Toxicity/ADR, Metabolism/PK 1 1
hormonal contraceptives for systemic use response - Toxicity/ADR 1 1
imipramine response - Dosage, Toxicity/ADR 1 1
infliximab response - Efficacy 1 1
interferon alfa-2b, recombinant and ribavirin response - Dosage, Toxicity/ADR 1 1
interferons, peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy 1 1
irinotecan response - Other 1 1
ivacaftor / lumacaftor response - Efficacy 1 1
lamotrigine response - Other 1 1
latanoprost response - Efficacy 1 1
leucovorin response - Toxicity/ADR 1 1
lorazepam response - Other 1 1
lovastatin response - Efficacy 1 1
meperidine response - Dosage 1 1
mercaptopurine response - Dosage, Toxicity/ADR 1 1
metformin response - Efficacy 1 1
methadone response - Dosage 1 1
methotrexate response - Dosage, Efficacy, Toxicity/ADR 1 1
methotrexate response - Efficacy 1 1
mirtazapine response - Efficacy 1 1
morphine response - Dosage 1 1
morphine response - Dosage, Efficacy, Metabolism/PK 1 1
naloxone response - Efficacy 1 1
nicotine response - Efficacy 1 1
nicotine response - Efficacy, Toxicity/ADR 1 1
nicotine response - Metabolism/PK 1 1
nicotine response - Toxicity/ADR, Metabolism/PK 1 1
nortriptyline response - Dosage, Toxicity/ADR 1 1
opioids response - Dosage 1 1
opioids response - Dosage, Efficacy, Metabolism/PK 1 1
oxaliplatin response - Efficacy 1 1
oxaliplatin response - Efficacy, Toxicity/ADR 1 1
oxazepam response - Other 1 1
paclitaxel response - Efficacy 1 1
paclitaxel response - Efficacy, Toxicity/ADR 1 1
paliperidone response - Toxicity/ADR 1 1
panitumumab response - Dosage 1 1
peginterferon alfa-2a response - Efficacy 1 1
peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy 1 1
peginterferon alfa-2b and ribavirin response - Efficacy 1 1
pentazocine response - Dosage 1 1
phenytoin response - Dosage 1 1
platinum response - Efficacy 1 1
platinum response - Efficacy, Toxicity/ADR 1 1
platinum response - Toxicity/ADR 1 1
pravastatin response - Metabolism/PK 1 1
prednisolone response - Toxicity/ADR 1 1
quetiapine response - Toxicity/ADR 1 1
radiotherapy response - Efficacy 1 1
remifentanil response - Dosage, Efficacy 1 1
risperidone response - Efficacy 1 1
rituximab response - Efficacy 1 1
rosiglitazone response - Metabolism/PK 1 1
rosuvastatin response - Efficacy 1 1
rosuvastatin response - Other 1 1
rosuvastatin response - Toxicity/ADR 1 1
salmeterol response - Efficacy 1 1
selective beta-2-adrenoreceptor agonists response - Efficacy 1 1
sildenafil response - Efficacy 1 1
simvastatin acid response - Metabolism/PK 1 1
sirolimus response - Dosage 1 1
sirolimus response - Metabolism/PK 1 1
sufentanil response - Dosage, Efficacy 1 1
sunitinib response - Toxicity/ADR 1 1
tacrolimus response (donor genotype) - Dosage, Metabolism/PK 1 1
tacrolimus response (recipient genotype) - Dosage, Metabolism/PK 1 1
tacrolimus response - Dosage 1 1
tacrolimus response - Efficacy 1 1
tamoxifen response - Efficacy 1 1
tamoxifen response - Efficacy, Toxicity/ADR 1 1
tenofovir response - Metabolism/PK 1 1
tramadol response - Dosage, Efficacy, Metabolism/PK 1 1
triamcinolone response - Efficacy 1 1
trimipramine response - Dosage, Toxicity/ADR 1 1
venlafaxine response - Efficacy 1 1
warfarin response - Dosage, Toxicity/ADR 1 1
warfarin response - Efficacy 1 1
warfarin response - Efficacy, Toxicity/ADR 1 1
warfarin response - Other 1 1
ziprasidone response - Toxicity/ADR 1 1

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