Variants from A.C.Camargo Cancer Center / LGBM, A.C.Camargo Cancer Center

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
63	1	28	0	0	92

Gene and significance breakdown #

Total genes and gene combinations: 8

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	total
BRCA2	11	0	16	27
BRCA1	20	0	5	25
MLH1	12	1	2	15
MSH2	11	0	0	11
MSH6	3	0	3	6
BRCA1, LOC126862571	3	0	2	5
TP53	2	0	0	2
CHEK2	1	0	0	1

Condition and significance breakdown #

Total conditions: 3

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Condition	pathogenic	likely pathogenic	uncertain significance	total
Breast neoplasm	32	0	22	54
Lynch syndrome	26	1	5	32
Familial cancer of breast	5	0	1	6

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