Variants from Institute of Reproductive Genetics, University of Münster

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
42	47	43	5	0	131

Gene and significance breakdown #

Total genes and gene combinations: 36

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	likely benign	total
AR	6	7	10	0	22
CFTR	9	2	2	1	14
TEX14	6	2	4	0	12
TRIM71	0	1	8	2	11
NR5A1	1	7	3	0	9
TEX15	1	0	5	1	7
M1AP	1	0	5	0	6
FKBP6	2	3	0	0	5
DDX3Y	0	4	0	0	4
MSH4	0	4	0	0	4
CFTR, LOC111674472	3	0	0	0	3
MSH5, MSH5-SAPCD1	2	1	0	0	3
SPOCD1	0	3	0	0	3
SYCP2	3	3	0	0	3
KLHL10	0	0	2	0	2
RXFP2	1	1	0	0	2
STAG3	0	2	0	0	2
ADAD2, LOC126862424, LOC654780	1	0	0	0	1
ADGRG2	1	0	0	0	1
AR, LOC109504725	0	1	0	0	1
CFTR, LOC113664106, LOC113664107	1	0	0	0	1
DMRT1	0	1	0	0	1
DMRT1, LOC130001446	0	0	1	0	1
DNMT3B	0	0	1	0	1
GCNA	0	1	0	0	1
INSL3	0	1	0	0	1
MCM9	0	1	0	0	1
MON1B, SYCE1L	0	0	0	1	1
RAD21L1	1	0	0	0	1
REC8	0	0	1	0	1
RNF212	0	0	1	0	1
SHOC1	1	0	0	0	1
SPO11	0	1	0	0	1
TERB1	1	0	0	0	1
TERB2	0	1	0	0	1
ZMYND15	1	0	0	0	1

Condition and significance breakdown #

Total conditions: 8

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Condition	pathogenic	likely pathogenic	uncertain significance	likely benign	total
Non-obstructive azoospermia	21	21	25	4	71
Male infertility	8	15	13	0	36
Obstructive azoospermia	14	2	2	1	19
Cryptozoospermia	0	2	4	0	6
Bilateral cryptorchidism	1	2	0	0	3
Male infertility with azoospermia or oligozoospermia due to single gene mutation	0	3	0	0	3
Non-obstructive azoospermia; Spermatogenesis maturation arrest	0	2	0	0	2
Spermatocyte maturation arrest	0	1	0	0	1

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