ClinVar Miner

Variants from German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne

Location: Germany — Primary collection method: research
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign total
246 173 0 0 0 419

Gene and significance breakdown #

Total genes and gene combinations: 25
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Gene or gene combination pathogenic likely pathogenic total
TP53 87 137 224
BRCA1 64 4 68
BRCA2 30 1 31
PTEN 12 9 21
PIK3CA 6 7 13
FANCM 8 0 8
RAD51C 6 2 8
PALB2 3 4 7
MAP3K1 4 1 5
MSH6 4 1 5
RAD51D, RAD51L3-RFFL 2 2 4
ATM 3 0 3
BRIP1 2 1 3
CHEK1 2 1 3
MSH2 3 0 3
ATM, C11orf65 1 1 2
CHEK2 2 0 2
MRE11 2 0 2
ABRAXAS1 1 0 1
BARD1 0 1 1
BUB1B, BUB1B-PAK6 1 0 1
NBN 1 0 1
PMS2 1 0 1
RAD50 0 1 1
XRCC2 1 0 1

Condition and significance breakdown #

Total conditions: 1
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Condition pathogenic likely pathogenic total
Ovarian Neoplasms 246 173 419

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