List of variants in gene FLNA reported as uncertain significance by Ambry Genetics

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants: 204

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HGVS	dbSNP	gnomAD frequency
NM_001110556.2(FLNA):c.65A>G (p.Asp22Gly)	rs782598729	0.00032
NM_001110556.2(FLNA):c.5313+4C>T	rs377330443	0.00028
NM_001110556.2(FLNA):c.2813C>T (p.Thr938Met)	rs782180774	0.00014
NM_001110556.2(FLNA):c.1933G>A (p.Val645Ile)	rs373286506	0.00012
NM_001110556.2(FLNA):c.1238C>T (p.Thr413Met)	rs782549299	0.00011
NM_001110556.2(FLNA):c.1310G>A (p.Arg437Gln)	rs782320818	0.00011
NM_001110556.2(FLNA):c.1771G>A (p.Val591Ile)	rs200673062	0.00011
NM_001110556.2(FLNA):c.1376C>T (p.Thr459Met)	rs375463904	0.00010
NM_001110556.2(FLNA):c.7135T>C (p.Tyr2379His)	rs781881872	0.00010
NM_001110556.2(FLNA):c.2123G>A (p.Arg708Gln)	rs371707134	0.00009
NM_001110556.2(FLNA):c.4075C>T (p.Arg1359Cys)	rs369768801	0.00009
NM_001110556.2(FLNA):c.2183A>G (p.Asn728Ser)	rs375038091	0.00008
NM_001110556.2(FLNA):c.2323T>C (p.Tyr775His)	rs371839875	0.00008
NM_001110556.2(FLNA):c.2614G>A (p.Ala872Thr)	rs185503240	0.00008
NM_001110556.2(FLNA):c.5911A>T (p.Ile1971Phe)	rs190712778	0.00008
NM_001110556.2(FLNA):c.3106C>T (p.Arg1036Cys)	rs781844419	0.00007
NM_001110556.2(FLNA):c.7172G>A (p.Arg2391His)	rs727503930	0.00007
NM_001110556.2(FLNA):c.7205T>C (p.Ile2402Thr)	rs202152952	0.00007
NM_001110556.2(FLNA):c.2843A>G (p.Asn948Ser)	rs372718245	0.00006
NM_001110556.2(FLNA):c.4060G>A (p.Asp1354Asn)	rs377390031	0.00006
NM_001110556.2(FLNA):c.5492G>A (p.Arg1831Gln)	rs781882457	0.00006
NM_001110556.2(FLNA):c.1042C>G (p.Pro348Ala)	rs782643025	0.00005
NM_001110556.2(FLNA):c.4475-4C>T	rs199652065	0.00005
NM_001110556.2(FLNA):c.4945+3G>A	rs372673802	0.00005
NM_001110556.2(FLNA):c.5342A>G (p.Asn1781Ser)	rs373089783	0.00005
NM_001110556.2(FLNA):c.968C>T (p.Pro323Leu)	rs371830740	0.00005
NM_001110556.2(FLNA):c.1327C>T (p.Arg443Cys)	rs782673341	0.00004
NM_001110556.2(FLNA):c.1964G>A (p.Arg655His)	rs782563602	0.00004
NM_001110556.2(FLNA):c.2023-5G>A	rs782694533	0.00004
NM_001110556.2(FLNA):c.4183C>T (p.Pro1395Ser)	rs782161982	0.00004
NM_001110556.2(FLNA):c.5138C>T (p.Thr1713Met)	rs782555986	0.00004
NM_001110556.2(FLNA):c.6175G>A (p.Glu2059Lys)	rs782779958	0.00004
NM_001110556.2(FLNA):c.6314C>G (p.Thr2105Ser)	rs200200745	0.00004
NM_001110556.2(FLNA):c.1019G>A (p.Arg340His)	rs371368679	0.00003
NM_001110556.2(FLNA):c.1609G>A (p.Val537Met)	rs782067087	0.00003
NM_001110556.2(FLNA):c.2057G>A (p.Gly686Asp)	rs1360829798	0.00003
NM_001110556.2(FLNA):c.2077G>A (p.Ala693Thr)	rs782158357	0.00003
NM_001110556.2(FLNA):c.2405-5C>T	rs781892155	0.00003
NM_001110556.2(FLNA):c.2925G>C (p.Lys975Asn)	rs375495397	0.00003
NM_001110556.2(FLNA):c.3224C>T (p.Pro1075Leu)	rs782406278	0.00003
NM_001110556.2(FLNA):c.3242G>A (p.Ser1081Asn)	rs782561908	0.00003
NM_001110556.2(FLNA):c.3367T>G (p.Ser1123Ala)	rs368441729	0.00003
NM_001110556.2(FLNA):c.3368C>G (p.Ser1123Cys)	rs782361719	0.00003
NM_001110556.2(FLNA):c.3985C>T (p.His1329Tyr)	rs782746289	0.00003
NM_001110556.2(FLNA):c.4106C>T (p.Thr1369Ile)	rs376774130	0.00003
NM_001110556.2(FLNA):c.5062G>A (p.Val1688Met)	rs782751731	0.00003
NM_001110556.2(FLNA):c.5219C>T (p.Ala1740Val)	rs782714867	0.00003
NM_001110556.2(FLNA):c.5951C>T (p.Thr1984Met)	rs782639698	0.00003
NM_001110556.2(FLNA):c.6863G>A (p.Arg2288His)	rs782275601	0.00003
NM_001110556.2(FLNA):c.6871G>A (p.Gly2291Ser)	rs797044739	0.00003
NM_001110556.2(FLNA):c.7059T>G (p.Phe2353Leu)	rs864622713	0.00003
NM_001110556.2(FLNA):c.1060C>T (p.His354Tyr)	rs1489530369	0.00002
NM_001110556.2(FLNA):c.1406C>T (p.Pro469Leu)	rs782434140	0.00002
NM_001110556.2(FLNA):c.1454C>T (p.Ala485Val)	rs782262202	0.00002
NM_001110556.2(FLNA):c.1894G>A (p.Asp632Asn)	rs782718606	0.00002
NM_001110556.2(FLNA):c.2162C>T (p.Ala721Val)	rs781840723	0.00002
NM_001110556.2(FLNA):c.2179G>A (p.Gly727Ser)	rs1460177575	0.00002
NM_001110556.2(FLNA):c.2205C>T (p.Tyr735=)	rs782551055	0.00002
NM_001110556.2(FLNA):c.2405-4G>A	rs368187218	0.00002
NM_001110556.2(FLNA):c.2662G>A (p.Glu888Lys)	rs782580568	0.00002
NM_001110556.2(FLNA):c.2974A>G (p.Thr992Ala)	rs782445995	0.00002
NM_001110556.2(FLNA):c.3251C>T (p.Ser1084Phe)	rs1557177797	0.00002
NM_001110556.2(FLNA):c.3611C>T (p.Pro1204Leu)	rs376726422	0.00002
NM_001110556.2(FLNA):c.3934C>T (p.Arg1312Cys)	rs781928289	0.00002
NM_001110556.2(FLNA):c.4420G>A (p.Asp1474Asn)	rs782129236	0.00002
NM_001110556.2(FLNA):c.4759C>T (p.Pro1587Ser)	rs782258746	0.00002
NM_001110556.2(FLNA):c.6002G>A (p.Arg2001Gln)	rs1483960506	0.00002
NM_001110556.2(FLNA):c.61G>T (p.Val21Phe)	rs1223954254	0.00002
NM_001110556.2(FLNA):c.6728C>G (p.Ala2243Gly)	rs953454766	0.00002
NM_001110556.2(FLNA):c.7259T>C (p.Val2420Ala)	rs782289803	0.00002
NM_001110556.2(FLNA):c.841C>G (p.Pro281Ala)	rs2067770833	0.00002
NM_001110556.2(FLNA):c.1045G>A (p.Glu349Lys)	rs370490152	0.00001
NM_001110556.2(FLNA):c.1270A>G (p.Met424Val)	rs782066542	0.00001
NM_001110556.2(FLNA):c.1399C>T (p.Arg467Cys)	rs367948333	0.00001
NM_001110556.2(FLNA):c.1439C>T (p.Pro480Leu)	rs782168634	0.00001
NM_001110556.2(FLNA):c.1684G>A (p.Gly562Arg)	rs781806203	0.00001
NM_001110556.2(FLNA):c.1687C>T (p.Arg563Cys)	rs782477178	0.00001
NM_001110556.2(FLNA):c.1688G>A (p.Arg563His)	rs781852373	0.00001
NM_001110556.2(FLNA):c.1765G>A (p.Gly589Ser)	rs782371876	0.00001
NM_001110556.2(FLNA):c.2104G>A (p.Gly702Ser)	rs781988346	0.00001
NM_001110556.2(FLNA):c.2254G>A (p.Val752Ile)	rs1297013254	0.00001
NM_001110556.2(FLNA):c.2492A>G (p.Asn831Ser)	rs781846227	0.00001
NM_001110556.2(FLNA):c.2791A>G (p.Asn931Asp)	rs190437842	0.00001
NM_001110556.2(FLNA):c.2826+4G>A	rs1037180469	0.00001
NM_001110556.2(FLNA):c.2831C>T (p.Pro944Leu)	rs782451202	0.00001
NM_001110556.2(FLNA):c.3643G>A (p.Gly1215Ser)	rs782482207	0.00001
NM_001110556.2(FLNA):c.3814C>T (p.Arg1272Cys)	rs1420631223	0.00001
NM_001110556.2(FLNA):c.3815G>A (p.Arg1272His)	rs2067691676	0.00001
NM_001110556.2(FLNA):c.3886C>T (p.Arg1296Cys)	rs781816229	0.00001
NM_001110556.2(FLNA):c.3925G>A (p.Val1309Ile)	rs782412141	0.00001
NM_001110556.2(FLNA):c.4207A>G (p.Met1403Val)	rs781976719	0.00001
NM_001110556.2(FLNA):c.4208T>G (p.Met1403Arg)	rs886039174	0.00001
NM_001110556.2(FLNA):c.4243A>C (p.Ile1415Leu)	rs2067686132	0.00001
NM_001110556.2(FLNA):c.4294C>A (p.Gln1432Lys)	rs192337215	0.00001
NM_001110556.2(FLNA):c.4666A>G (p.Asn1556Asp)	rs782605190	0.00001
NM_001110556.2(FLNA):c.4825G>A (p.Val1609Met)	rs782314291	0.00001
NM_001110556.2(FLNA):c.5127C>A (p.Asp1709Glu)	rs1557176627	0.00001
NM_001110556.2(FLNA):c.5257C>T (p.Arg1753Trp)	rs782147650	0.00001
NM_001110556.2(FLNA):c.5533C>T (p.Arg1845Cys)	rs782307604	0.00001
NM_001110556.2(FLNA):c.5591A>G (p.Asn1864Ser)	rs782095418	0.00001
NM_001110556.2(FLNA):c.5753G>A (p.Gly1918Glu)	rs373862172	0.00001
NM_001110556.2(FLNA):c.5786C>T (p.Pro1929Leu)	rs782359458	0.00001
NM_001110556.2(FLNA):c.5875C>T (p.Arg1959Cys)	rs10458342	0.00001
NM_001110556.2(FLNA):c.6019G>A (p.Val2007Met)	rs200956777	0.00001
NM_001110556.2(FLNA):c.6601C>T (p.Arg2201Cys)	rs782621818	0.00001
NM_001110556.2(FLNA):c.6607G>A (p.Val2203Ile)	rs782562592	0.00001
NM_001110556.2(FLNA):c.6719A>G (p.Lys2240Arg)	rs797045581	0.00001
NM_001110556.2(FLNA):c.6725G>A (p.Arg2242Gln)	rs781984274	0.00001
NM_001110556.2(FLNA):c.6763G>C (p.Val2255Leu)	rs1557175926	0.00001
NM_001110556.2(FLNA):c.7013C>G (p.Ser2338Cys)	rs781878646	0.00001
NM_001110556.2(FLNA):c.7055C>T (p.Ser2352Phe)	rs1557175646	0.00001
NM_001110556.2(FLNA):c.7361C>T (p.Thr2454Met)	rs781788290	0.00001
NM_001110556.2(FLNA):c.7388C>T (p.Ser2463Leu)	rs1460574102	0.00001
NM_001110556.2(FLNA):c.7453G>A (p.Val2485Ile)	rs782190081	0.00001
NM_001110556.2(FLNA):c.7463C>A (p.Thr2488Asn)	rs909387820	0.00001
NM_001110556.2(FLNA):c.76G>C (p.Ala26Pro)	rs886038966	0.00001
NM_001110556.2(FLNA):c.1018C>T (p.Arg340Cys)
NM_001110556.2(FLNA):c.1019G>C (p.Arg340Pro)
NM_001110556.2(FLNA):c.1165C>T (p.Pro389Ser)	rs2148117979
NM_001110556.2(FLNA):c.1246G>C (p.Val416Leu)
NM_001110556.2(FLNA):c.1342C>T (p.Pro448Ser)
NM_001110556.2(FLNA):c.1354G>A (p.Gly452Ser)
NM_001110556.2(FLNA):c.1355G>A (p.Gly452Asp)	rs2067757148
NM_001110556.2(FLNA):c.1366G>A (p.Val456Met)	rs782495199
NM_001110556.2(FLNA):c.1387G>T (p.Val463Leu)
NM_001110556.2(FLNA):c.1516T>C (p.Tyr506His)
NM_001110556.2(FLNA):c.1609G>C (p.Val537Leu)	rs782067087
NM_001110556.2(FLNA):c.1635G>A (p.Met545Ile)
NM_001110556.2(FLNA):c.1698C>G (p.Phe566Leu)	rs781830848
NM_001110556.2(FLNA):c.1769T>G (p.Val590Gly)
NM_001110556.2(FLNA):c.1799A>G (p.Glu600Gly)	rs1603362451
NM_001110556.2(FLNA):c.1807G>T (p.Gly603Trp)	rs200116438
NM_001110556.2(FLNA):c.1883A>T (p.Asp628Val)
NM_001110556.2(FLNA):c.188G>T (p.Arg63Leu)
NM_001110556.2(FLNA):c.1939G>T (p.Val647Leu)
NM_001110556.2(FLNA):c.1997C>G (p.Ala666Gly)	rs374295965
NM_001110556.2(FLNA):c.2021G>A (p.Arg674Lys)
NM_001110556.2(FLNA):c.2171A>G (p.Lys724Arg)
NM_001110556.2(FLNA):c.2203T>C (p.Tyr735His)
NM_001110556.2(FLNA):c.2280+5G>A
NM_001110556.2(FLNA):c.2360A>G (p.His787Arg)
NM_001110556.2(FLNA):c.2447G>C (p.Gly816Ala)
NM_001110556.2(FLNA):c.2493T>A (p.Asn831Lys)
NM_001110556.2(FLNA):c.25G>T (p.Gly9Cys)	rs782292045
NM_001110556.2(FLNA):c.2629G>C (p.Ala877Pro)	rs377046577
NM_001110556.2(FLNA):c.2632G>A (p.Glu878Lys)	rs1569551740
NM_001110556.2(FLNA):c.2899C>T (p.Pro967Ser)
NM_001110556.2(FLNA):c.2909A>G (p.Asp970Gly)
NM_001110556.2(FLNA):c.29A>C (p.Gln10Pro)
NM_001110556.2(FLNA):c.3127G>T (p.Val1043Leu)	rs1475916528
NM_001110556.2(FLNA):c.3212A>C (p.Lys1071Thr)
NM_001110556.2(FLNA):c.3234G>C (p.Gln1078His)	rs1569551691
NM_001110556.2(FLNA):c.331C>G (p.Leu111Val)
NM_001110556.2(FLNA):c.3350A>G (p.Asn1117Ser)	rs1209865046
NM_001110556.2(FLNA):c.34G>A (p.Ala12Thr)
NM_001110556.2(FLNA):c.3619G>A (p.Val1207Met)
NM_001110556.2(FLNA):c.3638G>A (p.Gly1213Asp)	rs886038999
NM_001110556.2(FLNA):c.3709G>A (p.Gly1237Ser)
NM_001110556.2(FLNA):c.3775C>G (p.Gln1259Glu)
NM_001110556.2(FLNA):c.3934C>G (p.Arg1312Gly)
NM_001110556.2(FLNA):c.4147G>A (p.Ala1383Thr)
NM_001110556.2(FLNA):c.4438G>A (p.Val1480Met)
NM_001110556.2(FLNA):c.4465G>C (p.Gly1489Arg)	rs782276039
NM_001110556.2(FLNA):c.4520A>G (p.Gln1507Arg)
NM_001110556.2(FLNA):c.4525G>A (p.Val1509Ile)	rs782018054
NM_001110556.2(FLNA):c.4525G>T (p.Val1509Phe)
NM_001110556.2(FLNA):c.4544G>A (p.Arg1515Gln)	rs782597696
NM_001110556.2(FLNA):c.4612A>G (p.Lys1538Glu)
NM_001110556.2(FLNA):c.4749G>C (p.Gln1583His)
NM_001110556.2(FLNA):c.4834G>A (p.Val1612Met)	rs782082407
NM_001110556.2(FLNA):c.487G>A (p.Ala163Thr)	rs1569551875
NM_001110556.2(FLNA):c.4919G>C (p.Gly1640Ala)
NM_001110556.2(FLNA):c.5075_5092dup (p.Asp1692_Asp1697dup)	rs781960834
NM_001110556.2(FLNA):c.5129TCT[1] (p.Phe1711del)
NM_001110556.2(FLNA):c.5140G>A (p.Ala1714Thr)	rs886039102
NM_001110556.2(FLNA):c.5184C>T (p.Gly1728=)	rs2148107375
NM_001110556.2(FLNA):c.5208C>T (p.Phe1736=)
NM_001110556.2(FLNA):c.5252C>T (p.Pro1751Leu)
NM_001110556.2(FLNA):c.5261C>T (p.Ser1754Phe)	rs1557176515
NM_001110556.2(FLNA):c.5506G>A (p.Glu1836Lys)	rs1557176399
NM_001110556.2(FLNA):c.5659A>G (p.Thr1887Ala)	rs886039107
NM_001110556.2(FLNA):c.5734T>G (p.Cys1912Gly)
NM_001110556.2(FLNA):c.5851C>T (p.Arg1951Trp)
NM_001110556.2(FLNA):c.5873T>G (p.Met1958Arg)	rs587780336
NM_001110556.2(FLNA):c.5933C>T (p.Thr1978Met)	rs1603359437
NM_001110556.2(FLNA):c.6085C>T (p.His2029Tyr)
NM_001110556.2(FLNA):c.6372C>G (p.His2124Gln)	rs781999359
NM_001110556.2(FLNA):c.6379+5G>A	rs781923813
NM_001110556.2(FLNA):c.6411G>A (p.Glu2137=)
NM_001110556.2(FLNA):c.6498C>G (p.Ile2166Met)
NM_001110556.2(FLNA):c.6514C>A (p.Gln2172Lys)
NM_001110556.2(FLNA):c.6585C>G (p.Asn2195Lys)
NM_001110556.2(FLNA):c.6705A>C (p.Glu2235Asp)	rs1057520156
NM_001110556.2(FLNA):c.7136A>C (p.Tyr2379Ser)
NM_001110556.2(FLNA):c.7252A>T (p.Ile2418Phe)
NM_001110556.2(FLNA):c.7255C>G (p.Arg2419Gly)	rs782308324
NM_001110556.2(FLNA):c.7425T>G (p.Asp2475Glu)
NM_001110556.2(FLNA):c.7442A>G (p.Glu2481Gly)
NM_001110556.2(FLNA):c.76G>A (p.Ala26Thr)	rs886038966
NM_001110556.2(FLNA):c.79G>A (p.Glu27Lys)
NM_001110556.2(FLNA):c.827G>A (p.Arg276Gln)
NM_001110556.2(FLNA):c.830C>T (p.Pro277Leu)	rs1557179540
NM_001110556.2(FLNA):c.873C>G (p.Ile291Met)	rs782140428
NM_001110556.2(FLNA):c.900G>T (p.Lys300Asn)

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