ClinVar Miner

Variants with conflicting interpretations studied for Breast-ovarian cancer, familial 3

Coded as:
Minimum review status of the submission for Breast-ovarian cancer, familial 3: Y axis collection method of the submission for Breast-ovarian cancer, familial 3:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
3 21 0 13 4 5 0 21

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Breast-ovarian cancer, familial 3 pathogenic likely pathogenic uncertain significance likely benign benign risk factor
pathogenic 0 3 0 0 0 1
likely pathogenic 1 0 0 0 0 0
uncertain significance 0 0 0 3 2 0
likely benign 0 0 1 0 6 0
benign 0 0 0 4 0 0
risk factor 3 2 0 0 0 0

Condition to condition summary #

Total conditions: 10
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
Hereditary cancer-predisposing syndrome 0 23 0 9 4 5 0 17
Fanconi anemia, complementation group O 0 31 0 4 1 4 0 9
not provided 0 17 0 5 2 3 0 9
not specified 0 7 0 6 3 0 0 9
Breast-ovarian cancer, familial 3; Fanconi anemia, complementation group O 0 4 0 1 1 2 0 4
Breast and Ovarian Cancer Susceptibility 0 1 0 3 0 0 0 3
Fanconi anemia 0 1 0 3 0 0 0 3
Hereditary breast and ovarian cancer syndrome 0 4 0 0 1 2 0 3
Breast-ovarian cancer, familial 3 43 0 0 1 0 1 0 2
Ovarian Neoplasms 0 1 0 1 0 0 0 1

All variants with conflicting interpretations #

Total variants: 21
Download table as spreadsheet
HGVS dbSNP
NM_058216.3(RAD51C):c.1026+5_1026+7del rs587781410
NM_058216.3(RAD51C):c.134A>G (p.Glu45Gly) rs587781383
NM_058216.3(RAD51C):c.145+12T>G rs377297129
NM_058216.3(RAD51C):c.146-8A>G rs201079501
NM_058216.3(RAD51C):c.186A>G (p.Gln62=) rs28363303
NM_058216.3(RAD51C):c.195A>G (p.Arg65=) rs45511291
NM_058216.3(RAD51C):c.376G>A (p.Ala126Thr) rs61758784
NM_058216.3(RAD51C):c.397C>T (p.Gln133Ter) rs387907159
NM_058216.3(RAD51C):c.414G>C (p.Leu138Phe) rs267606999
NM_058216.3(RAD51C):c.459T>G (p.Gly153=) rs769486350
NM_058216.3(RAD51C):c.506T>C (p.Val169Ala) rs587780256
NM_058216.3(RAD51C):c.571+16A>G rs141621051
NM_058216.3(RAD51C):c.572-1G>C rs1413872299
NM_058216.3(RAD51C):c.706-18T>C rs56401264
NM_058216.3(RAD51C):c.706-2A>G rs587780259
NM_058216.3(RAD51C):c.790G>A (p.Gly264Ser) rs147241704
NM_058216.3(RAD51C):c.837+1G>A rs760235677
NM_058216.3(RAD51C):c.859A>G (p.Thr287Ala) rs28363317
NM_058216.3(RAD51C):c.904+5G>T rs587782702
NM_058216.3(RAD51C):c.90G>A (p.Ala30=) rs115414895
NM_058216.3(RAD51C):c.93del (p.Phe32fs) rs730881942

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