ClinVar Miner

Variants with conflicting interpretations studied for Colorectal cancer 10

Coded as:
Minimum review status of the submission for Colorectal cancer 10: Y axis collection method of the submission for Colorectal cancer 10:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
731 290 0 33 52 3 0 78

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Colorectal cancer 10 pathogenic likely pathogenic uncertain significance likely benign benign risk factor
pathogenic 0 1 0 0 0 1
likely pathogenic 2 0 0 0 0 2
uncertain significance 0 0 0 35 2 1
likely benign 0 0 20 0 25 0
benign 0 0 1 7 0 0
risk factor 2 2 1 0 0 0

Condition to condition summary #

Total conditions: 5
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
not provided 0 185 0 24 17 0 0 36
not specified 0 98 0 10 23 0 0 33
Hereditary cancer-predisposing syndrome 0 127 0 9 20 1 0 28
Colorectal cancer 10 1048 43 0 2 4 3 0 8
Familial colorectal cancer 0 14 0 0 2 0 0 2

All variants with conflicting interpretations #

Total variants: 78
Download table as spreadsheet
HGVS dbSNP
NM_001256849.1(POLD1):c.1138-8A>G rs41544624
NM_001256849.1(POLD1):c.1383+8C>T rs374719944
NM_001256849.1(POLD1):c.1384-13C>G rs536467012
NM_001256849.1(POLD1):c.1494+5C>T rs565428379
NM_001256849.1(POLD1):c.1687-5C>T rs199733325
NM_001256849.1(POLD1):c.2007-4G>A rs202035484
NM_001256849.1(POLD1):c.2007-5C>T rs199506387
NM_001256849.1(POLD1):c.202+3A>G rs375365167
NM_001256849.1(POLD1):c.202+6G>T
NM_001256849.1(POLD1):c.2155-6C>T rs112481714
NM_001256849.1(POLD1):c.2250+4G>A rs370478977
NM_001256849.1(POLD1):c.2251-4G>A rs768364989
NM_001256849.1(POLD1):c.2388+4C>T rs371542643
NM_001256849.1(POLD1):c.2388+9C>G rs1001555540
NM_001256849.1(POLD1):c.2718-4G>A rs755348897
NM_001256849.1(POLD1):c.2718-5C>T rs368965066
NM_001256849.1(POLD1):c.2821-4G>A rs369042179
NM_001256849.1(POLD1):c.2953+4C>T rs1057521166
NM_001256849.1(POLD1):c.3067+6C>T rs1057522005
NM_001256849.1(POLD1):c.3068-5C>T rs759650325
NM_001256849.1(POLD1):c.3120+6A>G rs1231856737
NM_001256849.1(POLD1):c.3120+6_3120+21del rs1064792944
NM_001256849.1(POLD1):c.3121-8G>A rs762920108
NM_001256849.1(POLD1):c.317-5C>T rs768082423
NM_001256849.1(POLD1):c.3218+10A>G rs2463239
NM_001256849.1(POLD1):c.3218+9_3218+10inv
NM_001256849.1(POLD1):c.3219-19C>A rs374168125
NM_001256849.1(POLD1):c.463+8G>T rs1726802
NM_001256849.1(POLD1):c.463+8_463+9delinsTT rs796285537
NM_001256849.1(POLD1):c.758+4C>G rs771346692
NM_001256849.1(POLD1):c.758+4C>T rs771346692
NM_002691.4(POLD1):c.1092G>C (p.Leu364=) rs139883454
NM_002691.4(POLD1):c.1118A>G (p.Lys373Arg) rs770407151
NM_002691.4(POLD1):c.1148C>T (p.Thr383Ile) rs201654210
NM_002691.4(POLD1):c.1421T>C (p.Leu474Pro) rs587777627
NM_002691.4(POLD1):c.1433G>A (p.Ser478Asn) rs397514632
NM_002691.4(POLD1):c.1449C>T (p.Gly483=) rs878854522
NM_002691.4(POLD1):c.1527T>A (p.Ala509=) rs1229053013
NM_002691.4(POLD1):c.1539G>A (p.Leu513=) rs2230246
NM_002691.4(POLD1):c.1548C>T (p.Ala516=) rs2230247
NM_002691.4(POLD1):c.1620C>T (p.Gly540=) rs140216790
NM_002691.4(POLD1):c.1795G>A (p.Ala599Thr) rs149569984
NM_002691.4(POLD1):c.17G>A (p.Arg6Gln) rs778275831
NM_002691.4(POLD1):c.1860G>A (p.Thr620=) rs1726790
NM_002691.4(POLD1):c.1893C>G (p.Gly631=) rs774216194
NM_002691.4(POLD1):c.1977C>T (p.Ile659=) rs45605236
NM_002691.4(POLD1):c.2052G>C (p.Gln684His) rs144143245
NM_002691.4(POLD1):c.2115C>T (p.Gly705=) rs777115075
NM_002691.4(POLD1):c.2178G>C (p.Gln726His) rs747483140
NM_002691.4(POLD1):c.2251-8G>A rs56051075
NM_002691.4(POLD1):c.2275G>A (p.Val759Ile) rs145473716
NM_002691.4(POLD1):c.2337G>A (p.Ala779=) rs147108748
NM_002691.4(POLD1):c.2429C>T (p.Ala810Val) rs765981178
NM_002691.4(POLD1):c.2433C>T (p.Gly811=) rs1051057675
NM_002691.4(POLD1):c.2577C>T (p.Gly859=) rs149366027
NM_002691.4(POLD1):c.2757C>T (p.Gly919=) rs757406292
NM_002691.4(POLD1):c.2838G>A (p.Leu946=) rs1060501814
NM_002691.4(POLD1):c.2967G>A (p.Thr989=) rs3218752
NM_002691.4(POLD1):c.3054G>A (p.Val1018=) rs369613619
NM_002691.4(POLD1):c.399G>A (p.Glu133=) rs757940686
NM_002691.4(POLD1):c.455C>T (p.Ala152Val) rs41563714
NM_002691.4(POLD1):c.495A>G (p.Gln165=) rs756717437
NM_002691.4(POLD1):c.534G>T (p.Gly178=) rs376129517
NM_002691.4(POLD1):c.55C>T (p.Arg19Cys) rs368033860
NM_002691.4(POLD1):c.56G>A (p.Arg19His) rs3218773
NM_002691.4(POLD1):c.583C>T (p.Arg195Ter) rs377690809
NM_002691.4(POLD1):c.589A>C (p.Ser197Arg) rs1040524947
NM_002691.4(POLD1):c.714G>A (p.Thr238=) rs149096523
NM_002691.4(POLD1):c.773C>T (p.Thr258Met) rs76131127
NM_002691.4(POLD1):c.798G>A (p.Leu266=) rs1017934812
NM_002691.4(POLD1):c.80A>T (p.Asp27Val) rs150066950
NM_002691.4(POLD1):c.849G>T (p.Gln283His) rs113282414
NM_002691.4(POLD1):c.883G>A (p.Val295Met) rs199545019
NM_002691.4(POLD1):c.88C>T (p.Arg30Trp) rs3218772
NM_002691.4(POLD1):c.900G>A (p.Pro300=) rs142407935
NM_002691.4(POLD1):c.971-5C>G rs778993986
NM_002691.4(POLD1):c.980C>T (p.Pro327Leu) rs397514633
NM_002691.4(POLD1):c.99A>G (p.Gln33=) rs751090809

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