ClinVar Miner

Variants with conflicting interpretations studied for FLNB-related condition

Minimum review status of the submission for FLNB-related condition: Collection method of the submission for FLNB-related condition:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
17 24 0 17 34 0 0 47

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
FLNB-related condition uncertain significance likely benign benign
uncertain significance 0 9 0
likely benign 24 0 14
benign 1 3 0

Condition to condition summary #

Total conditions: 3
Download table as spreadsheet
Condition Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
not provided 0 34 0 17 21 0 0 37
FLNB-Related Spectrum Disorders 0 14 0 1 15 0 0 16
not specified 0 8 0 4 3 0 0 7

All variants with conflicting interpretations #

Total variants: 47
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_001457.4(FLNB):c.3240G>A (p.Pro1080=) rs77989135 0.00333
NM_001457.4(FLNB):c.1559C>T (p.Pro520Leu) rs138220431 0.00247
NM_001457.4(FLNB):c.274A>G (p.Ile92Val) rs62622011 0.00229
NM_001457.4(FLNB):c.1472T>C (p.Met491Thr) rs147575358 0.00203
NM_001457.4(FLNB):c.6231C>T (p.Asp2077=) rs145280904 0.00184
NM_001457.4(FLNB):c.6683T>C (p.Ile2228Thr) rs149629209 0.00148
NM_001457.4(FLNB):c.7668C>T (p.Cys2556=) rs144621434 0.00125
NM_001457.4(FLNB):c.6047G>A (p.Arg2016Gln) rs137885421 0.00117
NM_001457.4(FLNB):c.3522G>A (p.Ser1174=) rs140993979 0.00111
NM_001457.4(FLNB):c.2453G>A (p.Arg818Gln) rs151259375 0.00091
NM_001457.4(FLNB):c.3288C>T (p.Ser1096=) rs77934864 0.00071
NM_001457.4(FLNB):c.4307G>A (p.Arg1436Gln) rs140018418 0.00067
NM_001457.4(FLNB):c.6843C>T (p.Ile2281=) rs140332932 0.00062
NM_001457.4(FLNB):c.4495G>A (p.Asp1499Asn) rs150445941 0.00046
NM_001457.4(FLNB):c.1196A>G (p.Lys399Arg) rs145673747 0.00043
NM_001457.4(FLNB):c.4058C>G (p.Thr1353Ser) rs142718547 0.00043
NM_001457.4(FLNB):c.3594G>A (p.Thr1198=) rs143566075 0.00024
NM_001457.4(FLNB):c.7255G>A (p.Val2419Ile) rs202143851 0.00024
NM_001457.4(FLNB):c.3052G>A (p.Val1018Met) rs2276742 0.00022
NM_001457.4(FLNB):c.5445C>T (p.Tyr1815=) rs755702006 0.00019
NM_001457.4(FLNB):c.4390+8T>A rs377095569 0.00018
NM_001457.4(FLNB):c.4590T>C (p.Tyr1530=) rs141477764 0.00014
NM_001457.4(FLNB):c.864C>T (p.Asp288=) rs141151998 0.00014
NM_001457.4(FLNB):c.7164C>T (p.Ser2388=) rs757418085 0.00006
NM_001457.4(FLNB):c.2935G>A (p.Val979Met) rs376511120 0.00004
NM_001457.4(FLNB):c.3784G>A (p.Gly1262Arg) rs139932035 0.00004
NM_001457.4(FLNB):c.6531C>T (p.Thr2177=) rs778562859 0.00004
NM_001457.4(FLNB):c.2005A>G (p.Thr669Ala) rs147481678 0.00003
NM_001457.4(FLNB):c.4170C>T (p.Phe1390=) rs374070003 0.00003
NM_001457.4(FLNB):c.1107C>T (p.Asn369=) rs538953239 0.00002
NM_001457.4(FLNB):c.1402C>T (p.Arg468Cys) rs139664696 0.00002
NM_001457.4(FLNB):c.3325G>A (p.Val1109Ile) rs200947960 0.00002
NM_001457.4(FLNB):c.6108C>T (p.Ser2036=) rs767210448 0.00002
NM_001457.4(FLNB):c.7749G>A (p.Leu2583=) rs535252967 0.00002
NM_001457.4(FLNB):c.1384C>T (p.Leu462=) rs139725835 0.00001
NM_001457.4(FLNB):c.5043G>A (p.Pro1681=) rs886042162 0.00001
NM_001457.4(FLNB):c.6755A>T (p.Tyr2252Phe) rs200567066 0.00001
NM_001457.4(FLNB):c.852C>T (p.Ala284=) rs765017696 0.00001
NM_001457.4(FLNB):c.9A>G (p.Val3=) rs199846967 0.00001
NM_001457.4(FLNB):c.107G>A (p.Arg36His) rs142568031
NM_001457.4(FLNB):c.1327G>A (p.Val443Ile) rs200902568
NM_001457.4(FLNB):c.2130G>C (p.Pro710=) rs371850879
NM_001457.4(FLNB):c.2622G>T (p.Gly874=)
NM_001457.4(FLNB):c.4172_4173inv (p.Ala1391Val)
NM_001457.4(FLNB):c.4515-24GT[4] rs151085835
NM_001457.4(FLNB):c.5274A>G (p.Gly1758=)
NM_001457.4(FLNB):c.5343C>T (p.Asp1781=)

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