ClinVar Miner

Variants with conflicting interpretations studied for Hereditary diffuse gastric cancer

Coded as:
Minimum review status of the submission for Hereditary diffuse gastric cancer: Y axis collection method of the submission for Hereditary diffuse gastric cancer:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
382 475 3 93 90 0 11 172

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Hereditary diffuse gastric cancer pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 26 4 3 3
likely pathogenic 34 0 2 1 1
uncertain significance 3 5 2 79 13
likely benign 3 0 31 0 43
benign 3 1 14 27 1

Condition to condition summary #

Total conditions: 13
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
Hereditary cancer-predisposing syndrome 0 462 0 57 72 0 7 123
not provided 0 224 3 49 36 0 3 74
not specified 0 72 0 45 39 0 4 74
Hereditary diffuse gastric cancer 833 141 0 36 25 0 3 55
Neoplasm of stomach 0 0 0 1 1 0 2 3
Endometrial carcinoma 0 0 0 0 0 0 2 2
Adenocarcinoma of stomach 0 0 0 0 1 0 1 1
Breast cancer, lobular 0 0 0 1 0 0 0 1
Colon cancer 0 0 0 0 1 0 0 1
Craniopharyngioma 0 0 0 0 1 0 0 1
Neoplasm of ovary 0 0 0 0 0 0 1 1
Neoplasm of the breast 0 0 0 1 0 0 0 1
Orofacial clefting 0 0 0 1 1 0 0 1

All variants with conflicting interpretations #

Total variants: 172
Download table as spreadsheet
HGVS dbSNP
NM_004360.5(CDH1):c.*54C>T rs1801026
NM_004360.5(CDH1):c.*8G>A rs201223411
NM_004360.5(CDH1):c.-49G>T rs564350060
NM_004360.5(CDH1):c.-54G>C rs5030874
NM_004360.5(CDH1):c.-71C>G rs34033771
NM_004360.5(CDH1):c.1008+5_1008+8dup rs1555515665
NM_004360.5(CDH1):c.1008+8G>T
NM_004360.5(CDH1):c.1008G>A (p.Glu336=) rs267606712
NM_004360.5(CDH1):c.1008G>T (p.Glu336Asp) rs267606712
NM_004360.5(CDH1):c.1009-14C>T rs368293695
NM_004360.5(CDH1):c.1018A>G (p.Thr340Ala) rs116093741
NM_004360.5(CDH1):c.1019C>T (p.Thr340Met) rs61747631
NM_004360.5(CDH1):c.1020G>A (p.Thr340=) rs61747632
NM_004360.5(CDH1):c.1118C>T (p.Pro373Leu) rs587782359
NM_004360.5(CDH1):c.1137+1G>A rs876660771
NM_004360.5(CDH1):c.1137+86T>G rs35160345
NM_004360.5(CDH1):c.1137+9A>G rs780705655
NM_004360.5(CDH1):c.1137G>A (p.Thr379=) rs587783050
NM_004360.5(CDH1):c.1138-3C>T rs36103202
NM_004360.5(CDH1):c.1161C>T (p.Asn387=) rs111266450
NM_004360.5(CDH1):c.1162G>A (p.Glu388Lys) rs372838203
NM_004360.5(CDH1):c.1168A>G (p.Asn390Asp) rs1555515870
NM_004360.5(CDH1):c.1170C>T (p.Asn390=) rs766505270
NM_004360.5(CDH1):c.1174G>A (p.Val392Ile) rs141864044
NM_004360.5(CDH1):c.1223C>T (p.Ala408Val) rs138135866
NM_004360.5(CDH1):c.1224G>A (p.Ala408=) rs200161607
NM_004360.5(CDH1):c.1225T>C (p.Trp409Arg) rs587778176
NM_004360.5(CDH1):c.1239C>T (p.Tyr413=) rs36074916
NM_004360.5(CDH1):c.1243A>G (p.Ile415Val) rs1060501239
NM_004360.5(CDH1):c.1266A>G (p.Gln422=) rs776805501
NM_004360.5(CDH1):c.1273G>A (p.Val425Ile) rs570930882
NM_004360.5(CDH1):c.1296C>G (p.Asn432Lys) rs187862045
NM_004360.5(CDH1):c.1297G>A (p.Asp433Asn) rs199886166
NM_004360.5(CDH1):c.1298A>G (p.Asp433Gly) rs376097289
NM_004360.5(CDH1):c.1302C>T (p.Gly434=) rs754580159
NM_004360.5(CDH1):c.1308G>A (p.Leu436=) rs557551011
NM_004360.5(CDH1):c.1359C>T (p.His453=) rs114861467
NM_004360.5(CDH1):c.1360G>A (p.Val454Ile) rs587780112
NM_004360.5(CDH1):c.1363G>A (p.Ala455Thr) rs876659762
NM_004360.5(CDH1):c.1409C>T (p.Thr470Ile) rs370864592
NM_004360.5(CDH1):c.1416C>T (p.Thr472=) rs139937234
NM_004360.5(CDH1):c.1417G>A (p.Val473Ile) rs36087757
NM_004360.5(CDH1):c.1458_1459TG[1] (p.Val487fs) rs1567508939
NM_004360.5(CDH1):c.1500C>T (p.Gly500=) rs781317341
NM_004360.5(CDH1):c.1565+2_1565+3insTT rs1555516200
NM_004360.5(CDH1):c.1565+5G>A rs786201861
NM_004360.5(CDH1):c.1585A>G (p.Thr529Ala) rs776890776
NM_004360.5(CDH1):c.163+4_163+6dup rs1205684749
NM_004360.5(CDH1):c.164-4G>A rs780375749
NM_004360.5(CDH1):c.164T>G (p.Val55Gly) rs587778174
NM_004360.5(CDH1):c.1679C>G (p.Thr560Arg) rs746481984
NM_004360.5(CDH1):c.1680G>C (p.Thr560=) rs35741240
NM_004360.5(CDH1):c.1684A>G (p.Thr562Ala) rs587782061
NM_004360.5(CDH1):c.1685C>G (p.Thr562Arg) rs587782381
NM_004360.5(CDH1):c.1689C>T (p.Ala563=) rs587780786
NM_004360.5(CDH1):c.1710T>C (p.Asn570=) rs202115589
NM_004360.5(CDH1):c.1711+1G>C rs886041161
NM_004360.5(CDH1):c.1711+2_1711+7del rs786203089
NM_004360.5(CDH1):c.1711+7G>T rs762005138
NM_004360.5(CDH1):c.1744C>T (p.Leu582=) rs1801025
NM_004360.5(CDH1):c.1774G>A (p.Ala592Thr) rs35187787
NM_004360.5(CDH1):c.1789C>T (p.Pro597Ser) rs201625049
NM_004360.5(CDH1):c.1849G>A (p.Ala617Thr) rs33935154
NM_004360.5(CDH1):c.1888C>G (p.Leu630Val) rs2276331
NM_004360.5(CDH1):c.188G>A (p.Arg63Gln) rs587780117
NM_004360.5(CDH1):c.1891_1892AC[2] (p.His632fs) rs1060501224
NM_004360.5(CDH1):c.1896C>T (p.His632=) rs33969373
NM_004360.5(CDH1):c.1901C>T (p.Ala634Val) rs121964878
NM_004360.5(CDH1):c.1921C>T (p.Gln641Ter) rs587782750
NM_004360.5(CDH1):c.1936+5G>A rs1567512631
NM_004360.5(CDH1):c.1936A>G (p.Thr646Ala) rs771064558
NM_004360.5(CDH1):c.1937-423G>A rs144719031
NM_004360.5(CDH1):c.1937-4C>T rs1057523153
NM_004360.5(CDH1):c.1942G>T (p.Glu648Ter) rs971882211
NM_004360.5(CDH1):c.2020A>T (p.Asn674Tyr) rs201637081
NM_004360.5(CDH1):c.2029dup (p.Gln677fs) rs1555517100
NM_004360.5(CDH1):c.202del (p.Tyr68fs) rs786202151
NM_004360.5(CDH1):c.2079C>T (p.Gly693=) rs771993728
NM_004360.5(CDH1):c.2080G>A (p.Val694Ile) rs587780118
NM_004360.5(CDH1):c.208dup (p.Ser70fs) rs1555514406
NM_004360.5(CDH1):c.2100del (p.Val701fs) rs1555517136
NM_004360.5(CDH1):c.2104G>A (p.Glu702Lys) rs149127230
NM_004360.5(CDH1):c.2104G>T (p.Glu702Ter) rs149127230
NM_004360.5(CDH1):c.2131C>G (p.Leu711Val) rs121964871
NM_004360.5(CDH1):c.2136G>T (p.Gly712=) rs763402728
NM_004360.5(CDH1):c.214G>A (p.Asp72Asn) rs35606263
NM_004360.5(CDH1):c.2164+3A>G rs750651204
NM_004360.5(CDH1):c.2165-15C>A rs552874184
NM_004360.5(CDH1):c.2195G>A (p.Arg732Gln) rs1060501244
NM_004360.5(CDH1):c.223T>C (p.Phe75Leu) rs587782193
NM_004360.5(CDH1):c.2287G>T (p.Glu763Ter) rs587780787
NM_004360.5(CDH1):c.2292C>T (p.Asp764=) rs61747636
NM_004360.5(CDH1):c.2296-1G>A rs1057517542
NM_004360.5(CDH1):c.2324del (p.Gly775fs) rs1060501248
NM_004360.5(CDH1):c.2329G>A (p.Asp777Asn) rs372989292
NM_004360.5(CDH1):c.2343A>G (p.Glu781=) rs587780119
NM_004360.5(CDH1):c.2343A>T (p.Glu781Asp) rs587780119
NM_004360.5(CDH1):c.2374A>C (p.Met792Leu) rs759380419
NM_004360.5(CDH1):c.2386dup (p.Arg796fs) rs1375617541
NM_004360.5(CDH1):c.2387G>A (p.Arg796Gln) rs587782549
NM_004360.5(CDH1):c.2413G>A (p.Asp805Asn) rs200894246
NM_004360.5(CDH1):c.2430del (p.Phe810fs) rs786203752
NM_004360.5(CDH1):c.2439+10C>T rs35236080
NM_004360.5(CDH1):c.2439+5_2439+8del rs587782810
NM_004360.5(CDH1):c.2440-2A>G rs1555518210
NM_004360.5(CDH1):c.2440-6C>G rs139757930
NM_004360.5(CDH1):c.2451G>A (p.Ala817=) rs149450874
NM_004360.5(CDH1):c.2494G>A (p.Val832Met) rs35572355
NM_004360.5(CDH1):c.2505T>C (p.Tyr835=) rs786202613
NM_004360.5(CDH1):c.2506G>T (p.Glu836Ter) rs1555518239
NM_004360.5(CDH1):c.2512A>G (p.Ser838Gly) rs121964872
NM_004360.5(CDH1):c.2520C>T (p.Ser840=) rs140328601
NM_004360.5(CDH1):c.2589C>T (p.Asn863=) rs115817750
NM_004360.5(CDH1):c.2634C>T (p.Gly878=) rs2229044
NM_004360.5(CDH1):c.2635G>A (p.Gly879Ser) rs200911775
NM_004360.5(CDH1):c.2638G>A (p.Glu880Lys) rs34507583
NM_004360.5(CDH1):c.269G>A (p.Arg90Gln) rs587782647
NM_004360.5(CDH1):c.286A>G (p.Ile96Val) rs749306433
NM_004360.5(CDH1):c.297G>A (p.Leu99=) rs876660223
NM_004360.5(CDH1):c.300C>G (p.Val100=) rs786201463
NM_004360.5(CDH1):c.303C>T (p.Tyr101=) rs150789339
NM_004360.5(CDH1):c.304G>A (p.Ala102Thr) rs368492235
NM_004360.5(CDH1):c.337A>T (p.Lys113Ter) rs876661106
NM_004360.5(CDH1):c.33G>C (p.Leu11=) rs730881654
NM_004360.5(CDH1):c.345G>A (p.Thr115=) rs1801023
NM_004360.5(CDH1):c.34C>T (p.Leu12=) rs781696878
NM_004360.5(CDH1):c.370C>T (p.Arg124Cys) rs748086082
NM_004360.5(CDH1):c.371G>A (p.Arg124His) rs115418995
NM_004360.5(CDH1):c.382del (p.His128fs) rs1555514492
NM_004360.5(CDH1):c.387+1G>A rs587781919
NM_004360.5(CDH1):c.387+5G>A rs113055163
NM_004360.5(CDH1):c.387+6T>C rs764434962
NM_004360.5(CDH1):c.394G>A (p.Val132Ile) rs142498771
NM_004360.5(CDH1):c.408A>G (p.Gln136=) rs1060501229
NM_004360.5(CDH1):c.447_453CAGAAGA[1] (p.Gln152fs) rs1131690815
NM_004360.5(CDH1):c.457_460del (p.Lys153fs) rs1555515214
NM_004360.5(CDH1):c.48+15_48+16del rs730881655
NM_004360.5(CDH1):c.48+5C>G rs77312180
NM_004360.5(CDH1):c.48+5C>T rs77312180
NM_004360.5(CDH1):c.48+5_48+6delinsTT rs1555509656
NM_004360.5(CDH1):c.49-3C>T rs587782366
NM_004360.5(CDH1):c.49-8C>T rs774761552
NM_004360.5(CDH1):c.49-9C>A rs1555509752
NM_004360.5(CDH1):c.4G>A (p.Gly2Ser) rs786201212
NM_004360.5(CDH1):c.531+10G>C rs33963999
NM_004360.5(CDH1):c.531+1G>A rs1131690808
NM_004360.5(CDH1):c.532-18C>T rs200673941
NM_004360.5(CDH1):c.558C>T (p.Gly186=) rs876660863
NM_004360.5(CDH1):c.604G>A (p.Val202Ile) rs546716073
NM_004360.5(CDH1):c.656del (p.Pro219fs) rs1555515284
NM_004360.5(CDH1):c.670C>T (p.Arg224Cys) rs200310662
NM_004360.5(CDH1):c.671G>A (p.Arg224His) rs201511530
NM_004360.5(CDH1):c.671G>T (p.Arg224Leu) rs201511530
NM_004360.5(CDH1):c.687+1G>A rs1567504977
NM_004360.5(CDH1):c.69G>A (p.Gln23=) rs786202657
NM_004360.5(CDH1):c.707C>A (p.Ser236Ter) rs730881663
NM_004360.5(CDH1):c.715G>A (p.Gly239Arg) rs587780537
NM_004360.5(CDH1):c.720del (p.Asn240fs) rs1131690819
NM_004360.5(CDH1):c.724G>A (p.Val242Ile) rs111662525
NM_004360.5(CDH1):c.76G>T (p.Glu26Ter) rs786201058
NM_004360.5(CDH1):c.781G>T (p.Glu261Ter) rs121964873
NM_004360.5(CDH1):c.808T>G (p.Ser270Ala) rs587776399
NM_004360.5(CDH1):c.820G>A (p.Gly274Ser) rs781513008
NM_004360.5(CDH1):c.832+17G>C rs373179391
NM_004360.5(CDH1):c.832+1G>A rs878854697
NM_004360.5(CDH1):c.832+6T>G rs1567505832
NM_004360.5(CDH1):c.867G>A (p.Ala289=) rs754143182
NM_004360.5(CDH1):c.88C>A (p.Pro30Thr) rs139866691
NM_004360.5(CDH1):c.892G>A (p.Ala298Thr) rs142822590
NM_004360.5(CDH1):c.8C>G (p.Pro3Arg) rs587782484
NM_004360.5(CDH1):c.907A>T (p.Thr303Ser) rs876660744
NM_004360.5(CDH1):c.933C>G (p.Leu311=) rs35539711

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