ClinVar Miner

Variants with conflicting interpretations studied for Malignant tumor of prostate

Coded as:
Minimum review status of the submission for Malignant tumor of prostate: Y axis collection method of the submission for Malignant tumor of prostate:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
473 3 7 2 7 0 11 24

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Malignant tumor of prostate pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 0 1 0 0
likely pathogenic 1 0 1 0 0
uncertain significance 6 7 7 5 4
likely benign 0 0 1 0 1

Condition to condition summary #

Total conditions: 50
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
Hereditary cancer-predisposing syndrome 0 4 2 1 2 0 3 8
Li-Fraumeni syndrome 0 0 2 0 0 0 3 5
not provided 0 3 0 0 1 0 4 5
not specified 0 2 0 1 4 0 0 5
Hepatocellular carcinoma 0 0 0 0 0 0 4 4
Ovarian Neoplasms 0 0 0 1 0 0 3 4
Lung adenocarcinoma 0 0 0 0 0 0 3 3
Malignant melanoma of skin 0 1 0 0 0 0 3 3
Neoplasm of the breast 0 1 0 1 0 0 2 3
Squamous cell carcinoma of the head and neck 0 1 0 0 0 0 3 3
Acute myeloid leukemia 0 0 0 0 0 0 2 2
Adenocarcinoma of prostate 0 1 0 0 0 0 2 2
Adenocarcinoma of stomach 0 1 0 0 0 0 2 2
Breast-ovarian cancer, familial 1 0 0 0 1 2 0 0 2
Carcinoma of esophagus 0 0 0 0 0 0 2 2
Hereditary breast and ovarian cancer syndrome 0 2 0 1 1 0 0 2
Malignant neoplasm of body of uterus 0 1 0 0 0 0 2 2
Neoplasm of brain 0 1 0 0 0 0 2 2
Neoplasm of the large intestine 0 0 0 1 0 0 1 2
Ovarian Serous Cystadenocarcinoma 0 0 0 0 0 0 2 2
Small cell lung cancer 0 0 0 0 0 0 2 2
Squamous cell carcinoma of the skin 0 0 0 0 0 0 2 2
Squamous cell lung carcinoma 0 0 0 0 0 0 2 2
Transitional cell carcinoma of the bladder 0 1 0 0 0 0 2 2
Uterine Carcinosarcoma 0 1 0 0 0 0 2 2
Adrenocortical carcinoma 0 0 0 0 0 0 1 1
Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 0 0 0 0 0 0 1 1
Autosomal recessive polycystic kidney disease 0 0 1 0 0 0 0 1
Breast-ovarian cancer, familial 2 0 2 0 0 1 0 0 1
Carcinoma of colon 0 0 0 1 0 0 0 1
Chronic lymphocytic leukemia 0 0 0 0 0 0 1 1
Craniopharyngioma 0 0 0 0 0 0 1 1
Cutaneous melanoma 0 0 0 0 0 0 1 1
Familial cancer of breast 0 0 0 0 1 0 0 1
Fanconi anemia 0 0 0 0 1 0 0 1
Ganglioneuroblastoma 0 0 1 0 0 0 0 1
Glioblastoma 0 1 0 0 0 0 1 1
Hepatoblastoma 0 0 0 0 0 0 1 1
History of neurodevelopmental disorder 0 0 0 0 1 0 0 1
Hypocalciuric hypercalcemia, familial, type 1; Hypocalcemia, autosomal dominant 1 0 0 1 0 0 0 0 1
Li-Fraumeni syndrome 1 0 0 0 0 0 0 1 1
Malignant tumor of prostate 499 0 0 0 0 0 1 1
Medulloblastoma 0 1 0 0 0 0 1 1
Microcephaly, normal intelligence and immunodeficiency 0 1 1 0 0 0 0 1
Nasopharyngeal Neoplasms 0 0 0 0 0 0 1 1
Neoplasm 0 0 0 0 0 0 1 1
Osteogenesis imperfecta type I 0 0 1 0 0 0 0 1
Ovarian epithelial cancer 0 0 0 1 0 0 0 1
Pancreatic adenocarcinoma 0 0 0 0 0 0 1 1
Uterine cervical neoplasms 0 1 0 0 0 0 1 1

All variants with conflicting interpretations #

Total variants: 24
Download table as spreadsheet
HGVS dbSNP
NM_000059.3(BRCA2):c.8356G>A (p.Ala2786Thr) rs80359077
NM_000088.3(COL1A1):c.3277C>T (p.Arg1093Cys) rs72656307
NM_000135.2(FANCA):c.3263C>T (p.Ser1088Phe) rs17233497
NM_000388.3(CASR):c.3121C>T (p.Arg1041Trp) rs193921082
NM_000546.5(TP53):c.817C>T (p.Arg273Cys) rs121913343
NM_001007228.1(SPOP):c.305T>G (p.Phe102Cys) rs193920894
NM_001007228.1(SPOP):c.399C>G (p.Phe133Leu) rs193921065
NM_001126115.1(TP53):c.318T>G (p.Cys106Trp) rs193920789
NM_001126115.1(TP53):c.401G>A (p.Gly134Glu) rs193920774
NM_001126115.1(TP53):c.443G>T (p.Arg148Ile) rs121912660
NM_001126115.1(TP53):c.85G>A (p.Ala29Thr) rs193920817
NM_001127608.2(FAM189A2):c.704-5delA rs193921010
NM_001904.3(CTNNB1):c.101G>T (p.Gly34Val) rs28931589
NM_002485.4(NBN):c.244A>G (p.Lys82Glu) rs193921030
NM_005732.3(RAD50):c.1513A>G (p.Ile505Val) rs193921012
NM_006218.4(PIK3CA):c.1636C>A (p.Gln546Lys) rs121913286
NM_006260.4(DNAJC3):c.580C>T (p.Arg194Ter) rs727502865
NM_007194.4(CHEK2):c.538C>T (p.Arg180Cys) rs77130927
NM_007294.3(BRCA1):c.2167A>G (p.Asn723Asp) rs4986845
NM_007294.3(BRCA1):c.3022A>G (p.Met1008Val) rs56321129
NM_016218.3(POLK):c.410C>T (p.Ser137Phe) rs863225454
NM_138715.2(MSR1):c.877C>T (p.Arg293Ter) rs41341748
NM_170724.2(PKHD1):c.544G>A (p.Ala182Thr) rs142346881
NM_198270.3(NHS):c.2141G>A (p.Arg714His) rs193921046

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