ClinVar Miner

Variants with conflicting interpretations studied for Nasopharyngeal Neoplasms

Coded as:
Minimum review status of the submission for Nasopharyngeal Neoplasms: Y axis collection method of the submission for Nasopharyngeal Neoplasms:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
0 5 0 17 0 4 6 22

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Nasopharyngeal Neoplasms pathogenic uncertain significance drug response
likely pathogenic 17 6 4

Condition to condition summary #

Total conditions: 37
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
not provided 0 0 0 7 0 0 1 8
Li-Fraumeni syndrome 0 0 0 2 0 0 5 7
Neoplasm of the large intestine 0 13 0 6 0 0 0 6
Cutaneous melanoma 0 1 0 5 0 0 0 5
Non-small cell lung cancer 0 1 0 5 0 0 0 5
Neoplasm of the breast 0 18 0 4 0 0 0 4
Costello syndrome 0 0 0 3 0 0 0 3
Epidermal nevus 0 0 0 3 0 0 0 3
Hereditary cancer-predisposing syndrome 0 3 0 2 0 0 1 3
Rasopathy 0 0 0 2 0 0 1 3
Carcinoma of colon 0 0 0 2 0 0 0 2
Congenital giant melanocytic nevus 0 0 0 2 0 0 0 2
Congenital giant melanocytic nevus; Epidermal nevus syndrome; Bladder cancer, somatic; Costello syndrome; Epidermal nevus; Follicular thyroid carcinoma 0 0 0 2 0 0 0 2
Neurocutaneous melanosis 0 0 0 2 0 0 0 2
Nevus sebaceous 0 0 0 2 0 0 0 2
Ovarian Neoplasms 0 3 0 2 0 0 0 2
Breast adenocarcinoma 0 0 0 1 0 0 0 1
Epidermal nevus syndrome 0 0 0 1 0 0 0 1
Epidermal nevus with urothelial cancer, somatic 0 0 0 1 0 0 0 1
Follicular thyroid carcinoma 0 0 0 1 0 0 0 1
Hepatocellular carcinoma 0 22 0 1 0 0 0 1
Histone Methylation Therapy response 0 0 0 0 0 1 0 1
Inborn genetic diseases 0 0 0 1 0 0 0 1
Keratosis, seborrheic 0 0 0 1 0 0 0 1
Li-Fraumeni syndrome 1 0 0 0 1 0 0 0 1
Malignant tumor of prostate 0 0 0 0 0 0 1 1
Megalencephaly cutis marmorata telangiectatica congenita 0 0 0 1 0 0 0 1
Myopathy, congenital, with excess of muscle spindles 0 0 0 1 0 0 0 1
Nasopharyngeal carcinoma 0 0 0 1 0 0 0 1
Neoplasm of ovary 0 0 0 1 0 0 0 1
Neoplasm of stomach 0 0 0 1 0 0 0 1
Nevus, woolly hair 0 0 0 1 0 0 0 1
Ovarian epithelial cancer 0 0 0 1 0 0 0 1
PARP Inhibitor response 0 0 0 0 0 1 0 1
PIK3CA related overgrowth spectrum 0 0 0 1 0 0 0 1
Pemigatinib resistance 0 0 0 0 0 1 0 1
RAS Inhibitor response 0 0 0 0 0 1 0 1

All variants with conflicting interpretations #

Total variants: 22
Download table as spreadsheet
HGVS dbSNP
NM_000141.4(FGFR2):c.1645A>C (p.Asn549His) rs1057519045
NM_000546.5(TP53):c.523C>G (p.Arg175Gly) rs138729528
NM_000546.5(TP53):c.523C>T (p.Arg175Cys) rs138729528
NM_000546.5(TP53):c.638G>A (p.Arg213Gln) rs587778720
NM_000546.5(TP53):c.638G>C (p.Arg213Pro) rs587778720
NM_000546.5(TP53):c.838A>G (p.Arg280Gly) rs753660142
NM_000546.5(TP53):c.839G>A (p.Arg280Lys) rs121912660
NM_000546.5(TP53):c.839G>C (p.Arg280Thr) rs121912660
NM_000546.5(TP53):c.839G>T (p.Arg280Ile) rs121912660
NM_002524.5(NRAS):c.181C>A (p.Gln61Lys) rs121913254
NM_002524.5(NRAS):c.182A>C (p.Gln61Pro) rs11554290
NM_002524.5(NRAS):c.182A>G (p.Gln61Arg) rs11554290
NM_002524.5(NRAS):c.182A>T (p.Gln61Leu) rs11554290
NM_002524.5(NRAS):c.183A>T (p.Gln61His) rs121913255
NM_005343.4(HRAS):c.34G>A (p.Gly12Ser) rs104894229
NM_005343.4(HRAS):c.34G>T (p.Gly12Cys) rs104894229
NM_005343.4(HRAS):c.35G>C (p.Gly12Ala) rs104894230
NM_006218.4(PIK3CA):c.1633G>A (p.Glu545Lys) rs104886003
NM_006218.4(PIK3CA):c.1633G>C (p.Glu545Gln) rs104886003
NM_006218.4(PIK3CA):c.1634A>C (p.Glu545Ala) rs121913274
NM_006218.4(PIK3CA):c.1634A>G (p.Glu545Gly) rs121913274
NM_006218.4(PIK3CA):c.1635G>T (p.Glu545Asp) rs121913275

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