ClinVar Miner

Variants with conflicting interpretations studied for Neoplasm of ovary

Coded as:
Minimum review status of the submission for Neoplasm of ovary: Y axis collection method of the submission for Neoplasm of ovary:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
35 38 5 49 20 1 7 67

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Neoplasm of ovary pathogenic likely pathogenic uncertain significance likely benign benign risk factor
pathogenic 5 13 3 1 0 1
likely pathogenic 8 0 1 1 0 0
uncertain significance 1 1 0 11 2 0
likely benign 0 0 9 0 18 0
benign 0 0 0 10 0 0

Condition to condition summary #

Total conditions: 56
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
Hereditary cancer-predisposing syndrome 0 56 0 21 10 0 1 32
not provided 0 45 0 17 5 0 4 25
not specified 0 25 0 16 4 0 1 21
Familial cancer of breast; Fanconi anemia, complementation group J 0 55 0 16 3 0 0 19
Neoplasm of the breast 0 6 0 6 7 0 1 14
Fanconi anemia 0 0 0 6 7 0 0 13
Adenocarcinoma of prostate 0 0 0 8 0 0 0 8
Adenocarcinoma of stomach 0 0 0 8 0 0 0 8
Malignant neoplasm of body of uterus 0 0 0 7 0 0 0 7
Hepatocellular carcinoma 0 0 0 6 0 0 0 6
Lung adenocarcinoma 0 0 0 6 0 0 0 6
Squamous cell carcinoma of the head and neck 0 0 0 6 0 0 0 6
Squamous cell lung carcinoma 0 0 0 6 0 0 0 6
Transitional cell carcinoma of the bladder 0 0 0 6 0 0 0 6
Uterine cervical neoplasms 0 0 0 6 0 0 0 6
Carcinoma of esophagus 0 0 0 5 0 0 0 5
Glioblastoma 0 0 0 5 0 0 0 5
Malignant melanoma of skin 0 0 0 4 0 0 0 4
Medulloblastoma 0 0 0 4 0 0 0 4
Neoplasm of brain 0 0 0 4 0 0 0 4
Ovarian Neoplasms 0 5 0 4 0 0 0 4
Small cell lung cancer 0 0 0 4 0 0 0 4
Uterine Carcinosarcoma 0 0 0 4 0 0 0 4
Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 0 0 3 0 0 0 0 3
Ovarian Serous Cystadenocarcinoma 0 0 0 3 0 0 0 3
Pancreatic adenocarcinoma 0 0 0 3 0 0 0 3
Brainstem glioma 0 0 0 2 0 0 0 2
Breast cancer, early-onset 0 0 0 1 0 0 1 2
Familial cancer of breast 0 3 1 0 1 0 0 2
Fanconi anemia, complementation group J 0 83 0 2 0 0 0 2
Papillary renal cell carcinoma, sporadic 0 0 0 2 0 0 0 2
Renal cell carcinoma, papillary, 1 0 0 0 2 0 0 0 2
Acute myeloid leukemia 0 0 0 1 0 0 0 1
Adenoid cystic carcinoma 0 0 0 1 0 0 0 1
Adrenocortical carcinoma 0 0 0 1 0 0 0 1
BRIP1-Related Disorders 0 2 0 1 0 0 0 1
Breast-ovarian cancer, familial 2 0 0 0 1 0 0 0 1
Carcinoma of gallbladder 0 0 0 1 0 0 0 1
Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation 0 0 0 1 0 0 0 1
Familial cancer of breast; Fanconi anemia, complementation group J; Tracheoesophageal fistula 0 0 0 1 0 0 0 1
Hereditary breast and ovarian cancer syndrome 0 2 0 1 0 0 0 1
Hereditary diffuse gastric cancer 0 0 0 0 0 0 1 1
Li-Fraumeni syndrome 0 1 0 0 0 0 1 1
Lung cancer 0 0 0 1 0 0 0 1
Meningeal Neoplasms 0 0 0 1 0 0 0 1
Nasopharyngeal Neoplasms 0 0 0 1 0 0 0 1
Neoplasm 0 0 0 1 0 0 0 1
Neoplasm of the large intestine 0 7 0 1 0 0 0 1
Neoplasm of the thyroid gland 0 2 0 1 0 0 0 1
Osteosarcoma 0 0 0 1 0 0 0 1
Ovarian Adenocarcinoma 0 0 0 1 0 0 0 1
Pancreatic cancer, susceptibility to 0 0 0 0 0 1 0 1
Prostate neoplasm 0 0 0 1 0 0 0 1
Proteus syndrome 0 0 1 0 0 0 0 1
Squamous cell carcinoma of the skin 0 0 0 1 0 0 0 1
Vascular Tumors Including Pyogenic Granuloma 0 0 0 1 0 0 0 1

All variants with conflicting interpretations #

Total variants: 67
Download table as spreadsheet
HGVS dbSNP
NC_012920.1:m.15511T>C rs527236188
NM_000059.3(BRCA2):c.7806-2A>G rs81002836
NM_000546.5(TP53):c.746G>T (p.Arg249Met) rs587782329
NM_001005862.2(ERBB2):c.2480A>G (p.Asn827Ser) rs28933370
NM_001904.3(CTNNB1):c.110C>G (p.Ser37Cys) rs121913403
NM_004360.5(CDH1):c.2512A>G (p.Ser838Gly) rs121964872
NM_004562.2(PRKN):c.719C>T (p.Thr240Met) rs137853054
NM_004985.4(KRAS):c.35G>A (p.Gly12Asp) rs121913529
NM_005163.2(AKT1):c.49G>A (p.Glu17Lys) rs121434592
NM_006218.3(PIK3CA):c.1634A>C (p.Glu545Ala) rs121913274
NM_006218.4(PIK3CA):c.1258T>C (p.Cys420Arg) rs121913272
NM_006218.4(PIK3CA):c.1624G>A (p.Glu542Lys) rs121913273
NM_006218.4(PIK3CA):c.1637A>G (p.Gln546Arg) rs397517201
NM_006218.4(PIK3CA):c.3140A>G (p.His1047Arg) rs121913279
NM_007294.3(BRCA1):c.5266dupC (p.Gln1756Profs) rs397507247
NM_032043.2(BRIP1):c.1141-94G>T rs114901675
NM_032043.2(BRIP1):c.1240C>T (p.Gln414Ter) rs368796923
NM_032043.2(BRIP1):c.139C>G (p.Pro47Ala) rs28903098
NM_032043.2(BRIP1):c.1433A>G (p.His478Arg) rs45501097
NM_032043.2(BRIP1):c.1455T>C (p.Ala485=) rs773489367
NM_032043.2(BRIP1):c.1735C>T (p.Arg579Cys) rs28997571
NM_032043.2(BRIP1):c.1853_1854insG (p.Pro619Thrfs) rs587781985
NM_032043.2(BRIP1):c.1890A>G (p.Thr630=) rs145796331
NM_032043.2(BRIP1):c.1935+11_1935+13delGTT rs730881641
NM_032043.2(BRIP1):c.195A>G (p.Gln65=) rs141436143
NM_032043.2(BRIP1):c.1A>G (p.Met1Val) rs764585550
NM_032043.2(BRIP1):c.2038_2039dupTT (p.Leu680Phefs) rs587778134
NM_032043.2(BRIP1):c.205+1delG rs1057517648
NM_032043.2(BRIP1):c.206-21T>C rs2048717
NM_032043.2(BRIP1):c.2097+7G>A rs4988352
NM_032043.2(BRIP1):c.2097+8A>C rs730881642
NM_032043.2(BRIP1):c.2111T>A (p.Leu704Ter) rs1057517643
NM_032043.2(BRIP1):c.2220G>T (p.Gln740His) rs45589637
NM_032043.2(BRIP1):c.2232C>T (p.Asp744=) rs374362388
NM_032043.2(BRIP1):c.2236A>G (p.Ile746Val) rs111536363
NM_032043.2(BRIP1):c.2286T>C (p.Arg762=) rs61754141
NM_032043.2(BRIP1):c.2392C>T (p.Arg798Ter) rs137852986
NM_032043.2(BRIP1):c.2637A>G (p.Glu879=) rs4986765
NM_032043.2(BRIP1):c.2706A>G (p.Ile902Met) rs587780244
NM_032043.2(BRIP1):c.2755T>C (p.Ser919Pro) rs4986764
NM_032043.2(BRIP1):c.2765T>G (p.Leu922Ter) rs587782410
NM_032043.2(BRIP1):c.290_293delACAA (p.Asn97Metfs) rs763009188
NM_032043.2(BRIP1):c.2937A>G (p.Lys979=) rs75091137
NM_032043.2(BRIP1):c.297C>T (p.Asp99=) rs201617644
NM_032043.2(BRIP1):c.2990_2993delCAAA (p.Thr997Argfs) rs771028677
NM_032043.2(BRIP1):c.3099T>C (p.Pro1033=) rs202228407
NM_032043.2(BRIP1):c.3103C>T (p.Arg1035Cys) rs45437094
NM_032043.2(BRIP1):c.312T>G (p.Thr104=) rs769190318
NM_032043.2(BRIP1):c.316C>T (p.Arg106Cys) rs587780247
NM_032043.2(BRIP1):c.3378A>C (p.Glu1126Asp) rs145855459
NM_032043.2(BRIP1):c.3411T>C (p.Tyr1137=) rs4986763
NM_032043.2(BRIP1):c.3444C>A (p.Asp1148Glu) rs28997573
NM_032043.2(BRIP1):c.3459T>C (p.Asp1153=) rs4987050
NM_032043.2(BRIP1):c.36G>T (p.Gly12=) rs45566938
NM_032043.2(BRIP1):c.380-17dupT rs545021924
NM_032043.2(BRIP1):c.430G>A (p.Ala144Thr) rs116952709
NM_032043.2(BRIP1):c.517C>T (p.Arg173Cys) rs4988345
NM_032043.2(BRIP1):c.577G>A (p.Val193Ile) rs4988346
NM_032043.2(BRIP1):c.584T>C (p.Leu195Pro) rs4988347
NM_032043.2(BRIP1):c.612C>G (p.Ser204=) rs587780832
NM_032043.2(BRIP1):c.679C>G (p.Gln227Glu) rs45459799
NM_032043.2(BRIP1):c.689C>T (p.Ser230Leu) rs759031349
NM_032043.2(BRIP1):c.702G>A (p.Lys234=) rs45512798
NM_032043.2(BRIP1):c.852C>T (p.Val284=) rs144940449
NM_032043.2(BRIP1):c.854A>G (p.His285Arg) rs141055990
NM_032043.2(BRIP1):c.890A>G (p.Lys297Arg) rs28997570
NM_032043.2(BRIP1):c.918+15T>A rs117820198

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