ClinVar Miner

Variants with conflicting interpretations studied for Ovarian Neoplasms

Coded as:
Minimum review status of the submission for Ovarian Neoplasms: Y axis collection method of the submission for Ovarian Neoplasms:
Minimum review status of the other submission: Collection method of the other submission:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
147 134 9 110 0 10 58 155

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

All conditions
Ovarian Neoplasms pathogenic likely pathogenic uncertain significance likely benign drug response risk factor other
pathogenic 7 32 3 0 1 6 1
likely pathogenic 80 2 54 1 1 0 2

Condition to condition summary #

Total conditions: 97
Download table as spreadsheet
Condition Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
Hereditary cancer-predisposing syndrome 0 139 0 44 0 0 26 68
Li-Fraumeni syndrome 0 32 0 30 0 0 37 65
not provided 0 114 2 35 0 0 3 39
Li-Fraumeni syndrome 1 0 4 0 10 0 0 2 12
Adenocarcinoma of prostate 0 33 0 10 0 0 0 10
Glioblastoma 0 50 0 10 0 0 0 10
Neoplasm of brain 0 60 0 10 0 0 0 10
Squamous cell carcinoma of the head and neck 0 71 0 10 0 0 0 10
Adenocarcinoma of stomach 0 60 0 9 0 0 0 9
Malignant melanoma of skin 0 40 0 9 0 0 0 9
Malignant neoplasm of body of uterus 0 52 0 9 0 0 0 9
Uterine cervical neoplasms 0 11 0 9 0 0 0 9
Hepatocellular carcinoma 0 58 0 8 0 0 0 8
Lung adenocarcinoma 0 74 0 8 0 0 0 8
Squamous cell lung carcinoma 0 55 0 8 0 0 0 8
not specified 0 20 0 2 0 0 6 8
Neoplasm of the large intestine 0 71 0 7 0 0 0 7
Transitional cell carcinoma of the bladder 0 50 0 7 0 0 0 7
Uterine Carcinosarcoma 0 43 0 7 0 0 0 7
Breast-ovarian cancer, familial 1 0 46 0 5 0 1 1 6
Carcinoma of esophagus 0 62 0 6 0 0 0 6
Familial cancer of breast 0 18 3 2 0 0 1 6
Neoplasm of the breast 0 89 0 6 0 0 0 6
PTEN hamartoma tumor syndrome 0 5 0 6 0 0 0 6
Renal cell carcinoma, papillary, 1 0 18 0 6 0 0 0 6
Small cell lung cancer 0 26 0 6 0 0 0 6
Brainstem glioma 0 20 0 5 0 0 0 5
Medulloblastoma 0 14 0 3 0 2 0 5
Papillary renal cell carcinoma, sporadic 0 9 0 5 0 0 0 5
Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 0 0 3 1 0 0 0 4
Hereditary breast and ovarian cancer syndrome 0 56 0 4 0 0 0 4
Li-Fraumeni-like syndrome 0 0 0 4 0 0 0 4
Malignant tumor of prostate 0 0 0 1 0 0 3 4
Neoplasm of ovary 0 5 0 4 0 0 0 4
Ovarian Serous Cystadenocarcinoma 0 65 0 4 0 0 0 4
Pancreatic adenocarcinoma 0 63 0 4 0 0 0 4
Acute myeloid leukemia 0 21 0 3 0 0 0 3
Adrenocortical carcinoma, hereditary; Familial cancer of breast; Glioma susceptibility 1; Osteosarcoma; Li-Fraumeni syndrome 1; Nasopharyngeal carcinoma; Carcinoma of pancreas; Choroid plexus papilloma; Carcinoma of colon; Basal cell carcinoma, susceptibility to, 7; Hepatocellular carcinoma 0 0 0 3 0 0 0 3
Breast-ovarian cancer, familial 2 0 21 0 2 0 0 1 3
Neoplasm 0 6 0 3 0 0 0 3
Non-small cell lung cancer 0 11 0 3 0 0 0 3
Pilomatrixoma 0 0 0 3 0 0 0 3
Adrenocortical carcinoma 0 12 0 2 0 0 0 2
Breast adenocarcinoma 0 3 0 2 0 0 0 2
Carcinoma of colon 0 3 0 1 0 0 1 2
Carcinoma of gallbladder 0 8 0 2 0 0 0 2
Cowden syndrome 1 0 5 0 2 0 0 0 2
Lung cancer 0 2 0 2 0 0 0 2
Megalencephaly cutis marmorata telangiectatica congenita 0 0 1 2 0 0 0 2
Multiple myeloma 0 24 0 2 0 0 0 2
Nasopharyngeal Neoplasms 0 3 0 2 0 0 0 2
Ovarian Neoplasms 429 5 0 2 0 0 0 2
PIK3CA related overgrowth spectrum 0 2 0 2 0 0 0 2
Acute megakaryoblastic leukemia; Mediastinal germ cell tumor 0 0 0 1 0 0 0 1
Anaplastic thyroid carcinoma 0 0 0 1 0 0 0 1
Astrocytoma 0 0 0 0 0 0 1 1
Astrocytoma, anaplastic 0 0 0 1 0 0 0 1
Astrocytoma, anaplastic; Pleomorphic xanthoastrocytoma 0 0 0 1 0 0 0 1
Ataxia-telangiectasia-like disorder 1 0 0 0 1 0 0 0 1
Atypical teratoid/rhabdoid tumor 0 0 0 1 0 0 0 1
Breast and colorectal cancer, susceptibility to 0 0 0 0 0 1 0 1
Breast and/or ovarian cancer 0 15 0 0 0 0 1 1
Breast cancer, susceptibility to 0 0 0 0 0 1 0 1
Breast-ovarian cancer, familial 3 0 1 0 1 0 0 0 1
Breast-ovarian cancer, familial 3; Fanconi anemia, complementation group O 0 0 0 1 0 0 0 1
Breast-ovarian cancer, familial 4 0 2 0 1 0 0 0 1
Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth 0 2 0 1 0 0 0 1
Carcinoma of cervix 0 0 0 1 0 0 0 1
Colorectal cancer 0 1 0 0 0 1 0 1
Cowden syndrome 0 2 0 1 0 0 0 1
Cutaneous melanoma 0 2 0 1 0 0 0 1
Familial cancer of breast; Fanconi anemia, complementation group J 0 1 0 1 0 0 0 1
Fanconi anemia 0 0 0 0 0 1 0 1
Fanconi anemia, complementation group A 0 0 0 1 0 0 0 1
Fanconi anemia, complementation group O 0 4 0 1 0 0 0 1
Ganglioneuroblastoma 0 0 0 0 0 0 1 1
Gastrointestinal stroma tumor 0 1 0 1 0 0 0 1
Head and Neck Neoplasms 0 0 0 1 0 0 0 1
Hepatoblastoma 0 0 0 1 0 0 0 1
Keratosis, seborrheic 0 1 0 1 0 0 0 1
Malignant Colorectal Neoplasm 0 0 0 1 0 0 0 1
Malignant tumor of esophagus 0 0 0 1 0 0 0 1
Malignant tumor of floor of mouth 0 0 0 1 0 0 0 1
Neoplasm of stomach 0 2 0 1 0 0 0 1
Neoplasm of the colon 0 0 0 1 0 0 0 1
Osteosarcoma 0 0 0 1 0 0 0 1
Ovarian epithelial cancer 0 2 0 1 0 0 0 1
PARP Inhibitor response 0 0 0 0 0 1 0 1
Pancreatic cancer 2 0 0 0 0 0 1 0 1
Pancreatic cancer 4 0 0 0 0 0 1 0 1
Pancreatic cancer, susceptibility to 0 0 0 0 0 1 0 1
Pectus excavatum; Acute myeloid leukemia; Short stature; Cognitive impairment; Webbed neck; Pancytopenia; Abnormality of the tongue 0 0 0 1 0 0 0 1
Prostate cancer, susceptibility to 0 0 0 0 0 1 0 1
Sarcoma 0 1 0 1 0 0 0 1
Trametinib-Dabrafenib Response 0 0 0 0 0 1 0 1
Vascular Tumors Including Pyogenic Granuloma 0 0 0 1 0 0 0 1
Vemurafenib-Cobimetinib Response 0 0 0 0 0 1 0 1

All variants with conflicting interpretations #

Total variants: 155
Download table as spreadsheet
HGVS dbSNP
NM_000059.3(BRCA2):c.3264dupT (p.Gln1089Serfs) rs80359380
NM_000059.3(BRCA2):c.5946del (p.Ser1982fs) rs80359550
NM_000059.3(BRCA2):c.7976G>A (p.Arg2659Lys) rs80359027
NM_000059.3(BRCA2):c.9253dupA (p.Thr3085Asnfs) rs80359752
NM_000314.7(PTEN):c.1003C>T (p.Arg335Ter) rs121909231
NM_000314.7(PTEN):c.1027-1G>A rs1057517809
NM_000314.7(PTEN):c.182A>G (p.His61Arg) rs398123316
NM_000314.7(PTEN):c.209+4_209+7del rs398123318
NM_000314.7(PTEN):c.388C>T (p.Arg130Ter) rs121909224
NM_000314.7(PTEN):c.389G>A (p.Arg130Gln) rs121909229
NM_000314.7(PTEN):c.403A>G (p.Ile135Val) rs587782360
NM_000314.7(PTEN):c.406T>C (p.Cys136Arg) rs786201044
NM_000314.7(PTEN):c.509G>T (p.Ser170Ile) rs876660507
NM_000314.7(PTEN):c.70G>C (p.Asp24His) rs786201995
NM_000546.5(TP53):c.560-1G>C rs1202793339
NM_001024688.2(NBN):c.411_415del (p.Lys137fs) rs587776650
NM_001126112.2(TP53):c.1009C>T (p.Arg337Cys) rs587782529
NM_001126112.2(TP53):c.1025G>C (p.Arg342Pro) rs375338359
NM_001126112.2(TP53):c.329G>T (p.Arg110Leu) rs11540654
NM_001126112.2(TP53):c.332T>C (p.Leu111Pro) rs1057519997
NM_001126112.2(TP53):c.358A>G (p.Lys120Glu) rs121912658
NM_001126112.2(TP53):c.375+5G>A rs1555526466
NM_001126112.2(TP53):c.376-1G>A rs868137297
NM_001126112.2(TP53):c.376T>G (p.Tyr126Asp) rs886039483
NM_001126112.2(TP53):c.377A>G (p.Tyr126Cys) rs1555526335
NM_001126112.2(TP53):c.380C>T (p.Ser127Phe) rs730881999
NM_001126112.2(TP53):c.395A>G (p.Lys132Arg) rs1057519996
NM_001126112.2(TP53):c.396G>T (p.Lys132Asn) rs866775781
NM_001126112.2(TP53):c.403T>G (p.Cys135Gly) rs1057519975
NM_001126112.2(TP53):c.422G>A (p.Cys141Tyr) rs587781288
NM_001126112.2(TP53):c.431A>C (p.Gln144Pro) rs786203071
NM_001126112.2(TP53):c.434T>A (p.Leu145Gln) rs587782197
NM_001126112.2(TP53):c.434T>C (p.Leu145Pro) rs587782197
NM_001126112.2(TP53):c.451C>T (p.Pro151Ser) rs28934874
NM_001126112.2(TP53):c.452C>A (p.Pro151His) rs1057520000
NM_001126112.2(TP53):c.467G>C (p.Arg156Pro) rs371524413
NM_001126112.2(TP53):c.469G>T (p.Val157Phe) rs121912654
NM_001126112.2(TP53):c.475G>C (p.Ala159Pro) rs730882000
NM_001126112.2(TP53):c.481G>A (p.Ala161Thr) rs193920817
NM_001126112.2(TP53):c.488A>G (p.Tyr163Cys) rs148924904
NM_001126112.2(TP53):c.517G>A (p.Val173Met) rs876660754
NM_001126112.2(TP53):c.517G>T (p.Val173Leu) rs876660754
NM_001126112.2(TP53):c.523C>G (p.Arg175Gly) rs138729528
NM_001126112.2(TP53):c.523C>T (p.Arg175Cys) rs138729528
NM_001126112.2(TP53):c.524G>A (p.Arg175His) rs28934578
NM_001126112.2(TP53):c.526T>G (p.Cys176Gly) rs967461896
NM_001126112.2(TP53):c.528C>G (p.Cys176Trp) rs1057519980
NM_001126112.2(TP53):c.535C>T (p.His179Tyr) rs587780070
NM_001126112.2(TP53):c.536A>G (p.His179Arg) rs1057519991
NM_001126112.2(TP53):c.560-1G>A rs1202793339
NM_001126112.2(TP53):c.578A>T (p.His193Leu) rs786201838
NM_001126112.2(TP53):c.581T>A (p.Leu194His) rs1057519998
NM_001126112.2(TP53):c.581T>G (p.Leu194Arg) rs1057519998
NM_001126112.2(TP53):c.584T>A (p.Ile195Asn) rs760043106
NM_001126112.2(TP53):c.584T>C (p.Ile195Thr) rs760043106
NM_001126112.2(TP53):c.590T>A (p.Val197Glu) rs1567551903
NM_001126112.2(TP53):c.643A>G (p.Ser215Gly) rs886039484
NM_001126112.2(TP53):c.644G>T (p.Ser215Ile) rs587782177
NM_001126112.2(TP53):c.645T>G (p.Ser215Arg) rs1057520001
NM_001126112.2(TP53):c.646G>A (p.Val216Met) rs730882025
NM_001126112.2(TP53):c.658T>C (p.Tyr220His) rs530941076
NM_001126112.2(TP53):c.659A>C (p.Tyr220Ser) rs121912666
NM_001126112.2(TP53):c.659A>G (p.Tyr220Cys) rs121912666
NM_001126112.2(TP53):c.673-2A>G rs1555525585
NM_001126112.2(TP53):c.700T>C (p.Tyr234His) rs864622237
NM_001126112.2(TP53):c.701A>G (p.Tyr234Cys) rs587780073
NM_001126112.2(TP53):c.711G>A (p.Met237Ile) rs587782664
NM_001126112.2(TP53):c.713G>A (p.Cys238Tyr) rs730882005
NM_001126112.2(TP53):c.722C>T (p.Ser241Phe) rs28934573
NM_001126112.2(TP53):c.725G>A (p.Cys242Tyr) rs121912655
NM_001126112.2(TP53):c.725G>T (p.Cys242Phe) rs121912655
NM_001126112.2(TP53):c.731G>A (p.Gly244Asp) rs985033810
NM_001126112.2(TP53):c.733G>A (p.Gly245Ser) rs28934575
NM_001126112.2(TP53):c.734G>A (p.Gly245Asp) rs121912656
NM_001126112.2(TP53):c.736A>G (p.Met246Val) rs483352695
NM_001126112.2(TP53):c.737T>C (p.Met246Thr) rs587780074
NM_001126112.2(TP53):c.740A>T (p.Asn247Ile) rs786201762
NM_001126112.2(TP53):c.742C>T (p.Arg248Trp) rs121912651
NM_001126112.2(TP53):c.743G>A (p.Arg248Gln) rs11540652
NM_001126112.2(TP53):c.745A>G (p.Arg249Gly) rs587782082
NM_001126112.2(TP53):c.746G>T (p.Arg249Met) rs587782329
NM_001126112.2(TP53):c.747G>T (p.Arg249Ser) rs28934571
NM_001126112.2(TP53):c.751A>C (p.Ile251Leu) rs730882007
NM_001126112.2(TP53):c.770T>A (p.Leu257Gln) rs28934577
NM_001126112.2(TP53):c.772G>A (p.Glu258Lys) rs121912652
NM_001126112.2(TP53):c.796G>A (p.Gly266Arg) rs1057519990
NM_001126112.2(TP53):c.797G>A (p.Gly266Glu) rs193920774
NM_001126112.2(TP53):c.814G>A (p.Val272Met) rs121912657
NM_001126112.2(TP53):c.817C>G (p.Arg273Gly) rs121913343
NM_001126112.2(TP53):c.817C>T (p.Arg273Cys) rs121913343
NM_001126112.2(TP53):c.818G>A (p.Arg273His) rs28934576
NM_001126112.2(TP53):c.818G>C (p.Arg273Pro) rs28934576
NM_001126112.2(TP53):c.818G>T (p.Arg273Leu) rs28934576
NM_001126112.2(TP53):c.824G>A (p.Cys275Tyr) rs863224451
NM_001126112.2(TP53):c.826G>C (p.Ala276Pro) rs1131691029
NM_001126112.2(TP53):c.832C>A (p.Pro278Thr) rs17849781
NM_001126112.2(TP53):c.832C>G (p.Pro278Ala) rs17849781
NM_001126112.2(TP53):c.832C>T (p.Pro278Ser) rs17849781
NM_001126112.2(TP53):c.833C>G (p.Pro278Arg) rs876659802
NM_001126112.2(TP53):c.833C>T (p.Pro278Leu) rs876659802
NM_001126112.2(TP53):c.836G>A (p.Gly279Glu) rs1064793881
NM_001126112.2(TP53):c.838A>G (p.Arg280Gly) rs753660142
NM_001126112.2(TP53):c.841G>A (p.Asp281Asn) rs764146326
NM_001126112.2(TP53):c.843C>A (p.Asp281Glu) rs1057519984
NM_001126112.2(TP53):c.843C>G (p.Asp281Glu) rs1057519984
NM_001126112.2(TP53):c.844C>G (p.Arg282Gly) rs28934574
NM_001126112.2(TP53):c.844C>T (p.Arg282Trp) rs28934574
NM_001126112.2(TP53):c.916C>T (p.Arg306Ter) rs121913344
NM_001126112.2(TP53):c.920-1G>A rs587781702
NM_001126112.2(TP53):c.920-1G>T rs587781702
NM_001126112.2(TP53):c.920-2A>G rs397516439
NM_001126112.2(TP53):c.993+1G>A rs11575997
NM_001304718.2(PTEN):c.-363C>G rs121909224
NM_001904.4(CTNNB1):c.101G>A (p.Gly34Glu) rs28931589
NM_001904.4(CTNNB1):c.110C>G (p.Ser37Cys) rs121913403
NM_001904.4(CTNNB1):c.110C>T (p.Ser37Phe) rs121913403
NM_001904.4(CTNNB1):c.98C>G (p.Ser33Cys) rs121913400
NM_002878.3(RAD51D):c.576+1G>A rs781161543
NM_004333.6(BRAF):c.1790T>G (p.Leu597Arg) rs121913366
NM_004333.6(BRAF):c.1799T>A (p.Val600Glu) rs113488022
NM_004985.5(KRAS):c.35G>A (p.Gly12Asp) rs121913529
NM_004985.5(KRAS):c.35G>T (p.Gly12Val) rs121913529
NM_005431.2(XRCC2):c.96del (p.Phe32fs) rs730882048
NM_005590.4(MRE11):c.1222dup (p.Thr408fs) rs774440500
NM_005591.4(MRE11):c.1714C>T (p.Arg572Ter) rs137852761
NM_006218.4(PIK3CA):c.1258T>C (p.Cys420Arg) rs121913272
NM_006218.4(PIK3CA):c.1357G>A (p.Glu453Lys) rs1057519925
NM_006218.4(PIK3CA):c.1624G>A (p.Glu542Lys) rs121913273
NM_006218.4(PIK3CA):c.1624G>C (p.Glu542Gln) rs121913273
NM_006218.4(PIK3CA):c.1633G>A (p.Glu545Lys) rs104886003
NM_006218.4(PIK3CA):c.1634A>C (p.Glu545Ala) rs121913274
NM_006218.4(PIK3CA):c.1636C>A (p.Gln546Lys) rs121913286
NM_006218.4(PIK3CA):c.1637A>C (p.Gln546Pro) rs397517201
NM_006218.4(PIK3CA):c.1637A>G (p.Gln546Arg) rs397517201
NM_006218.4(PIK3CA):c.3140A>G (p.His1047Arg) rs121913279
NM_006218.4(PIK3CA):c.3140A>T (p.His1047Leu) rs121913279
NM_007194.4(CHEK2):c.1100del (p.Thr367fs) rs555607708
NM_007194.4(CHEK2):c.85C>T (p.Gln29Ter) rs761494650
NM_007294.3(BRCA1):c.212G>C (p.Arg71Thr) rs80356913
NM_007294.3(BRCA1):c.3752_3755GTCT[1] (p.Ser1253fs) rs80357868
NM_007294.3(BRCA1):c.5074G>C (p.Asp1692His) rs80187739
NM_007294.3(BRCA1):c.5096G>A (p.Arg1699Gln) rs41293459
NM_007294.3(BRCA1):c.5266dupC (p.Gln1756Profs) rs80357906
NM_007294.3(BRCA1):c.5333-1G>T rs80358126
NM_007294.3(BRCA1):c.66_67AG[1] (p.Glu23fs) rs80357914
NM_007300.4(BRCA1):c.5566C>T (p.Arg1856Ter) rs41293465
NM_020937.4(FANCM):c.5101C>T (p.Gln1701Ter) rs147021911
NM_024675.3(PALB2):c.3113+5G>C rs876659463
NM_024675.3(PALB2):c.3362del (p.Gly1121fs) rs515726117
NM_032043.2(BRIP1):c.1741C>T (p.Arg581Ter) rs780020495
NM_032043.2(BRIP1):c.2258-1G>A rs1064793887
NM_033360.4(KRAS):c.34G>T (p.Gly12Cys) rs121913530
NM_033360.4(KRAS):c.35G>C (p.Gly12Ala) rs121913529
NM_033360.4(KRAS):c.38G>A (p.Gly13Asp) rs112445441
NM_058216.3(RAD51C):c.706-2A>G rs587780259

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