Variants in gene APC with conflicting interpretations "uncertain significance" and "benign"

Submission 1 (uncertain significance) minimum review status:		Submission 1 (uncertain significance) method:
Submission 2 (benign) minimum review status:		Submission 2 (benign) method:
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

Total variants with conflicting interpretations: 113

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HGVS	dbSNP	gnomAD frequency
NM_000038.6(APC):c.3920T>A (p.Ile1307Lys)	rs1801155	0.00116
NM_000038.6(APC):c.1825G>A (p.Val609Ile)	rs147863331	0.00096
NM_000038.6(APC):c.6821C>T (p.Ala2274Val)	rs34919187	0.00088
NM_000038.6(APC):c.1604C>T (p.Ser535Phe)	rs75870842	0.00071
NM_000038.6(APC):c.3173A>G (p.Asp1058Gly)	rs148725540	0.00056
NM_000038.6(APC):c.4336G>A (p.Ala1446Thr)	rs146572883	0.00056
NM_000038.6(APC):c.1240C>T (p.Arg414Cys)	rs137854567	0.00053
NM_000038.6(APC):c.295C>T (p.Arg99Trp)	rs139196838	0.00048
NM_000038.6(APC):c.2847G>T (p.Met949Ile)	rs147394539	0.00039
NM_000038.6(APC):c.3650A>C (p.Asn1217Thr)	rs138933660	0.00038
NM_000038.6(APC):c.5690A>C (p.His1897Pro)	rs112610898	0.00038
NM_000038.6(APC):c.6857C>T (p.Ala2286Val)	rs200587641	0.00036
NM_000038.6(APC):c.607C>G (p.Gln203Glu)	rs141576417	0.00034
NM_000038.6(APC):c.2232T>G (p.Ser744=)	rs145751759	0.00032
NM_000038.6(APC):c.7490C>T (p.Ser2497Leu)	rs141010008	0.00031
NM_000038.6(APC):c.2593C>T (p.Pro865Ser)	rs192620988	0.00028
NM_000038.6(APC):c.3511C>T (p.Arg1171Cys)	rs201830995	0.00028
NM_000038.6(APC):c.5274T>A (p.Ser1758=)	rs199600387	0.00024
NM_000038.6(APC):c.6526T>C (p.Leu2176=)	rs183468041	0.00023
NM_000038.6(APC):c.7036C>T (p.Pro2346Ser)	rs200756935	0.00022
NM_000038.6(APC):c.3352A>G (p.Asn1118Asp)	rs140493115	0.00021
NM_000038.6(APC):c.564A>G (p.Gln188=)	rs377493489	0.00021
NM_000038.6(APC):c.6782C>T (p.Pro2261Leu)	rs376494248	0.00021
NM_000038.6(APC):c.8462A>G (p.Asp2821Gly)	rs780049836	0.00021
NM_000038.6(APC):c.2205G>A (p.Ala735=)	rs141001261	0.00019
NM_000038.6(APC):c.3249T>G (p.Asp1083Glu)	rs201629780	0.00019
NM_000038.6(APC):c.3374T>C (p.Val1125Ala)	rs377278397	0.00018
NM_000038.6(APC):c.4237A>G (p.Met1413Val)	rs141519952	0.00018
NM_000038.6(APC):c.6637A>G (p.Met2213Val)	rs186926737	0.00018
NM_000038.6(APC):c.3479C>A (p.Thr1160Lys)	rs201004111	0.00017
NM_000038.6(APC):c.7193C>T (p.Ser2398Phe)	rs150882838	0.00017
NM_000038.6(APC):c.7625A>G (p.Asn2542Ser)	rs151163793	0.00016
NM_000038.6(APC):c.6985A>G (p.Ile2329Val)	rs146048493	0.00015
NM_001127511.3(APC):c.119G>C (p.Ser40Thr)	rs587778028	0.00013
NM_000038.6(APC):c.1631T>C (p.Ile544Thr)	rs144056494	0.00012
NM_000038.6(APC):c.2204C>T (p.Ala735Val)	rs147655929	0.00012
NM_000038.6(APC):c.450A>G (p.Lys150=)	rs116020626	0.00012
NM_000038.6(APC):c.5392A>G (p.Asn1798Asp)	rs200794097	0.00012
NM_000038.6(APC):c.5801C>T (p.Pro1934Leu)	rs587780600	0.00012
NM_000038.6(APC):c.277C>G (p.Leu93Val)	rs201567345	0.00011
NM_000038.6(APC):c.388A>G (p.Ser130Gly)	rs150973053	0.00010
NM_000038.6(APC):c.4918C>T (p.Arg1640Trp)	rs373440614	0.00010
NM_000038.6(APC):c.5072C>T (p.Pro1691Leu)	rs1060503346	0.00009
NM_000038.6(APC):c.6525A>G (p.Thr2175=)	rs200151646	0.00009
NM_000038.6(APC):c.6724A>G (p.Ser2242Gly)	rs201375478	0.00008
NM_000038.6(APC):c.934-14C>T	rs778707022	0.00007
NM_000038.6(APC):c.1005A>G (p.Leu335=)	rs3797704	0.00006
NM_000038.6(APC):c.1139G>A (p.Arg380Gln)	rs587782886	0.00006
NM_000038.6(APC):c.2461G>A (p.Val821Ile)	rs138498551	0.00006
NM_000038.6(APC):c.4478C>T (p.Thr1493Met)	rs374892194	0.00006
NM_000038.6(APC):c.5774C>A (p.Pro1925His)	rs762682111	0.00006
NM_000038.6(APC):c.7399C>A (p.Pro2467Thr)	rs372305287	0.00006
NM_000038.6(APC):c.7577A>G (p.His2526Arg)	rs750012595	0.00006
NM_000038.6(APC):c.7929A>G (p.Leu2643=)	rs138796072	0.00006
NM_000038.6(APC):c.8332G>T (p.Ala2778Ser)	rs587778046	0.00006
NM_001127511.3(APC):c.125G>A (p.Gly42Asp)	rs1057517570	0.00006
NM_000038.6(APC):c.7986G>A (p.Glu2662=)	rs571645304	0.00005
NM_000038.6(APC):c.1762G>A (p.Val588Ile)	rs372416031	0.00004
NM_000038.6(APC):c.2627G>A (p.Arg876Gln)	rs373428732	0.00004
NM_000038.6(APC):c.317G>A (p.Arg106His)	rs201764637	0.00004
NM_000038.6(APC):c.3383C>G (p.Ser1128Cys)	rs755586334	0.00004
NM_000038.6(APC):c.4055T>C (p.Val1352Ala)	rs528724202	0.00004
NM_000038.6(APC):c.5500G>A (p.Val1834Ile)	rs555944438	0.00004
NM_000038.6(APC):c.5528C>T (p.Pro1843Leu)	rs368080169	0.00004
NM_000038.6(APC):c.6639G>A (p.Met2213Ile)	rs35540155	0.00004
NM_000038.6(APC):c.7786T>G (p.Ser2596Ala)	rs138137162	0.00004
NM_000038.6(APC):c.8261G>A (p.Ser2754Asn)	rs369721828	0.00004
NM_000038.6(APC):c.883A>G (p.Ser295Gly)	rs587780611	0.00004
NM_000038.6(APC):c.995G>A (p.Arg332Gln)	rs377665107	0.00004
NM_000038.6(APC):c.2090C>T (p.Ala697Val)	rs761733547	0.00003
NM_000038.6(APC):c.3529A>G (p.Ile1177Val)	rs369834416	0.00003
NM_000038.6(APC):c.385G>C (p.Glu129Gln)	rs376628500	0.00003
NM_000038.6(APC):c.5506G>A (p.Gly1836Arg)	rs766739164	0.00003
NM_000038.6(APC):c.5912C>G (p.Ser1971Cys)	rs754691867	0.00003
NM_000038.6(APC):c.7150T>A (p.Leu2384Ile)	rs755345693	0.00003
NM_000038.6(APC):c.7174C>A (p.Pro2392Thr)	rs730881257	0.00003
NM_000038.6(APC):c.8383G>A (p.Ala2795Thr)	rs369264968	0.00003
NM_001127511.3(APC):c.130G>A (p.Ala44Thr)	rs367773779	0.00003
NM_000038.6(APC):c.1685C>T (p.Thr562Met)	rs587783034	0.00002
NM_000038.6(APC):c.2780C>G (p.Ala927Gly)	rs587781500	0.00002
NM_000038.6(APC):c.4310A>G (p.Lys1437Arg)	rs745825088	0.00002
NM_000038.6(APC):c.4399C>T (p.Pro1467Ser)	rs749142480	0.00002
NM_000038.6(APC):c.4913T>C (p.Met1638Thr)	rs201797422	0.00002
NM_000038.6(APC):c.5290C>G (p.Gln1764Glu)	rs529543591	0.00002
NM_000038.6(APC):c.5363G>A (p.Arg1788His)	rs201472075	0.00002
NM_000038.6(APC):c.6487A>C (p.Lys2163Gln)	rs759728732	0.00002
NM_000038.6(APC):c.8141G>A (p.Arg2714His)	rs747362422	0.00002
NM_000038.6(APC):c.8429A>G (p.Asn2810Ser)	rs758044862	0.00002
NM_000038.6(APC):c.2958T>C (p.Tyr986=)	rs746581330	0.00001
NM_000038.6(APC):c.3909A>G (p.Gln1303=)	rs746289994	0.00001
NM_000038.6(APC):c.4376C>G (p.Thr1459Ser)	rs756048549	0.00001
NM_000038.6(APC):c.4766G>A (p.Arg1589His)	rs374048423	0.00001
NM_000038.6(APC):c.4919G>A (p.Arg1640Gln)	rs529480958	0.00001
NM_000038.6(APC):c.5017G>A (p.Glu1673Lys)	rs587779796	0.00001
NM_000038.6(APC):c.5981A>T (p.Asp1994Val)	rs774815653	0.00001
NM_000038.6(APC):c.6403A>G (p.Ile2135Val)	rs757633174	0.00001
NM_000038.6(APC):c.7262C>T (p.Ser2421Leu)	rs536557651	0.00001
NM_000038.6(APC):c.8298C>T (p.Ser2766=)	rs876658523	0.00001
NM_000038.6(APC):c.835-4T>G	rs756807560	0.00001
NM_000038.6(APC):c.*2AG[2]	rs758692443
NM_000038.6(APC):c.2630G>C (p.Gly877Ala)	rs558732083
NM_000038.6(APC):c.3462AGA[2] (p.Glu1157del)	rs386833391
NM_000038.6(APC):c.423-4del	rs730881230
NM_000038.6(APC):c.5078A>G (p.Glu1693Gly)	rs533667536
NM_000038.6(APC):c.5486A>G (p.Asn1829Ser)	rs767612847
NM_000038.6(APC):c.5723A>G (p.Asn1908Ser)	rs1064795748
NM_000038.6(APC):c.6354TGC[5] (p.Ala2122dup)	rs587780602
NM_000038.6(APC):c.6907G>A (p.Gly2303Arg)	rs544549596
NM_000038.6(APC):c.715G>C (p.Ala239Pro)	rs777760565
NM_000038.6(APC):c.719C>G (p.Thr240Arg)	rs751648064
NM_000038.6(APC):c.730-3C>T	rs786203125
NM_000038.6(APC):c.7543A>G (p.Ile2515Val)	rs554356011
NM_000038.6(APC):c.777G>T (p.Arg259=)	rs147704593

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