ClinVar Miner

Variants in gene CYP27A1 with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
164 16 24 22 7 0 8 45

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 21 18 7 1 1
likely pathogenic 18 0 3 0 0
uncertain significance 7 3 0 4 4
likely benign 1 0 4 0 4
benign 1 0 4 4 3

All variants with conflicting interpretations #

Total variants: 45
Download table as spreadsheet
HGVS dbSNP
NM_000784.3(CYP27A1):c.-6C>T rs199891090
NM_000784.3(CYP27A1):c.1016C>T (p.Thr339Met) rs121908102
NM_000784.3(CYP27A1):c.1151C>T (p.Pro384Leu) rs41272687
NM_000784.3(CYP27A1):c.1183C>A (p.Arg395Ser) rs121908096
NM_000784.3(CYP27A1):c.1184+1G>A rs587778777
NM_000784.3(CYP27A1):c.1184G>A (p.Arg395His) rs587778778
NM_000784.3(CYP27A1):c.11_20dupTGGGCTGCGC (p.Arg8Glyfs) rs886041342
NM_000784.3(CYP27A1):c.1209C>G (p.Asn403Lys) rs587778781
NM_000784.3(CYP27A1):c.1213C>T (p.Arg405Trp) rs573951598
NM_000784.3(CYP27A1):c.1214G>A (p.Arg405Gln) rs121908099
NM_000784.3(CYP27A1):c.1263+1G>A rs397515355
NM_000784.3(CYP27A1):c.1419C>T (p.Val473=) rs138596741
NM_000784.3(CYP27A1):c.1420C>T (p.Arg474Trp) rs121908098
NM_000784.3(CYP27A1):c.1421G>A (p.Arg474Gln) rs121908097
NM_000784.3(CYP27A1):c.1435C>G (p.Arg479Gly) rs72551322
NM_000784.3(CYP27A1):c.1435C>T (p.Arg479Cys) rs72551322
NM_000784.3(CYP27A1):c.1471G>T (p.Ala491Ser) rs72551323
NM_000784.3(CYP27A1):c.243G>A (p.Leu81=) rs75897848
NM_000784.3(CYP27A1):c.276C>T (p.Tyr92=) rs141519183
NM_000784.3(CYP27A1):c.379C>T (p.Arg127Trp) rs201114717
NM_000784.3(CYP27A1):c.380G>A (p.Arg127Gln) rs376230356
NM_000784.3(CYP27A1):c.409C>T (p.Arg137Trp) rs72551312
NM_000784.3(CYP27A1):c.410G>A (p.Arg137Gln) rs587778818
NM_000784.3(CYP27A1):c.434G>A (p.Gly145Glu) rs72551313
NM_000784.3(CYP27A1):c.435G>T (p.Gly145=) rs587778796
NM_000784.3(CYP27A1):c.438G>A (p.Pro146=) rs692003
NM_000784.3(CYP27A1):c.446+1G>A rs587778797
NM_000784.3(CYP27A1):c.475C>T (p.Gln159Ter) rs72551314
NM_000784.3(CYP27A1):c.526delG (p.Asp176Metfs) rs765512351
NM_000784.3(CYP27A1):c.578G>A (p.Arg193Gln) rs181649030
NM_000784.3(CYP27A1):c.666_678delCGAGAAACGCATT (p.Phe222Leufs) rs755532803
NM_000784.3(CYP27A1):c.745C>T (p.Gln249Ter) rs72551316
NM_000784.3(CYP27A1):c.776A>G (p.Lys259Arg) rs72551317
NM_000784.3(CYP27A1):c.789C>T (p.Pro263=) rs143600636
NM_000784.3(CYP27A1):c.792G>A (p.Val264=) rs144018609
NM_000784.3(CYP27A1):c.808C>T (p.Arg270Ter) rs72551318
NM_000784.3(CYP27A1):c.819delT (p.Asp273Glufs) rs587778812
NM_000784.3(CYP27A1):c.844+1G>A rs397515354
NM_000784.3(CYP27A1):c.845-1G>A rs397515353
NM_000784.3(CYP27A1):c.882G>A (p.Glu294=) rs59428328
NM_000784.3(CYP27A1):c.888A>G (p.Gln296=) rs61733619
NM_000784.3(CYP27A1):c.944_948delTGGCC (p.Leu315Glnfs) rs397515356
NM_000784.4(CYP27A1):c.1183C>T (p.Arg395Cys) rs121908096
NM_000784.4(CYP27A1):c.1185-1G>T rs587778779
NM_000784.4(CYP27A1):c.256-1G>T rs886556800

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